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Term:latanoprost free acid
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Accession:CHEBI:63925 term browser browse the term
Definition:A prostaglandin Falpha that is an analogue of prostaglandin F2alpha in which the pentyl group has been replaced by 2-phenylethyl and where the the 13,14-double bond has undergone formal hydrogenation. Its isopropyl ester prodrug, latanoprost, is used in the treatment of open-angle glaucoma and ocular hypertension.
Synonyms:exact_synonym: (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoic acid
 related_synonym: 13,14-dihydro-17-phenyl-18,19,20-trinor-PGF2alpha;   Formula=C23H34O5;   InChI=1S/C23H34O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,18-22,24-26H,2,7,10-16H2,(H,27,28)/b6-1-/t18-,19+,20+,21-,22+/m0/s1;   InChIKey=HNPFPERDNWXAGS-NFVOFSAMSA-N;   Phxa 85;   SMILES=O[C@H](CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\\C=C/CCCC(O)=O)CCc1ccccc1;   latanoprost acid
 xref: CAS:41639-83-2 "ChemIDplus";   PMID:18451496 "Europe PMC";   PMID:19084521 "Europe PMC";   PMID:19289115 "Europe PMC";   PMID:20019365 "Europe PMC";   PMID:21396362 "Europe PMC";   PMID:21788077 "Europe PMC";   PMID:21791206 "Europe PMC";   PMID:22124989 "Europe PMC";   PMID:22136089 "Europe PMC";   Reaxys:5911495 "Reaxys"

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latanoprost term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      application 19232
        pharmaceutical 19094
          drug 19094
            cardiovascular drug 7560
              antihypertensive agent 1637
                latanoprost free acid 1
                  17-phenyl-trinor-prostaglandin F2alpha 0
                  latanoprost 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      carboxylic acid 17921
                                        monocarboxylic acid 17256
                                          fatty acid 15817
                                            fatty acid derivative 1011
                                              icosanoid 451
                                                prostanoid 394
                                                  prostaglandin 389
                                                    prostaglandins F 97
                                                      prostaglandins Falpha 96
                                                        latanoprost free acid 1
                                                          17-phenyl-trinor-prostaglandin F2alpha 0
                                                          latanoprost 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.