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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:latanoprost free acid
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Accession:CHEBI:63925 term browser browse the term
Definition:A prostaglandin Falpha that is an analogue of prostaglandin F2alpha in which the pentyl group has been replaced by 2-phenylethyl and where the the 13,14-double bond has undergone formal hydrogenation. Its isopropyl ester prodrug, latanoprost, is used in the treatment of open-angle glaucoma and ocular hypertension.
Synonyms:exact_synonym: (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoic acid
 related_synonym: 13,14-dihydro-17-phenyl-18,19,20-trinor-PGF2alpha;   Formula=C23H34O5;   InChI=1S/C23H34O5/c24-18(13-12-17-8-4-3-5-9-17)14-15-20-19(21(25)16-22(20)26)10-6-1-2-7-11-23(27)28/h1,3-6,8-9,18-22,24-26H,2,7,10-16H2,(H,27,28)/b6-1-/t18-,19+,20+,21-,22+/m0/s1;   InChIKey=HNPFPERDNWXAGS-NFVOFSAMSA-N;   Phxa 85;   SMILES=O[C@H](CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\\C=C/CCCC(O)=O)CCc1ccccc1;   latanoprost acid
 xref: CAS:41639-83-2;   PMID:18451496;   PMID:19084521;   PMID:19289115;   PMID:20019365;   PMID:21396362;   PMID:21788077;   PMID:21791206;   PMID:22124989;   PMID:22136089;   Reaxys:5911495



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latanoprost term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO latanoprost results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      application 19498
        pharmaceutical 19356
          drug 19356
            cardiovascular drug 7706
              antihypertensive agent 1870
                latanoprost free acid 1
                  17-phenyl-trinor-prostaglandin F2alpha 0
                  latanoprost 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        monocarboxylic acid 17622
                                          fatty acid 16011
                                            fatty acid derivative 1059
                                              icosanoid 462
                                                prostanoid 400
                                                  prostaglandin 395
                                                    prostaglandins F 101
                                                      prostaglandins Falpha 100
                                                        latanoprost free acid 1
                                                          17-phenyl-trinor-prostaglandin F2alpha 0
                                                          latanoprost 1
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