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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:riddelliine
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Accession:CHEBI:63924 term browser browse the term
Definition:A macrodiolide that is 13,19-didehydrosenecionan bearing two additional hydroxy substituents at positions 12 and 18 as well as two additional oxo groups at positions 11 and 16.
Synonyms:exact_synonym: (15Z)-12,18-dihydroxy-13,19-didehydrosenecionan-11,16-dione
 related_synonym: 18-Hydroxyseneciphylline;   Formula=C18H23NO6;   InChI=1S/C18H23NO6/c1-3-12-8-11(2)18(23,10-20)17(22)24-9-13-4-6-19-7-5-14(15(13)19)25-16(12)21/h3-4,14-15,20,23H,2,5-10H2,1H3/b12-3-/t14-,15-,18-/m1/s1;   InChIKey=SVCNNZDUGWLODJ-RAYFHMIRSA-N;   Riddeliin;   Riddeliine;   Riddelline;   SMILES=[H][C@@]12[C@H]3CCN1CC=C2COC(=O)[C@@](O)(CO)C(=C)C\\C(=C\\C)C(=O)O3
 xref: CAS:23246-96-0;   KEGG:C10375;   KNApSAcK:C00002110
 xref_mesh: MESH:C013672
 xref: PMID:11170513;   PMID:12140173;   PMID:14580895;   PMID:18842697;   PMID:19412857;   PMID:1949039;   PMID:20078085;   PMID:20737008;   PMID:2083039;   PMID:21170807;   PMID:21822322;   PMID:21976715;   PMID:3507253;   Reaxys:1042830;   Wikipedia:Riddelliine



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riddelliine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression EXP riddelliine results in increased expression of ABCB1 mRNA; riddelliine results in increased expression of ABCB1A mRNA CTD PMID:18047722 PMID:18047727 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb9 ATP binding cassette subfamily B member 9 decreases expression EXP riddelliine results in decreased expression of ABCB9 mRNA CTD PMID:18047722 NCBI chr12:32,499,225...32,531,932
Ensembl chr12:32,499,225...32,531,931
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP riddelliine results in increased expression of ABCC3 mRNA CTD PMID:18047722 PMID:18047727 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc8 ATP binding cassette subfamily C member 8 decreases expression EXP riddelliine results in decreased expression of ABCC8 mRNA CTD PMID:18047722 PMID:18047727 NCBI chr 1:96,598,663...96,679,495
Ensembl chr 1:96,598,647...96,679,510
JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 decreases expression EXP riddelliine results in decreased expression of ABCC9 mRNA CTD PMID:18047727 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
JBrowse link
G Adm adrenomedullin decreases expression EXP riddelliine results in decreased expression of ADM mRNA CTD PMID:18047727 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Ahr aryl hydrocarbon receptor increases expression EXP riddelliine results in increased expression of AHR mRNA CTD PMID:18047727 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Anapc1 anaphase promoting complex subunit 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ANAPC1 mRNA CTD PMID:33884520 NCBI chr 3:115,850,117...115,930,259
Ensembl chr 3:115,850,185...115,930,273
JBrowse link
G Arid2 AT-rich interaction domain 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ARID2 mRNA CTD PMID:33884520 NCBI chr 7:127,447,192...127,565,987
Ensembl chr 7:127,447,278...127,563,512
JBrowse link
G Atp13a5 ATPase 13A5 decreases expression EXP riddelliine results in decreased expression of ATP13A5 mRNA CTD PMID:18047722 NCBI chr11:71,376,388...71,515,789
Ensembl chr11:71,376,422...71,515,789
JBrowse link
G Aurka aurora kinase A multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of AURKA mRNA CTD PMID:33884520 NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
JBrowse link
G Babam2 BRISC and BRCA1 A complex member 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of BABAM2 mRNA CTD PMID:33884520 NCBI chr 6:24,369,021...24,833,335
Ensembl chr 6:24,369,022...24,833,951
JBrowse link
G Bard1 BRCA1 associated RING domain 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BARD1 mRNA CTD PMID:33884520 NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265
JBrowse link
G Blm BLM RecQ like helicase multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BLM mRNA CTD PMID:33884520 NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
JBrowse link
G Bora bora, aurora kinase A activator multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BORA mRNA CTD PMID:33884520 NCBI chr15:75,797,624...75,835,599
Ensembl chr15:75,797,891...75,821,322
JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA1 mRNA CTD PMID:33884520 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Brca2 BRCA2, DNA repair associated multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA2 mRNA CTD PMID:33884520 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G Brip1 BRCA1 interacting helicase 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRIP1 mRNA CTD PMID:33884520 NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB1 mRNA CTD PMID:33884520 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnb2 cyclin B2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB2 mRNA CTD PMID:33884520 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC20 mRNA CTD PMID:33884520 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cdc23 cell division cycle 23 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC23 mRNA CTD PMID:33884520 NCBI chr18:26,236,891...26,260,611
Ensembl chr18:26,236,890...26,291,163
JBrowse link
G Cdc25a cell division cycle 25A multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25A mRNA CTD PMID:33884520 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cdc25b cell division cycle 25B multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25B mRNA CTD PMID:33884520 NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
JBrowse link
G Cdc25c cell division cycle 25C multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25C mRNA CTD PMID:33884520 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK1 mRNA CTD PMID:33884520 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK2 mRNA CTD PMID:33884520 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of CDKN1A mRNA CTD PMID:33884520 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP riddelliine results in increased expression of CES2 mRNA CTD PMID:18047722 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CHEK1 mRNA CTD PMID:33884520 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Clspn claspin multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CLSPN mRNA CTD PMID:33884520 NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases expression EXP riddelliine results in increased expression of CXCR1 mRNA CTD PMID:18047727 NCBI chr 9:75,768,124...75,771,122
Ensembl chr 9:75,766,770...75,771,084
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression EXP riddelliine results in increased expression of CYP26A1 mRNA CTD PMID:18047727 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP riddelliine results in decreased expression of CYP2C mRNA CTD PMID:18047722 PMID:18047727 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 increases expression EXP riddelliine results in increased expression of CYP2C12 mRNA CTD PMID:18047727 NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019
JBrowse link
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 decreases expression EXP riddelliine results in decreased expression of CYP2C13 mRNA CTD PMID:18047727 NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191
JBrowse link
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 decreases expression EXP riddelliine results in decreased expression of CYP2C22 mRNA CTD PMID:18047727 NCBI chr 1:238,991,698...239,031,323
Ensembl chr 1:238,991,610...239,021,738
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression EXP riddelliine results in increased expression of CYP2E1 mRNA CTD PMID:18047722 PMID:18047727 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a18 cytochrome P450, family 3, subfamily a, polypeptide 18 decreases expression EXP riddelliine results in decreased expression of CYP3A18 mRNA CTD PMID:18047727 NCBI chr12:8,880,528...8,930,382
Ensembl chr12:8,880,528...8,930,381
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression
multiple interactions
increases metabolic processing
EXP
ISO
riddelliine results in decreased expression of CYP3A2 mRNA
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ANAPC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ARID2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ATRIP mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of AURKA mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BARD1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BLM mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BORA mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRIP1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC20 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC23 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25B mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25C mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CLSPN mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F5 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F8 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ESPL1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCA mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCB mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCC mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCD2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FBXO5 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF11 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF23 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MDC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MRE11 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH6 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of NBN mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PBRM1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PHF10 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PKMYT1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK4 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of POU2F1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPM1L mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R1B mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R2A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PRC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PTTG1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD21 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBBP8 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC3 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC4 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC5 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RPA1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMARCC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMC3 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of STAG2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TLK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOP2A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOPBP1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of WEE1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of BABAM2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of CDKN1A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of GADD45A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK3 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PPP2CB mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of SMARCA2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of STAT1 mRNA
CTD PMID:18047727 PMID:33884520 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression EXP riddelliine results in increased expression of CYP3A9 mRNA CTD PMID:18047727 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 decreases expression EXP riddelliine results in decreased expression of CYP4A8 mRNA CTD PMID:18047727 NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476
JBrowse link
G E2f1 E2F transcription factor 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F1 mRNA CTD PMID:33884520 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G E2f5 E2F transcription factor 5 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F5 mRNA CTD PMID:33884520 NCBI chr 2:86,997,331...87,012,901
Ensembl chr 2:86,997,332...87,012,990
JBrowse link
G E2f8 E2F transcription factor 8 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F8 mRNA CTD PMID:33884520 NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
JBrowse link
G Egr1 early growth response 1 increases expression EXP riddelliine results in increased expression of EGR1 mRNA CTD PMID:18047727 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 decreases expression EXP riddelliine results in decreased expression of ENPP2 mRNA CTD PMID:18047727 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
JBrowse link
G Espl1 extra spindle pole bodies like 1, separase multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ESPL1 mRNA CTD PMID:33884520 NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984
JBrowse link
G F11r F11 receptor decreases expression EXP riddelliine results in decreased expression of F11R mRNA CTD PMID:18047727 NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402
JBrowse link
G F3 coagulation factor III, tissue factor decreases expression EXP riddelliine results in decreased expression of F3 mRNA CTD PMID:18047727 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G F7 coagulation factor VII increases expression EXP riddelliine results in increased expression of F7 mRNA CTD PMID:18047727 NCBI chr16:76,489,779...76,500,636
Ensembl chr16:76,489,717...76,500,610
JBrowse link
G Fanca FA complementation group A multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCA mRNA CTD PMID:33884520 NCBI chr19:51,304,021...51,362,586
Ensembl chr19:51,304,021...51,362,527
JBrowse link
G Fancb FA complementation group B multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCB mRNA CTD PMID:33884520 NCBI chr  X:29,403,771...29,420,484
Ensembl chr  X:29,403,771...29,420,192
JBrowse link
G Fancc FA complementation group C multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCC mRNA CTD PMID:33884520 NCBI chr17:1,680,660...1,822,610
Ensembl chr17:1,681,324...1,829,376
JBrowse link
G Fancd2 FA complementation group D2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCD2 mRNA CTD PMID:33884520 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
JBrowse link
G Fas Fas cell surface death receptor increases expression EXP riddelliine results in increased expression of FAS mRNA CTD PMID:18047727 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fbxo5 F-box protein 5 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FBXO5 mRNA CTD PMID:33884520 NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437
JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 increases expression EXP riddelliine results in increased expression of FMO5 mRNA CTD PMID:18047722 NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of GADD45A mRNA CTD PMID:33884520 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression EXP riddelliine results in increased expression of GSTA3 mRNA CTD PMID:18047722 PMID:18047727 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression EXP riddelliine results in decreased expression of GSTM1 mRNA CTD PMID:18047727 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP riddelliine results in decreased expression of GSTM2 mRNA CTD PMID:18047727 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G H2ax H2A.X variant histone increases phosphorylation
increases expression
EXP
ISO
riddelliine results in increased phosphorylation of H2AX protein
riddelliine results in increased expression of H2AX protein
CTD PMID:31154085 PMID:31289892 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hgf hepatocyte growth factor increases expression EXP riddelliine results in increased expression of HGF mRNA CTD PMID:18047727 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP riddelliine results in increased expression of IGFBP1 mRNA CTD PMID:18047727 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression EXP riddelliine results in increased expression of IGFBP2 mRNA CTD PMID:18047727 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Il11 interleukin 11 increases expression EXP riddelliine results in increased expression of IL11 mRNA CTD PMID:18047727 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
JBrowse link
G Il15 interleukin 15 increases expression EXP riddelliine results in increased expression of IL15 mRNA CTD PMID:18047727 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il7 interleukin 7 decreases expression EXP riddelliine results in decreased expression of IL7 mRNA CTD PMID:18047727 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression EXP riddelliine results in decreased expression of INMT mRNA CTD PMID:18047722 NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
JBrowse link
G Itga4 integrin subunit alpha 4 increases expression EXP riddelliine results in increased expression of ITGA4 mRNA CTD PMID:18047727 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
JBrowse link
G Itga6 integrin subunit alpha 6 decreases expression EXP riddelliine results in decreased expression of ITGA6 mRNA CTD PMID:18047727 NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428
JBrowse link
G Kdr kinase insert domain receptor multiple interactions
increases expression
EXP riddelliine results in increased phosphorylation of and results in increased activity of KDR protein
riddelliine results in increased expression of KDR protein
CTD PMID:12460743 PMID:15384251 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Kif11 kinesin family member 11 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF11 mRNA CTD PMID:33884520 NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
JBrowse link
G Kif23 kinesin family member 23 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF23 mRNA CTD PMID:33884520 NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072
JBrowse link
G Kras KRAS proto-oncogene, GTPase increases mutagenesis ISO riddelliine results in increased mutagenesis of KRAS gene CTD PMID:13678655 PMID:20737008 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Lepr leptin receptor increases expression EXP riddelliine results in increased expression of LEPR mRNA CTD PMID:18047727 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MDC1 mRNA CTD PMID:33884520 NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression EXP riddelliine results in decreased expression of MMP7 mRNA CTD PMID:18047727 NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MRE11 mRNA CTD PMID:33884520 NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
JBrowse link
G Msh2 mutS homolog 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH2 mRNA CTD PMID:33884520 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
JBrowse link
G Msh6 mutS homolog 6 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH6 mRNA CTD PMID:33884520 NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
JBrowse link
G Mt1 metallothionein 1 increases expression EXP riddelliine results in increased expression of MT1A mRNA CTD PMID:18047727 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases expression EXP riddelliine results in decreased expression of MTHFD2 mRNA CTD PMID:18047727 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
JBrowse link
G Nbn nibrin multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of NBN mRNA CTD PMID:33884520 NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP riddelliine results in increased expression of NQO1 mRNA CTD PMID:18047722 PMID:18047727 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pbrm1 polybromo 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PBRM1 mRNA CTD PMID:33884520 NCBI chr16:6,213,507...6,312,895
Ensembl chr16:6,213,300...6,311,780
JBrowse link
G Phf10 PHD finger protein 10 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PHF10 mRNA CTD PMID:33884520 NCBI chr 1:55,952,249...55,968,994
Ensembl chr 1:55,952,253...55,969,038
JBrowse link
G Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PKMYT1 mRNA CTD PMID:33884520 NCBI chr10:12,748,221...12,758,995
Ensembl chr10:12,748,237...12,758,995
JBrowse link
G Plk1 polo-like kinase 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK1 mRNA CTD PMID:33884520 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Plk2 polo-like kinase 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK2 mRNA CTD PMID:33884520 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
JBrowse link
G Plk3 polo-like kinase 3 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK3 mRNA CTD PMID:33884520 NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317
JBrowse link
G Plk4 polo-like kinase 4 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK4 mRNA CTD PMID:33884520 NCBI chr 2:123,802,512...123,820,942
Ensembl chr 2:123,802,512...123,820,942
JBrowse link
G Pou2f1 POU class 2 homeobox 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of POU2F1 mRNA CTD PMID:33884520 NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression EXP riddelliine results in decreased expression of PPARG mRNA CTD PMID:18047727 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppm1l protein phosphatase, Mg2+/Mn2+ dependent, 1L multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPM1L mRNA CTD PMID:33884520 NCBI chr 2:153,566,653...153,839,434
Ensembl chr 2:153,566,653...153,839,434
JBrowse link
G Ppp2cb protein phosphatase 2 catalytic subunit beta multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PPP2CB mRNA CTD PMID:33884520 NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
JBrowse link
G Ppp2r1b protein phosphatase 2 scaffold subunit A beta multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R1B mRNA CTD PMID:33884520 NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485
JBrowse link
G Ppp2r2a protein phosphatase 2, regulatory subunit B, alpha multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R2A mRNA CTD PMID:33884520 NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924
JBrowse link
G Prc1 protein regulator of cytokinesis 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PRC1 mRNA CTD PMID:33884520 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
JBrowse link
G Prkca protein kinase C, alpha increases expression EXP riddelliine results in increased expression of PRKCA mRNA CTD PMID:18047727 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcz protein kinase C, zeta increases expression EXP riddelliine results in increased expression of PRKCZ mRNA CTD PMID:18047727 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PTTG1 mRNA CTD PMID:33884520 NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
JBrowse link
G Rad1 RAD1 checkpoint DNA exonuclease multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD1 mRNA CTD PMID:33884520 NCBI chr 2:59,461,597...59,469,707
Ensembl chr 2:59,461,607...59,469,689
JBrowse link
G Rad21 RAD21 cohesin complex component multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD21 mRNA CTD PMID:33884520 NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
JBrowse link
G Rbbp8 RB binding protein 8, endonuclease multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBBP8 mRNA CTD PMID:33884520 NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846
JBrowse link
G Rbl1 RB transcriptional corepressor like 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL1 mRNA CTD PMID:33884520 NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL2 mRNA CTD PMID:33884520 NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
JBrowse link
G Ren renin increases expression EXP riddelliine results in increased expression of REN mRNA CTD PMID:18047727 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Rfc1 replication factor C subunit 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC1 mRNA CTD PMID:33884520 NCBI chr14:42,966,279...43,041,372
Ensembl chr14:42,966,324...43,041,370
JBrowse link
G Rfc2 replication factor C subunit 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC2 mRNA CTD PMID:33884520 NCBI chr12:22,120,449...22,133,576
Ensembl chr12:22,120,010...22,133,557
JBrowse link
G Rfc3 replication factor C subunit 3 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC3 mRNA CTD PMID:33884520 NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778
JBrowse link
G Rfc4 replication factor C subunit 4 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC4 mRNA CTD PMID:33884520 NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122
JBrowse link
G Rfc5 replication factor C subunit 5 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC5 mRNA CTD PMID:33884520 NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312
JBrowse link
G Rpa1 replication protein A1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RPA1 mRNA CTD PMID:33884520 NCBI chr10:60,148,869...60,199,999
Ensembl chr10:60,148,793...60,199,949
JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 decreases expression EXP riddelliine results in decreased expression of S1PR2 mRNA CTD PMID:18047727 NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574
JBrowse link
G Slc13a5 solute carrier family 13 member 5 decreases expression EXP riddelliine results in decreased expression of SLC13A5 mRNA CTD PMID:18047722 NCBI chr10:56,866,249...56,891,189
Ensembl chr10:56,866,249...56,890,945
JBrowse link
G Slc16a4 solute carrier family 16, member 4 decreases expression EXP riddelliine results in decreased expression of SLC16A4 mRNA CTD PMID:18047722 NCBI chr 2:194,911,075...194,933,162
Ensembl chr 2:194,911,236...194,933,117
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases expression EXP riddelliine results in decreased expression of SLC22A6 mRNA CTD PMID:18047722 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases expression EXP riddelliine results in decreased expression of SLC22A8 mRNA CTD PMID:18047722 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc25a21 solute carrier family 25 member 21 increases expression EXP riddelliine results in increased expression of SLC25A21 mRNA CTD PMID:18047722 NCBI chr 6:74,203,439...74,702,902
Ensembl chr 6:74,203,440...74,702,680
JBrowse link
G Slc25a30 solute carrier family 25, member 30 decreases expression EXP riddelliine results in decreased expression of SLC25A30 mRNA CTD PMID:18047722 NCBI chr15:51,076,998...51,099,613
Ensembl chr15:51,077,002...51,099,613
JBrowse link
G Slc7a5 solute carrier family 7 member 5 increases expression EXP riddelliine results in increased expression of SLC7A5 mRNA CTD PMID:18047727 NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
JBrowse link
G Smarca2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of SMARCA2 mRNA CTD PMID:33884520 NCBI chr 1:224,191,125...224,358,640
Ensembl chr 1:224,191,125...224,358,684
JBrowse link
G Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMARCC1 mRNA CTD PMID:33884520 NCBI chr 8:110,111,097...110,214,727
Ensembl chr 8:110,111,122...110,214,720
JBrowse link
G Smc3 structural maintenance of chromosomes 3 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMC3 mRNA CTD PMID:33884520 NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases expression EXP riddelliine results in increased expression of SRC mRNA CTD PMID:18047727 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Stag2 stromal antigen 2 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of STAG2 mRNA CTD PMID:33884520 NCBI chr  X:120,974,687...121,105,677
Ensembl chr  X:120,974,857...121,105,677
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of STAT1 mRNA CTD PMID:33884520 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Sult1c3 sulfotransferase family 1C member 3 decreases expression EXP riddelliine results in decreased expression of SULT1C1 mRNA CTD PMID:18047722 NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030
JBrowse link
G Tgfa transforming growth factor alpha decreases expression EXP riddelliine results in decreased expression of TGFA mRNA CTD PMID:18047727 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tlk1 tousled-like kinase 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TLK1 mRNA CTD PMID:33884520 NCBI chr 3:55,520,559...55,627,580
Ensembl chr 3:55,503,358...55,691,968
JBrowse link
G Tnf tumor necrosis factor decreases expression EXP riddelliine results in decreased expression of TNF mRNA CTD PMID:18047727 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression EXP riddelliine results in increased expression of TNFSF10 mRNA CTD PMID:18047727 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOP2A mRNA CTD PMID:33884520 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOPBP1 mRNA CTD PMID:33884520 NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674
JBrowse link
G Tp53 tumor protein p53 increases expression
increases mutagenesis
EXP
ISO
riddelliine results in increased expression of TP53 protein
riddelliine results in increased mutagenesis of TRP53 gene
CTD PMID:12460743 PMID:13678655 PMID:20737008 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Wee1 WEE1 G2 checkpoint kinase multiple interactions ISO [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of WEE1 mRNA CTD PMID:33884520 NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        aetiopathogenetic role 19022
          genotoxin 17462
            riddelliine 138
              riddelliine N-oxide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic group 18713
                              organic divalent group 18697
                                organodiyl group 18697
                                  carbonyl group 18646
                                    carbonyl compound 18646
                                      carboxylic ester 15881
                                        lactone 11255
                                          macrocyclic lactone 5560
                                            macrolide 5513
                                              macropolylide 748
                                                macrodiolide 745
                                                  riddelliine 138
                                                    riddelliine N-oxide 0
paths to the root