CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: riddelliine
Accession: CHEBI:63924
browse the term
Definition: A macrodiolide that is 13,19-didehydrosenecionan bearing two additional hydroxy substituents at positions 12 and 18 as well as two additional oxo groups at positions 11 and 16.
Synonyms: exact_synonym: (15Z)-12,18-dihydroxy-13,19-didehydrosenecionan-11,16-dione
related_synonym: 18-Hydroxyseneciphylline; Formula=C18H23NO6; InChI=1S/C18H23NO6/c1-3-12-8-11(2)18(23,10-20)17(22)24-9-13-4-6-19-7-5-14(15(13)19)25-16(12)21/h3-4,14-15,20,23H,2,5-10H2,1H3/b12-3-/t14-,15-,18-/m1/s1; InChIKey=SVCNNZDUGWLODJ-RAYFHMIRSA-N; Riddeliin; Riddeliine; Riddelline; SMILES=[H][C@@]12[C@H]3CCN1CC=C2COC(=O)[C@@](O)(CO)C(=C)C\\C(=C\\C)C(=O)O3
xref: CAS:23246-96-0; KEGG:C10375; KNApSAcK:C00002110
xref_mesh: MESH:C013672
xref: PMID:11170513; PMID:12140173; PMID:14580895; PMID:18842697; PMID:19412857; PMID:1949039; PMID:20078085; PMID:20737008; PMID:2083039; PMID:21170807; PMID:21822322; PMID:21976715; PMID:3507253; Reaxys:1042830; Wikipedia:Riddelliine
G
Abcb1a
ATP binding cassette subfamily B member 1A
increases expression
EXP
riddelliine results in increased expression of ABCB1 mRNA; riddelliine results in increased expression of ABCB1A mRNA
CTD
PMID:18047722 PMID:18047727
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Abcb9
ATP binding cassette subfamily B member 9
decreases expression
EXP
riddelliine results in decreased expression of ABCB9 mRNA
CTD
PMID:18047722
NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931
G
Abcc3
ATP binding cassette subfamily C member 3
increases expression
EXP
riddelliine results in increased expression of ABCC3 mRNA
CTD
PMID:18047722 PMID:18047727
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
G
Abcc8
ATP binding cassette subfamily C member 8
decreases expression
EXP
riddelliine results in decreased expression of ABCC8 mRNA
CTD
PMID:18047722 PMID:18047727
NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
G
Abcc9
ATP binding cassette subfamily C member 9
decreases expression
EXP
riddelliine results in decreased expression of ABCC9 mRNA
CTD
PMID:18047727
NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
G
Adm
adrenomedullin
decreases expression
EXP
riddelliine results in decreased expression of ADM mRNA
CTD
PMID:18047727
NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
G
Ahr
aryl hydrocarbon receptor
increases expression
EXP
riddelliine results in increased expression of AHR mRNA
CTD
PMID:18047727
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
Anapc1
anaphase promoting complex subunit 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ANAPC1 mRNA
CTD
PMID:33884520
NCBI chr 3:115,850,117...115,930,259
Ensembl chr 3:115,850,185...115,930,273
G
Arid2
AT-rich interaction domain 2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ARID2 mRNA
CTD
PMID:33884520
NCBI chr 7:127,447,192...127,565,987
Ensembl chr 7:127,447,278...127,563,512
G
Atp13a5
ATPase 13A5
decreases expression
EXP
riddelliine results in decreased expression of ATP13A5 mRNA
CTD
PMID:18047722
NCBI chr11:71,376,388...71,515,789
Ensembl chr11:71,376,422...71,515,789
G
Aurka
aurora kinase A
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of AURKA mRNA
CTD
PMID:33884520
NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
G
Babam2
BRISC and BRCA1 A complex member 2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of BABAM2 mRNA
CTD
PMID:33884520
NCBI chr 6:24,369,021...24,788,416
Ensembl chr 6:24,369,022...24,833,951
G
Bard1
BRCA1 associated RING domain 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BARD1 mRNA
CTD
PMID:33884520
NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265
G
Blm
BLM RecQ like helicase
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BLM mRNA
CTD
PMID:33884520
NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
G
Bora
bora, aurora kinase A activator
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BORA mRNA
CTD
PMID:33884520
NCBI chr15:75,797,624...75,835,599
Ensembl chr15:75,797,891...75,821,322
G
Brca1
BRCA1, DNA repair associated
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA1 mRNA
CTD
PMID:33884520
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
G
Brca2
BRCA2, DNA repair associated
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA2 mRNA
CTD
PMID:33884520
NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
G
Brip1
BRCA1 interacting helicase 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRIP1 mRNA
CTD
PMID:33884520
NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324
G
Ccnb1
cyclin B1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB1 mRNA
CTD
PMID:33884520
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
G
Ccnb2
cyclin B2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB2 mRNA
CTD
PMID:33884520
NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
G
Cdc20
cell division cycle 20
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC20 mRNA
CTD
PMID:33884520
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
G
Cdc23
cell division cycle 23
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC23 mRNA
CTD
PMID:33884520
NCBI chr18:26,236,891...26,260,611
Ensembl chr18:26,236,890...26,291,163
G
Cdc25a
cell division cycle 25A
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25A mRNA
CTD
PMID:33884520
NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
G
Cdc25b
cell division cycle 25B
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25B mRNA
CTD
PMID:33884520
NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
G
Cdc25c
cell division cycle 25C
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25C mRNA
CTD
PMID:33884520
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
G
Cdk1
cyclin-dependent kinase 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK1 mRNA
CTD
PMID:33884520
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
G
Cdk2
cyclin dependent kinase 2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK2 mRNA
CTD
PMID:33884520
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of CDKN1A mRNA
CTD
PMID:33884520
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
G
Ces2h
carboxylesterase 2H
increases expression
EXP
riddelliine results in increased expression of CES2 mRNA
CTD
PMID:18047722
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
G
Chek1
checkpoint kinase 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CHEK1 mRNA
CTD
PMID:33884520
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
G
Clspn
claspin
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CLSPN mRNA
CTD
PMID:33884520
NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034
G
Cxcr1
C-X-C motif chemokine receptor 1
increases expression
EXP
riddelliine results in increased expression of CXCR1 mRNA
CTD
PMID:18047727
NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084
G
Cyp26a1
cytochrome P450, family 26, subfamily a, polypeptide 1
increases expression
EXP
riddelliine results in increased expression of CYP26A1 mRNA
CTD
PMID:18047727
NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
decreases expression
EXP
riddelliine results in decreased expression of CYP2C mRNA
CTD
PMID:18047722 PMID:18047727
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
G
Cyp2c12
cytochrome P450, family 2, subfamily c, polypeptide 12
increases expression
EXP
riddelliine results in increased expression of CYP2C12 mRNA
CTD
PMID:18047727
NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019
G
Cyp2c13
cytochrome P450, family 2, subfamily c, polypeptide 13
decreases expression
EXP
riddelliine results in decreased expression of CYP2C13 mRNA
CTD
PMID:18047727
NCBI chr 1:238,786,764...238,867,195
Ensembl chr 1:238,786,765...238,867,191
G
Cyp2c22
cytochrome P450, family 2, subfamily c, polypeptide 22
decreases expression
EXP
riddelliine results in decreased expression of CYP2C22 mRNA
CTD
PMID:18047727
NCBI chr 1:238,991,698...239,031,323
Ensembl chr 1:238,991,610...239,021,738
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
EXP
riddelliine results in increased expression of CYP2E1 mRNA
CTD
PMID:18047722 PMID:18047727
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Cyp3a18
cytochrome P450, family 3, subfamily a, polypeptide 18
decreases expression
EXP
riddelliine results in decreased expression of CYP3A18 mRNA
CTD
PMID:18047727
NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases expression increases metabolic processing multiple interactions increases response to substance
EXP ISO
riddelliine results in decreased expression of CYP3A2 mRNA CYP3A4 protein results in increased metabolism of riddelliine [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ANAPC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ARID2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ATRIP mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of AURKA mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BARD1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BLM mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BORA mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRCA2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of BRIP1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CCNB2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC20 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC23 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25B mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDC25C mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CDK2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of CLSPN mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F5 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F8 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ESPL1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCA mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCB mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCC mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCD2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FBXO5 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF11 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF23 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MDC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MRE11 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH6 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of NBN mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PBRM1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PHF10 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PKMYT1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK4 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of POU2F1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPM1L mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R1B mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R2A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PRC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PTTG1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD21 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBBP8 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC3 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC4 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC5 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RPA1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMARCC1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMC3 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of STAG2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TLK1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOP2A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOPBP1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of WEE1 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of BABAM2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of CDKN1A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of GADD45A mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK3 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PPP2CB mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of SMARCA2 mRNA; [CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of STAT1 mRNA CYP3A4 protein results in increased susceptibility to riddelliine
CTD
PMID:18047727 PMID:32910235 PMID:33884520
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases expression
EXP
riddelliine results in increased expression of CYP3A9 mRNA
CTD
PMID:18047727
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
G
Cyp4a8
cytochrome P450, family 4, subfamily a, polypeptide 8
decreases expression
EXP
riddelliine results in decreased expression of CYP4A8 mRNA
CTD
PMID:18047727
NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476
G
E2f1
E2F transcription factor 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F1 mRNA
CTD
PMID:33884520
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
G
E2f5
E2F transcription factor 5
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F5 mRNA
CTD
PMID:33884520
NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990
G
E2f8
E2F transcription factor 8
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of E2F8 mRNA
CTD
PMID:33884520
NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
G
Egr1
early growth response 1
increases expression
EXP
riddelliine results in increased expression of EGR1 mRNA
CTD
PMID:18047727
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
G
Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
decreases expression
EXP
riddelliine results in decreased expression of ENPP2 mRNA
CTD
PMID:18047727
NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
G
Espl1
extra spindle pole bodies like 1, separase
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of ESPL1 mRNA
CTD
PMID:33884520
NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984
G
F11r
F11 receptor
decreases expression
EXP
riddelliine results in decreased expression of F11R mRNA
CTD
PMID:18047727
NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402
G
F3
coagulation factor III, tissue factor
decreases expression
EXP
riddelliine results in decreased expression of F3 mRNA
CTD
PMID:18047727
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
G
F7
coagulation factor VII
increases expression
EXP
riddelliine results in increased expression of F7 mRNA
CTD
PMID:18047727
NCBI chr16:76,489,775...76,500,636
Ensembl chr16:76,489,717...76,500,610
G
Fanca
FA complementation group A
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCA mRNA
CTD
PMID:33884520
NCBI chr19:51,304,126...51,362,586
Ensembl chr19:51,304,021...51,362,527
G
Fancb
FA complementation group B
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCB mRNA
CTD
PMID:33884520
NCBI chr X:29,403,771...29,420,484
Ensembl chr X:29,403,771...29,420,192
G
Fancc
FA complementation group C
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCC mRNA
CTD
PMID:33884520
NCBI chr17:1,680,660...1,822,610
Ensembl chr17:1,681,324...1,829,376
G
Fancd2
FA complementation group D2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FANCD2 mRNA
CTD
PMID:33884520
NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
G
Fas
Fas cell surface death receptor
increases expression
EXP
riddelliine results in increased expression of FAS mRNA
CTD
PMID:18047727
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Fbxo5
F-box protein 5
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of FBXO5 mRNA
CTD
PMID:33884520
NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437
G
Fmo5
flavin containing dimethylaniline monoxygenase 5
increases expression
EXP
riddelliine results in increased expression of FMO5 mRNA
CTD
PMID:18047722
NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of GADD45A mRNA
CTD
PMID:33884520
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
G
Gsta3
glutathione S-transferase alpha 3
increases expression
EXP
riddelliine results in increased expression of GSTA3 mRNA
CTD
PMID:18047722 PMID:18047727
NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
G
Gstm1
glutathione S-transferase mu 1
decreases expression
EXP
riddelliine results in decreased expression of GSTM1 mRNA
CTD
PMID:18047727
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
G
Gstm2
glutathione S-transferase mu 2
decreases expression
EXP
riddelliine results in decreased expression of GSTM2 mRNA
CTD
PMID:18047727
NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
G
H2ax
H2A.X variant histone
increases phosphorylation increases expression
EXP ISO
riddelliine results in increased phosphorylation of H2AX protein riddelliine results in increased expression of H2AX protein
CTD
PMID:31154085 PMID:31289892
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
G
Hgf
hepatocyte growth factor
increases expression
EXP
riddelliine results in increased expression of HGF mRNA
CTD
PMID:18047727
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
G
Igfbp1
insulin-like growth factor binding protein 1
increases expression
EXP
riddelliine results in increased expression of IGFBP1 mRNA
CTD
PMID:18047727
NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
G
Igfbp2
insulin-like growth factor binding protein 2
increases expression
EXP
riddelliine results in increased expression of IGFBP2 mRNA
CTD
PMID:18047727
NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
G
Il11
interleukin 11
increases expression
EXP
riddelliine results in increased expression of IL11 mRNA
CTD
PMID:18047727
NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
G
Il15
interleukin 15
increases expression
EXP
riddelliine results in increased expression of IL15 mRNA
CTD
PMID:18047727
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
G
Il7
interleukin 7
decreases expression
EXP
riddelliine results in decreased expression of IL7 mRNA
CTD
PMID:18047727
NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
G
Inmt
indolethylamine N-methyltransferase
decreases expression
EXP
riddelliine results in decreased expression of INMT mRNA
CTD
PMID:18047722
NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
G
Itga4
integrin subunit alpha 4
increases expression
EXP
riddelliine results in increased expression of ITGA4 mRNA
CTD
PMID:18047727
NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
G
Itga6
integrin subunit alpha 6
decreases expression
EXP
riddelliine results in decreased expression of ITGA6 mRNA
CTD
PMID:18047727
NCBI chr 3:56,604,512...56,689,428
Ensembl chr 3:56,617,268...56,689,428
G
Kdr
kinase insert domain receptor
multiple interactions increases expression
EXP
riddelliine results in increased phosphorylation of and results in increased activity of KDR protein riddelliine results in increased expression of KDR protein
CTD
PMID:12460743 PMID:15384251
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
G
Kif11
kinesin family member 11
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF11 mRNA
CTD
PMID:33884520
NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
G
Kif23
kinesin family member 23
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of KIF23 mRNA
CTD
PMID:33884520
NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072
G
Kras
KRAS proto-oncogene, GTPase
increases mutagenesis
ISO
riddelliine results in increased mutagenesis of KRAS gene
CTD
PMID:13678655 PMID:20737008
NCBI chr 4:178,185,418...178,218,484
G
Lepr
leptin receptor
increases expression
EXP
riddelliine results in increased expression of LEPR mRNA
CTD
PMID:18047727
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
G
Mdc1
mediator of DNA damage checkpoint 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MDC1 mRNA
CTD
PMID:33884520
NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240
G
Mmp7
matrix metallopeptidase 7
decreases expression
EXP
riddelliine results in decreased expression of MMP7 mRNA
CTD
PMID:18047727
NCBI chr 8:4,848,186...4,855,908
Ensembl chr 8:4,848,186...4,855,902
G
Mre11
MRE11 homolog, double strand break repair nuclease
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MRE11 mRNA
CTD
PMID:33884520
NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
G
Msh2
mutS homolog 2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH2 mRNA
CTD
PMID:33884520
NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
G
Msh6
mutS homolog 6
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of MSH6 mRNA
CTD
PMID:33884520
NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
G
Mt1
metallothionein 1
increases expression
EXP
riddelliine results in increased expression of MT1A mRNA
CTD
PMID:18047727
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
G
Mthfd2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
decreases expression
EXP
riddelliine results in decreased expression of MTHFD2 mRNA
CTD
PMID:18047727
NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
G
Nbn
nibrin
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of NBN mRNA
CTD
PMID:33884520
NCBI chr 5:29,459,574...29,494,152
Ensembl chr 5:29,459,457...29,494,150
G
Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
EXP
riddelliine results in increased expression of NQO1 mRNA
CTD
PMID:18047722 PMID:18047727
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
G
Pbrm1
polybromo 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PBRM1 mRNA
CTD
PMID:33884520
NCBI chr16:6,213,507...6,312,895
Ensembl chr16:6,213,300...6,311,780
G
Phf10
PHD finger protein 10
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PHF10 mRNA
CTD
PMID:33884520
NCBI chr 1:55,952,249...55,968,994
Ensembl chr 1:55,952,253...55,969,038
G
Pkmyt1
protein kinase, membrane associated tyrosine/threonine 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PKMYT1 mRNA
CTD
PMID:33884520
NCBI chr10:12,748,221...12,758,995
Ensembl chr10:12,748,237...12,758,995
G
Plk1
polo-like kinase 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK1 mRNA
CTD
PMID:33884520
NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
G
Plk2
polo-like kinase 2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK2 mRNA
CTD
PMID:33884520
NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
G
Plk3
polo-like kinase 3
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PLK3 mRNA
CTD
PMID:33884520
NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317
G
Plk4
polo-like kinase 4
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PLK4 mRNA
CTD
PMID:33884520
NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942
G
Pou2f1
POU class 2 homeobox 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of POU2F1 mRNA
CTD
PMID:33884520
NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363
G
Pparg
peroxisome proliferator-activated receptor gamma
decreases expression
EXP
riddelliine results in decreased expression of PPARG mRNA
CTD
PMID:18047727
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
G
Ppm1l
protein phosphatase, Mg2+/Mn2+ dependent, 1L
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPM1L mRNA
CTD
PMID:33884520
NCBI chr 2:153,566,653...153,839,434
Ensembl chr 2:153,566,653...153,839,434
G
Ppp2cb
protein phosphatase 2 catalytic subunit beta
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of PPP2CB mRNA
CTD
PMID:33884520
NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
G
Ppp2r1b
protein phosphatase 2 scaffold subunit A beta
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R1B mRNA
CTD
PMID:33884520
NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485
G
Ppp2r2a
protein phosphatase 2, regulatory subunit B, alpha
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PPP2R2A mRNA
CTD
PMID:33884520
NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924
G
Prc1
protein regulator of cytokinesis 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PRC1 mRNA
CTD
PMID:33884520
NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
G
Prkca
protein kinase C, alpha
increases expression
EXP
riddelliine results in increased expression of PRKCA mRNA
CTD
PMID:18047727
NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
G
Prkcz
protein kinase C, zeta
increases expression
EXP
riddelliine results in increased expression of PRKCZ mRNA
CTD
PMID:18047727
NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
G
Pttg1
PTTG1 regulator of sister chromatid separation, securin
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of PTTG1 mRNA
CTD
PMID:33884520
NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
G
Rad1
RAD1 checkpoint DNA exonuclease
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD1 mRNA
CTD
PMID:33884520
NCBI chr 2:59,461,597...59,469,707
Ensembl chr 2:59,461,607...59,469,689
G
Rad21
RAD21 cohesin complex component
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RAD21 mRNA
CTD
PMID:33884520
NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
G
Rbbp8
RB binding protein 8, endonuclease
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBBP8 mRNA
CTD
PMID:33884520
NCBI chr18:2,922,985...2,988,851
Ensembl chr18:2,921,286...2,988,846
G
Rbl1
RB transcriptional corepressor like 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL1 mRNA
CTD
PMID:33884520
NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
G
Rbl2
RB transcriptional corepressor like 2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RBL2 mRNA
CTD
PMID:33884520
NCBI chr19:15,876,852...15,923,632
Ensembl chr19:15,876,853...15,923,572
G
Ren
renin
increases expression
EXP
riddelliine results in increased expression of REN mRNA
CTD
PMID:18047727
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
G
Rfc1
replication factor C subunit 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC1 mRNA
CTD
PMID:33884520
NCBI chr14:42,966,279...43,041,372
Ensembl chr14:42,966,324...43,041,370
G
Rfc2
replication factor C subunit 2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC2 mRNA
CTD
PMID:33884520
NCBI chr12:22,120,449...22,133,576
Ensembl chr12:22,120,010...22,133,557
G
Rfc3
replication factor C subunit 3
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC3 mRNA
CTD
PMID:33884520
NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778
G
Rfc4
replication factor C subunit 4
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC4 mRNA
CTD
PMID:33884520
NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122
G
Rfc5
replication factor C subunit 5
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RFC5 mRNA
CTD
PMID:33884520
NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312
G
Rpa1
replication protein A1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of RPA1 mRNA
CTD
PMID:33884520
NCBI chr10:60,148,869...60,199,970
Ensembl chr10:60,148,793...60,199,949
G
S1pr2
sphingosine-1-phosphate receptor 2
decreases expression
EXP
riddelliine results in decreased expression of S1PR2 mRNA
CTD
PMID:18047727
NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574
G
Slc13a5
solute carrier family 13 member 5
decreases expression
EXP
riddelliine results in decreased expression of SLC13A5 mRNA
CTD
PMID:18047722
NCBI chr10:56,866,249...56,891,189
Ensembl chr10:56,866,249...56,890,945
G
Slc16a4
solute carrier family 16, member 4
decreases expression
EXP
riddelliine results in decreased expression of SLC16A4 mRNA
CTD
PMID:18047722
NCBI chr 2:194,911,075...194,933,162
Ensembl chr 2:194,911,236...194,933,117
G
Slc22a6
solute carrier family 22 member 6
decreases expression
EXP
riddelliine results in decreased expression of SLC22A6 mRNA
CTD
PMID:18047722
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
G
Slc22a8
solute carrier family 22 member 8
decreases expression
EXP
riddelliine results in decreased expression of SLC22A8 mRNA
CTD
PMID:18047722
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
G
Slc25a21
solute carrier family 25 member 21
increases expression
EXP
riddelliine results in increased expression of SLC25A21 mRNA
CTD
PMID:18047722
NCBI chr 6:74,203,439...74,702,902
Ensembl chr 6:74,203,440...74,702,680
G
Slc25a30
solute carrier family 25, member 30
decreases expression
EXP
riddelliine results in decreased expression of SLC25A30 mRNA
CTD
PMID:18047722
NCBI chr15:51,076,998...51,099,613
Ensembl chr15:51,077,002...51,099,613
G
Slc7a5
solute carrier family 7 member 5
increases expression
EXP
riddelliine results in increased expression of SLC7A5 mRNA
CTD
PMID:18047727
NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
G
Smarca2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of SMARCA2 mRNA
CTD
PMID:33884520
NCBI chr 1:224,191,125...224,358,640
Ensembl chr 1:224,191,125...224,358,684
G
Smarcc1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMARCC1 mRNA
CTD
PMID:33884520
NCBI chr 8:110,111,097...110,214,734
Ensembl chr 8:110,111,122...110,214,720
G
Smc3
structural maintenance of chromosomes 3
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of SMC3 mRNA
CTD
PMID:33884520
NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
G
Src
SRC proto-oncogene, non-receptor tyrosine kinase
increases expression
EXP
riddelliine results in increased expression of SRC mRNA
CTD
PMID:18047727
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
G
Stag2
STAG2 cohesin complex component
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of STAG2 mRNA
CTD
PMID:33884520
NCBI chr X:120,974,687...121,105,677
Ensembl chr X:120,974,857...121,105,677
G
Stat1
signal transducer and activator of transcription 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in increased expression of STAT1 mRNA
CTD
PMID:33884520
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
G
Sult1c3
sulfotransferase family 1C member 3
decreases expression
EXP
riddelliine results in decreased expression of SULT1C1 mRNA
CTD
PMID:18047722
NCBI chr 9:7,221,580...7,266,991
Ensembl chr 9:7,221,578...7,267,030
G
Tgfa
transforming growth factor alpha
decreases expression
EXP
riddelliine results in decreased expression of TGFA mRNA
CTD
PMID:18047727
NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
G
Tlk1
tousled-like kinase 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TLK1 mRNA
CTD
PMID:33884520
NCBI chr 3:55,520,559...55,627,580
Ensembl chr 3:55,503,358...55,691,968
G
Tnf
tumor necrosis factor
decreases expression
EXP
riddelliine results in decreased expression of TNF mRNA
CTD
PMID:18047727
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tnfsf10
TNF superfamily member 10
increases expression
EXP
riddelliine results in increased expression of TNFSF10 mRNA
CTD
PMID:18047727
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
G
Top2a
DNA topoisomerase II alpha
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOP2A mRNA
CTD
PMID:33884520
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
G
Topbp1
DNA topoisomerase II binding protein 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of TOPBP1 mRNA
CTD
PMID:33884520
NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674
G
Tp53
tumor protein p53
increases expression increases mutagenesis
EXP ISO
riddelliine results in increased expression of TP53 protein riddelliine results in increased mutagenesis of TRP53 gene
CTD
PMID:12460743 PMID:13678655 PMID:20737008
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Wee1
WEE1 G2 checkpoint kinase
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of riddelliine] which results in decreased expression of WEE1 mRNA
CTD
PMID:33884520
NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all