Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner
Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:artesunate
go back to main search page
Accession:CHEBI:63918 term browser browse the term
Definition:An artemisinin derivative that is the hemisuccinate ester of the lactol resulting from the reduction of the lactone carbonyl group of artemisinin. It is used, generally as the sodium salt, for the treatment of malaria.
Synonyms:exact_synonym: 4-oxo-4-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j][1,2]benzodioxepin-10-yl]oxy}butanoic acid
 related_synonym: AS;   Formula=C19H28O8;   InChI=1S/C19H28O8/c1-10-4-5-13-11(2)16(23-15(22)7-6-14(20)21)24-17-19(13)12(10)8-9-18(3,25-17)26-27-19/h10-13,16-17H,4-9H2,1-3H3,(H,20,21)/t10-,11-,12+,13+,16-,17-,18-,19-/m1/s1;   InChIKey=FIHJKUPKCHIPAT-AHIGJZGOSA-N;   SMILES=[H][C@@]12CC[C@@]3(C)OO[C@@]11[C@@]([H])(CC[C@H]2C)[C@@H](C)[C@H](OC(=O)CCC(O)=O)O[C@]1([H])O3;   artesunato;   artesunatum;   artesunic acid;   butanedioic acid, 1-[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester;   dihydroqinghasu hemsuccinate
 alt_id: MESH:C039726
 xref: CAS:182824-33-5;   CAS:88495-63-0;   Drug_Central:247;   KEGG:D02482
 xref_mesh: MESH:C039726
 xref: Reaxys:6003212;   Wikipedia:Artesunate

show annotations for term's descendants           Sort by:
 
artesunate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin, alpha 2, smooth muscle, aorta multiple interactions
decreases expression		 EXP
ISO		 Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA]		 CTD PMID:30551460 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590 		JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 affects localization ISO artesunate affects the localization of AIFM1 protein CTD PMID:24704559 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563 		JBrowse link
G Ar androgen receptor multiple interactions ISO artesunate binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:98,148,757...98,323,218
Ensembl chr  X:98,148,769...98,323,215 		JBrowse link
G Atg12 autophagy related 12 increases expression ISO Artesunate results in increased expression of ATG12 mRNA CTD PMID:30551460 NCBI chr18:46,732,417...46,741,724
Ensembl chr18:46,730,144...46,741,580 		JBrowse link
G Atg3 autophagy related 3 increases expression ISO Artesunate results in increased expression of ATG3 mRNA CTD PMID:30551460 NCBI chr16:45,158,829...45,188,538
Ensembl chr16:45,158,785...45,188,538 		JBrowse link
G Atg5 autophagy related 5 increases expression ISO Artesunate results in increased expression of ATG5 mRNA CTD PMID:30551460 NCBI chr10:44,268,322...44,364,299
Ensembl chr10:44,268,358...44,364,291 		JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions		 ISO artesunate results in increased expression of BAX protein
[1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein		 CTD PMID:24704559 PMID:29031619 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 decreases expression
multiple interactions		 ISO artesunate results in decreased expression of BCL2 protein
[1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein		 CTD PMID:24704559 PMID:29031619 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274 		JBrowse link
G Bst1 bone marrow stromal cell antigen 1 increases response to substance ISO BST1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:43,818,880...43,843,468
Ensembl chr 5:43,818,885...43,843,986 		JBrowse link
G Casp3 caspase 3 increases activity ISO artesunate results in increased activity of CASP3 protein CTD PMID:19513562 PMID:24704559 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689 		JBrowse link
G Casp9 caspase 9 affects expression ISO artesunate affects the expression of CASP9 protein CTD PMID:24704559 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976 		JBrowse link
G Cat catalase increases expression
decreases response to substance		 ISO artesunate results in increased expression of CAT protein
CAT protein results in decreased susceptibility to artesunate		 CTD PMID:19513562 PMID:20144594 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160 		JBrowse link
G Cct2 chaperonin containing Tcp1, subunit 2 (beta) decreases response to substance ISO CCT2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:117,050,997...117,063,852
Ensembl chr10:117,051,001...117,063,814 		JBrowse link
G Chek1 checkpoint kinase 1 increases phosphorylation
multiple interactions		 ISO Artesunate results in increased phosphorylation of CHEK1 protein
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein]		 CTD PMID:31664825 NCBI chr 9:36,708,482...36,726,658
Ensembl chr 9:36,708,482...36,727,065 		JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases phosphorylation		 ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein] CTD PMID:31664825 NCBI chr 5:110,839,800...110,874,140
Ensembl chr 5:110,839,979...110,874,145 		JBrowse link
G Clip4 CAP-GLY domain containing linker protein family, member 4 increases response to substance ISO CLIP4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr17:71,769,674...71,864,210
Ensembl chr17:71,768,473...71,864,273 		JBrowse link
G Coq8a coenzyme Q8A decreases response to substance ISO COQ8A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:180,165,238...180,196,020
Ensembl chr 1:180,165,238...180,199,602 		JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 multiple interactions ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein] CTD PMID:29031619 NCBI chr 9:120,933,400...120,960,507
Ensembl chr 9:120,929,216...120,960,507 		JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 affects metabolic processing ISO CYP2A6 protein affects the metabolism of Artesunate CTD PMID:12920490 NCBI chr 7:26,835,339...26,843,264
Ensembl chr 7:26,835,305...26,843,548 		JBrowse link
G Dbh dopamine beta hydroxylase increases response to substance ISO DBH mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 2:27,165,507...27,183,204
Ensembl chr 2:27,165,233...27,183,200 		JBrowse link
G Des desmin decreases expression
multiple interactions		 ISO Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA]		 CTD PMID:30551460 NCBI chr 1:75,360,292...75,368,579
Ensembl chr 1:75,360,329...75,368,579 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO artesunate binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614 		JBrowse link
G Fas Fas (TNF receptor superfamily member 6) increases expression ISO artesunate results in increased expression of FAS protein CTD PMID:19513562 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772 		JBrowse link
G Flna filamin, alpha increases response to substance ISO FLNA mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr  X:74,223,461...74,249,854
Ensembl chr  X:74,223,461...74,249,820 		JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression		 ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA]
Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein		 CTD PMID:30551460 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200 		JBrowse link
G Fth1 ferritin heavy polypeptide 1 decreases expression
multiple interactions		 ISO Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein
Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]		 CTD PMID:30551460 NCBI chr19:9,980,600...9,985,111
Ensembl chr19:9,980,598...9,985,098 		JBrowse link
G Fzd7 frizzled class receptor 7 increases response to substance ISO FZD7 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:59,482,147...59,486,955
Ensembl chr 1:59,482,424...59,486,955 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects response to substance
decreases response to substance		 ISO GCLC mRNA affects the susceptibility to artesunate
GCLC mRNA results in decreased susceptibility to artesunate		 CTD PMID:15796179 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit decreases response to substance ISO GCLM mRNA results in decreased susceptibility to artesunate CTD PMID:15796179 NCBI chr 3:122,245,487...122,267,215
Ensembl chr 3:122,245,557...122,270,732 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions
decreases activity		 EXP
ISO		 Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein]
Artesunate results in decreased activity of GPX4 protein		 CTD PMID:30551460 NCBI chr10:80,047,166...80,056,439
Ensembl chr10:80,047,166...80,056,439 		JBrowse link
G Gstm4 glutathione S-transferase, mu 4 affects response to substance ISO GSTM4 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 3:108,030,571...108,045,179
Ensembl chr 3:108,040,408...108,044,894 		JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases expression ISO artesunate results in decreased expression of GSTP1 protein CTD PMID:19513562 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985 		JBrowse link
G Gstz1 glutathione transferase zeta 1 (maleylacetoacetate isomerase) affects response to substance ISO GSTZ1 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr12:87,147,161...87,164,723
Ensembl chr12:87,147,165...87,164,723 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein] CTD PMID:27474069 PMID:30031708 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein] CTD PMID:27474069 PMID:30031708 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981 		JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) increases response to substance ISO ITGB1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 8:128,685,654...128,733,579
Ensembl chr 8:128,685,654...128,733,200 		JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 affects response to substance ISO MGST3 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 1:167,371,966...167,393,841
Ensembl chr 1:167,371,966...167,393,841 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 multiple interactions ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] CTD PMID:29031619 NCBI chr 7:135,689,784...135,716,450
Ensembl chr 7:135,689,784...135,716,361 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression		 ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein]
Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]		 CTD PMID:29031619 PMID:30551460 NCBI chr 2:164,940,326...164,955,850
Ensembl chr 2:164,940,780...164,955,850 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:27474069 NCBI chr11:87,793,784...87,804,412
Ensembl chr11:87,793,581...87,804,413 		JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase decreases response to substance ISO MTHFD2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 6:83,305,704...83,326,011
Ensembl chr 6:83,305,691...83,325,908 		JBrowse link
G Myd88 myeloid differentiation primary response gene 88 multiple interactions ISO artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein] CTD PMID:30031708 NCBI chr 9:119,335,934...119,340,018
Ensembl chr 9:119,335,934...119,341,411 		JBrowse link
G Naca nascent polypeptide-associated complex alpha polypeptide decreases response to substance ISO NACA mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:128,035,346...128,048,637
Ensembl chr10:128,035,575...128,048,637 		JBrowse link
G Nckap1 NCK-associated protein 1 increases response to substance ISO NCKAP1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 2:80,500,512...80,581,182
Ensembl chr 2:80,500,512...80,581,380 		JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions
decreases expression		 ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA]
Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein		 CTD PMID:30551460 NCBI chr14:32,159,879...32,179,855
Ensembl chr14:32,159,865...32,179,855 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 affects localization ISO artesunate affects the localization of NFE2L2 protein CTD PMID:26340163 NCBI chr 2:75,675,513...75,704,663
Ensembl chr 2:75,675,513...75,704,641 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein] CTD PMID:30031708 NCBI chr11:59,541,569...59,566,955
Ensembl chr11:59,541,568...59,566,956 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases cleavage ISO artesunate results in increased cleavage of PARP1 protein CTD PMID:24704559 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:29031619 NCBI chr 2:132,249,286...132,253,180
Ensembl chr 2:132,249,162...132,253,314 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO artesunate binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 9:8,898,900...8,968,611
Ensembl chr 9:8,899,833...8,968,611 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein CTD PMID:30551460 NCBI chr 1:150,100,031...150,108,234
Ensembl chr 1:150,100,031...150,108,227 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein] CTD PMID:27474069 PMID:30031708 NCBI chr19:5,637,442...5,648,134
Ensembl chr19:5,637,483...5,648,130 		JBrowse link
G Rpa2 replication protein A2 increases phosphorylation ISO Artesunate results in increased phosphorylation of RPA2 protein CTD PMID:31664825 NCBI chr 4:132,768,360...132,778,746
Ensembl chr 4:132,768,332...132,778,752 		JBrowse link
G Rpl41 ribosomal protein L41 decreases response to substance ISO RPL41 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:128,548,110...128,549,168
Ensembl chr10:128,548,114...128,549,305 		JBrowse link
G Rpl6 ribosomal protein L6 decreases response to substance ISO RPL6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:121,204,501...121,209,241
Ensembl chr 5:121,204,481...121,209,241 		JBrowse link
G Rpl7 ribosomal protein L7 decreases response to substance ISO RPL7 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:16,101,295...16,104,433
Ensembl chr 1:16,101,295...16,104,662 		JBrowse link
G Rps12 ribosomal protein S12 decreases response to substance ISO RPS12 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:23,785,183...23,787,383
Ensembl chr10:23,785,183...23,787,275 		JBrowse link
G Rps15a ribosomal protein S15A decreases response to substance ISO RPS15A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:118,104,374...118,116,147
Ensembl chr 7:118,104,372...118,116,188 		JBrowse link
G Rps6 ribosomal protein S6 decreases response to substance ISO RPS6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 4:86,854,099...86,857,367
Ensembl chr 4:86,854,660...86,857,412 		JBrowse link
G Slc25a19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 decreases response to substance ISO SLC25A19 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr11:115,614,165...115,628,296
Ensembl chr11:115,614,178...115,628,295 		JBrowse link
G Sp1 trans-acting transcription factor 1 decreases expression ISO artesunate results in decreased expression of SP1 protein CTD PMID:19513562 NCBI chr15:102,406,316...102,436,404
Ensembl chr15:102,406,143...102,436,404 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression
multiple interactions		 ISO Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein
Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]		 CTD PMID:30551460 NCBI chr11:50,200,152...50,210,820
Ensembl chr11:50,199,366...50,210,827 		JBrowse link
G Srsf2 serine and arginine-rich splicing factor 2 decreases response to substance ISO SRSF2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr11:116,849,897...116,853,675
Ensembl chr11:116,849,901...116,853,094 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 multiple interactions
increases expression		 ISO Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA] CTD PMID:30551460 NCBI chr  X:20,870,166...20,874,737
Ensembl chr  X:20,870,166...20,874,735 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] CTD PMID:30031708 NCBI chr 4:66,827,551...66,846,581
Ensembl chr 4:66,827,584...66,930,284 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein] CTD PMID:27474069 PMID:30031708 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007 		JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 affects response to substance ISO TPT1 protein affects the susceptibility to artesunate CTD PMID:15878303 NCBI chr14:75,845,256...75,848,303
Ensembl chr14:75,845,093...75,848,525 		JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases response to substance ISO TUFM mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:126,487,271...126,490,731
Ensembl chr 7:126,487,361...126,490,731 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein] CTD PMID:29031619 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369 		JBrowse link
G Yy1 YY1 transcription factor decreases expression ISO artesunate results in decreased expression of YY1 protein CTD PMID:19513562 NCBI chr12:108,792,945...108,820,148
Ensembl chr12:108,792,973...108,820,148 		JBrowse link
G Zbtb4 zinc finger and BTB domain containing 4 increases response to substance ISO ZBTB4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr11:69,765,912...69,784,026
Ensembl chr11:69,765,912...69,784,023 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21560
    chemical entity 21558
      atom 21546
        nonmetal atom 21426
          carbon atom 21135
            organic molecular entity 21135
              semisynthetic derivative 1624
                artesunate 71
Path 2
Term Annotations click to browse term
  CHEBI ontology 21560
    subatomic particle 21546
      composite particle 21546
        hadron 21546
          baryon 21546
            nucleon 21546
              atomic nucleus 21546
                atom 21546
                  main group element atom 21449
                    p-block element atom 21449
                      carbon group element atom 21240
                        carbon atom 21135
                          organic molecular entity 21135
                            organic group 19569
                              organic divalent group 19559
                                organodiyl group 19559
                                  carbonyl group 19540
                                    carbonyl compound 19540
                                      dicarboxylic acids and O-substituted derivatives 10536
                                        dicarboxylic acid 10526
                                          alpha,omega-dicarboxylic acid 2802
                                            succinic acid 223
                                              succinate ester 110
                                                hemisuccinate 106
                                                  artesunate 71
paths to the root