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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:latanoprost
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Accession:CHEBI:6384 term browser browse the term
Definition:A prostaglandin Falpha that is the isopropyl ester prodrug of latanoprost free acid. Used in the treatment of open-angle glaucoma and ocular hypertension.
Synonyms:exact_synonym: isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinorprost-5-en-1-oate
 related_synonym: Formula=C26H40O5;   InChI=1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3-/t21-,22+,23+,24-,25+/m0/s1;   InChIKey=GGXICVAJURFBLW-CEYXHVGTSA-N;   PhXA 41;   SMILES=CC(C)OC(=O)CCC\\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1;   Xalatan;   isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate;   latanoprostum;   propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
 xref: Beilstein:5912370;   CAS:130209-82-4;   DrugBank:DB00654;   Drug_Central:1551;   HMDB:HMDB0014792;   KEGG:D00356
 xref_mesh: MESH:C072042
 xref: PMID:21278589;   PMID:21858678;   PMID:22040280;   PMID:22049909;   PMID:22167538;   PMID:22167539;   PMID:22275814;   PMID:22275828;   PMID:22283238;   PMID:22289195;   PMID:22289196;   PMID:22320418;   PMID:22323882;   Reaxys:5912370;   Wikipedia:Latanoprost



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latanoprost term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO latanoprost results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      application 19745
        pro-agent 10144
          prodrug 9948
            latanoprost 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        monocarboxylic acid 17840
                                          fatty acid 16464
                                            fatty acid derivative 8752
                                              icosanoid 465
                                                prostanoid 402
                                                  prostaglandin 397
                                                    prostaglandins F 102
                                                      prostaglandins Falpha 101
                                                        latanoprost free acid 1
                                                          latanoprost 1
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