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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:latanoprost
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Accession:CHEBI:6384 term browser browse the term
Definition:A prostaglandin Falpha that is the isopropyl ester prodrug of latanoprost free acid. Used in the treatment of open-angle glaucoma and ocular hypertension.
Synonyms:exact_synonym: isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinorprost-5-en-1-oate
 related_synonym: Formula=C26H40O5;   InChI=1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3-/t21-,22+,23+,24-,25+/m0/s1;   InChIKey=GGXICVAJURFBLW-CEYXHVGTSA-N;   PhXA 41;   SMILES=CC(C)OC(=O)CCC\\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1;   Xalatan;   isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate;   latanoprostum;   propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
 xref: Beilstein:5912370;   CAS:130209-82-4;   DrugBank:DB00654;   Drug_Central:1551;   HMDB:HMDB0014792;   KEGG:D00356
 xref_mesh: MESH:C072042
 xref: PMID:21278589;   PMID:21858678;   PMID:22040280;   PMID:22049909;   PMID:22167538;   PMID:22167539;   PMID:22275814;   PMID:22275828;   PMID:22283238;   PMID:22289195;   PMID:22289196;   PMID:22320418;   PMID:22323882;   Reaxys:5912370;   Wikipedia:Latanoprost



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latanoprost term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO latanoprost results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      application 19486
        pro-agent 10100
          prodrug 9904
            latanoprost 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      carboxylic acid 18376
                                        monocarboxylic acid 17639
                                          fatty acid 16011
                                            fatty acid derivative 1044
                                              icosanoid 457
                                                prostanoid 397
                                                  prostaglandin 392
                                                    prostaglandins F 101
                                                      prostaglandins Falpha 100
                                                        latanoprost free acid 1
                                                          latanoprost 1
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