Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:latanoprost
go back to main search page
Accession:CHEBI:6384 term browser browse the term
Definition:A prostaglandin Falpha that is the isopropyl ester prodrug of latanoprost free acid. Used in the treatment of open-angle glaucoma and ocular hypertension.
Synonyms:exact_synonym: isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinorprost-5-en-1-oate
 related_synonym: Formula=C26H40O5;   InChI=1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3-/t21-,22+,23+,24-,25+/m0/s1;   InChIKey=GGXICVAJURFBLW-CEYXHVGTSA-N;   PhXA 41;   SMILES=CC(C)OC(=O)CCC\\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1;   Xalatan;   isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate;   latanoprostum;   propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
 xref: Beilstein:5912370;   CAS:130209-82-4;   DrugBank:DB00654;   Drug_Central:1551;   HMDB:HMDB0014792;   KEGG:D00356
 xref_mesh: MESH:C072042
 xref: PMID:21278589;   PMID:21858678;   PMID:22040280;   PMID:22049909;   PMID:22167538;   PMID:22167539;   PMID:22275814;   PMID:22275828;   PMID:22283238;   PMID:22289195;   PMID:22289196;   PMID:22320418;   PMID:22323882;   Reaxys:5912370;   Wikipedia:Latanoprost



show annotations for term's descendants           Sort by:
latanoprost term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO latanoprost results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19863
    role 19835
      application 19677
        pro-agent 11550
          prodrug 11311
            latanoprost 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19863
    subatomic particle 19861
      composite particle 19861
        hadron 19861
          baryon 19861
            nucleon 19861
              atomic nucleus 19861
                atom 19861
                  main group element atom 19807
                    p-block element atom 19807
                      carbon group element atom 19748
                        carbon atom 19744
                          organic molecular entity 19744
                            heteroorganic entity 19498
                              organochalcogen compound 19259
                                organooxygen compound 19175
                                  carbon oxoacid 18642
                                    carboxylic acid 18639
                                      monocarboxylic acid 18012
                                        fatty acid 16842
                                          fatty acid derivative 8979
                                            icosanoid 471
                                              prostanoid 407
                                                prostaglandin 399
                                                  prostaglandins F 102
                                                    prostaglandins Falpha 101
                                                      latanoprost free acid 1
                                                        latanoprost 1
paths to the root