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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bromosulfophthalein
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Accession:CHEBI:63836 term browser browse the term
Definition:An organosulfonic acid that consists of phthalide bearing four bromo substituents at positions 4, 5, 6 and 7 as well as two 4-hydroxy-3-sulfophenyl groups both located at position 1.
Synonyms:exact_synonym: 3,3'-(4,5,6,7-tetrabromo-3-oxo-1,3-dihydro-2-benzofuran-1,1-diyl)bis(6-hydroxybenzenesulfonic acid)
 related_synonym: 4,5,6,7-tetrabromo-3',3''-disulfophenolphthalein;   Formula=C20H10Br4O10S2;   InChI=1S/C20H10Br4O10S2/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33/h1-6,25-26H,(H,28,29,30)(H,31,32,33);   InChIKey=OHTXTCNTQJFRIG-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1S(O)(=O)=O)C1(OC(=O)c2c(Br)c(Br)c(Br)c(Br)c12)c1ccc(O)c(c1)S(O)(=O)=O;   Sulphobromophthalein
 xref: CAS:297-83-6;   Drug_Central:2531;   KEGG:C11363;   KEGG:D08548
 xref_mesh: MESH:D013448
 xref: PDBeChem:BSP;   Reaxys:380936
 cyclic_relationship: is_conjugate_acid_of CHEBI:63832


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bromosulfophthalein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 affects transport EXP ABCB4 protein affects the transport of Sulfobromophthalein CTD PMID:15304119 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export ISO ABCC2 protein affects the export of Sulfobromophthalein CTD PMID:16046661 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Cck cholecystokinin multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of CCK protein modified form] CTD PMID:25106415 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
affects binding
ISO
EXP
Sulfobromophthalein binds to and affects the folding of and affects the activity of GSTA1 protein
Sulfobromophthalein binds to [GSTA1 protein co-treated with GSTA1 protein]; Sulfobromophthalein binds to [GSTA3 protein co-treated with GSTA1 protein]
Sulfobromophthalein binds to GSTA1 protein
CTD PMID:3783048 PMID:9826190 PMID:15147239 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 decreases activity
multiple interactions
EXP Sulfobromophthalein results in decreased activity of GSTA3 protein
Sulfobromophthalein binds to [GSTA3 protein co-treated with GSTA1 protein]
CTD PMID:3783048 PMID:8968379 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases activity EXP Sulfobromophthalein results in decreased activity of GSTM2 protein CTD PMID:8968379 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Hgf hepatocyte growth factor multiple interactions EXP Sulfobromophthalein inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:18031729 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Ifng interferon gamma multiple interactions ISO Sulfobromophthalein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Sulfobromophthalein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases glutathionylation
decreases transport
ISO KEAP1 protein results in decreased glutathionylation of Sulfobromophthalein
KEAP1 protein results in decreased transport of Sulfobromophthalein
CTD PMID:19246623 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects abundance
increases transport
increases glutathionylation
ISO NFE2L2 protein affects the abundance of Sulfobromophthalein
NFE2L2 protein results in increased transport of Sulfobromophthalein
NFE2L2 protein results in increased glutathionylation of Sulfobromophthalein
CTD PMID:19246623 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC10A1 protein results in increased uptake of Taurocholic Acid] CTD PMID:25106415 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:68,725,365...68,848,572
Ensembl chr  X:68,723,261...68,848,771
JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity
EXP Sulfobromophthalein inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
Sulfobromophthalein results in decreased activity of SLC19A1 protein
CTD PMID:14612385 NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:11602689 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] CTD PMID:12065749 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP Sulfobromophthalein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] CTD PMID:10224140 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
decreases activity
ISO
EXP
Sulfobromophthalein inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]
Sulfobromophthalein results in decreased activity of SLC46A1 protein
CTD PMID:17475902 PMID:18174275 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin] CTD PMID:24947867 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 affects import
increases import
increases response to substance
increases uptake
multiple interactions
ISO SLCO1B3 protein affects the import of Sulfobromophthalein
SLCO1B3 protein results in increased import of Sulfobromophthalein
SLCO1B3 protein results in increased susceptibility to Sulfobromophthalein
SLCO1B3 protein results in increased uptake of Sulfobromophthalein
Apigenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Budesonide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Clarithromycin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; kaempferol inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Pioglitazone affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Quercetin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Rutin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased import of cyanoginosin LR]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of (5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of CCK protein modified form]
CTD PMID:16046661 PMID:17369605 PMID:20171238 PMID:21430235 PMID:21661758 More... NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 affects import
decreases activity
multiple interactions
increases uptake
ISO SLCO2B1 protein affects the import of Sulfobromophthalein
Sulfobromophthalein results in decreased activity of SLCO2B1 protein
Budesonide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Cyclosporine inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Pioglitazone affects the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Pravastatin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]
CTD PMID:16046661 PMID:21430235 PMID:23121773 PMID:25106415 PMID:27450509 More... NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
JBrowse link

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  CHEBI ontology 19812
    role 19761
      application 19471
        dye 1313
          bromosulfophthalein 21
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic ester 15889
                                        lactone 11245
                                          gamma-lactone 6749
                                            2-benzofuran-1(3H)-one 93
                                              bromosulfophthalein 21
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