Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:bromosulfophthalein
go back to main search page
Accession:CHEBI:63836 term browser browse the term
Definition:An organosulfonic acid that consists of phthalide bearing four bromo substituents at positions 4, 5, 6 and 7 as well as two 4-hydroxy-3-sulfophenyl groups both located at position 1.
Synonyms:exact_synonym: 3,3'-(4,5,6,7-tetrabromo-3-oxo-1,3-dihydro-2-benzofuran-1,1-diyl)bis(6-hydroxybenzenesulfonic acid)
 related_synonym: 4,5,6,7-tetrabromo-3',3''-disulfophenolphthalein;   Formula=C20H10Br4O10S2;   InChI=1S/C20H10Br4O10S2/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33/h1-6,25-26H,(H,28,29,30)(H,31,32,33);   InChIKey=OHTXTCNTQJFRIG-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1S(O)(=O)=O)C1(OC(=O)c2c(Br)c(Br)c(Br)c(Br)c12)c1ccc(O)c(c1)S(O)(=O)=O;   Sulphobromophthalein
 xref: CAS:297-83-6;   Drug_Central:2531;   KEGG:C11363;   KEGG:D08548
 xref_mesh: MESH:D013448
 xref: PDBeChem:BSP;   Reaxys:380936
 cyclic_relationship: is_conjugate_acid_of CHEBI:63832


show annotations for term's descendants           Sort by:
 
bromosulfophthalein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 affects transport EXP ABCB4 protein affects the transport of Sulfobromophthalein CTD PMID:15304119 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export ISO ABCC2 protein affects the export of Sulfobromophthalein CTD PMID:16046661 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Cck cholecystokinin multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of CCK protein modified form] CTD PMID:25106415 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions
affects binding
ISO
EXP
Sulfobromophthalein binds to and affects the folding of and affects the activity of GSTA1 protein
Sulfobromophthalein binds to [GSTA1 protein co-treated with GSTA1 protein]; Sulfobromophthalein binds to [GSTA3 protein co-treated with GSTA1 protein]
Sulfobromophthalein binds to GSTA1 protein
CTD PMID:3783048, PMID:9826190, PMID:15147239 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 multiple interactions
decreases activity
EXP Sulfobromophthalein binds to [GSTA3 protein co-treated with GSTA1 protein]
Sulfobromophthalein results in decreased activity of GSTA3 protein
CTD PMID:3783048, PMID:8968379 NCBI chr 9:27,357,490...27,417,023
Ensembl chr 9:27,402,381...27,417,023
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases activity EXP Sulfobromophthalein results in decreased activity of GSTM2 protein CTD PMID:8968379 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Hgf hepatocyte growth factor multiple interactions EXP Sulfobromophthalein inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:18031729 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Ifng interferon gamma multiple interactions ISO Sulfobromophthalein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Sulfobromophthalein inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of IL12B protein] CTD PMID:11907163 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases glutathionylation
decreases transport
ISO KEAP1 protein results in decreased glutathionylation of Sulfobromophthalein
KEAP1 protein results in decreased transport of Sulfobromophthalein
CTD PMID:19246623 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects abundance
increases transport
increases glutathionylation
ISO NFE2L2 protein affects the abundance of Sulfobromophthalein
NFE2L2 protein results in increased transport of Sulfobromophthalein
NFE2L2 protein results in increased glutathionylation of Sulfobromophthalein
CTD PMID:19246623 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC10A1 protein results in increased uptake of Taurocholic Acid] CTD PMID:25106415 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:74,578,600...74,706,068
Ensembl chr  X:74,577,131...74,706,214
JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity
EXP Sulfobromophthalein inhibits the reaction [SLC19A1 protein affects the transport of Methotrexate]
Sulfobromophthalein results in decreased activity of SLC19A1 protein
CTD PMID:14612385 NCBI chr20:12,334,675...12,354,517
Ensembl chr20:12,334,676...12,352,377
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:11602689 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates] CTD PMID:12065749 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP Sulfobromophthalein inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] CTD PMID:10224140 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc46a1 solute carrier family 46 member 1 multiple interactions
decreases activity
ISO
EXP
Sulfobromophthalein inhibits the reaction [SLC46A1 protein results in increased transport of Folic Acid]
Sulfobromophthalein results in decreased activity of SLC46A1 protein
CTD PMID:17475902, PMID:18174275 NCBI chr10:65,728,508...65,741,708
Ensembl chr10:65,733,991...65,740,828
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO Sulfobromophthalein inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin] CTD PMID:24947867 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 affects import
increases import
increases response to substance
increases uptake
multiple interactions
ISO SLCO1B3 protein affects the import of Sulfobromophthalein
SLCO1B3 protein results in increased import of Sulfobromophthalein
SLCO1B3 protein results in increased susceptibility to Sulfobromophthalein
SLCO1B3 protein results in increased uptake of Sulfobromophthalein
Apigenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Budesonide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Clarithromycin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Cyclosporine inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; glimepiride affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; kaempferol inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Pioglitazone affects the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Quercetin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein]; Rutin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased import of cyanoginosin LR]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to cyanoginosin LR]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased susceptibility to Okadaic Acid]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of (5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-yl)isoxazol-5-yl)-2H-tetrazol-2-yl)acetic acid]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Sulfobromophthalein inhibits the reaction [SLCO1B3 protein results in increased uptake of CCK protein modified form]
CTD PMID:16046661, PMID:17369605, PMID:20171238, PMID:21430235, PMID:21661758, PMID:22394605, PMID:23121773, PMID:25106415, PMID:26134461 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 affects import
decreases activity
multiple interactions
increases uptake
ISO SLCO2B1 protein affects the import of Sulfobromophthalein
Sulfobromophthalein results in decreased activity of SLCO2B1 protein
Budesonide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Cyclosporine inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; glimepiride inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Pioglitazone affects the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Pravastatin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Rifampin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased import of estrone sulfate]; Sulfobromophthalein inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]
CTD PMID:16046661, PMID:21430235, PMID:23121773, PMID:25106415, PMID:27450509, PMID:31364238 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        dye 1296
          bromosulfophthalein 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic ester 14073
                                        lactone 5978
                                          gamma-lactone 1214
                                            2-benzofuran-1(3H)-one 91
                                              bromosulfophthalein 20
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.