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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-hydroxyphenytoin
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Accession:CHEBI:63804 term browser browse the term
Definition:A imidazolidine-2,4-dione that consists of hydantoin bearing phenyl and 4-hydroxyphenyl substituents at position 5.
Synonyms:exact_synonym: 5-(4-hydroxyphenyl)-5-phenylimidazolidine-2,4-dione
 related_synonym: (Hydroxyphenyl)phenylhydantoin;   (p-Hydroxyphenyl)phenylhydantoin;   4-Hydroxydiphenylhydantoin;   5-(4'-Hydroxyphenyl)-5-phenylhydantoin;   5-(p-Hydroxyphenyl)-5-phenylhydantoin;   Formula=C15H12N2O3;   Hydroxydiphenylhydantoin;   Hydroxyphenytoin;   InChI=1S/C15H12N2O3/c18-12-8-6-11(7-9-12)15(10-4-2-1-3-5-10)13(19)16-14(20)17-15/h1-9,18H,(H2,16,17,19,20);   InChIKey=XEEDURHPFVXALT-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1)C1(NC(=O)NC1=O)c1ccccc1;   p-Hydroxydiphenylhydantoin;   p-Hydroxyphenytoin;   para-Hydroxyphenytoin
 xref: CAS:2784-27-2
 xref_mesh: MESH:C001419
 xref: PMID:1298726;   PMID:20664118;   PMID:4008572;   PMID:4049465;   PMID:6619238;   PMID:6716263;   PMID:6740735;   PMID:6874875;   PMID:7333696;   PMID:9444669;   Reaxys:89178


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4-hydroxyphenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO UGT1A1 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions ISO UGT1A4 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO UGT1A6 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:95,241,609...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO UGT1A9 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19816
    role 19764
      biological role 19764
        biochemical role 19313
          metabolite 19294
            4-hydroxyphenytoin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteromonocyclic compound 16469
                                    diazolidine 587
                                      imidazolidines 577
                                        imidazolidinone 478
                                          imidazolidine-2,4-dione 457
                                            hydantoin 411
                                              4-hydroxyphenytoin 4
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