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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-hydroxyphenytoin
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Accession:CHEBI:63804 term browser browse the term
Definition:A imidazolidine-2,4-dione that consists of hydantoin bearing phenyl and 4-hydroxyphenyl substituents at position 5.
Synonyms:exact_synonym: 5-(4-hydroxyphenyl)-5-phenylimidazolidine-2,4-dione
 related_synonym: (Hydroxyphenyl)phenylhydantoin;   (p-Hydroxyphenyl)phenylhydantoin;   4-Hydroxydiphenylhydantoin;   5-(4'-Hydroxyphenyl)-5-phenylhydantoin;   5-(p-Hydroxyphenyl)-5-phenylhydantoin;   Formula=C15H12N2O3;   Hydroxydiphenylhydantoin;   Hydroxyphenytoin;   InChI=1S/C15H12N2O3/c18-12-8-6-11(7-9-12)15(10-4-2-1-3-5-10)13(19)16-14(20)17-15/h1-9,18H,(H2,16,17,19,20);   InChIKey=XEEDURHPFVXALT-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1)C1(NC(=O)NC1=O)c1ccccc1;   p-Hydroxydiphenylhydantoin;   p-Hydroxyphenytoin;   para-Hydroxyphenytoin
 xref: CAS:2784-27-2
 xref_mesh: MESH:C001419
 xref: PMID:1298726;   PMID:20664118;   PMID:4008572;   PMID:4049465;   PMID:6619238;   PMID:6716263;   PMID:6740735;   PMID:6874875;   PMID:7333696;   PMID:9444669;   Reaxys:89178


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4-hydroxyphenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO UGT1A1 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions ISO UGT1A4 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:88,762,250...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO UGT1A6 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO UGT1A9 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:88,696,981...88,808,465 JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        biochemical role 19389
          metabolite 19364
            4-hydroxyphenytoin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  organic heteromonocyclic compound 17084
                                    diazolidine 985
                                      imidazolidines 976
                                        imidazolidinone 611
                                          imidazolidine-2,4-dione 476
                                            hydantoin 412
                                              4-hydroxyphenytoin 4
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