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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-hydroxyphenytoin
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Accession:CHEBI:63804 term browser browse the term
Definition:A imidazolidine-2,4-dione that consists of hydantoin bearing phenyl and 4-hydroxyphenyl substituents at position 5.
Synonyms:exact_synonym: 5-(4-hydroxyphenyl)-5-phenylimidazolidine-2,4-dione
 related_synonym: (Hydroxyphenyl)phenylhydantoin;   (p-Hydroxyphenyl)phenylhydantoin;   4-Hydroxydiphenylhydantoin;   5-(4'-Hydroxyphenyl)-5-phenylhydantoin;   5-(p-Hydroxyphenyl)-5-phenylhydantoin;   Formula=C15H12N2O3;   Hydroxydiphenylhydantoin;   Hydroxyphenytoin;   InChI=1S/C15H12N2O3/c18-12-8-6-11(7-9-12)15(10-4-2-1-3-5-10)13(19)16-14(20)17-15/h1-9,18H,(H2,16,17,19,20);   InChIKey=XEEDURHPFVXALT-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1)C1(NC(=O)NC1=O)c1ccccc1;   p-Hydroxydiphenylhydantoin;   p-Hydroxyphenytoin;   para-Hydroxyphenytoin
 xref: CAS:2784-27-2
 xref_mesh: MESH:C001419
 xref: PMID:1298726;   PMID:20664118;   PMID:4008572;   PMID:4049465;   PMID:6619238;   PMID:6716263;   PMID:6740735;   PMID:6874875;   PMID:7333696;   PMID:9444669;   Reaxys:89178



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4-hydroxyphenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO UGT1A1 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions ISO UGT1A4 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 multiple interactions ISO UGT1A6 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:88,747,229...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 multiple interactions ISO UGT1A9 protein results in increased glucuronidation of and results in decreased activity of hydroxyphenytoin CTD PMID:15855726 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19659
    role 19634
      biological role 19633
        biochemical role 19388
          metabolite 19333
            4-hydroxyphenytoin 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19659
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19700
                atom 19658
                  main group element atom 19607
                    p-block element atom 19607
                      carbon group element atom 19550
                        carbon atom 19547
                          organic molecular entity 19588
                            organic molecule 19506
                              organic cyclic compound 19324
                                organic heterocyclic compound 18682
                                  organic heteromonocyclic compound 17501
                                    diazolidine 996
                                      imidazolidines 987
                                        imidazolidinone 610
                                          imidazolidine-2,4-dione 477
                                            hydantoin 412
                                              4-hydroxyphenytoin 4
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