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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lenalidomide
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Accession:CHEBI:63791 term browser browse the term
Definition:A dicarboximide that consists of 1-oxoisoindoline bearing an amino substituent at position 4 and a 2,6-dioxopiperidin-3-yl group at position 2. Inhibits the secretion of TNF-alpha.
Synonyms:exact_synonym: 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
 related_synonym: 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline;   3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione;   Formula=C13H13N3O3;   InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18);   InChIKey=GOTYRUGSSMKFNF-UHFFFAOYSA-N;   Revlimid;   SMILES=Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O
 xref: CAS:191732-72-6;   DrugBank:DB00480;   Drug_Central:3317;   KEGG:D04687;   LINCS:LSM-6187
 xref_mesh: MESH:C467567
 xref: PMID:21533608;   PMID:21823830;   PMID:21835953;   PMID:22001752;   PMID:22066855;   PMID:22107129;   PMID:22143062;   PMID:22211836;   PMID:22241792;   PMID:22245427;   PMID:22245805;   PMID:22245806;   PMID:22246035;   PMID:22253550;   PMID:22261445;   Reaxys:8335210;   Wikipedia:Lenalidomide


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lenalidomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP1 caspase 1 multiple interactions ISO Lenalidomide inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein] CTD PMID:30660605 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CRBN cereblon multiple interactions
affects binding
increases response to substance		 EXP lenalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]
lenalidomide binds to [CRBN protein binds to DDB1 protein]; lenalidomide binds to [SALL4 protein binds to CRBN protein]
CRBN results in increased susceptibility to lenalidomide		 CTD PMID:25043012 PMID:25108355 PMID:26186254 PMID:30067223 NCBI chr 3:3,149,633...3,179,717
Ensembl chr 3:3,144,628...3,179,727 		JBrowse link
G CSNK1A1 casein kinase 1 alpha 1 multiple interactions EXP lenalidomide results in increased degradation of and results in decreased expression of CSNK1A1 protein CTD PMID:30067223 NCBI chr 5:149,492,982...149,551,439
Ensembl chr 5:149,492,982...149,551,471 		JBrowse link
G DDB1 damage specific DNA binding protein 1 affects binding EXP lenalidomide binds to [CRBN protein binds to DDB1 protein] CTD PMID:25108355 NCBI chr11:61,299,451...61,333,105
Ensembl chr11:61,299,451...61,342,596 		JBrowse link
G F2R coagulation factor II thrombin receptor decreases expression EXP lenalidomide results in decreased expression of F2R mRNA; lenalidomide results in decreased expression of F2R protein CTD PMID:15618473 NCBI chr 5:76,716,126...76,735,770
Ensembl chr 5:76,716,126...76,735,770 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions EXP [Dexamethasone co-treated with Lenalidomide co-treated with Bortezomib] results in increased expression of F3 mRNA; [Dexamethasone co-treated with Lenalidomide co-treated with Bortezomib] results in increased expression of F3 protein; [Dexamethasone co-treated with Lenalidomide] results in increased expression of F3 mRNA; [Dexamethasone co-treated with Lenalidomide] results in increased expression of F3 protein CTD PMID:23696885 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759 		JBrowse link
G FAM83F family with sequence similarity 83 member F multiple interactions EXP lenalidomide results in increased degradation of and results in decreased expression of FAM83F protein CTD PMID:30067223 NCBI chr22:39,994,954...40,043,534
Ensembl chr22:39,994,954...40,043,534 		JBrowse link
G FASLG Fas ligand multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA] CTD PMID:16510725 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 affects expression EXP Lenalidomide affects the expression of FGFR1 mRNA CTD PMID:30834740 NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834 		JBrowse link
G FGFR2 fibroblast growth factor receptor 2 decreases expression EXP Lenalidomide results in decreased expression of FGFR2 mRNA; Lenalidomide results in decreased expression of FGFR2 protein CTD PMID:30834740 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,332...121,598,458 		JBrowse link
G FGFR3 fibroblast growth factor receptor 3 decreases expression EXP Lenalidomide results in decreased expression of FGFR3 mRNA CTD PMID:30834740 NCBI chr 4:1,793,293...1,808,867
Ensembl chr 4:1,793,293...1,808,872 		JBrowse link
G IL12B interleukin 12B multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA] CTD PMID:16510725 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL1A interleukin 1 alpha multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL1A mRNA] CTD PMID:16510725 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1B interleukin 1 beta multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL1B mRNA]
Lenalidomide inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]		 CTD PMID:16510725 PMID:30660605 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL1R1 interleukin 1 receptor type 1 decreases expression EXP lenalidomide results in decreased expression of IL1R1 mRNA CTD PMID:15618473 NCBI chr 2:102,070,390...102,179,874
Ensembl chr 2:102,064,544...102,179,874 		JBrowse link
G IL1RN interleukin 1 receptor antagonist multiple interactions ISO lenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA] CTD PMID:16510725 NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016 		JBrowse link
G IL2 interleukin 2 multiple interactions EXP lenalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein] CTD PMID:16241859 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer decreases expression EXP lenalidomide results in decreased expression of IL6ST mRNA CTD PMID:15618473 NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022 		JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO Lenalidomide inhibits the reaction [Arsenic Trioxide inhibits the reaction [[Glucose co-treated with Lipopolysaccharides] results in increased secretion of INS1 protein]] CTD PMID:30660605 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209 		JBrowse link
G MEIS2 Meis homeobox 2 multiple interactions EXP lenalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein] CTD PMID:25043012 NCBI chr15:36,889,204...37,101,311
Ensembl chr15:36,889,204...37,101,299 		JBrowse link
G RAB28 RAB28, member RAS oncogene family multiple interactions EXP lenalidomide results in increased degradation of and results in decreased expression of RAB28 protein CTD PMID:30067223 NCBI chr 4:13,367,724...13,484,340
Ensembl chr 4:13,361,354...13,484,365 		JBrowse link
G SALL4 spalt like transcription factor 4 multiple interactions
affects binding		 EXP lenalidomide results in increased degradation of and results in decreased expression of SALL4 protein
lenalidomide binds to [SALL4 protein binds to CRBN protein]		 CTD PMID:30067223 NCBI chr20:51,782,331...51,802,521
Ensembl chr20:51,782,331...51,802,521 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA]; lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA]; lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL1A mRNA]; lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL1B mRNA]; lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]; lenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA]; lenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA] CTD PMID:16510725 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G TEK TEK receptor tyrosine kinase decreases expression EXP lenalidomide results in decreased expression of TEK mRNA CTD PMID:15618473 NCBI chr 9:27,109,141...27,230,178
Ensembl chr 9:27,109,141...27,230,174 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO lenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA] CTD PMID:16510725 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 decreases expression EXP lenalidomide results in decreased expression of TGFBR1 mRNA; lenalidomide results in decreased expression of TGFBR1 protein CTD PMID:15618473 NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]
Lenalidomide inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of TNF protein]		 CTD PMID:16510725 PMID:30660605 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A decreases expression EXP lenalidomide results in decreased expression of TNFRSF1A mRNA CTD PMID:15618473 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B decreases expression EXP lenalidomide results in decreased expression of TNFRSF1B mRNA CTD PMID:15618473 NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,991...12,209,228 		JBrowse link
G ZNF827 zinc finger protein 827 multiple interactions EXP lenalidomide results in increased degradation of and results in decreased expression of ZNF827 protein CTD PMID:30067223 NCBI chr 4:145,757,627...145,938,823
Ensembl chr 4:145,757,627...145,938,823 		JBrowse link
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  CHEBI ontology 26034
    role 25961
      biological role 25929
        immunomodulator 16304
          lenalidomide 30
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            organic molecule 25222
                              organic cyclic compound 24274
                                organic heterocyclic compound 22328
                                  organic heteropolycyclic compound 21329
                                    organic heterobicyclic compound 18570
                                      benzopyrrole 10281
                                        isoindoles 1165
                                          lenalidomide 30
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