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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lenalidomide
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Accession:CHEBI:63791 term browser browse the term
Definition:A dicarboximide that consists of 1-oxoisoindoline bearing an amino substituent at position 4 and a 2,6-dioxopiperidin-3-yl group at position 2. Inhibits the secretion of TNF-alpha.
Synonyms:exact_synonym: 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
 related_synonym: 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline;   3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione;   Formula=C13H13N3O3;   InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18);   InChIKey=GOTYRUGSSMKFNF-UHFFFAOYSA-N;   Revlimid;   SMILES=Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O
 xref: CAS:191732-72-6;   DrugBank:DB00480;   Drug_Central:3317;   KEGG:D04687;   LINCS:LSM-6187
 xref_mesh: MESH:C467567
 xref: PMID:21533608;   PMID:21823830;   PMID:21835953;   PMID:22001752;   PMID:22066855;   PMID:22107129;   PMID:22143062;   PMID:22211836;   PMID:22241792;   PMID:22245427;   PMID:22245805;   PMID:22245806;   PMID:22246035;   PMID:22253550;   PMID:22261445;   Reaxys:8335210;   Wikipedia:Lenalidomide


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lenalidomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 multiple interactions EXP Lenalidomide inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein] CTD PMID:30660605 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Crbn cereblon multiple interactions
increases response to substance
affects binding
ISO lenalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]
CRBN results in increased susceptibility to lenalidomide
lenalidomide binds to [CRBN protein binds to DDB1 protein]; lenalidomide binds to [SALL4 protein binds to CRBN protein]
CTD PMID:25043012, PMID:25108355, PMID:26186254, PMID:30067223 NCBI chr 4:138,864,910...138,885,786
Ensembl chr 4:138,866,761...138,885,556
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 multiple interactions ISO lenalidomide results in increased degradation of and results in decreased expression of CSNK1A1 protein CTD PMID:30067223 NCBI chr18:56,887,722...56,910,610
Ensembl chr18:56,887,354...56,918,345
JBrowse link
G Ddb1 damage-specific DNA binding protein 1 affects binding ISO lenalidomide binds to [CRBN protein binds to DDB1 protein] CTD PMID:25108355 NCBI chr 1:226,657,561...226,683,356
Ensembl chr 1:226,657,561...226,683,347
JBrowse link
G F2r coagulation factor II (thrombin) receptor decreases expression ISO lenalidomide results in decreased expression of F2R mRNA; lenalidomide results in decreased expression of F2R protein CTD PMID:15618473 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO [Dexamethasone co-treated with Lenalidomide co-treated with Bortezomib] results in increased expression of F3 mRNA; [Dexamethasone co-treated with Lenalidomide co-treated with Bortezomib] results in increased expression of F3 protein; [Dexamethasone co-treated with Lenalidomide] results in increased expression of F3 mRNA; [Dexamethasone co-treated with Lenalidomide] results in increased expression of F3 protein CTD PMID:23696885 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Fam83f family with sequence similarity 83, member F multiple interactions ISO lenalidomide results in increased degradation of and results in decreased expression of FAM83F protein CTD PMID:30067223 NCBI chr 7:121,889,157...121,918,772
Ensembl chr 7:121,889,157...121,918,772
JBrowse link
G Faslg Fas ligand multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA] CTD PMID:16510725 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects expression ISO Lenalidomide affects the expression of FGFR1 mRNA CTD PMID:30834740 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO Lenalidomide results in decreased expression of FGFR2 mRNA; Lenalidomide results in decreased expression of FGFR2 protein CTD PMID:30834740 NCBI chr 1:200,590,951...200,696,946
Ensembl chr 1:200,590,953...200,696,928
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases expression ISO Lenalidomide results in decreased expression of FGFR3 mRNA CTD PMID:30834740 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Il12b interleukin 12B multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA] CTD PMID:16510725 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL1A mRNA] CTD PMID:16510725 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL1B mRNA]
Lenalidomide inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]
CTD PMID:16510725, PMID:30660605 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO lenalidomide results in decreased expression of IL1R1 mRNA CTD PMID:15618473 NCBI chr 9:46,962,291...47,038,139
Ensembl chr 9:46,962,288...47,036,670
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO lenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA] CTD PMID:16510725 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il2 interleukin 2 multiple interactions ISO lenalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein] CTD PMID:16241859 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6st interleukin 6 signal transducer decreases expression ISO lenalidomide results in decreased expression of IL6ST mRNA CTD PMID:15618473 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Meis2 Meis homeobox 2 multiple interactions ISO lenalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein] CTD PMID:25043012 NCBI chr 3:107,560,172...107,762,732
Ensembl chr 3:107,559,997...107,760,589
JBrowse link
G Rab28 RAB28, member RAS oncogene family multiple interactions ISO lenalidomide results in increased degradation of and results in decreased expression of RAB28 protein CTD PMID:30067223 NCBI chr14:73,888,968...73,963,209
Ensembl chr14:73,889,213...73,963,202
JBrowse link
G Sall4 spalt-like transcription factor 4 affects binding
multiple interactions
ISO lenalidomide binds to [SALL4 protein binds to CRBN protein]
lenalidomide results in increased degradation of and results in decreased expression of SALL4 protein
CTD PMID:30067223 NCBI chr 3:165,520,155...165,538,176
Ensembl chr 3:165,520,392...165,537,940
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA]; lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA]; lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL1A mRNA]; lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL1B mRNA]; lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]; lenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA]; lenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA] CTD PMID:16510725 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Tek TEK receptor tyrosine kinase decreases expression ISO lenalidomide results in decreased expression of TEK mRNA CTD PMID:15618473 NCBI chr 5:113,725,717...113,852,799
Ensembl chr 5:113,725,717...113,852,799
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO lenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA] CTD PMID:16510725 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression ISO lenalidomide results in decreased expression of TGFBR1 mRNA; lenalidomide results in decreased expression of TGFBR1 protein CTD PMID:15618473 NCBI chr 5:63,056,071...63,119,635
Ensembl chr 5:63,050,758...63,119,635
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]
Lenalidomide inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of TNF protein]
CTD PMID:16510725, PMID:30660605 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression ISO lenalidomide results in decreased expression of TNFRSF1A mRNA CTD PMID:15618473 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B decreases expression ISO lenalidomide results in decreased expression of TNFRSF1B mRNA CTD PMID:15618473 NCBI chr 5:163,136,390...163,167,299
Ensembl chr 5:163,136,390...163,167,299
JBrowse link
G Zfp827 zinc finger protein 827 multiple interactions ISO lenalidomide results in increased degradation of and results in decreased expression of ZNF827 protein CTD PMID:30067223 NCBI chr19:32,396,155...32,616,648
Ensembl chr19:32,401,661...32,528,965
JBrowse link

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  CHEBI ontology 19787
    role 19734
      biological role 19734
        immunomodulator 13691
          lenalidomide 29
Path 2
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  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  organic heteropolycyclic compound 17824
                                    organic heterobicyclic compound 16744
                                      benzopyrrole 9340
                                        isoindoles 544
                                          lenalidomide 29
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.