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ONTOLOGY REPORT - ANNOTATIONS


Term:lenalidomide
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Accession:CHEBI:63791 term browser browse the term
Definition:A dicarboximide that consists of 1-oxoisoindoline bearing an amino substituent at position 4 and a 2,6-dioxopiperidin-3-yl group at position 2. Inhibits the secretion of TNF-alpha.
Synonyms:exact_synonym: 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
 related_synonym: 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline;   3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione;   Formula=C13H13N3O3;   InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18);   InChIKey=GOTYRUGSSMKFNF-UHFFFAOYSA-N;   Revlimid;   SMILES=Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O
 xref: CAS:191732-72-6 "ChemIDplus";   DrugBank:DB00480;   Drug_Central:3317 "DrugCentral";   KEGG:D04687;   LINCS:LSM-6187
 xref_mesh: MESH:C467567
 xref: PMID:21533608 "Europe PMC";   PMID:21823830 "Europe PMC";   PMID:21835953 "Europe PMC";   PMID:22001752 "Europe PMC";   PMID:22066855 "Europe PMC";   PMID:22107129 "Europe PMC";   PMID:22143062 "Europe PMC";   PMID:22211836 "Europe PMC";   PMID:22241792 "Europe PMC";   PMID:22245427 "Europe PMC";   PMID:22245805 "Europe PMC";   PMID:22245806 "Europe PMC";   PMID:22246035 "Europe PMC";   PMID:22253550 "Europe PMC";   PMID:22261445 "Europe PMC";   Reaxys:8335210 "Reaxys";   Wikipedia:Lenalidomide


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lenalidomide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:6480464
G Crbn cereblon JBrowse link 4 138,864,910 138,885,786 RGD:6480464
G Csnk1a1 casein kinase 1, alpha 1 JBrowse link 18 56,887,722 56,910,610 RGD:6480464
G Ddb1 damage-specific DNA binding protein 1 JBrowse link 1 226,657,561 226,683,356 RGD:6480464
G F2r coagulation factor II (thrombin) receptor JBrowse link 2 26,118,760 26,135,340 RGD:6480464
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:6480464
G Fam83f family with sequence similarity 83, member F JBrowse link 7 121,889,157 121,918,772 RGD:6480464
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:6480464
G Fgfr1 Fibroblast growth factor receptor 1 JBrowse link 16 71,265,390 71,319,046 RGD:6480464
G Fgfr2 fibroblast growth factor receptor 2 JBrowse link 1 200,590,951 200,696,946 RGD:6480464
G Fgfr3 fibroblast growth factor receptor 3 JBrowse link 14 82,272,322 82,287,739 RGD:6480464
G Il12b interleukin 12B JBrowse link 10 30,034,447 30,048,774 RGD:6480464
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il1r1 interleukin 1 receptor type 1 JBrowse link 9 46,962,291 47,038,139 RGD:6480464
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:6480464
G Il2 interleukin 2 JBrowse link 2 123,847,150 123,851,854 RGD:6480464
G Il6st interleukin 6 signal transducer JBrowse link 2 44,279,199 44,319,427 RGD:6480464
G Meis2 Meis homeobox 2 JBrowse link 3 107,560,172 107,762,732 RGD:6480464
G Rab28 RAB28, member RAS oncogene family JBrowse link 14 73,888,968 73,963,209 RGD:6480464
G Sall4 spalt-like transcription factor 4 JBrowse link 3 165,520,155 165,538,176 RGD:6480464
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:6480464
G Tek TEK receptor tyrosine kinase JBrowse link 5 113,725,717 113,852,799 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tgfbr1 transforming growth factor, beta receptor 1 JBrowse link 5 63,056,071 63,119,635 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:6480464
G Tnfrsf1b TNF receptor superfamily member 1B JBrowse link 5 163,136,390 163,167,299 RGD:6480464
G Zfp827 zinc finger protein 827 JBrowse link 19 32,396,155 32,616,648 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        immunomodulator 12645
          lenalidomide 29
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic molecule 19337
                              organic cyclic compound 19089
                                organic heterocyclic compound 18164
                                  organic heteropolycyclic compound 17427
                                    organic heterobicyclic compound 15905
                                      benzopyrrole 5756
                                        isoindoles 508
                                          lenalidomide 29
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.