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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lenalidomide
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Accession:CHEBI:63791 term browser browse the term
Definition:A dicarboximide that consists of 1-oxoisoindoline bearing an amino substituent at position 4 and a 2,6-dioxopiperidin-3-yl group at position 2. Inhibits the secretion of TNF-alpha.
Synonyms:exact_synonym: 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione
 related_synonym: 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline;   3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione;   Formula=C13H13N3O3;   InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18);   InChIKey=GOTYRUGSSMKFNF-UHFFFAOYSA-N;   Revlimid;   SMILES=Nc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O
 xref: CAS:191732-72-6;   DrugBank:DB00480;   Drug_Central:3317;   KEGG:D04687;   LINCS:LSM-6187
 xref_mesh: MESH:C467567
 xref: PMID:21533608;   PMID:21823830;   PMID:21835953;   PMID:22001752;   PMID:22066855;   PMID:22107129;   PMID:22143062;   PMID:22211836;   PMID:22241792;   PMID:22245427;   PMID:22245805;   PMID:22245806;   PMID:22246035;   PMID:22253550;   PMID:22261445;   Reaxys:8335210;   Wikipedia:Lenalidomide


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lenalidomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 multiple interactions EXP Lenalidomide inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein] CTD PMID:30660605 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Crbn cereblon multiple interactions
increases response to substance
affects binding
ISO lenalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]
CRBN results in increased susceptibility to lenalidomide
lenalidomide binds to [CRBN protein binds to DDB1 protein]; lenalidomide binds to [SALL4 protein binds to CRBN protein]
CTD PMID:25043012 PMID:25108355 PMID:26186254 PMID:30067223 NCBI chr 4:139,701,154...139,719,949
Ensembl chr 4:139,701,094...139,719,938
JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 multiple interactions ISO lenalidomide results in increased degradation of and results in decreased expression of CSNK1A1 protein CTD PMID:30067223 NCBI chr18:55,017,049...55,050,184
Ensembl chr18:55,017,055...55,049,271
JBrowse link
G Ddb1 damage-specific DNA binding protein 1 affects binding ISO lenalidomide binds to [CRBN protein binds to DDB1 protein] CTD PMID:25108355 NCBI chr 1:207,252,890...207,278,685
Ensembl chr 1:207,252,890...207,278,676
JBrowse link
G F2r coagulation factor II (thrombin) receptor decreases expression ISO lenalidomide results in decreased expression of F2R mRNA; lenalidomide results in decreased expression of F2R protein CTD PMID:15618473 NCBI chr 2:26,869,343...26,885,856
Ensembl chr 2:26,868,404...26,885,870
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO [Dexamethasone co-treated with Lenalidomide co-treated with Bortezomib] results in increased expression of F3 mRNA; [Dexamethasone co-treated with Lenalidomide co-treated with Bortezomib] results in increased expression of F3 protein; [Dexamethasone co-treated with Lenalidomide] results in increased expression of F3 mRNA; [Dexamethasone co-treated with Lenalidomide] results in increased expression of F3 protein CTD PMID:23696885 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fam83f family with sequence similarity 83, member F multiple interactions ISO lenalidomide results in increased degradation of and results in decreased expression of FAM83F protein CTD PMID:30067223 NCBI chr 7:112,211,164...112,240,454
Ensembl chr 7:112,211,164...112,240,452
JBrowse link
G Faslg Fas ligand multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA] CTD PMID:16510725 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 affects expression ISO Lenalidomide affects the expression of FGFR1 mRNA CTD PMID:30834740 NCBI chr16:66,492,445...66,546,731
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO Lenalidomide results in decreased expression of FGFR2 mRNA; Lenalidomide results in decreased expression of FGFR2 protein CTD PMID:30834740 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases expression ISO Lenalidomide results in decreased expression of FGFR3 mRNA CTD PMID:30834740 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
JBrowse link
G Il12b interleukin 12B multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA] CTD PMID:16510725 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL1A mRNA] CTD PMID:16510725 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL1B mRNA]
Lenalidomide inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]
CTD PMID:16510725 PMID:30660605 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1r1 interleukin 1 receptor type 1 decreases expression ISO lenalidomide results in decreased expression of IL1R1 mRNA CTD PMID:15618473 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions ISO lenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA] CTD PMID:16510725 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il2 interleukin 2 multiple interactions ISO lenalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein] CTD PMID:16241859 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6st interleukin 6 cytokine family signal transducer decreases expression ISO lenalidomide results in decreased expression of IL6ST mRNA CTD PMID:15618473 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
JBrowse link
G Meis2 Meis homeobox 2 multiple interactions ISO lenalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein] CTD PMID:25043012 NCBI chr 3:102,742,905...102,944,833
Ensembl chr 3:102,742,900...102,949,696
JBrowse link
G Rab28 RAB28, member RAS oncogene family multiple interactions ISO lenalidomide results in increased degradation of and results in decreased expression of RAB28 protein CTD PMID:30067223 NCBI chr14:69,245,846...69,322,968
Ensembl chr14:69,245,854...69,322,967
JBrowse link
G Sall4 spalt-like transcription factor 4 affects binding
multiple interactions
ISO lenalidomide binds to [SALL4 protein binds to CRBN protein]
lenalidomide results in increased degradation of and results in decreased expression of SALL4 protein
CTD PMID:30067223 NCBI chr 3:157,474,067...157,491,055
Ensembl chr 3:157,474,642...157,490,822
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA]; lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA]; lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL1A mRNA]; lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL1B mRNA]; lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]; lenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA]; lenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA] CTD PMID:16510725 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Tek TEK receptor tyrosine kinase decreases expression ISO lenalidomide results in decreased expression of TEK mRNA CTD PMID:15618473 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO lenalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA] CTD PMID:16510725 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 decreases expression ISO lenalidomide results in decreased expression of TGFBR1 mRNA; lenalidomide results in decreased expression of TGFBR1 protein CTD PMID:15618473 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
lenalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]
Lenalidomide inhibits the reaction [[Arsenic Trioxide co-treated with Lipopolysaccharides] results in increased expression of TNF protein]
CTD PMID:16510725 PMID:30660605 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A decreases expression ISO lenalidomide results in decreased expression of TNFRSF1A mRNA CTD PMID:15618473 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B decreases expression ISO lenalidomide results in decreased expression of TNFRSF1B mRNA CTD PMID:15618473 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Zfp827 zinc finger protein 827 multiple interactions ISO lenalidomide results in increased degradation of and results in decreased expression of ZNF827 protein CTD PMID:30067223 NCBI chr19:28,720,568...28,887,381
Ensembl chr19:28,721,021...28,887,191
JBrowse link

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  CHEBI ontology 19812
    role 19761
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        immunomodulator 14903
          lenalidomide 29
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organic heteropolycyclic compound 18059
                                    organic heterobicyclic compound 16869
                                      benzopyrrole 9559
                                        isoindoles 1127
                                          lenalidomide 29
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