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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1,1-diol
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Accession:CHEBI:63732 term browser browse the term
Definition:Any alcohol in which two hydroxy groups are bonded to the same atom.
Synonyms:related_synonym: 1,1-diols;   gem-diol;   gem-diols;   geminal diol;   geminal diols



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chloral hydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2 family member multiple interactions ISO
EXP
[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in decreased metabolism of Nitroglycerin
[Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyceraldehyde; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to glycolaldehyde; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Glyoxal; [Chloral Hydrate results in decreased activity of ALDH2 protein] which results in increased susceptibility to Pyruvaldehyde
CTD PMID:18272654 PMID:21334317 PMID:21376711 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions EXP Chloral Hydrate inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA] CTD PMID:7513451 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 multiple interactions EXP Chloral Hydrate inhibits the reaction [Phenobarbital results in increased expression of CYP2B2 mRNA] CTD PMID:7513451 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases chemical synthesis
multiple interactions
EXP CYP2E1 protein results in increased chemical synthesis of Chloral Hydrate
[CYP2E1 protein results in increased metabolism of Trichloroethylene] which results in increased chemical synthesis of Chloral Hydrate
CTD PMID:1739413 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Chloral Hydrate inhibits the reaction [Cocaine results in increased expression of FOS protein] CTD PMID:15219685 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 multiple interactions ISO Chloral Hydrate inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of GABBR1 protein] CTD PMID:10683198 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions ISO Chloral Hydrate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:37,096,995...37,230,030
Ensembl chr14:37,097,279...37,228,944
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO Chloral Hydrate promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein binds to GABRB1 protein]] CTD PMID:10683198 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948
JBrowse link
G Gast gastrin multiple interactions EXP Chloral Hydrate inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:10864877 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
JBrowse link
G Gja1 gap junction protein, alpha 1 decreases expression
increases expression
EXP Chloral Hydrate results in decreased expression of GJA1 mRNA; Chloral Hydrate results in decreased expression of GJA1 protein
Chloral Hydrate results in increased expression of GJA1 protein
CTD PMID:21243523 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gjb2 gap junction protein, beta 2 decreases expression
increases expression
EXP Chloral Hydrate results in decreased expression of GJB2 mRNA
Chloral Hydrate results in increased expression of GJB2 protein
CTD PMID:21243523 NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177
JBrowse link
G Glra1 glycine receptor, alpha 1 multiple interactions ISO Chloral Hydrate promotes the reaction [Glycine Agents results in increased activity of GLRA1 protein] CTD PMID:10683198 NCBI chr10:39,625,853...39,727,897
Ensembl chr10:39,629,459...39,727,162
JBrowse link
G Hmox1 heme oxygenase 1 affects expression EXP Chloral Hydrate affects the expression of HMOX1 mRNA CTD PMID:22954530 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP Chloral Hydrate results in increased expression of IL1B mRNA
Ozone inhibits the reaction [Chloral Hydrate results in increased expression of IL1B mRNA]
CTD PMID:15207037 PMID:15207038 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 increases expression EXP Chloral Hydrate results in increased expression of IL6 mRNA CTD PMID:15207037 PMID:15207038 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO Chloral Hydrate inhibits the reaction [SLC2A1 protein results in increased transport of Glucose] CTD PMID:18455367 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
neosaxitoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor multiple interactions ISO neosaxitoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; neosaxitoxin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] CTD PMID:32471037 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
saxitoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects activity
ISO [Thioctic Acid co-treated with Saxitoxin] affects the activity of ABCB1 protein
Saxitoxin affects the activity of ABCB1 protein
CTD PMID:29128272 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    chemical entity 20049
      molecular entity 20047
        polyatomic entity 19974
          heteroatomic molecular entity 19913
            hydroxides 19375
              organic hydroxy compound 18890
                alcohol 15177
                  1,1-diol 18
                    aldehyde hydrate + 16
                    dihydroxymalonic acid 0
                    ketone hydrate + 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      p-block molecular entity 19948
                        chalcogen molecular entity 19673
                          oxygen molecular entity 19644
                            hydroxides 19375
                              organic hydroxy compound 18890
                                alcohol 15177
                                  1,1-diol 18
                                    aldehyde hydrate + 16
                                    dihydroxymalonic acid 0
                                    ketone hydrate + 2
paths to the root