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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:neuroprotective agent
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Accession:CHEBI:63726 term browser browse the term
Definition:Any compound that can be used for the treatment of neurodegenerative disorders.
Synonyms:related_synonym: neuroprotectant;   neuroprotectants;   neuroprotective agents


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cilostazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression EXP Cilostazol results in decreased expression of MYC mRNA CTD PMID:19545562 NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309 		JBrowse link
melittin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions
increases secretion		 EXP G(M1) Ganglioside inhibits the reaction [Melitten results in increased secretion of HEXB protein]; sialogangliosides inhibits the reaction [Melitten results in increased secretion of HEXB protein]; trisialoganglioside GT1 inhibits the reaction [Melitten results in increased secretion of HEXB protein] CTD PMID:21334356 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417 		JBrowse link
nicotinamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARG peroxisome proliferator activated receptor gamma increases expression
multiple interactions		 EXP Niacinamide results in increased expression of PPARG protein
Resveratrol inhibits the reaction [Niacinamide results in increased expression of PPARG protein]		 CTD PMID:22539994 NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981 		JBrowse link
G RUNX2 RUNX family transcription factor 2 increases acetylation
multiple interactions
decreases expression		 EXP Niacinamide results in increased acetylation of RUNX2 protein
Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide results in increased acetylation of RUNX2 protein]		 CTD PMID:22539994 NCBI chr12:13,723,535...13,842,565
Ensembl chr12:13,628,539...13,840,785
Ensembl chr12:13,628,539...13,840,785 		JBrowse link
G SIRT1 sirtuin 1 decreases expression
multiple interactions		 EXP Niacinamide results in decreased expression of SIRT1 protein
Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of SIRT1 protein]		 CTD PMID:22539994 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279 		JBrowse link
rifampicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression EXP Rifampin results in increased expression of ABCB1 mRNA; Rifampin results in increased expression of ABCB1 protein CTD PMID:22620706 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Rifampin results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
valproic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPNE6 copine 6 decreases activity EXP Valproic Acid results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
WIN 55212-2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNR2 cannabinoid receptor 2 affects binding EXP (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone binds to CNR2 protein CTD PMID:21871882 NCBI chr 2:75,640,636...75,662,000
Ensembl chr 2:75,658,999...75,660,126 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 494
    role 501
      application 452
        pharmaceutical 453
          drug 446
            protective agent 196
              neuroprotective agent 9
                (+)-SKF-10,047 0
                (+)-schisandrin B 0
                (+)-sesamin + 0
                (-)-N(6)-(2-phenylisopropyl)adenosine 0
                (-)-epigallocatechin 3-gallate + 0
                (25R)-cholest-5-ene-3beta,26-diol + 0
                (3R,4S,1'R)-3-(1'-hydroxyethyl)-4-methyldihydrofuran-2(3H)-one 0
                (E,E)-germacrone 0
                (R,R)-5,11-diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol 0
                1-hydroxy-5-phenyl-3-pentanone 0
                1-isothiocyanato-6-(methylsulfanyl)hexane 0
                3-hydroxymethyl-4-methyl-furan-2(5H)-one 0
                4-amino-TEMPO + 0
                4-hydroxy-TEMPO + 0
                5,5-dimethyl-1-pyrroline N-oxide 0
                5-methoxytryptamine + 0
                6alpha-methylprednisolone + 0
                7-chlorokynurenic acid 0
                7-ketocholesterol 0
                7beta-hydroxyepiandrosterone 0
                AMN082 dihydrochloride 0
                CDP-choline 0
                CGP-42112A 0
                CORM 3 0
                Delta(9)-tetrahydrocannabinolic acid 0
                Glu-Asp-Arg 0
                KU-55933 0
                L-2-aminopentanoic acid 0
                L-779976 0
                L-817818 0
                LY 379268 0
                N(5)-ethyl-L-glutamine 0
                N,N'-bis(diphenylmethyl)ethane-1,2-diamine 0
                N-[2-(4-phenoxybenzyl)benzimidazol-5-yl]methanesulfonamide 0
                N-\{2-[(4-benzylpiperidin-1-yl)methyl]benzimidazol-5-yl\}methanesulfonamide 0
                N-arachidonoyl-L-serine 0
                N-benzylhexadecanamide 0
                N-palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]-Cys-Ser-Lys-Lys-Lys-Lys 0
                N-tert-butyl(3,5,6-trimethylpyrazin-2-yl)methanimine N-oxide 0
                NNC 55-0396 (free base) + 0
                NNC 55-0396 dihydrochloride 0
                PJ34 0
                PJ34 hydrochloride 0
                Ro 25-6981 0
                Ro 25-6981 maleate 0
                S-methyl-L-thiocitrulline 0
                SB 203580 0
                SB 415286 0
                SL-327 0
                SU4312 0
                TDZD-8 0
                Trolox 0
                WIN 55212-2 1
                Z-DEVD-FMK 0
                acteoside 0
                ajugaciliatin B 0
                ajugamarin A1 chlorohydrin 0
                ajugamarin A2 chlorohydrin 0
                akebia saponin D 0
                albiflorin + 0
                alliin + 0
                alliin zwitterion 0
                alpha-tocotrienol 0
                amburoside A 0
                anacardic acid 0
                ananolignan F 0
                ananolignan L 0
                apelin-12 0
                apelin-13 0
                arachidonyl-2'-chloroethylamide 0
                argon(0) 0
                aspernigrin B 0
                aspirin-triggered protectin D1 0
                astragaloside IV 0
                astressin 0
                auraptene 0
                baicalin 0
                bis(7)-tacrine 0
                bis-(4-hydroxybenzyl)sulfide 0
                cannabigerol 0
                carnosine + 0
                choline alfoscerate 0
                cilostazol 1
                creatine + 0
                curcumin + 0
                cyanidin cation + 0
                cycloheximide 0
                dantrolene 0
                dihydrolipoic acid + 0
                dimethyloxalylglycine 0
                dizocilpine 0
                dizocilpine maleate 0
                ebselen 0
                eliprodil 0
                etazolate 0
                ethoxyquin 0
                ethylisopropylamiloride 0
                fangchinoline 0
                fasudil 0
                fasudil hydrochloride + 0
                fasudil hydrochloride hydrate 0
                felbamate 0
                ferrostatin-1 + 0
                flavalin A 0
                flavalin B 0
                fucoxanthin 0
                galgravin 0
                ginkgolide B 0
                ginsenoside Rb1 0
                ginsenoside Rb3 0
                ginsenoside Rd + 0
                ginsenoside Re 0
                ginsenoside Rg1 0
                glycoursodeoxycholic acid 0
                gossypin 0
                hinokiflavone 0
                huperzine A 0
                hydroxysafflor yellow A 0
                ilomastat 0
                indirubin-3'-monoxime 0
                interiotherin C 0
                jaspamide 0
                juglanin A 0
                ketone body + 0
                kynurenic acid + 0
                lanthionine ketimine 0
                leucettine L41 0
                liraglutide 0
                lixisenatide 0
                loganin + 0
                maysin 0
                meldonium 0
                melittin 1
                memantine 0
                memantine hydrochloride 0
                menaquinone-4 + 0
                methanol extract of Sorbus alnifolia 0
                methyl 3,4-dihydroxybenzoate 0
                methylene blue 0
                methylparaben 0
                michigazone 0
                midafotel 0
                morin 0
                necrosulfonamide 0
                neriifolin + 0
                nerolidol + 0
                nicotinamide + 3
                notoginsenoside R1 0
                oleocanthal 0
                oleuropein aglycone 0
                p-Glu-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe 0
                paliperidone 0
                paliperidone palmitate 0
                palmitoyl ethanolamide 0
                phenethyl caffeate 0
                pinocembrin + 0
                protectin D1 + 0
                pterostilbene 0
                pyrrolidine dithiocarbamate 0
                rasagiline 0
                rifampicin + 2
                rivastigmine 0
                rivastigmine tartrate 0
                rubimaillin 0
                salvianolic acid B 0
                salvigenin 0
                semaglutide 0
                sodium phenylbutyrate 0
                sunitinib + 0
                taltirelin + 0
                tauroursodeoxycholic acid 0
                tenocyclidine 0
                teprenone 0
                tetrahydroxycurcumin 0
                tetramethylpyrazine 0
                tideglusib 0
                trans-rhaponticin + 0
                tropisetron 0
                tropisetron hydrochloride 0
                uridine triacetate 0
                valproic acid + 1
                xyloketal B 0
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