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ONTOLOGY REPORT - ANNOTATIONS


Term:tenofovir disoproxil fumarate
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Accession:CHEBI:63718 term browser browse the term
Definition:A fumarate salt prepared from equimolar amounts of tenofovir disoproxil and fumaric acid. It is used in combination therapy for the treatment of HIV infection.
Synonyms:exact_synonym: bis({[(propan-2-yloxy)carbonyl]oxy}methyl) ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonate (2E)-but-2-enedioate
 related_synonym: 9-((R)-2-((bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine fumarate;   Formula=C23H34N5O14P;   InChI=1S/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t14-;/m1./s1;   InChIKey=VCMJCVGFSROFHV-WZGZYPNHSA-N;   SMILES=OC(=O)\\C=C\\C(O)=O.CC(C)OC(=O)OCOP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)OCOC(=O)OC(C)C;   TDF;   Viread;   tenofovir DF
 alt_id: MESH:D000068698
 xref: CAS:202138-50-9 "ChemIDplus";   DrugBank:DB00300;   KEGG:D01982
 xref_mesh: MESH:D000068698
 xref: PMID:12064015 "Europe PMC";   PMID:15482138 "Europe PMC";   PMID:15669881 "Europe PMC";   PMID:18434949 "Europe PMC";   PMID:19372836 "Europe PMC";   PMID:22077579 "Europe PMC";   PMID:22210639 "Europe PMC";   PMID:22928893 "Europe PMC";   PMID:23466649 "Europe PMC";   Reaxys:9831556 "Reaxys";   Wikipedia:Tenofovir


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tenofovir disoproxil fumarate term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:6480464
G Acacb acetyl-CoA carboxylase beta JBrowse link 12 48,127,149 48,238,969 RGD:6480464
G Bnip3l BCL2 interacting protein 3 like JBrowse link 15 43,643,897 43,667,123 RGD:6480464
G Ccl20 C-C motif chemokine ligand 20 JBrowse link 9 88,918,359 88,921,017 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha JBrowse link 6 102,048,372 102,073,041 RGD:6480464
G Havcr1 hepatitis A virus cellular receptor 1 JBrowse link 10 31,813,819 31,860,934 RGD:6480464
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 JBrowse link 13 111,946,626 111,996,536 RGD:6480464
G Hspd1 heat shock protein family D (Hsp60) member 1 JBrowse link 9 61,680,529 61,691,202 RGD:6480464
G Lipe lipase E, hormone sensitive type JBrowse link 1 82,248,031 82,266,727 RGD:6480464
G Lonp1 lon peptidase 1, mitochondrial JBrowse link 9 10,428,853 10,441,180 RGD:6480464
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6480464
G Mt-co2 mitochondrially encoded cytochrome c oxidase II JBrowse link MT 7,006 7,689 RGD:6480464
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 31,728,373 32,704,022 RGD:6480464
G Nt5e 5' nucleotidase, ecto JBrowse link 8 95,969,002 96,012,733 RGD:6480464
G Nt5m 5',3'-nucleotidase, mitochondrial JBrowse link 10 46,216,494 46,244,478 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Sirt3 sirtuin 3 JBrowse link 1 213,613,502 213,636,061 RGD:6480464
G Slc22a6 solute carrier family 22 member 6 JBrowse link 1 224,824,809 224,833,284 RGD:6480464
G Slc22a8 solute carrier family 22 member 8 JBrowse link 1 224,799,444 224,818,482 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19654
    role 19598
      application 19220
        pro-agent 8766
          prodrug 8563
            tenofovir disoproxil fumarate 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 19654
    subatomic particle 19650
      composite particle 19650
        hadron 19650
          baryon 19650
            nucleon 19650
              atomic nucleus 19650
                atom 19650
                  main group element atom 19531
                    p-block element atom 19531
                      carbon group element atom 19413
                        carbon atom 19405
                          organic molecular entity 19405
                            heteroorganic entity 18990
                              organochalcogen compound 18705
                                organooxygen compound 18615
                                  carbohydrates and carbohydrate derivatives 11721
                                    carbohydrate 11721
                                      carbohydrate derivative 11336
                                        glycosyl compound 10287
                                          N-glycosyl compound 4203
                                            nucleoside analogue 697
                                              tenofovir (anhydrous) 27
                                                tenofovir disoproxil 27
                                                  tenofovir disoproxil fumarate 27
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.