CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: lamotrigine
Accession: CHEBI:6367
browse the term
Definition: A member of the class of 1,2,4-triazines in which the triazene skeleton is substituted by amino groups at positions 3 and 5, and by a 2,3-dichlorophenyl group at position 6.
Synonyms: exact_synonym: 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
related_synonym: 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine; Formula=C9H7Cl2N5; InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16); InChIKey=PYZRQGJRPPTADH-UHFFFAOYSA-N; Lamictal; SMILES=Nc1nnc(c(N)n1)-c1cccc(Cl)c1Cl; lamotrigina; lamotriginum
xref: CAS:84057-84-1; DrugBank:DB00555; Drug_Central:1540; HMDB:HMDB0014695; KEGG:D00354; LINCS:LSM-4104
xref_mesh: MESH:C047781
xref: PMID:19430925; PMID:20825390; PMID:21242744; Reaxys:7589268; Wikipedia:Lamotrigine
G
Abcb1a
ATP binding cassette subfamily B member 1A
decreases activity
ISO
lamotrigine results in decreased activity of ABCB1 protein
CTD
PMID:18408562
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
G
Amh
anti-Mullerian hormone
multiple interactions
ISO
[Carbamazepine co-treated with Lamotrigine] results in increased secretion of AMH protein
CTD
PMID:37505509
NCBI chr 7:8,906,776...8,909,192
Ensembl chr 7:8,906,836...8,909,282
G
Bcl2
BCL2, apoptosis regulator
increases expression
EXP
lamotrigine results in increased expression of BCL2 mRNA; lamotrigine results in increased expression of BCL2 protein
CTD
PMID:18719996
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Bdnf
brain-derived neurotrophic factor
increases expression
EXP
lamotrigine results in increased expression of BDNF mRNA; lamotrigine results in increased expression of BDNF protein
CTD
PMID:18719996
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
G
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
decreases activity
ISO
lamotrigine results in decreased activity of CYP17A1 protein
CTD
PMID:15730543
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
G
Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
decreases activity
ISO
lamotrigine results in decreased activity of CYP19A1 protein
CTD
PMID:17959350
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases glutathionylation
EXP
CYP1A1 protein results in increased glutathionylation of lamotrigine
CTD
PMID:19961160
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases glutathionylation
ISO
CYP2B6 protein results in increased glutathionylation of lamotrigine
CTD
PMID:19961160
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
increases activity multiple interactions increases glutathionylation
EXP
CYP2C11 protein results in increased activity of lamotrigine Cimetidine inhibits the reaction [CYP2C11 protein results in increased glutathionylation of lamotrigine]
CTD
PMID:19961160
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
increases glutathionylation
EXP
CYP2C6V1 protein results in increased glutathionylation of lamotrigine
CTD
PMID:19961160
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Cyp2d2
cytochrome P450, family 2, subfamily d, polypeptide 2
increases glutathionylation
EXP
CYP2D2 protein results in increased glutathionylation of lamotrigine
CTD
PMID:19961160
NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209
G
Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
increases glutathionylation
ISO
CYP2D6 protein results in increased glutathionylation of lamotrigine
CTD
PMID:19961160
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases glutathionylation multiple interactions
ISO
CYP2E1 protein results in increased glutathionylation of lamotrigine Ditiocarb inhibits the reaction [CYP2E1 protein results in increased glutathionylation of lamotrigine]
CTD
PMID:19961160
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases glutathionylation
ISO
CYP3A4 protein results in increased glutathionylation of Lamotrigine
CTD
PMID:19961160
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases glutathionylation
EXP
CYP3A23-3A1 protein results in increased glutathionylation of Lamotrigine
CTD
PMID:19961160
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
G
Dbh
dopamine beta-hydroxylase
increases response to substance
ISO
DBH protein results in increased susceptibility to lamotrigine
CTD
PMID:20021991
NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
G
Drd2
dopamine receptor D2
increases response to substance
ISO
DRD2 protein results in increased susceptibility to lamotrigine
CTD
PMID:20021991
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
G
Hrh1
histamine receptor H 1
increases response to substance
ISO
HRH1 protein results in increased susceptibility to lamotrigine
CTD
PMID:20021991
NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
G
Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
decreases activity
ISO
lamotrigine results in decreased activity of HSD3B2 protein
CTD
PMID:15730543
NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
lamotrigine results in decreased activity of KCNH2 protein
CTD
PMID:15716081
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Kyat1
kynurenine aminotransferase 1
increases activity
EXP
lamotrigine results in increased activity of KYAT1 protein
CTD
PMID:16765940
NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
G
Lin28a
lin-28 homolog A
decreases expression
ISO
Lamotrigine results in decreased expression of LIN28A mRNA
CTD
PMID:37505509
NCBI chr 5:146,227,119...146,244,122
Ensembl chr 5:146,227,119...146,244,122
G
Mc2r
melanocortin 2 receptor
increases response to substance
ISO
MC2R protein results in increased susceptibility to lamotrigine
CTD
PMID:20021991
NCBI chr18:62,001,980...62,015,567
Ensembl chr18:62,004,948...62,015,488
G
Mir155
microRNA 155
increases expression
ISO
lamotrigine results in increased expression of MIR155 mRNA
CTD
PMID:29644860
NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
G
Mir18a
microRNA 18a
increases expression
ISO
lamotrigine results in increased expression of MIR18A mRNA
CTD
PMID:29644860
NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860
G
Mir21
microRNA 21
increases expression
ISO
lamotrigine results in increased expression of MIR21 mRNA
CTD
PMID:29644860
NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
G
Nos2
nitric oxide synthase 2
increases expression
EXP
lamotrigine results in increased expression of NOS2 protein
CTD
PMID:14511393
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
increases response to substance
ISO
NR3C1 protein results in increased susceptibility to lamotrigine
CTD
PMID:20021991
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
G
Pou5f1
POU class 5 homeobox 1
decreases expression
ISO
Lamotrigine results in decreased expression of POU5F1 mRNA
CTD
PMID:37505509
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
G
Scn2a
sodium voltage-gated channel alpha subunit 2
decreases activity
ISO
lamotrigine results in decreased activity of SCN2A protein
CTD
PMID:11212204
NCBI chr 3:50,302,781...50,437,504
Ensembl chr 3:50,302,877...50,437,214
G
Star
steroidogenic acute regulatory protein
decreases expression
ISO
Lamotrigine results in decreased expression of STAR mRNA
CTD
PMID:37505509
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
G
Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
increases glucuronidation
ISO
UGT1A3 protein results in increased glucuronidation of lamotrigine
CTD
PMID:17151188
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a5
UDP glucuronosyltransferase family 1 member A5
multiple interactions increases glucuronidation
ISO
[Phenobarbital results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine; [pirinixic acid results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine; [Pregnenolone Carbonitrile results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine UGT1A4 protein results in increased glucuronidation of lamotrigine
CTD
PMID:17151188 PMID:19845433
NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all