Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lamotrigine
go back to main search page
Accession:CHEBI:6367 term browser browse the term
Definition:A member of the class of 1,2,4-triazines in which the triazene skeleton is substituted by amino groups at positions 3 and 5, and by a 2,3-dichlorophenyl group at position 6.
Synonyms:exact_synonym: 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
 related_synonym: 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine;   Formula=C9H7Cl2N5;   InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16);   InChIKey=PYZRQGJRPPTADH-UHFFFAOYSA-N;   Lamictal;   SMILES=Nc1nnc(c(N)n1)-c1cccc(Cl)c1Cl;   lamotrigina;   lamotriginum
 xref: CAS:84057-84-1;   DrugBank:DB00555;   Drug_Central:1540;   HMDB:HMDB0014695;   KEGG:D00354;   LINCS:LSM-4104
 xref_mesh: MESH:C047781
 xref: PMID:19430925;   PMID:20825390;   PMID:21242744;   Reaxys:7589268;   Wikipedia:Lamotrigine



show annotations for term's descendants           Sort by:
 
lamotrigine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO lamotrigine results in decreased activity of ABCB1 protein CTD PMID:18408562 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP lamotrigine results in increased expression of BCL2 mRNA; lamotrigine results in increased expression of BCL2 protein CTD PMID:18719996 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP lamotrigine results in increased expression of BDNF mRNA; lamotrigine results in increased expression of BDNF protein CTD PMID:18719996 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO lamotrigine results in decreased activity of CYP17A1 protein CTD PMID:15730543 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO lamotrigine results in decreased activity of CYP19A1 protein CTD PMID:17959350 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases glutathionylation EXP CYP1A1 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases glutathionylation ISO CYP2B6 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases activity
increases glutathionylation
multiple interactions
EXP CYP2C11 protein results in increased activity of lamotrigine
CYP2C11 protein results in increased glutathionylation of lamotrigine
Cimetidine inhibits the reaction [CYP2C11 protein results in increased glutathionylation of lamotrigine]
CTD PMID:19961160 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases glutathionylation EXP CYP2C6V1 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 increases glutathionylation EXP CYP2D2 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 7:113,935,138...113,939,209
Ensembl chr 7:113,935,138...113,939,209
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases glutathionylation ISO CYP2D6 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases glutathionylation
multiple interactions
ISO CYP2E1 protein results in increased glutathionylation of lamotrigine
Ditiocarb inhibits the reaction [CYP2E1 protein results in increased glutathionylation of lamotrigine]
CTD PMID:19961160 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases glutathionylation ISO CYP3A4 protein results in increased glutathionylation of Lamotrigine CTD PMID:19961160 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases glutathionylation EXP CYP3A23-3A1 protein results in increased glutathionylation of Lamotrigine CTD PMID:19961160 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Drd2 dopamine receptor D2 increases response to substance ISO DRD2 protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Hrh1 histamine receptor H 1 increases response to substance ISO HRH1 protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases activity ISO lamotrigine results in decreased activity of HSD3B2 protein CTD PMID:15730543 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO lamotrigine results in decreased activity of KCNH2 protein CTD PMID:15716081 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Kyat1 kynurenine aminotransferase 1 increases activity EXP lamotrigine results in increased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
JBrowse link
G Mc2r melanocortin 2 receptor increases response to substance ISO MC2R protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr18:62,001,980...62,015,567
Ensembl chr18:62,004,948...62,015,488
JBrowse link
G Mir155 microRNA 155 increases expression ISO lamotrigine results in increased expression of MIR155 mRNA CTD PMID:29644860 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
JBrowse link
G Mir18a microRNA 18a increases expression ISO lamotrigine results in increased expression of MIR18A mRNA CTD PMID:29644860 NCBI chr15:92,180,765...92,180,860
Ensembl chr15:92,180,765...92,180,860
JBrowse link
G Mir21 microRNA 21 increases expression ISO lamotrigine results in increased expression of MIR21 mRNA CTD PMID:29644860 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP lamotrigine results in increased expression of NOS2 protein CTD PMID:14511393 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases response to substance ISO NR3C1 protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G RT1-A1 RT1 class Ia, locus A1 affects response to substance ISO HLA-B gene polymorphism affects the susceptibility to Lamotrigine CTD PMID:20235791 PMID:20485159 NCBI chr20:4,905,309...4,914,593 JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 decreases activity ISO lamotrigine results in decreased activity of SCN2A protein CTD PMID:11212204 NCBI chr 3:50,302,781...50,437,504
Ensembl chr 3:50,302,877...50,437,214
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of lamotrigine CTD PMID:17151188 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions
increases glucuronidation
ISO [Phenobarbital results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine; [pirinixic acid results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine; [Pregnenolone Carbonitrile results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine
UGT1A4 protein results in increased glucuronidation of lamotrigine
CTD PMID:17151188 PMID:19845433 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        xenobiotic 18699
          lamotrigine 30
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    main group molecular entity 19960
                      s-block molecular entity 19784
                        hydrogen molecular entity 19777
                          hydrides 19115
                            inorganic hydride 17901
                              pnictogen hydride 17884
                                nitrogen hydride 17773
                                  azane 17503
                                    ammonia 17521
                                      organic amino compound 17521
                                        primary amino compound 8282
                                          primary amine 5868
                                            primary arylamine 3136
                                              lamotrigine 30
paths to the root