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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lamotrigine
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Accession:CHEBI:6367 term browser browse the term
Definition:A member of the class of 1,2,4-triazines in which the triazene skeleton is substituted by amino groups at positions 3 and 5, and by a 2,3-dichlorophenyl group at position 6.
Synonyms:exact_synonym: 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
 related_synonym: 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine;   Formula=C9H7Cl2N5;   InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16);   InChIKey=PYZRQGJRPPTADH-UHFFFAOYSA-N;   Lamictal;   SMILES=Nc1nnc(c(N)n1)-c1cccc(Cl)c1Cl;   lamotrigina;   lamotriginum
 xref: CAS:84057-84-1;   DrugBank:DB00555;   Drug_Central:1540;   HMDB:HMDB0014695;   KEGG:D00354;   LINCS:LSM-4104
 xref_mesh: MESH:C047781
 xref: PMID:20825390;   PMID:21242744;   Reaxys:7589268;   Wikipedia:Lamotrigine


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lamotrigine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO lamotrigine results in decreased activity of ABCB1 protein CTD PMID:18408562 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP lamotrigine results in increased expression of BCL2 mRNA; lamotrigine results in increased expression of BCL2 protein CTD PMID:18719996 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP lamotrigine results in increased expression of BDNF mRNA; lamotrigine results in increased expression of BDNF protein CTD PMID:18719996 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO lamotrigine results in decreased activity of CYP17A1 protein CTD PMID:15730543 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO lamotrigine results in decreased activity of CYP19A1 protein CTD PMID:17959350 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases glutathionylation EXP CYP1A1 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases glutathionylation ISO CYP2B6 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases activity
increases glutathionylation
multiple interactions
EXP CYP2C11 protein results in increased activity of lamotrigine
CYP2C11 protein results in increased glutathionylation of lamotrigine
Cimetidine inhibits the reaction [CYP2C11 protein results in increased glutathionylation of lamotrigine]
CTD PMID:19961160 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases glutathionylation EXP CYP2C6V1 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 increases glutathionylation EXP CYP2D2 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 7:123,651,827...123,655,896
Ensembl chr 7:123,651,827...123,655,896
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases glutathionylation ISO CYP2D6 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases glutathionylation
multiple interactions
ISO CYP2E1 protein results in increased glutathionylation of lamotrigine
Ditiocarb inhibits the reaction [CYP2E1 protein results in increased glutathionylation of lamotrigine]
CTD PMID:19961160 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases glutathionylation EXP CYP3A23-3A1 protein results in increased glutathionylation of Lamotrigine CTD PMID:19961160 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases glutathionylation ISO CYP3A4 protein results in increased glutathionylation of Lamotrigine CTD PMID:19961160 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr 3:5,709,236...5,731,895
Ensembl chr 3:5,709,236...5,731,898
JBrowse link
G Drd2 dopamine receptor D2 increases response to substance ISO DRD2 protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Hrh1 histamine receptor H 1 increases response to substance ISO HRH1 protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases activity ISO lamotrigine results in decreased activity of HSD3B2 protein CTD PMID:15730543 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO lamotrigine results in decreased activity of KCNH2 protein CTD PMID:15716081 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kyat1 kynurenine aminotransferase 1 increases activity EXP lamotrigine results in increased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Mc2r melanocortin 2 receptor increases response to substance ISO MC2R protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr18:64,166,959...64,178,729
Ensembl chr18:64,167,191...64,177,729
JBrowse link
G Mir155 microRNA 155 increases expression ISO lamotrigine results in increased expression of MIR155 mRNA CTD PMID:29644860 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Mir18a microRNA 18a increases expression ISO lamotrigine results in increased expression of MIR18A mRNA CTD PMID:29644860 NCBI chr15:100,180,015...100,180,110
Ensembl chr15:100,180,015...100,180,110
JBrowse link
G Mir21 microRNA 21 increases expression ISO lamotrigine results in increased expression of MIR21 mRNA CTD PMID:29644860 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP lamotrigine results in increased expression of NOS2 protein CTD PMID:14511393 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases response to substance ISO NR3C1 protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 decreases activity ISO lamotrigine results in decreased activity of SCN2A protein CTD PMID:11212204 NCBI chr 3:51,687,910...51,822,008
Ensembl chr 3:51,687,809...51,822,250
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of lamotrigine CTD PMID:17151188 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions
increases glucuronidation
ISO [Phenobarbital results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine; [pirinixic acid results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine; [Pregnenolone Carbonitrile results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine
UGT1A4 protein results in increased glucuronidation of lamotrigine
CTD PMID:17151188 PMID:19845433 NCBI chr 9:95,256,628...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

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    subatomic particle 19771
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                  main group element atom 19665
                    main group molecular entity 19665
                      s-block molecular entity 19430
                        hydrogen molecular entity 19424
                          hydrides 18758
                            inorganic hydride 17457
                              pnictogen hydride 17432
                                nitrogen hydride 17277
                                  azane 17009
                                    ammonia 17008
                                      organic amino compound 17007
                                        primary amino compound 7907
                                          primary amine 5696
                                            primary arylamine 2970
                                              lamotrigine 29
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