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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lamotrigine
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Accession:CHEBI:6367 term browser browse the term
Definition:A member of the class of 1,2,4-triazines in which the triazene skeleton is substituted by amino groups at positions 3 and 5, and by a 2,3-dichlorophenyl group at position 6.
Synonyms:exact_synonym: 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
 related_synonym: 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine;   Formula=C9H7Cl2N5;   InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16);   InChIKey=PYZRQGJRPPTADH-UHFFFAOYSA-N;   Lamictal;   SMILES=Nc1nnc(c(N)n1)-c1cccc(Cl)c1Cl;   lamotrigina;   lamotriginum
 xref: CAS:84057-84-1;   DrugBank:DB00555;   Drug_Central:1540;   HMDB:HMDB0014695;   KEGG:D00354;   LINCS:LSM-4104
 xref_mesh: MESH:C047781
 xref: PMID:19430925;   PMID:20825390;   PMID:21242744;   Reaxys:7589268;   Wikipedia:Lamotrigine


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lamotrigine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO lamotrigine results in decreased activity of ABCB1 protein CTD PMID:18408562 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Amh anti-Mullerian hormone multiple interactions ISO [Carbamazepine co-treated with Lamotrigine] results in increased secretion of AMH protein CTD PMID:37505509 NCBI chr 7:9,557,451...9,559,867
Ensembl chr 7:8,906,836...8,909,282 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP lamotrigine results in increased expression of BCL2 mRNA; lamotrigine results in increased expression of BCL2 protein CTD PMID:18719996 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression EXP lamotrigine results in increased expression of BDNF mRNA; lamotrigine results in increased expression of BDNF protein CTD PMID:18719996 NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO lamotrigine results in decreased activity of CYP17A1 protein CTD PMID:15730543 NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO lamotrigine results in decreased activity of CYP19A1 protein CTD PMID:17959350 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases glutathionylation EXP CYP1A1 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases glutathionylation ISO CYP2B6 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases activity
multiple interactions
increases glutathionylation		 EXP CYP2C11 protein results in increased activity of lamotrigine
Cimetidine inhibits the reaction [CYP2C11 protein results in increased glutathionylation of lamotrigine]		 CTD PMID:19961160 NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases glutathionylation EXP CYP2C6 protein results in increased glutathionylation of Lamotrigine CTD PMID:19961160 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 increases glutathionylation EXP CYP2D2 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 7:115,815,212...115,819,281
Ensembl chr 7:113,935,138...113,939,209 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases glutathionylation ISO CYP2D6 protein results in increased glutathionylation of lamotrigine CTD PMID:19961160 NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases glutathionylation
multiple interactions		 ISO CYP2E1 protein results in increased glutathionylation of lamotrigine
Ditiocarb inhibits the reaction [CYP2E1 protein results in increased glutathionylation of lamotrigine]		 CTD PMID:19961160 NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases glutathionylation ISO CYP3A4 protein results in increased glutathionylation of Lamotrigine CTD PMID:19961160 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases glutathionylation EXP CYP3A23-3A1 protein results in increased glutathionylation of Lamotrigine CTD PMID:19961160 NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr 3:30,886,313...30,903,313
Ensembl chr 3:10,488,260...10,505,248 		JBrowse link
G Drd2 dopamine receptor D2 increases response to substance ISO DRD2 protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Hrh1 histamine receptor H 1 increases response to substance ISO HRH1 protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases activity ISO lamotrigine results in decreased activity of HSD3B2 protein CTD PMID:15730543 NCBI chr 2:188,784,614...188,812,535
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
G Ins1 insulin 1 multiple interactions
increases expression		 EXP Curcumin inhibits the reaction [Lamotrigine results in increased expression of INS1 protein] CTD PMID:38050455 NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO lamotrigine results in decreased activity of KCNH2 protein CTD PMID:15716081 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kyat1 kynurenine aminotransferase 1 increases activity EXP lamotrigine results in increased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 3:33,857,407...33,891,153
Ensembl chr 3:13,459,591...13,493,355 		JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Lamotrigine results in decreased expression of LHB protein CTD PMID:38050455 NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Lin28a lin-28 homolog A decreases expression ISO Lamotrigine results in decreased expression of LIN28A mRNA CTD PMID:37505509 NCBI chr 5:151,510,891...151,527,884
Ensembl chr 5:146,227,119...146,244,122 		JBrowse link
G Mc2r melanocortin 2 receptor increases response to substance ISO MC2R protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr18:64,279,878...64,291,775
Ensembl chr18:62,004,948...62,015,488 		JBrowse link
G Mir155 microRNA 155 increases expression ISO lamotrigine results in increased expression of MIR155 mRNA CTD PMID:29644860 NCBI chr11:37,261,114...37,261,178
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir18a microRNA 18a increases expression ISO lamotrigine results in increased expression of MIR18A mRNA CTD PMID:29644860 NCBI chr15:98,587,984...98,588,079
Ensembl chr15:92,180,765...92,180,860 		JBrowse link
G Mir21 microRNA 21 increases expression ISO lamotrigine results in increased expression of MIR21 mRNA CTD PMID:29644860 NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression
multiple interactions		 EXP Lamotrigine results in decreased expression of MKI67 protein
Curcumin inhibits the reaction [Lamotrigine results in decreased expression of MKI67 protein]		 CTD PMID:38050455 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP lamotrigine results in increased expression of NOS2 protein CTD PMID:14511393 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases response to substance ISO NR3C1 protein results in increased susceptibility to lamotrigine CTD PMID:20021991 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Lamotrigine results in decreased expression of POU5F1 mRNA CTD PMID:37505509 NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression		 EXP Curcumin inhibits the reaction [Lamotrigine results in decreased expression of PPARG protein] CTD PMID:38050455 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 decreases activity ISO lamotrigine results in decreased activity of SCN2A protein CTD PMID:11212204 NCBI chr 3:70,710,862...70,845,569
Ensembl chr 3:50,302,877...50,437,214 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO Lamotrigine results in decreased expression of STAR mRNA CTD PMID:37505509 NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of lamotrigine CTD PMID:17151188 NCBI chr 9:96,239,019...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 multiple interactions
increases glucuronidation		 ISO [Phenobarbital results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine; [pirinixic acid results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine; [Pregnenolone Carbonitrile results in increased activity of UGT1A4 protein] which results in increased glucuronidation of lamotrigine
UGT1A4 protein results in increased glucuronidation of lamotrigine		 CTD PMID:17151188 PMID:19845433 NCBI chr 9:96,210,053...96,256,264
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
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  CHEBI ontology 19887
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          lamotrigine 37
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                  main group element atom 19824
                    main group molecular entity 19824
                      s-block molecular entity 19658
                        hydrogen molecular entity 19640
                          hydrides 19145
                            inorganic hydride 18162
                              pnictogen hydride 18152
                                nitrogen hydride 18059
                                  azane 17869
                                    ammonia 17868
                                      organic amino compound 17868
                                        primary amino compound 9356
                                          primary amine 6367
                                            primary arylamine 3705
                                              lamotrigine 37
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