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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:vigabatrin
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Accession:CHEBI:63638 term browser browse the term
Definition:A gamma-amino acid having a gamma-vinyl GABA structure. It is an irreversible inhibitor of gamma-aminobutyric 664 acid transaminase
Synonyms:exact_synonym: 4-aminohex-5-enoic acid
 related_synonym: 4-Amino-5-hexenoic acid;   Formula=C6H11NO2;   GVG;   InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9);   InChIKey=PJDFLNIOAUIZSL-UHFFFAOYSA-N;   SMILES=NC(CCC(O)=O)C=C;   gamma-vinyl GABA;   gamma-vinyl-gamma-aminobutyric acid;   vigabatrina;   vigabatrine;   vigabatrinum
 alt_id: CHEBI:9979
 xref: CAS:60643-86-9;   DrugBank:DB01080;   Drug_Central:2819;   KEGG:C07500;   KEGG:D00535;   LINCS:LSM-4959
 xref_mesh: MESH:D020888
 xref: PMID:20018576;   PMID:20878340;   PMID:20926323;   PMID:21361740;   PMID:22061177;   PMID:22061178;   PMID:22061182;   PMID:22234618;   Patent:US3960927;   Wikipedia:Vigabatrin


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vigabatrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase decreases activity EXP Vigabatrin results in decreased activity of AADAT protein CTD PMID:16765940 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332 		JBrowse link
G Abat 4-aminobutyrate aminotransferase multiple interactions
decreases activity		 ISO
EXP		 [Vigabatrin results in decreased activity of ABAT protein] which results in increased abundance of gamma-Aminobutyric Acid CTD PMID:3933514 PMID:10951220 PMID:11468302 PMID:12748807 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835 		JBrowse link
G Ddc dopa decarboxylase decreases expression EXP Vigabatrin results in decreased expression of DDC mRNA CTD PMID:8717341 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 increases expression ISO Vigabatrin results in increased expression of FMR1 protein CTD PMID:21490592 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Vigabatrin results in increased expression of GAD1 protein CTD PMID:11673025 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333 		JBrowse link
G Gnat2 G protein subunit alpha transducin 2 increases response to substance ISO GNAT2 results in increased susceptibility to Vigabatrin CTD PMID:22970106 NCBI chr 2:195,726,371...195,735,866
Ensembl chr 2:195,726,762...195,735,866 		JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases activity EXP Vigabatrin results in decreased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases response to substance ISO MTHFR results in increased susceptibility to Vigabatrin CTD PMID:21490592 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Pde6g phosphodiesterase 6G increases response to substance ISO PDE6G results in increased susceptibility to Vigabatrin CTD PMID:22970106 NCBI chr10:105,721,502...105,726,150
Ensembl chr10:105,721,682...105,726,719 		JBrowse link
G Reln reelin increases expression ISO Vigabatrin results in increased expression of RELN protein CTD PMID:21490592 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      application 19650
        pharmaceutical 19491
          drug 19491
            central nervous system drug 16778
              central nervous system depressant 16292
                anticonvulsant 15332
                  vigabatrin 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    main group molecular entity 19779
                      s-block molecular entity 19617
                        hydrogen molecular entity 19604
                          hydrides 19102
                            inorganic hydride 18114
                              pnictogen hydride 18103
                                nitrogen hydride 18010
                                  azane 17819
                                    ammonia 17818
                                      organic amino compound 17818
                                        amino acid 15944
                                          non-proteinogenic amino acid 3986
                                            gamma-amino acid 184
                                              vigabatrin 10
paths to the root