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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:vigabatrin
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Accession:CHEBI:63638 term browser browse the term
Definition:A gamma-amino acid having a gamma-vinyl GABA structure. It is an irreversible inhibitor of gamma-aminobutyric 664 acid transaminase
Synonyms:exact_synonym: 4-aminohex-5-enoic acid
 related_synonym: 4-Amino-5-hexenoic acid;   Formula=C6H11NO2;   GVG;   InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9);   InChIKey=PJDFLNIOAUIZSL-UHFFFAOYSA-N;   SMILES=NC(CCC(O)=O)C=C;   gamma-vinyl GABA;   gamma-vinyl-gamma-aminobutyric acid;   vigabatrina;   vigabatrine;   vigabatrinum
 alt_id: CHEBI:9979
 xref: CAS:60643-86-9;   DrugBank:DB01080;   Drug_Central:2819;   KEGG:C07500;   KEGG:D00535;   LINCS:LSM-4959
 xref_mesh: MESH:D020888
 xref: PMID:20018576;   PMID:20878340;   PMID:20926323;   PMID:21361740;   PMID:22061177;   PMID:22061178;   PMID:22061182;   PMID:22234618;   Patent:US3960927;   Wikipedia:Vigabatrin


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vigabatrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase decreases activity EXP Vigabatrin results in decreased activity of AADAT protein CTD PMID:16765940 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702
JBrowse link
G Abat 4-aminobutyrate aminotransferase multiple interactions
decreases activity
ISO
EXP
[Vigabatrin results in decreased activity of ABAT protein] which results in increased abundance of gamma-Aminobutyric Acid CTD PMID:3933514 PMID:10951220 PMID:11468302 PMID:12748807 NCBI chr10:7,093,406...7,200,439
Ensembl chr10:7,093,405...7,200,499
JBrowse link
G Ddc dopa decarboxylase decreases expression EXP Vigabatrin results in decreased expression of DDC mRNA CTD PMID:8717341 NCBI chr14:91,905,919...91,996,816
Ensembl chr14:91,905,919...91,996,774
JBrowse link
G Fmr1 FMRP translational regulator 1 increases expression ISO Vigabatrin results in increased expression of FMR1 protein CTD PMID:21490592 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Vigabatrin results in increased expression of GAD1 protein CTD PMID:11673025 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gnat2 G protein subunit alpha transducin 2 increases response to substance ISO GNAT2 results in increased susceptibility to Vigabatrin CTD PMID:22970106 NCBI chr 2:210,880,754...210,890,765
Ensembl chr 2:210,880,777...210,889,881
JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases activity EXP Vigabatrin results in decreased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases response to substance ISO MTHFR results in increased susceptibility to Vigabatrin CTD PMID:21490592 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Pde6g phosphodiesterase 6G increases response to substance ISO PDE6G results in increased susceptibility to Vigabatrin CTD PMID:22970106 NCBI chr10:109,620,499...109,625,214
Ensembl chr10:109,620,980...109,622,745
JBrowse link
G Reln reelin increases expression ISO Vigabatrin results in increased expression of RELN protein CTD PMID:21490592 NCBI chr 4:9,347,533...9,774,257
Ensembl chr 4:9,347,528...9,773,670
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      application 19505
        pharmaceutical 19375
          drug 19375
            central nervous system drug 16508
              central nervous system depressant 16038
                anticonvulsant 15170
                  vigabatrin 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic group 18580
                              organic divalent group 18571
                                organodiyl group 18571
                                  carbonyl group 18479
                                    carbonyl compound 18479
                                      carboxylic acid 18153
                                        amino acid 14125
                                          non-proteinogenic amino acid 1801
                                            gamma-amino acid 171
                                              vigabatrin 10
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