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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:vigabatrin
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Accession:CHEBI:63638 term browser browse the term
Definition:A gamma-amino acid having a gamma-vinyl GABA structure. It is an irreversible inhibitor of gamma-aminobutyric 664 acid transaminase
Synonyms:exact_synonym: 4-aminohex-5-enoic acid
 related_synonym: 4-Amino-5-hexenoic acid;   Formula=C6H11NO2;   GVG;   InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9);   InChIKey=PJDFLNIOAUIZSL-UHFFFAOYSA-N;   SMILES=NC(CCC(O)=O)C=C;   gamma-vinyl GABA;   gamma-vinyl-gamma-aminobutyric acid;   vigabatrina;   vigabatrine;   vigabatrinum
 alt_id: CHEBI:9979
 xref: CAS:60643-86-9;   DrugBank:DB01080;   Drug_Central:2819;   KEGG:C07500;   KEGG:D00535;   LINCS:LSM-4959
 xref_mesh: MESH:D020888
 xref: PMID:20018576;   PMID:20878340;   PMID:20926323;   PMID:21361740;   PMID:22061177;   PMID:22061178;   PMID:22061182;   PMID:22234618;   Patent:US3960927;   Wikipedia:Vigabatrin



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vigabatrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase decreases activity EXP Vigabatrin results in decreased activity of AADAT protein CTD PMID:16765940 NCBI chr16:29,509,392...29,544,332
Ensembl chr16:29,509,394...29,544,332
JBrowse link
G Abat 4-aminobutyrate aminotransferase multiple interactions
decreases activity
ISO
EXP
[Vigabatrin results in decreased activity of ABAT protein] which results in increased abundance of gamma-Aminobutyric Acid CTD PMID:3933514 PMID:10951220 PMID:11468302 PMID:12748807 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
JBrowse link
G Ddc dopa decarboxylase decreases expression EXP Vigabatrin results in decreased expression of DDC mRNA CTD PMID:8717341 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Fmr1 FMRP translational regulator 1 increases expression ISO Vigabatrin results in increased expression of FMR1 protein CTD PMID:21490592 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050
JBrowse link
G Gad1 glutamate decarboxylase 1 increases expression EXP Vigabatrin results in increased expression of GAD1 protein CTD PMID:11673025 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gnat2 G protein subunit alpha transducin 2 increases response to substance ISO GNAT2 results in increased susceptibility to Vigabatrin CTD PMID:22970106 NCBI chr 2:195,726,371...195,735,866
Ensembl chr 2:195,726,762...195,735,866
JBrowse link
G Kyat1 kynurenine aminotransferase 1 decreases activity EXP Vigabatrin results in decreased activity of KYAT1 protein CTD PMID:16765940 NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
JBrowse link
G Mthfr methylenetetrahydrofolate reductase increases response to substance ISO MTHFR results in increased susceptibility to Vigabatrin CTD PMID:21490592 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797
JBrowse link
G Pde6g phosphodiesterase 6G increases response to substance ISO PDE6G results in increased susceptibility to Vigabatrin CTD PMID:22970106 NCBI chr10:105,721,502...105,727,204
Ensembl chr10:105,721,682...105,726,719
JBrowse link
G Reln reelin increases expression ISO Vigabatrin results in increased expression of RELN protein CTD PMID:21490592 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20050
    role 20001
      application 19737
        pharmaceutical 19610
          drug 19610
            central nervous system drug 16571
              central nervous system depressant 16072
                anticonvulsant 15195
                  vigabatrin 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic group 18937
                              organic divalent group 18922
                                organodiyl group 18922
                                  carbonyl group 18872
                                    carbonyl compound 18872
                                      carboxylic acid 18556
                                        amino acid 14930
                                          non-proteinogenic amino acid 2005
                                            gamma-amino acid 178
                                              vigabatrin 10
paths to the root