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ONTOLOGY REPORT - ANNOTATIONS


Term:topotecan
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Accession:CHEBI:63632 term browser browse the term
Definition:A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Synonyms:exact_synonym: (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
 related_synonym: 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin;   Formula=C23H23N3O5;   InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1;   InChIKey=UCFGDBYHRUNTLO-QHCPKHFHSA-N;   SMILES=CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O;   topotecane;   topotecanum
 alt_id: CHEBI:9634
 xref: CAS:123948-87-8 "ChemIDplus";   CAS:123948-87-8 "KEGG COMPOUND";   DrugBank:DB01030;   KEGG:C11158;   KEGG:D08618;   LINCS:LSM-5662
 xref_mesh: MESH:D019772
 xref: PDBeChem:TTC;   PMID:20574789 "Europe PMC";   PMID:21255983 "Europe PMC";   PMID:21352915 "Europe PMC";   PMID:21910214 "Europe PMC";   PMID:22028494 "Europe PMC";   PMID:22075006 "Europe PMC";   PMID:22136714 "Europe PMC";   PMID:22190039 "Europe PMC";   Patent:EP321122;   Reaxys:4279441 "Reaxys";   Wikipedia:Topotecan


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Path 1
Term Annotations click to browse term
  CHEBI ontology 20971
    role 20952
      application 20373
        pharmaceutical 19971
          drug 19971
            antineoplastic agent 17297
              topotecan 2658
Path 2
Term Annotations click to browse term
  CHEBI ontology 20971
    subatomic particle 20965
      composite particle 20965
        hadron 20965
          baryon 20965
            nucleon 20965
              atomic nucleus 20965
                atom 20965
                  main group element atom 20803
                    p-block element atom 20803
                      carbon group element atom 20543
                        carbon atom 20519
                          organic molecular entity 20519
                            organic molecule 20371
                              organic cyclic compound 20047
                                organic heterocyclic compound 18970
                                  organic heteropolycyclic compound 18397
                                    organic heteropentacyclic compound 13265
                                      pyranoindolizinoquinoline 3183
                                        topotecan 2658
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