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ONTOLOGY REPORT - ANNOTATIONS


Term:topotecan
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Accession:CHEBI:63632 term browser browse the term
Definition:A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Synonyms:exact_synonym: (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
 related_synonym: 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin;   Formula=C23H23N3O5;   InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1;   InChIKey=UCFGDBYHRUNTLO-QHCPKHFHSA-N;   SMILES=CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O;   topotecane;   topotecanum
 alt_id: CHEBI:9634
 xref: CAS:123948-87-8 "ChemIDplus";   CAS:123948-87-8 "KEGG COMPOUND";   DrugBank:DB01030;   KEGG:C11158;   KEGG:D08618;   LINCS:LSM-5662
 xref_mesh: MESH:D019772
 xref: PDBeChem:TTC;   PMID:20574789 "Europe PMC";   PMID:21255983 "Europe PMC";   PMID:21352915 "Europe PMC";   PMID:21910214 "Europe PMC";   PMID:22028494 "Europe PMC";   PMID:22075006 "Europe PMC";   PMID:22136714 "Europe PMC";   PMID:22190039 "Europe PMC";   Patent:EP321122;   Reaxys:4279441 "Reaxys";   Wikipedia:Topotecan


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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            antineoplastic agent 16555
              topotecan 2687
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic molecule 19343
                              organic cyclic compound 19093
                                organic heterocyclic compound 18157
                                  organic heteropolycyclic compound 17423
                                    organic heteropentacyclic compound 12864
                                      pyranoindolizinoquinoline 3204
                                        topotecan 2687
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