Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tolcapone
go back to main search page
Accession:CHEBI:63630 term browser browse the term
Definition:Benzophenone substituted on one of the phenyl rings at C-3 and C-4 by hydroxy groups and at C-5 by a nitro group, and on the other phenyl ring by a methyl group at C-4. It is an inhibitor of catechol O-methyltransferase.
Synonyms:exact_synonym: (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
 related_synonym: 3,4-dihydroxy-5-nitro-4'-methylbenzophenone;   4'-methyl-3,4-dihydroxy-5-nitrobenzophenone;   Formula=C14H11NO5;   InChI=1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)7-10/h2-7,16,18H,1H3;   InChIKey=MIQPIUSUKVNLNT-UHFFFAOYSA-N;   SMILES=Cc1ccc(cc1)C(=O)c1cc(O)c(O)c(c1)[N+]([O-])=O
 alt_id: CHEBI:9617
 xref: DrugBank:DB00323;   Drug_Central:2697;   KEGG:D00786;   LINCS:LSM-5282
 xref_mesh: MESH:C066340
 xref: PMID:20381177;   PMID:20502133;   PMID:21521027;   PMID:22136163;   Patent:EP237929;   Patent:US5236952;   Reaxys:8151577;   Wikipedia:Tolcapone


show annotations for term's descendants           Sort by:
 
tolcapone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadac arylacetamide deacetylase decreases expression EXP tolcapone results in decreased expression of AADAC mRNA CTD PMID:24136188 NCBI chr 2:150,146,234...150,157,480
Ensembl chr 2:150,146,234...150,157,480
JBrowse link
G Aars1 alanyl-tRNA synthetase 1 increases expression EXP tolcapone results in increased expression of AARS mRNA CTD PMID:24136188 NCBI chr19:43,193,264...43,215,281
Ensembl chr19:43,193,257...43,215,281
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO tolcapone results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 affects binding EXP tolcapone binds to ABCD2 protein CTD PMID:19783845 NCBI chr 7:132,294,564...132,343,169
Ensembl chr 7:132,294,562...132,343,169
JBrowse link
G Abhd10 abhydrolase domain containing 10, depalmitoylase affects binding EXP tolcapone binds to ABHD10 protein CTD PMID:19783845 NCBI chr11:60,053,719...60,068,142
Ensembl chr11:60,054,408...60,066,739
Ensembl chr11:60,054,408...60,066,739
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression EXP tolcapone results in increased expression of ACAT2 mRNA CTD PMID:24136188 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653
JBrowse link
G Acox3 acyl-CoA oxidase 3, pristanoyl affects binding EXP tolcapone binds to ACOX3 protein CTD PMID:19783845 NCBI chr14:80,313,202...80,358,115
Ensembl chr14:80,314,431...80,355,420
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 affects binding
decreases expression
EXP
ISO
tolcapone binds to ACSL1 protein
tolcapone results in decreased expression of ACSL1 mRNA; tolcapone results in decreased expression of ACSL1 protein
CTD PMID:19783845 PMID:29688484 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acsl5 acyl-CoA synthetase long-chain family member 5 decreases expression ISO tolcapone results in decreased expression of ACSL5 protein CTD PMID:29688484 NCBI chr 1:276,240,703...276,290,012
Ensembl chr 1:276,240,703...276,290,008
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 increases expression EXP tolcapone results in increased expression of ACSS2 mRNA CTD PMID:24136188 NCBI chr 3:151,032,925...151,075,856
Ensembl chr 3:151,032,952...151,075,856
JBrowse link
G Acta2 actin alpha 2, smooth muscle affects binding EXP tolcapone binds to ACTA2 protein CTD PMID:19783845 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adprhl1 ADP-ribosylhydrolase like 1 affects binding EXP tolcapone binds to ADPRHL1 protein CTD PMID:19783845 NCBI chr16:81,616,098...81,648,133
Ensembl chr16:81,616,604...81,632,030
JBrowse link
G Aga aspartylglucosaminidase decreases expression EXP tolcapone results in decreased expression of AGA mRNA CTD PMID:24136188 NCBI chr16:41,222,225...41,234,169
Ensembl chr16:41,222,238...41,234,095
JBrowse link
G Aif1 allograft inflammatory factor 1 decreases expression EXP tolcapone results in decreased expression of AIF1 mRNA CTD PMID:24136188 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Ak2 adenylate kinase 2 affects binding EXP tolcapone binds to AK2 protein CTD PMID:19783845 NCBI chr 5:147,185,474...147,204,050
Ensembl chr 5:147,185,474...147,204,050
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 affects binding EXP Tolcapone binds to AKR1C1 protein CTD PMID:19783845 NCBI chr17:69,441,253...69,460,334
Ensembl chr17:69,441,223...69,460,321
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases expression EXP tolcapone results in decreased expression of AKR1C3 mRNA CTD PMID:24136188 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akr1d1 aldo-keto reductase family 1, member D1 affects binding EXP tolcapone binds to AKR1D1 protein CTD PMID:19783845 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 affects binding EXP tolcapone binds to ALDH18A1 protein CTD PMID:19783845 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 affects binding EXP tolcapone binds to ALDH1B1 protein CTD PMID:19783845 NCBI chr 5:61,382,351...61,387,359
Ensembl chr 5:61,382,351...61,387,358
JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 increases expression EXP tolcapone results in increased expression of ALDH1L1 mRNA CTD PMID:24136188 NCBI chr 4:123,516,553...123,564,067
Ensembl chr 4:123,516,788...123,557,501
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 affects binding EXP tolcapone binds to ALDH3A2 protein CTD PMID:19783845 NCBI chr10:47,525,486...47,546,535
Ensembl chr10:47,525,493...47,546,345
JBrowse link
G Alg13 ALG13, UDP-N-acetylglucosaminyltransferase subunit decreases expression EXP tolcapone results in decreased expression of ALG13 mRNA CTD PMID:24136188 NCBI chr  X:115,561,329...115,589,792
Ensembl chr  X:115,561,332...115,619,505
JBrowse link
G Amfr autocrine motility factor receptor increases expression EXP tolcapone results in increased expression of AMFR mRNA CTD PMID:24136188 NCBI chr19:11,473,538...11,509,500
Ensembl chr19:11,473,541...11,508,102
JBrowse link
G Apmap adipocyte plasma membrane associated protein affects binding EXP tolcapone binds to APMAP protein CTD PMID:19783845 NCBI chr 3:146,376,828...146,407,259
Ensembl chr 3:146,376,828...146,407,252
JBrowse link
G Apoa1 apolipoprotein A1 affects binding EXP tolcapone binds to APOA1 protein CTD PMID:19783845 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apob apolipoprotein B decreases expression
decreases secretion
ISO tolcapone results in decreased expression of APOB mRNA
tolcapone results in decreased secretion of APOB protein alternative form
CTD PMID:29688484 NCBI chr 6:33,176,826...33,216,381
Ensembl chr 6:33,176,778...33,224,997
JBrowse link
G Apoc2 apolipoprotein C2 decreases expression EXP tolcapone results in decreased expression of APOC2 mRNA CTD PMID:24136188 NCBI chr 1:80,589,023...80,593,991
Ensembl chr 1:80,589,023...80,594,136
JBrowse link
G Apoe apolipoprotein E affects binding EXP tolcapone binds to APOE protein CTD PMID:19783845 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Apool apolipoprotein O-like decreases expression EXP tolcapone results in decreased expression of APOOL mRNA CTD PMID:24136188 NCBI chr  X:83,678,269...83,750,550
Ensembl chr  X:83,678,339...83,750,549
JBrowse link
G Arf4 ADP-ribosylation factor 4 affects binding EXP tolcapone binds to ARF4 protein CTD PMID:19783845 NCBI chr16:2,338,333...2,354,909
Ensembl chr16:2,338,333...2,354,909
JBrowse link
G Arl1 ADP-ribosylation factor like GTPase 1 affects binding EXP tolcapone binds to ARL1 protein CTD PMID:19783845 NCBI chr 7:29,282,411...29,293,455
Ensembl chr 7:29,282,305...29,293,399
JBrowse link
G Atad1 ATPase family, AAA domain containing 1 affects binding EXP tolcapone binds to ATAD1 protein CTD PMID:19783845 NCBI chr 1:251,234,702...251,386,996
Ensembl chr 1:251,235,508...251,387,002
JBrowse link
G Atad3a ATPase family, AAA domain containing 3A affects binding EXP tolcapone binds to ATAD3A protein CTD PMID:19783845 NCBI chr 5:173,189,590...173,209,809
Ensembl chr 5:173,189,592...173,209,768
JBrowse link
G Atf5 activating transcription factor 5 increases expression EXP tolcapone results in increased expression of ATF5 mRNA CTD PMID:24136188 NCBI chr 1:100,807,821...100,812,410
Ensembl chr 1:100,808,241...100,810,522
JBrowse link
G Atp1b3 ATPase Na+/K+ transporting subunit beta 3 affects binding EXP tolcapone binds to ATP1B3 protein CTD PMID:19783845 NCBI chr 8:104,190,032...104,221,342
Ensembl chr 8:104,190,032...104,221,342
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta affects binding EXP tolcapone binds to ATP5F1B protein CTD PMID:19783845 NCBI chr 7:2,504,708...2,511,748
Ensembl chr 7:2,504,695...2,511,749
JBrowse link
G Atp5f1c ATP synthase F1 subunit gamma affects binding EXP tolcapone binds to ATP5C1 protein CTD PMID:19783845 NCBI chr17:72,209,321...72,231,562
Ensembl chr17:72,209,373...72,394,271
JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon decreases expression EXP tolcapone results in decreased expression of ATP5F1E mRNA CTD PMID:24136188 NCBI chr 3:172,563,105...172,566,007
Ensembl chr 3:172,563,105...172,566,010
JBrowse link
G Atp5me ATP synthase membrane subunit e decreases expression
affects binding
EXP tolcapone results in decreased expression of ATP5ME mRNA
tolcapone binds to ATP5ME protein
CTD PMID:19783845 PMID:24136188 NCBI chr14:2,325,308...2,326,436
Ensembl chr14:2,325,308...2,326,436
JBrowse link
G Atp5mf ATP synthase membrane subunit f affects binding EXP tolcapone binds to ATP5MF protein CTD PMID:19783845 NCBI chr12:11,191,799...11,198,369
Ensembl chr12:11,191,812...11,198,369
JBrowse link
G Atp5mg ATP synthase membrane subunit g decreases expression
affects binding
EXP tolcapone results in decreased expression of ATP5MG mRNA
tolcapone binds to ATP5MG protein
CTD PMID:19783845 PMID:24136188 NCBI chr 8:49,220,441...49,227,273
Ensembl chr 8:49,220,443...49,227,273
JBrowse link
G Atp5mk ATP synthase membrane subunit k decreases expression EXP Tolcapone results in decreased expression of ATP5MK mRNA CTD PMID:24136188 NCBI chr 1:266,859,961...266,866,753
Ensembl chr 1:266,862,579...266,862,842
JBrowse link
G Atp5pf ATP synthase peripheral stalk subunit F6 decreases expression EXP tolcapone results in decreased expression of ATP5PF mRNA CTD PMID:24136188 NCBI chr11:24,286,806...24,294,419
Ensembl chr11:24,286,787...24,294,179
JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP affects binding EXP tolcapone binds to ATP5PO protein CTD PMID:19783845 NCBI chr11:32,081,606...32,087,918
Ensembl chr11:32,081,574...32,088,002
JBrowse link
G Auh AU RNA binding methylglutaconyl-CoA hydratase affects binding EXP tolcapone binds to AUH protein CTD PMID:19783845 NCBI chr17:12,310,178...12,405,224
Ensembl chr17:12,310,214...12,405,205
JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 decreases expression EXP tolcapone results in decreased expression of BBOX1 mRNA CTD PMID:24136188 NCBI chr 3:101,425,684...101,474,848
Ensembl chr 3:101,427,055...101,474,890
JBrowse link
G Bcam basal cell adhesion molecule (Lutheran blood group) affects binding EXP tolcapone binds to BCAM protein CTD PMID:19783845 NCBI chr 1:80,674,463...80,689,122
Ensembl chr 1:80,674,444...80,689,171
JBrowse link
G Bcap29 B-cell receptor-associated protein 29 decreases expression EXP tolcapone results in decreased expression of BCAP29 mRNA CTD PMID:24136188 NCBI chr 6:50,883,758...50,923,743
Ensembl chr 6:50,883,787...50,923,510
JBrowse link
G Bcas2 BCAS2, pre-mRNA processing factor decreases expression EXP tolcapone results in decreased expression of BCAS2 mRNA CTD PMID:24136188 NCBI chr 2:205,662,633...205,670,514
Ensembl chr 2:205,662,588...205,670,511
JBrowse link
G Bmper BMP-binding endothelial regulator affects binding EXP tolcapone binds to BMPER protein CTD PMID:19783845 NCBI chr 8:24,369,916...24,615,484
Ensembl chr 8:24,369,916...24,615,479
JBrowse link
G Bms1 BMS1 ribosome biogenesis factor affects binding EXP tolcapone binds to BMS1 protein CTD PMID:19783845 NCBI chr 4:150,433,567...150,471,783
Ensembl chr 4:150,433,570...150,471,834
JBrowse link
G Bpgm bisphosphoglycerate mutase decreases expression EXP tolcapone results in decreased expression of BPGM mRNA CTD PMID:24136188 NCBI chr 4:61,912,210...61,940,697
Ensembl chr 4:61,912,210...61,940,696
JBrowse link
G Btf3l4 basic transcription factor 3-like 4 decreases expression EXP tolcapone results in decreased expression of BTF3L4 mRNA CTD PMID:24136188 NCBI chr 5:128,432,049...128,450,530
Ensembl chr 5:128,432,433...128,446,725
JBrowse link
G C1d C1D nuclear receptor corepressor decreases expression EXP tolcapone results in decreased expression of C1D mRNA CTD PMID:24136188 NCBI chr14:100,415,645...100,427,878
Ensembl chr14:100,415,668...100,427,260
JBrowse link
G C1galt1c1 C1GALT1-specific chaperone 1 decreases expression EXP tolcapone results in decreased expression of C1GALT1C1 mRNA CTD PMID:24136188 NCBI chr  X:124,921,686...124,926,171
Ensembl chr  X:124,921,728...124,926,171
JBrowse link
G C4b complement C4B (Chido blood group) increases expression EXP tolcapone results in increased expression of C4B mRNA CTD PMID:24136188 NCBI chr20:4,302,344...4,316,752
Ensembl chr20:4,302,344...4,316,715
JBrowse link
G C5 complement C5 increases expression EXP tolcapone results in increased expression of C5 mRNA CTD PMID:24136188 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G C8a complement C8 alpha chain increases expression EXP tolcapone results in increased expression of C8A mRNA CTD PMID:24136188 NCBI chr 5:124,348,536...124,403,117
Ensembl chr 5:124,348,461...124,403,195
JBrowse link
G Cbr4 carbonyl reductase 4 decreases expression EXP tolcapone results in decreased expression of CBR4 mRNA CTD PMID:24136188 NCBI chr16:31,944,328...31,972,553
Ensembl chr16:31,956,753...31,972,507
JBrowse link
G Ccnl2 cyclin L2 increases expression EXP tolcapone results in increased expression of CCNL2 mRNA CTD PMID:24136188 NCBI chr 5:173,256,301...173,268,279
Ensembl chr 5:173,256,637...173,276,169
JBrowse link
G Cct7 chaperonin containing TCP1 subunit 7 affects binding EXP tolcapone binds to CCT7 protein CTD PMID:19783845 NCBI chr 4:117,235,023...117,252,265
Ensembl chr 4:117,235,023...117,252,265
JBrowse link
G Cd36 CD36 molecule increases expression ISO tolcapone results in increased expression of CD36 mRNA CTD PMID:29688484 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Cfb complement factor B increases expression EXP tolcapone results in increased expression of CFB mRNA CTD PMID:24136188 NCBI chr20:4,536,206...4,542,073
Ensembl chr20:4,536,203...4,561,066
Ensembl chr20:4,536,203...4,561,066
JBrowse link
G Chchd1 coiled-coil-helix-coiled-coil-helix domain containing 1 decreases expression EXP tolcapone results in decreased expression of CHCHD1 mRNA CTD PMID:24136188 NCBI chr15:4,025,455...4,026,637
Ensembl chr15:4,025,463...4,026,637
JBrowse link
G Chchd7 coiled-coil-helix-coiled-coil-helix domain containing 7 decreases expression EXP tolcapone results in decreased expression of CHCHD7 mRNA CTD PMID:24136188 NCBI chr 5:16,843,253...16,847,809
Ensembl chr 5:16,845,631...16,847,776
JBrowse link
G Chrac1 chromatin accessibility complex subunit 1 decreases expression EXP tolcapone results in decreased expression of CHRAC1 mRNA CTD PMID:24136188 NCBI chr 7:114,323,542...114,326,930
Ensembl chr 7:114,323,542...114,326,930
JBrowse link
G Churc1 churchill domain containing 1 decreases expression EXP tolcapone results in decreased expression of CHURC1 mRNA CTD PMID:24136188 NCBI chr 6:99,817,439...99,831,574
Ensembl chr 6:99,817,431...99,831,576
JBrowse link
G Ciao2a cytosolic iron-sulfur assembly component 2A decreases expression EXP tolcapone results in decreased expression of CIAO2A mRNA CTD PMID:24136188 NCBI chr 8:71,786,336...71,798,258
Ensembl chr 8:71,786,310...71,798,266
JBrowse link
G Cidea cell death-inducing DFFA-like effector a increases expression ISO tolcapone results in increased expression of CIDEA mRNA CTD PMID:29688484 NCBI chr18:63,082,861...63,108,450
Ensembl chr18:63,098,144...63,108,051
JBrowse link
G Cisd1 CDGSH iron sulfur domain 1 affects binding EXP tolcapone binds to CISD1 protein CTD PMID:19783845 NCBI chr20:18,493,538...18,506,923
Ensembl chr20:18,493,538...18,506,912
JBrowse link
G Cltc clathrin heavy chain affects binding EXP tolcapone binds to CLTC protein CTD PMID:19783845 NCBI chr10:74,014,560...74,070,578
Ensembl chr10:74,014,562...74,070,266
JBrowse link
G Cnih4 cornichon family AMPA receptor auxiliary protein 4 decreases expression EXP tolcapone results in decreased expression of CNIH4 mRNA CTD PMID:24136188 NCBI chr13:99,469,382...99,490,693
Ensembl chr13:99,473,044...99,489,263
JBrowse link
G Commd6 COMM domain containing 6 decreases expression EXP tolcapone results in decreased expression of COMMD6 mRNA CTD PMID:24136188 NCBI chr15:86,136,096...86,142,672
Ensembl chr15:86,136,096...86,142,672
JBrowse link
G Comt catechol-O-methyltransferase decreases activity
multiple interactions
increases methylation
affects binding
ISO
EXP
tolcapone results in decreased activity of COMT protein
[tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of Homocysteine]; [tolcapone results in decreased activity of COMT protein] inhibits the reaction [Levodopa results in increased abundance of S-Adenosylmethionine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Dopamine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Epinephrine; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Levodopa; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of Norepinephrine; tolcapone inhibits the reaction [COMT protein results in increased methylation of Levodopa]
[tolcapone results in decreased activity of COMT protein] promotes the reaction [Clozapine results in increased abundance of Dopamine]; [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Homovanillic Acid; [tolcapone results in decreased activity of COMT protein] which results in increased abundance of 3,4-Dihydroxyphenylacetic Acid; tolcapone inhibits the reaction [[COMT protein results in increased methylation of Epinephrine] which results in increased abundance of Metanephrine]
COMT protein results in increased methylation of tolcapone
tolcapone binds to COMT protein
CTD PMID:2089102 PMID:7566641 PMID:7768073 PMID:8821542 PMID:9333106 PMID:10047930 PMID:10064789 PMID:10809409 PMID:10872643 PMID:11248589 PMID:11432539 PMID:11793163 PMID:11793426 PMID:12584150 PMID:12898346 PMID:14975680 PMID:15190105 PMID:15566291 PMID:16012872 PMID:16758261 PMID:19783845 PMID:20334432 PMID:23206800 PMID:29688484 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Copg1 COPI coat complex subunit gamma 1 affects binding EXP tolcapone binds to COPG1 protein CTD PMID:19783845 NCBI chr 4:119,815,041...119,840,997
Ensembl chr 4:119,815,139...119,864,114
JBrowse link
G Copg2 COPI coat complex subunit gamma 2 decreases expression EXP tolcapone results in decreased expression of COPG2 mRNA CTD PMID:24136188 NCBI chr 4:58,064,394...58,195,242
Ensembl chr 4:58,064,833...58,195,143
JBrowse link
G Coq10a coenzyme Q10A decreases expression EXP tolcapone results in decreased expression of COQ10A mRNA CTD PMID:24136188 NCBI chr 7:2,780,930...2,788,189
Ensembl chr 7:2,780,930...2,786,949
JBrowse link
G Coq3 coenzyme Q3 methyltransferase decreases expression EXP tolcapone results in decreased expression of COQ3 mRNA CTD PMID:24136188 NCBI chr 5:36,024,673...36,056,664
Ensembl chr 5:36,024,649...36,056,669
JBrowse link
G Cox6c cytochrome c oxidase subunit 6C affects binding
decreases expression
EXP tolcapone binds to COX6C protein
tolcapone results in decreased expression of COX6C mRNA
CTD PMID:19783845 PMID:24136188 NCBI chr 7:74,723,177...74,735,650
Ensembl chr 7:74,723,179...74,735,650
JBrowse link
G Cox7a2 cytochrome c oxidase subunit 7A2 decreases expression EXP tolcapone results in decreased expression of COX7A2 mRNA CTD PMID:24136188 NCBI chr 8:87,209,529...87,213,627
Ensembl chr 8:87,209,530...87,213,627
JBrowse link
G Cox7b cytochrome c oxidase subunit 7B decreases expression EXP tolcapone results in decreased expression of COX7B mRNA CTD PMID:24136188 NCBI chr  X:77,065,427...77,071,676
Ensembl chr  X:77,065,397...77,071,676
JBrowse link
G Cp ceruloplasmin increases expression EXP tolcapone results in increased expression of CP mRNA CTD PMID:24136188 NCBI chr 2:104,744,249...104,803,034
Ensembl chr 2:104,744,461...104,799,853
JBrowse link
G Crem cAMP responsive element modulator decreases expression EXP tolcapone results in decreased expression of CREM mRNA CTD PMID:24136188 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Crip2 cysteine-rich protein 2 increases expression EXP tolcapone results in increased expression of CRIP2 mRNA CTD PMID:24136188 NCBI chr 6:137,953,545...137,958,491
Ensembl chr 6:137,953,545...137,958,490
JBrowse link
G Cse1l chromosome segregation 1 like affects binding EXP tolcapone binds to CSE1L protein CTD PMID:19783845 NCBI chr 3:163,664,074...163,702,074
Ensembl chr 3:163,664,136...163,702,060
JBrowse link
G Cstb cystatin B decreases expression EXP tolcapone results in decreased expression of CSTB mRNA CTD PMID:24136188 NCBI chr20:10,966,357...10,968,399
Ensembl chr20:10,966,331...10,968,432
JBrowse link
G Cyc1 cytochrome c-1 affects binding EXP tolcapone binds to CYC1 protein CTD PMID:19783845 NCBI chr 7:117,409,576...117,411,953
Ensembl chr 7:117,409,576...117,411,953
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP
ISO
tolcapone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:18493746 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases expression
EXP
ISO
tolcapone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
tolcapone results in increased expression of CYP1A2 mRNA
CTD PMID:18493746 PMID:24136188 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases response to substance ISO CYP3A4 protein results in increased susceptibility to Tolcapone CTD PMID:21540358 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP tolcapone results in increased expression of CYP51 mRNA CTD PMID:24136188 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Dap death-associated protein increases expression EXP tolcapone results in increased expression of DAP mRNA CTD PMID:24136188 NCBI chr 2:84,275,884...84,328,998
Ensembl chr 2:84,275,884...84,328,998
JBrowse link
G Dctd dCMP deaminase affects binding EXP tolcapone binds to DCTD protein CTD PMID:19783845 NCBI chr16:47,177,144...47,222,850
Ensembl chr16:47,177,145...47,208,110
JBrowse link
G Ddost dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit affects binding EXP tolcapone binds to DDOST protein CTD PMID:19783845 NCBI chr 5:156,668,924...156,676,036
Ensembl chr 5:156,668,712...156,676,035
JBrowse link
G Ddx18 DEAD-box helicase 18 affects binding EXP tolcapone binds to DDX18 protein CTD PMID:19783845 NCBI chr13:37,522,558...37,536,066
Ensembl chr13:37,522,561...37,536,066
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase affects binding
increases expression
EXP tolcapone binds to DHCR24 protein
tolcapone results in increased expression of DHCR24 mRNA
CTD PMID:19783845 PMID:24136188 NCBI chr 5:126,164,708...126,188,926
Ensembl chr 5:126,164,674...126,191,206
JBrowse link
G Dhcr7 7-dehydrocholesterol reductase affects binding EXP tolcapone binds to DHCR7 protein CTD PMID:19783845 NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
JBrowse link
G Dmac1 distal membrane arm assembly component 1 decreases expression EXP tolcapone results in decreased expression of DMAC1 mRNA CTD PMID:24136188 NCBI chr 5:92,038,050...92,039,146
Ensembl chr 5:92,038,050...92,039,146
JBrowse link
G Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 decreases expression EXP tolcapone results in decreased expression of DNAJC15 mRNA CTD PMID:24136188 NCBI chr15:59,990,131...60,056,710
Ensembl chr15:59,990,131...60,056,710
JBrowse link
G Dock11 dedicator of cytokinesis 11 decreases expression EXP tolcapone results in decreased expression of DOCK11 mRNA CTD PMID:24136188 NCBI chr  X:122,507,169...122,690,463
Ensembl chr  X:122,507,374...122,690,465
JBrowse link
G Dpm3 dolichyl-phosphate mannosyltransferase subunit 3, regulatory decreases expression EXP tolcapone results in decreased expression of DPM3 mRNA CTD PMID:24136188 NCBI chr 2:188,583,664...188,584,179
Ensembl chr 2:188,583,664...188,584,179
JBrowse link
G Dpy30 dpy-30 histone methyltransferase complex regulatory subunit decreases expression EXP tolcapone results in decreased expression of DPY30 mRNA CTD PMID:24136188 NCBI chr 6:22,296,128...22,316,894
Ensembl chr 6:22,296,128...22,316,894
JBrowse link
G Dtymk deoxythymidylate kinase decreases expression EXP tolcapone results in decreased expression of DTYMK mRNA CTD PMID:24136188 NCBI chr 9:100,921,565...100,930,399
Ensembl chr 9:100,921,565...100,930,399
JBrowse link
G Dynll1 dynein light chain LC8-type 1 decreases expression EXP tolcapone results in decreased expression of DYNLL1 mRNA CTD PMID:24136188 NCBI chr12:47,074,200...47,076,573
Ensembl chr12:47,074,200...47,076,572
JBrowse link
G Dynlt3 dynein light chain Tctex-type 3 decreases expression EXP tolcapone results in decreased expression of DYNLT3 mRNA CTD PMID:24136188 NCBI chr  X:14,633,342...14,642,356
Ensembl chr  X:14,633,342...14,642,424
JBrowse link
G Ebp EBP, cholestenol delta-isomerase increases expression EXP tolcapone results in increased expression of EBP mRNA CTD PMID:24136188 NCBI chr  X:15,049,394...15,055,782
Ensembl chr  X:15,049,462...15,055,781
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 affects binding EXP tolcapone binds to ECHS1 protein CTD PMID:19783845 NCBI chr 1:212,570,213...212,579,040
Ensembl chr 1:212,570,195...212,579,057
Ensembl chr 1:212,570,195...212,579,057
JBrowse link
G Eloc elongin C decreases expression EXP tolcapone results in decreased expression of ELOC mRNA CTD PMID:24136188 NCBI chr 5:2,042,991...2,059,357
Ensembl chr 5:2,042,991...2,059,351
JBrowse link
G Ereg epiregulin decreases expression ISO Tolcapone results in decreased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:18,577,620...18,591,395
Ensembl chr14:18,576,355...18,591,394
JBrowse link
G F5 coagulation factor V increases expression EXP tolcapone results in increased expression of F5 mRNA CTD PMID:24136188 NCBI chr13:82,479,997...82,535,540
Ensembl chr13:82,479,998...82,535,534
JBrowse link
G Fam162a family with sequence similarity 162, member A affects binding EXP tolcapone binds to FAM162A protein CTD PMID:19783845 NCBI chr11:67,618,683...67,646,253
Ensembl chr11:67,618,625...67,646,253
JBrowse link
G Fbll1 fibrillarin-like 1 affects binding EXP tolcapone binds to FBLL1 protein CTD PMID:19783845 NCBI chr10:20,620,957...20,622,600
Ensembl chr10:20,620,957...20,622,600
JBrowse link
G Fcf1 FCF1 rRNA-processing protein decreases expression EXP tolcapone results in decreased expression of FCF1 mRNA CTD PMID:24136188 NCBI chr 6:108,796,182...108,808,051
Ensembl chr 6:108,796,182...108,808,048
JBrowse link
G Fga fibrinogen alpha chain affects binding EXP tolcapone binds to FGA protein CTD PMID:19783845 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fmc1 formation of mitochondrial complex V assembly factor 1 decreases expression EXP tolcapone results in decreased expression of FMC1 mRNA CTD PMID:24136188 NCBI chr 4:66,276,835...66,284,868
Ensembl chr 4:66,276,835...66,284,868
JBrowse link
G Gcdh glutaryl-CoA dehydrogenase affects binding EXP tolcapone binds to GCDH protein CTD PMID:19783845 NCBI chr19:26,000,497...26,006,970
Ensembl chr19:26,000,497...26,006,970
JBrowse link
G Glg1 golgi glycoprotein 1 affects binding EXP tolcapone binds to GLG1 protein CTD PMID:19783845 NCBI chr19:42,983,879...43,088,074
Ensembl chr19:42,983,869...43,090,841
JBrowse link
G Gmfg glia maturation factor, gamma decreases expression EXP tolcapone results in decreased expression of GMFG mRNA CTD PMID:24136188 NCBI chr 1:85,312,473...85,322,860
Ensembl chr 1:85,312,528...85,317,968
JBrowse link
G Gng10 G protein subunit gamma 10 decreases expression EXP tolcapone results in decreased expression of GNG10 mRNA CTD PMID:24136188 NCBI chr 5:76,182,100...76,189,014
Ensembl chr 5:76,182,121...76,189,013
JBrowse link
G Gng5 G protein subunit gamma 5 decreases expression EXP tolcapone results in decreased expression of GNG5 mRNA CTD PMID:24136188 NCBI chr 2:252,359,976...252,368,473
Ensembl chr 2:252,359,976...252,368,473
JBrowse link
G Gpc3 glypican 3 affects binding EXP tolcapone binds to GPC3 protein CTD PMID:19783845 NCBI chr  X:139,579,268...139,947,093
Ensembl chr  X:139,579,268...139,916,883
JBrowse link
G Gtf2h5 general transcription factor IIH subunit 5 decreases expression EXP tolcapone results in decreased expression of GTF2H5 mRNA CTD PMID:24136188 NCBI chr 1:46,978,345...46,985,032
Ensembl chr 1:46,978,458...46,985,032
JBrowse link
G H2az2 H2A.Z variant histone 2 affects binding EXP Tolcapone binds to H2AZ2 protein CTD PMID:19783845 NCBI chr14:86,687,782...86,706,639
Ensembl chr14:86,687,782...86,706,626
JBrowse link
G Hbb hemoglobin subunit beta affects binding EXP tolcapone binds to HBB protein CTD PMID:19783845 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Higd1a HIG1 hypoxia inducible domain family, member 1A decreases expression EXP tolcapone results in decreased expression of HIGD1A mRNA CTD PMID:24136188 NCBI chr 8:130,482,492...130,491,888
Ensembl chr 8:130,482,493...130,491,998
JBrowse link
G Hint3 histidine triad nucleotide binding protein 3 decreases expression EXP tolcapone results in decreased expression of HINT3 mRNA CTD PMID:24136188 NCBI chr 1:29,413,425...29,423,288
Ensembl chr 1:29,413,365...29,423,347
JBrowse link
G Hist1h4b histone cluster 1 H4 family member B decreases expression EXP Tolcapone results in decreased expression of HIST1H4B mRNA CTD PMID:24136188 NCBI chr17:44,522,144...44,526,587
Ensembl chr17:44,522,140...44,526,583
JBrowse link
G Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 affects binding EXP tolcapone binds to HNRNPH1 protein CTD PMID:19783845 NCBI chr10:35,872,619...35,879,911
Ensembl chr10:35,870,232...35,879,910
JBrowse link
G Hsd17b11 hydroxysteroid (17-beta) dehydrogenase 11 affects binding EXP tolcapone binds to HSD17B11 protein CTD PMID:19783845 NCBI chr14:7,054,724...7,104,567
Ensembl chr14:7,073,445...7,104,566
JBrowse link
G Hsd17b12 hydroxysteroid (17-beta) dehydrogenase 12 affects binding EXP tolcapone binds to HSD17B12 protein CTD PMID:19783845 NCBI chr 3:82,924,699...83,048,465
Ensembl chr 3:82,924,687...83,048,435
JBrowse link
G Hsd17b13 hydroxysteroid (17-beta) dehydrogenase 13 affects binding EXP tolcapone binds to HSD17B13 protein CTD PMID:19783845 NCBI chr14:7,113,544...7,128,218
Ensembl chr14:7,113,544...7,128,218
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 affects binding EXP tolcapone binds to HSD17B4 protein CTD PMID:19783845 NCBI chr18:44,810,462...44,897,677
Ensembl chr18:44,810,388...44,897,640
JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 increases expression EXP tolcapone results in increased expression of HSDL2 mRNA CTD PMID:24136188 NCBI chr 5:76,812,881...76,848,853
Ensembl chr 5:76,812,931...76,848,101
JBrowse link
G Iftap intraflagellar transport associated protein decreases expression EXP Tolcapone results in decreased expression of IFTAP mRNA CTD PMID:24136188 NCBI chr 3:91,086,186...91,195,981
Ensembl chr 3:91,086,186...91,195,981
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression EXP tolcapone results in increased expression of IGFBP1 mRNA CTD PMID:24136188 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Il24 interleukin 24 decreases expression ISO Tolcapone results in decreased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Ipo7 importin 7 affects binding EXP tolcapone binds to IPO7 protein CTD PMID:19783845 NCBI chr 1:174,655,939...174,696,173
Ensembl chr 1:174,655,939...174,696,173
JBrowse link
G Itm2a integral membrane protein 2A affects binding EXP tolcapone binds to ITM2A protein CTD PMID:19783845 NCBI chr  X:78,490,872...78,496,814
Ensembl chr  X:78,490,866...78,496,847
JBrowse link
G Jagn1 jagunal homolog 1 affects binding EXP tolcapone binds to JAGN1 protein CTD PMID:19783845 NCBI chr 4:145,399,885...145,404,605
Ensembl chr 4:145,399,913...145,404,617
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO tolcapone results in decreased activity of KCNH2 protein CTD PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kng2 kininogen 2 increases expression EXP tolcapone results in increased expression of KNG1 mRNA CTD PMID:24136188 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lage3 L antigen family, member 3 decreases expression EXP tolcapone results in decreased expression of LAGE3 mRNA CTD PMID:24136188 NCBI chr  X:156,355,376...156,356,799
Ensembl chr  X:156,355,376...156,356,799
JBrowse link
G Lbp lipopolysaccharide binding protein increases expression EXP tolcapone results in increased expression of LBP mRNA CTD PMID:24136188 NCBI chr 3:154,786,232...154,812,910
Ensembl chr 3:154,786,215...154,813,464
JBrowse link
G Lrrc59 leucine rich repeat containing 59 affects binding EXP tolcapone binds to LRRC59 protein CTD PMID:19783845 NCBI chr10:82,352,390...82,367,047
Ensembl chr10:82,352,390...82,367,047
JBrowse link
G Lsm3 LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression EXP tolcapone results in decreased expression of LSM3 mRNA CTD PMID:24136188 NCBI chr 4:123,162,086...123,168,330
Ensembl chr 4:123,162,086...123,168,330
JBrowse link
G Lsm5 LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression EXP tolcapone results in decreased expression of LSM5 mRNA CTD PMID:24136188 NCBI chr 4:87,016,003...87,019,219
Ensembl chr 4:87,016,003...87,019,219
Ensembl chr 6:87,016,003...87,019,219
JBrowse link
G Lsm7 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated decreases expression EXP tolcapone results in decreased expression of LSM7 mRNA CTD PMID:24136188 NCBI chr 7:11,724,932...11,732,020
Ensembl chr 7:11,724,962...11,727,388
JBrowse link
G Magoh mago homolog, exon junction complex subunit decreases expression EXP tolcapone results in decreased expression of MAGOH mRNA CTD PMID:24136188 NCBI chr 5:127,480,465...127,487,617
Ensembl chr 5:127,480,485...127,487,603
JBrowse link
G Masp1 MBL associated serine protease 1 increases expression EXP tolcapone results in increased expression of MASP1 mRNA CTD PMID:24136188 NCBI chr11:80,736,424...80,806,278
Ensembl chr11:80,736,576...80,803,382
JBrowse link
G Matr3 matrin 3 decreases expression EXP tolcapone results in decreased expression of MATR3 mRNA CTD PMID:24136188 NCBI chr18:28,351,691...28,390,764
Ensembl chr18:28,361,283...28,390,717
JBrowse link
G Mcee methylmalonyl CoA epimerase decreases expression EXP tolcapone results in decreased expression of MCEE mRNA CTD PMID:24136188 NCBI chr 1:125,229,487...125,252,692
Ensembl chr 1:125,229,469...125,252,666
JBrowse link
G Mcts1 MCTS1, re-initiation and release factor decreases expression EXP tolcapone results in decreased expression of MCTS1 mRNA CTD PMID:24136188 NCBI chr  X:124,894,269...124,906,129
Ensembl chr  X:124,894,466...124,906,162
JBrowse link
G Med21 mediator complex subunit 21 decreases expression EXP tolcapone results in decreased expression of MED21 mRNA CTD PMID:24136188 NCBI chr 4:180,961,194...180,968,155
Ensembl chr 4:180,961,142...180,968,123
JBrowse link
G Med28 mediator complex subunit 28 decreases expression EXP tolcapone results in decreased expression of MED28 mRNA CTD PMID:24136188 NCBI chr14:70,089,225...70,098,021
Ensembl chr14:70,089,225...70,098,021
JBrowse link
G Med31 mediator complex subunit 31 decreases expression EXP tolcapone results in decreased expression of MED31 mRNA CTD PMID:24136188 NCBI chr10:58,780,987...58,784,369
Ensembl chr10:58,780,597...58,784,374
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Tolcapone results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mettl5 methyltransferase like 5 decreases expression EXP tolcapone results in decreased expression of METTL5 mRNA CTD PMID:24136188 NCBI chr 3:56,101,597...56,113,823
Ensembl chr 3:56,101,580...56,113,857
JBrowse link
G Mfsd5 major facilitator superfamily domain containing 5 decreases expression EXP tolcapone results in decreased expression of MFSD5 mRNA CTD PMID:24136188 NCBI chr 7:143,882,000...143,884,281
Ensembl chr 7:143,882,000...143,884,280
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 affects binding EXP tolcapone binds to MGST1 protein CTD PMID:19783845 NCBI chr 4:172,119,382...172,134,609
Ensembl chr 4:172,119,331...172,134,607
JBrowse link
G Mia3 MIA SH3 domain ER export factor 3 decreases expression EXP tolcapone results in decreased expression of MIA3 mRNA CTD PMID:24136188 NCBI chr13:101,727,434...101,770,127
Ensembl chr13:101,727,935...101,761,541
JBrowse link
G Mkks MKKS centrosomal shuttling protein decreases expression EXP tolcapone results in decreased expression of MKKS mRNA CTD PMID:24136188 NCBI chr 3:129,866,542...129,885,213
Ensembl chr 3:129,866,545...129,884,810
JBrowse link
G Mkrn1 makorin ring finger protein 1 decreases expression EXP tolcapone results in decreased expression of MKRN1 mRNA CTD PMID:24136188 NCBI chr 4:67,185,167...67,206,478
Ensembl chr 4:67,185,138...67,206,426
JBrowse link
G Mmadhc metabolism of cobalamin associated D decreases expression EXP tolcapone results in decreased expression of MMADHC mRNA CTD PMID:24136188 NCBI chr 3:35,783,511...35,801,474
Ensembl chr 3:35,783,623...35,801,614
JBrowse link
G Mrpl1 mitochondrial ribosomal protein L1 decreases expression EXP tolcapone results in decreased expression of MRPL1 mRNA CTD PMID:24136188 NCBI chr14:14,951,507...15,008,136
Ensembl chr14:14,951,495...15,008,150
JBrowse link
G Mrpl13 mitochondrial ribosomal protein L13 decreases expression EXP tolcapone results in decreased expression of MRPL13 mRNA CTD PMID:24136188 NCBI chr 7:95,288,400...95,309,997
Ensembl chr 7:95,288,376...95,310,005
JBrowse link
G Mrpl14 mitochondrial ribosomal protein L14 decreases expression EXP tolcapone results in decreased expression of MRPL14 mRNA CTD PMID:24136188 NCBI chr 9:17,687,622...17,698,591
Ensembl chr 9:17,687,622...17,698,569
JBrowse link
G Mrpl18 mitochondrial ribosomal protein L18 decreases expression EXP tolcapone results in decreased expression of MRPL18 mRNA CTD PMID:24136188 NCBI chr 1:48,033,531...48,038,726
Ensembl chr 1:48,033,768...48,038,726
JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 decreases expression EXP tolcapone results in decreased expression of MRPL20 mRNA CTD PMID:24136188 NCBI chr 5:173,248,245...173,252,775
Ensembl chr 5:173,248,245...173,252,775
JBrowse link
G Mrpl22 mitochondrial ribosomal protein L22 decreases expression EXP tolcapone results in decreased expression of MRPL22 mRNA CTD PMID:24136188 NCBI chr10:43,601,786...43,612,119
Ensembl chr10:43,601,689...43,612,121
JBrowse link
G Mrpl23 mitochondrial ribosomal protein L23 decreases expression EXP tolcapone results in decreased expression of MRPL23 mRNA CTD PMID:24136188 NCBI chr 1:215,701,544...215,709,313
Ensembl chr 1:215,701,544...215,709,313
JBrowse link
G Mrpl30 mitochondrial ribosomal protein L30 decreases expression EXP tolcapone results in decreased expression of MRPL30 mRNA CTD PMID:24136188 NCBI chr 9:44,483,809...44,496,116
Ensembl chr 9:44,483,875...44,571,331
JBrowse link
G Mrpl32 mitochondrial ribosomal protein L32 decreases expression EXP tolcapone results in decreased expression of MRPL32 mRNA CTD PMID:24136188 NCBI chr17:53,102,534...53,105,400
Ensembl chr17:53,102,534...53,105,400
JBrowse link
G Mrpl36 mitochondrial ribosomal protein L36 decreases expression EXP tolcapone results in decreased expression of MRPL36 mRNA CTD PMID:24136188 NCBI chr 1:31,261,370...31,264,715
Ensembl chr 1:31,261,370...31,262,466
Ensembl chr 1:31,261,370...31,262,466
JBrowse link
G Mrpl40 mitochondrial ribosomal protein L40 decreases expression EXP tolcapone results in decreased expression of MRPL40 mRNA CTD PMID:24136188 NCBI chr11:86,276,616...86,282,452
Ensembl chr11:86,276,616...86,282,451
JBrowse link
G Mrpl53 mitochondrial ribosomal protein L53 decreases expression EXP tolcapone results in decreased expression of MRPL53 mRNA CTD PMID:24136188 NCBI chr 4:113,942,037...113,942,927
Ensembl chr 4:113,942,041...113,942,674
Ensembl chr 4:113,942,041...113,942,674
JBrowse link
G Mrps14 mitochondrial ribosomal protein S14 decreases expression EXP tolcapone results in decreased expression of MRPS14 mRNA CTD PMID:24136188 NCBI chr13:77,940,454...77,946,201
Ensembl chr13:77,940,454...77,946,201
JBrowse link
G Mrps18c mitochondrial ribosomal protein S18C decreases expression EXP tolcapone results in decreased expression of MRPS18C mRNA CTD PMID:24136188 NCBI chr14:10,440,691...10,446,909
Ensembl chr14:10,440,691...10,446,909
JBrowse link
G Mrps24 mitochondrial ribosomal protein S24 decreases expression EXP tolcapone results in decreased expression of MRPS24 mRNA CTD PMID:24136188 NCBI chr14:85,947,763...85,951,891
Ensembl chr14:85,947,765...85,951,899
JBrowse link
G Mrps33 mitochondrial ribosomal protein S33 decreases expression EXP tolcapone results in decreased expression of MRPS33 mRNA CTD PMID:24136188 NCBI chr 4:67,606,971...67,616,056
Ensembl chr 4:67,607,273...67,610,710
JBrowse link
G Mrps36 mitochondrial ribosomal protein S36 decreases expression EXP tolcapone results in decreased expression of MRPS36 mRNA CTD PMID:24136188 NCBI chr 2:30,740,620...30,750,916
Ensembl chr 2:30,739,855...30,748,428
JBrowse link
G Mtap methylthioadenosine phosphorylase affects binding EXP tolcapone binds to MTAP protein CTD PMID:19783845 NCBI chr 5:107,711,077...107,777,530
Ensembl chr 5:107,711,077...107,777,530
JBrowse link
G Mttp microsomal triglyceride transfer protein increases expression ISO tolcapone results in increased expression of MTTP protein CTD PMID:29688484 NCBI chr 2:243,366,181...243,407,608
Ensembl chr 2:243,366,181...243,407,608
JBrowse link
G Mvk mevalonate kinase increases expression EXP tolcapone results in increased expression of MVK mRNA CTD PMID:24136188 NCBI chr12:47,904,266...47,920,457
Ensembl chr12:47,904,719...47,919,400
JBrowse link
G Naa20 N(alpha)-acetyltransferase 20, NatB catalytic subunit decreases expression EXP tolcapone results in decreased expression of NAA20 mRNA CTD PMID:24136188 NCBI chr 3:140,106,723...140,125,047
Ensembl chr 3:140,106,766...140,125,220
JBrowse link
G Nat10 N-acetyltransferase 10 affects binding EXP tolcapone binds to NAT10 protein CTD PMID:19783845 NCBI chr 3:93,658,119...93,698,136
Ensembl chr 3:93,658,117...93,698,136
JBrowse link
G Ndufa1 NADH:ubiquinone oxidoreductase subunit A1 decreases expression EXP tolcapone results in decreased expression of NDUFA1 mRNA CTD PMID:24136188 NCBI chr  X:123,803,109...123,806,760
Ensembl chr  X:124,513,269...124,516,705
Ensembl chr  X:124,513,269...124,516,705
JBrowse link
G Ndufa2 NADH:ubiquinone oxidoreductase subunit A2 decreases expression EXP tolcapone results in decreased expression of NDUFA2 mRNA CTD PMID:24136188 NCBI chr18:29,585,671...29,587,760
Ensembl chr18:29,585,671...29,587,760
JBrowse link
G Ndufa6 NADH:ubiquinone oxidoreductase subunit A6 decreases expression EXP tolcapone results in decreased expression of NDUFA6 mRNA CTD PMID:24136188 NCBI chr 7:123,583,062...123,586,919
Ensembl chr 7:123,583,062...123,586,919
JBrowse link
G Ndufa7 NADH:ubiquinone oxidoreductase subunit A7 decreases expression EXP tolcapone results in decreased expression of NDUFA7 mRNA CTD PMID:24136188 NCBI chr 7:18,683,553...18,696,332
Ensembl chr 7:18,683,553...18,696,330
JBrowse link
G Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 affects binding EXP tolcapone binds to NDUFA9 protein CTD PMID:19783845 NCBI chr 4:159,371,263...159,399,636
Ensembl chr 4:159,371,259...159,399,634
JBrowse link
G Ndufb6 NADH:ubiquinone oxidoreductase subunit B6 decreases expression EXP tolcapone results in decreased expression of NDUFB6 mRNA CTD PMID:24136188 NCBI chr 5:56,567,109...56,576,676
Ensembl chr 5:56,567,109...56,576,676
JBrowse link
G Ndufc2 NADH:ubiquinone oxidoreductase subunit C2 decreases expression EXP tolcapone results in decreased expression of NDUFC2 mRNA CTD PMID:24136188 NCBI chr 1:162,369,801...162,376,024
Ensembl chr 1:162,369,801...162,376,023
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 decreases expression EXP tolcapone results in decreased expression of NDUFS4 mRNA CTD PMID:24136188 NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203
JBrowse link
G Ndufs5 NADH:ubiquinone oxidoreductase subunit S5 decreases expression EXP tolcapone results in decreased expression of NDUFS5 mRNA CTD PMID:24136188 NCBI chr 5:141,390,577...141,405,507
Ensembl chr 5:141,390,580...141,405,453
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression ISO tolcapone results in decreased expression of NFE2L2 mRNA CTD PMID:28526448 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nipsnap1 nipsnap homolog 1 affects binding EXP tolcapone binds to NIPSNAP1 protein CTD PMID:19783845 NCBI chr14:85,113,578...85,137,457
Ensembl chr14:85,113,578...85,137,454
JBrowse link
G Nipsnap2 nipsnap homolog 2 affects binding EXP tolcapone binds to NIPSNAP2 protein CTD PMID:19783845 NCBI chr12:30,527,540...30,566,090
Ensembl chr12:30,527,540...30,566,032
JBrowse link
G Nme3 NME/NM23 nucleoside diphosphate kinase 3 decreases expression EXP tolcapone results in decreased expression of NME3 mRNA CTD PMID:24136188 NCBI chr10:14,258,232...14,259,365
Ensembl chr10:14,258,380...14,259,336
JBrowse link
G Nop56 NOP56 ribonucleoprotein affects binding EXP tolcapone binds to NOP56 protein CTD PMID:19783845 NCBI chr 3:122,803,726...122,808,564
Ensembl chr 3:122,803,772...122,808,558
JBrowse link
G Nphp1 nephrocystin 1 decreases expression EXP tolcapone results in decreased expression of NPHP1 mRNA CTD PMID:24136188 NCBI chr 3:120,316,048...120,370,089
Ensembl chr 3:120,316,047...120,373,500
JBrowse link
G Nploc4 NPL4 homolog, ubiquitin recognition factor increases expression EXP tolcapone results in increased expression of NPLOC4 mRNA CTD PMID:24136188 NCBI chr10:109,553,518...109,610,087
Ensembl chr10:109,552,649...109,610,030
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression EXP tolcapone results in decreased expression of NR3C1 mRNA CTD PMID:24136188 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nupr2 nuclear protein 2, transcriptional regulator decreases expression EXP tolcapone results in decreased expression of NUPR2 mRNA CTD PMID:24136188 NCBI chr12:30,300,936...30,304,041
Ensembl chr12:30,303,725...30,304,036
JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 affects binding EXP tolcapone binds to P4HA1 protein CTD PMID:19783845 NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966
JBrowse link
G Pc pyruvate carboxylase affects binding EXP tolcapone binds to PC protein CTD PMID:19783845 NCBI chr 1:219,759,157...219,859,854
Ensembl chr 1:219,759,183...219,859,848
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression EXP tolcapone results in decreased expression of PCNA mRNA CTD PMID:24136188 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1A, choline affects binding EXP tolcapone binds to PCYT1A protein CTD PMID:19783845 NCBI chr11:71,547,865...71,592,037
Ensembl chr11:71,548,222...71,591,502
JBrowse link
G Pdzd11 PDZ domain containing 11 decreases expression EXP tolcapone results in decreased expression of PDZD11 mRNA CTD PMID:24136188 NCBI chr  X:70,458,601...70,461,635
Ensembl chr  X:70,458,603...70,461,635
JBrowse link
G Pfdn1 prefoldin subunit 1 decreases expression EXP tolcapone results in decreased expression of PFDN1 mRNA CTD PMID:24136188 NCBI chr18:29,233,987...29,290,447
Ensembl chr18:29,233,987...29,290,447
JBrowse link
G Pfdn5 prefoldin subunit 5 decreases expression EXP tolcapone results in decreased expression of PFDN5 mRNA CTD PMID:24136188 NCBI chr 7:143,924,662...143,929,400
Ensembl chr 7:143,924,662...143,929,397
JBrowse link
G Pgm1 phosphoglucomutase 1 increases expression EXP tolcapone results in increased expression of PGM1 mRNA CTD PMID:24136188 NCBI chr 5:118,743,632...118,803,055
Ensembl chr 5:118,743,632...118,803,055
JBrowse link
G Pgr progesterone receptor multiple interactions ISO tolcapone binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pigp phosphatidylinositol glycan anchor biosynthesis, class P decreases expression EXP tolcapone results in decreased expression of PIGP mRNA CTD PMID:24136188 NCBI chr11:34,592,128...34,598,253
Ensembl chr11:34,592,121...34,598,275
JBrowse link
G Pigs phosphatidylinositol glycan anchor biosynthesis, class S affects binding EXP tolcapone binds to PIGS protein CTD PMID:19783845 NCBI chr10:65,591,638...65,606,175
Ensembl chr10:65,591,622...65,606,202
JBrowse link
G Pin4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 decreases expression EXP tolcapone results in decreased expression of PIN4 mRNA CTD PMID:24136188 NCBI chr  X:72,004,413...72,011,667
Ensembl chr  X:72,004,482...72,011,664
JBrowse link
G Plin2 perilipin 2 affects binding EXP tolcapone binds to PLIN2 protein CTD PMID:19783845 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
JBrowse link
G Plin3 perilipin 3 affects binding EXP tolcapone binds to PLIN3 protein CTD PMID:19783845 NCBI chr 9:10,769,739...10,781,659
Ensembl chr 9:10,773,901...10,781,109
JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 increases expression EXP tolcapone results in increased expression of PNPLA2 mRNA CTD PMID:24136188 NCBI chr 1:214,434,638...214,439,720
Ensembl chr 1:214,434,626...214,439,720
Ensembl chr 1:214,434,626...214,439,720
JBrowse link
G Polr1h RNA polymerase I subunit H decreases expression EXP Tolcapone results in decreased expression of POLR1H mRNA CTD PMID:24136188 NCBI chr20:2,088,518...2,092,436
Ensembl chr20:2,088,533...2,092,436
JBrowse link
G Polr2g RNA polymerase II subunit G decreases expression EXP tolcapone results in decreased expression of POLR2G mRNA CTD PMID:24136188 NCBI chr 1:224,991,250...224,998,355
Ensembl chr 1:224,991,222...224,994,653
JBrowse link
G Prpf8 pre-mRNA processing factor 8 affects binding EXP tolcapone binds to PRPF8 protein CTD PMID:19783845 NCBI chr10:63,635,239...63,658,360
Ensembl chr10:63,635,219...63,658,361
JBrowse link
G Prxl2a peroxiredoxin like 2A affects binding EXP tolcapone binds to PRXL2A protein CTD PMID:19783845 NCBI chr16:17,494,000...17,513,781
Ensembl chr16:17,493,953...17,513,870
JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 affects binding EXP tolcapone binds to PSMC5 protein CTD PMID:19783845 NCBI chr10:94,445,877...94,451,811
Ensembl chr10:94,445,877...94,451,811
JBrowse link
G Psme2 proteasome activator subunit 2 affects binding EXP tolcapone binds to PSME2 protein CTD PMID:19783845 NCBI chr15:34,265,552...34,269,851
Ensembl chr15:34,265,557...34,269,851
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Tolcapone results in increased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptrh2 peptidyl-tRNA hydrolase 2 affects binding EXP tolcapone binds to PTRH2 protein CTD PMID:19783845 NCBI chr10:74,002,151...74,012,182
Ensembl chr10:74,002,151...74,012,159
JBrowse link
G Ramac RNA guanine-7 methyltransferase activating subunit decreases expression EXP tolcapone results in decreased expression of RAMAC mRNA CTD PMID:24136188 NCBI chr 1:143,583,675...143,589,563
Ensembl chr 1:143,583,675...143,589,556
JBrowse link
G Ran RAN, member RAS oncogene family affects binding EXP tolcapone binds to RAN protein CTD PMID:19783845 NCBI chr12:31,319,556...31,324,105
Ensembl chr12:31,320,624...31,323,810
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family decreases expression EXP tolcapone results in decreased expression of RAP1A mRNA CTD PMID:24136188 NCBI chr 2:208,193,950...208,215,186
Ensembl chr 2:208,193,954...208,215,187
JBrowse link
G Rbis ribosomal biogenesis factor decreases expression EXP Tolcapone results in decreased expression of RBIS mRNA CTD PMID:24136188 NCBI chr 2:88,338,018...88,350,785
Ensembl chr 2:88,344,527...88,350,784
JBrowse link
G Rbm8a RNA binding motif protein 8A decreases expression EXP tolcapone results in decreased expression of RBM8A mRNA CTD PMID:24136188 NCBI chr 2:198,755,261...198,758,028
Ensembl chr 2:198,755,262...198,758,028
JBrowse link
G Rbp1 retinol binding protein 1 decreases expression EXP tolcapone results in decreased expression of RBP1 mRNA CTD PMID:24136188 NCBI chr 8:106,449,321...106,470,842
Ensembl chr 8:106,449,321...106,470,842
JBrowse link
G Reep6 receptor accessory protein 6 affects binding EXP tolcapone binds to REEP6 protein CTD PMID:19783845 NCBI chr 7:12,240,059...12,246,814
Ensembl chr 7:12,240,060...12,246,729
JBrowse link
G RGD1307100 similar to RIKEN cDNA D630029K19 increases expression EXP tolcapone results in increased expression of RGD1307100 mRNA CTD PMID:24136188 NCBI chr 2:123,555,742...123,766,675
Ensembl chr 2:123,555,673...123,766,676
JBrowse link
G RGD1309779 similar to ENSANGP00000021391 decreases expression EXP tolcapone results in decreased expression of RGD1309779 mRNA CTD PMID:24136188 NCBI chr 8:68,308,286...68,312,975
Ensembl chr 8:68,308,286...68,312,909
JBrowse link
G RGD1311745 similar to RIKEN cDNA 1110059G10 decreases expression EXP tolcapone results in decreased expression of RGD1311745 mRNA CTD PMID:24136188 NCBI chr 8:132,029,618...132,032,971
Ensembl chr 8:132,029,621...132,036,472
JBrowse link
G RGD1563941 similar to hypothetical protein FLJ20010 decreases expression EXP tolcapone results in decreased expression of RGD1563941 mRNA CTD PMID:24136188 NCBI chr 8:52,829,196...52,829,610
Ensembl chr 8:52,829,085...52,830,609
JBrowse link
G Rnf7 ring finger protein 7 decreases expression EXP tolcapone results in decreased expression of RNF7 mRNA CTD PMID:24136188 NCBI chr 8:104,326,719...104,336,098
Ensembl chr 8:104,326,719...104,335,729
JBrowse link
G Rnls renalase, FAD-dependent amine oxidase decreases expression EXP tolcapone results in decreased expression of RNLS mRNA CTD PMID:24136188 NCBI chr 1:251,828,285...252,101,963
Ensembl chr 1:251,828,290...252,100,759
JBrowse link
G Romo1 reactive oxygen species modulator 1 decreases expression EXP tolcapone results in decreased expression of ROMO1 mRNA CTD PMID:24136188 NCBI chr 3:151,688,213...151,689,813
Ensembl chr 3:151,688,454...151,689,711
Ensembl chr 3:151,688,454...151,689,711
JBrowse link
G Rpa3 replication protein A3 decreases expression EXP tolcapone results in decreased expression of RPA3 mRNA CTD PMID:24136188 NCBI chr 4:34,279,320...34,282,351
Ensembl chr 4:34,279,320...34,282,351
JBrowse link
G Rpl10a ribosomal protein L10A affects binding EXP tolcapone binds to RPL10A protein CTD PMID:19783845 NCBI chr20:7,908,309...7,910,867
Ensembl chr20:7,908,304...7,910,867
JBrowse link
G Rpl15 ribosomal protein L15 affects binding EXP tolcapone binds to RPL15 protein CTD PMID:19783845 NCBI chr15:8,188,717...8,192,153
Ensembl chr15:8,189,253...8,192,152
JBrowse link
G Rpl18a ribosomal protein L18A affects binding EXP tolcapone binds to RPL18A protein CTD PMID:19783845 NCBI chr16:20,293,277...20,295,283
Ensembl chr16:20,293,229...20,295,294
JBrowse link
G Rpl22 ribosomal protein L22 affects binding EXP tolcapone binds to RPL22 protein CTD PMID:19783845 NCBI chr 5:169,506,150...169,512,875
Ensembl chr 5:169,506,138...169,512,871
JBrowse link
G Rpl22l1 ribosomal protein L22 like 1 decreases expression EXP tolcapone results in decreased expression of RPL22L1 mRNA CTD PMID:24136188 NCBI chr 2:115,362,799...115,364,735
Ensembl chr 2:115,362,799...115,364,729
JBrowse link
G Rpl23 ribosomal protein L23 affects binding EXP tolcapone binds to RPL23 protein CTD PMID:19783845 NCBI chr10:85,721,398...85,725,359
Ensembl chr10:85,721,394...85,725,429
JBrowse link
G Rpl35a ribosomal protein L35a decreases expression EXP tolcapone results in decreased expression of RPL35A mRNA CTD PMID:24136188 NCBI chr11:70,963,223...70,967,146
Ensembl chr12:7,186,473...7,186,873
Ensembl chr 5:7,186,473...7,186,873
Ensembl chr 1:7,186,473...7,186,873
Ensembl chr 6:7,186,473...7,186,873
Ensembl chr12:7,186,473...7,186,873
JBrowse link
G Rpl36a ribosomal protein L36a decreases expression EXP tolcapone results in decreased expression of RPL36A mRNA CTD PMID:24136188 NCBI chr  X:105,402,867...105,405,580
Ensembl chr  X:105,402,867...105,405,580
JBrowse link
G Rpl41 ribosomal protein L41 decreases expression EXP tolcapone results in decreased expression of RPL41 mRNA CTD PMID:24136188 NCBI chr 7:2,972,897...2,973,977
Ensembl chr 7:2,972,900...2,973,977
JBrowse link
G Rpl7a ribosomal protein L7a affects binding EXP tolcapone binds to RPL7A protein CTD PMID:19783845 NCBI chr 3:5,458,985...5,461,627
Ensembl chr 3:5,459,160...5,461,583
Ensembl chr 3:5,459,160...5,461,583
JBrowse link
G Rpl7l1 ribosomal protein L7-like 1 affects binding EXP tolcapone binds to RPL7L1 protein CTD PMID:19783845 NCBI chr 9:16,508,477...16,516,502
Ensembl chr 9:16,508,799...16,513,120
JBrowse link
G Rpl9 ribosomal protein L9 decreases expression EXP tolcapone results in decreased expression of RPL9 mRNA CTD PMID:24136188 NCBI chr14:44,524,419...44,527,613
Ensembl chr14:44,524,416...44,527,613
JBrowse link
G Rpp21 ribonuclease P/MRP subunit p21 decreases expression EXP tolcapone results in decreased expression of RPP21 mRNA CTD PMID:24136188 NCBI chr20:2,515,541...2,517,471
Ensembl chr20:2,515,520...2,517,498
JBrowse link
G Rps11 ribosomal protein S11 affects binding EXP tolcapone binds to RPS11 protein CTD PMID:19783845 NCBI chr 1:101,116,641...101,118,749
Ensembl chr 1:101,116,635...101,118,825
JBrowse link
G Rps14 ribosomal protein S14 affects binding EXP tolcapone binds to RPS14 protein CTD PMID:19783845 NCBI chr18:56,042,532...56,047,316
Ensembl chr18:56,044,369...56,047,316
JBrowse link
G Rps15a ribosomal protein S15a decreases expression EXP tolcapone results in decreased expression of RPS15A mRNA CTD PMID:24136188 NCBI chr 1:187,759,865...187,766,734
Ensembl chr 1:187,759,480...187,766,709
JBrowse link
G Rps20 ribosomal protein S20 affects binding EXP tolcapone binds to RPS20 protein CTD PMID:19783845 NCBI chr 5:16,706,052...16,707,214
Ensembl chr 5:16,706,082...16,706,909
JBrowse link
G Rps21-ps1 ribosomal protein S21, pseudogene 1 decreases expression EXP tolcapone results in decreased expression of RPS21 mRNA CTD PMID:24136188 NCBI chr 5:159,606,647...159,606,990 JBrowse link
G Rps24 ribosomal protein S24 decreases expression EXP tolcapone results in decreased expression of RPS24 mRNA CTD PMID:24136188 NCBI chr16:757,390...762,091
Ensembl chr16:757,403...762,075
JBrowse link
G Rps25 ribosomal protein s25 decreases expression EXP tolcapone results in decreased expression of RPS25 mRNA CTD PMID:24136188 NCBI chr 8:48,727,346...48,729,722
Ensembl chr 8:48,727,618...48,729,580
JBrowse link
G Rps27 ribosomal protein S27 decreases expression EXP tolcapone results in decreased expression of RPS27 mRNA CTD PMID:24136188 NCBI chr 2:189,572,175...189,573,280
Ensembl chr 2:189,572,176...189,573,280
JBrowse link
G Rps27a ribosomal protein S27a affects binding EXP tolcapone binds to RPS27A protein CTD PMID:19783845 NCBI chr14:113,966,163...113,968,440
Ensembl chr14:113,966,611...113,968,268
Ensembl chr 5:113,966,611...113,968,268
JBrowse link
G S100a10 S100 calcium binding protein A10 decreases expression EXP tolcapone results in decreased expression of S100A10 mRNA CTD PMID:24136188 NCBI chr 2:193,892,589...193,901,236
Ensembl chr 2:193,892,589...193,901,236
JBrowse link
G Sc5d sterol-C5-desaturase increases expression EXP tolcapone results in increased expression of SC5D mRNA CTD PMID:24136188 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050
JBrowse link
G Scd stearoyl-CoA desaturase affects binding
decreases expression
EXP tolcapone binds to SCD protein
tolcapone results in decreased expression of SCD1 mRNA
CTD PMID:19783845 PMID:24136188 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A affects binding EXP tolcapone binds to SDHA protein CTD PMID:19783845 NCBI chr 1:31,545,631...31,570,601
Ensembl chr 1:31,545,631...31,570,601
JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B affects binding EXP tolcapone binds to SDHB protein CTD PMID:19783845 NCBI chr 5:159,484,378...159,505,063
Ensembl chr 5:159,484,370...159,505,064
JBrowse link
G Sec11c SEC11 homolog C, signal peptidase complex subunit affects binding EXP tolcapone binds to SEC11C protein CTD PMID:19783845 NCBI chr18:61,490,051...61,506,393
Ensembl chr18:61,490,031...61,506,508
JBrowse link
G Sec31a SEC31 homolog A, COPII coat complex component affects binding EXP tolcapone binds to SEC31A protein CTD PMID:19783845 NCBI chr14:10,854,713...10,909,579
Ensembl chr14:10,854,682...10,909,612
JBrowse link
G Serbp1 Serpine1 mRNA binding protein 1 affects binding EXP tolcapone binds to SERBP1 protein CTD PMID:19783845 NCBI chr 4:98,027,563...98,044,717
Ensembl chr 4:98,027,554...98,044,566
JBrowse link
G Sf3b6 splicing factor 3B, subunit 6 affects binding EXP tolcapone binds to SF3B6 protein CTD PMID:19783845 NCBI chr 6:29,991,232...29,999,668
Ensembl chr 6:29,991,307...29,999,410
JBrowse link
G Sfxn1 sideroflexin 1 affects binding EXP tolcapone binds to SFXN1 protein CTD PMID:19783845 NCBI chr17:11,046,588...11,082,219
Ensembl chr17:11,045,761...11,082,047
JBrowse link
G Sik3 SIK family kinase 3 increases expression EXP tolcapone results in increased expression of SIK3 mRNA CTD PMID:24136188 NCBI chr 8:50,310,263...50,520,284
Ensembl chr 8:50,310,405...50,520,173
JBrowse link
G Slc1a5 solute carrier family 1 member 5 affects binding EXP tolcapone binds to SLC1A5 protein CTD PMID:19783845 NCBI chr 1:78,710,686...78,724,789
Ensembl chr 1:78,710,539...78,724,794
JBrowse link
G Slc25a1 solute carrier family 25 member 1 affects binding EXP tolcapone binds to SLC25A1 protein CTD PMID:19783845 NCBI chr11:87,204,248...87,207,265
Ensembl chr11:87,204,175...87,207,264
JBrowse link
G Slc25a13 solute carrier family 25 member 13 affects binding EXP tolcapone binds to SLC25A13 protein CTD PMID:19783845 NCBI chr 4:31,134,165...31,757,006
Ensembl chr 4:31,608,269...31,730,386
JBrowse link
G Slc25a4 solute carrier family 25 member 4 affects binding EXP tolcapone binds to SLC25A4 protein CTD PMID:19783845 NCBI chr16:49,266,903...49,270,698
Ensembl chr16:49,266,903...49,270,698
JBrowse link
G Slc25a5 solute carrier family 25 member 5 affects binding EXP tolcapone binds to SLC25A5 protein CTD PMID:19783845 NCBI chr  X:123,404,570...123,407,637
Ensembl chr  X:123,404,518...123,407,645
JBrowse link
G Slc25a6 solute carrier family 25 member 6 affects binding EXP tolcapone binds to SLC25A6 protein CTD PMID:19783845 NCBI chr18:70,959,872...70,961,040
Ensembl chr18:70,959,887...70,960,786
JBrowse link
G Slc39a7 solute carrier family 39 member 7 affects binding EXP tolcapone binds to SLC39A7 protein CTD PMID:19783845 NCBI chr20:3,819,416...3,822,788
Ensembl chr20:3,819,414...3,822,778
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Tolcapone results in decreased expression of SLC7A11 mRNA CTD PMID:32816093 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO Tolcapone results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
JBrowse link
G Smim26 small integral membrane protein 26 decreases expression EXP tolcapone results in decreased expression of SMIM26 mRNA CTD PMID:24136188 NCBI chr 3:138,764,926...138,766,515
Ensembl chr 3:138,765,027...138,766,515
JBrowse link
G Snapin SNAP-associated protein decreases expression EXP tolcapone results in decreased expression of SNAPIN mRNA CTD PMID:24136188 NCBI chr 2:189,878,159...189,880,743
Ensembl chr 2:189,878,168...189,880,743
JBrowse link
G Snca synuclein alpha multiple interactions ISO tolcapone inhibits the reaction [SNCA protein binds to SNCA protein] CTD PMID:20150427 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Snrnp27 small nuclear ribonucleoprotein U4/U6.U5 subunit 27 decreases expression EXP tolcapone results in decreased expression of SNRNP27 mRNA CTD PMID:24136188 NCBI chr 4:118,478,075...118,487,633
Ensembl chr 4:118,478,075...118,534,280
JBrowse link
G Snrpb2 small nuclear ribonucleoprotein polypeptide B2 decreases expression EXP tolcapone results in decreased expression of SNRPB2 mRNA CTD PMID:24136188 NCBI chr 3:137,138,082...137,147,575
Ensembl chr 3:137,137,980...137,147,575
JBrowse link
G Snrpd3 small nuclear ribonucleoprotein D3 polypeptide decreases expression EXP tolcapone results in decreased expression of SNRPD3 mRNA CTD PMID:24136188 NCBI chr20:14,080,562...14,095,644
Ensembl chr20:14,080,565...14,095,181
JBrowse link
G Snrpe small nuclear ribonucleoprotein polypeptide E decreases expression EXP tolcapone results in decreased expression of SNRPE mRNA CTD PMID:24136188 NCBI chr13:50,252,707...50,258,951
Ensembl chr 8:129,371,556...129,371,973
JBrowse link
G Snrpf small nuclear ribonucleoprotein polypeptide F decreases expression EXP tolcapone results in decreased expression of SNRPF mRNA CTD PMID:24136188 NCBI chr 7:34,478,331...34,485,034
Ensembl chr 7:34,478,331...34,485,034
JBrowse link
G Snrpg small nuclear ribonucleoprotein polypeptide G decreases expression EXP tolcapone results in decreased expression of SNRPG mRNA CTD PMID:24136188 NCBI chr 4:118,167,267...118,174,846
Ensembl chr 4:118,167,294...118,174,842
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO tolcapone results in decreased expression of SOD1 mRNA CTD PMID:28526448 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO tolcapone results in decreased expression of SOD2 mRNA CTD PMID:28526448 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Srp14 signal recognition particle 14 decreases expression EXP tolcapone results in decreased expression of SRP14 mRNA CTD PMID:24136188 NCBI chr 3:110,245,936...110,249,627
Ensembl chr 3:110,245,936...110,249,627
JBrowse link
G Srprb SRP receptor subunit beta affects binding EXP tolcapone binds to SRPRB protein CTD PMID:19783845 NCBI chr 8:111,673,479...111,687,426 JBrowse link
G Ss18l2 SS18 like 2 decreases expression EXP tolcapone results in decreased expression of SS18L2 mRNA CTD PMID:24136188 NCBI chr 8:130,350,504...130,353,126
Ensembl chr 8:130,350,510...130,353,140
JBrowse link
G Ssr1 signal sequence receptor subunit 1 affects binding EXP tolcapone binds to SSR1 protein CTD PMID:19783845 NCBI chr17:27,496,369...27,512,781
Ensembl chr17:27,492,220...27,523,912
JBrowse link
G Stac3 SH3 and cysteine rich domain 3 decreases expression EXP tolcapone results in decreased expression of STAC3 mRNA CTD PMID:24136188 NCBI chr 7:70,807,427...70,815,271
Ensembl chr 7:70,807,867...70,815,270
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases expression EXP tolcapone results in increased expression of STAT3 mRNA CTD PMID:24136188 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 affects binding EXP tolcapone binds to SULT2A1 protein CTD PMID:19783845 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Taf9 TATA-box binding protein associated factor 9 decreases expression EXP tolcapone results in decreased expression of TAF9 mRNA CTD PMID:24136188 NCBI chr 2:30,664,407...30,668,414
Ensembl chr 2:30,664,639...30,668,414
JBrowse link
G Tbca tubulin folding cofactor A decreases expression EXP tolcapone results in decreased expression of TBCA mRNA CTD PMID:24136188 NCBI chr 2:24,449,498...24,505,351
Ensembl chr 2:24,449,485...24,505,334
JBrowse link
G Tceal8 transcription elongation factor A like 8 decreases expression EXP tolcapone results in decreased expression of TCEAL8 mRNA CTD PMID:24136188 NCBI chr  X:106,713,319...106,715,391
Ensembl chr  X:106,713,320...106,715,391
JBrowse link
G Tfr2 transferrin receptor 2 increases expression EXP tolcapone results in increased expression of TFR2 mRNA CTD PMID:24136188 NCBI chr12:22,177,382...22,194,330
Ensembl chr12:22,177,382...22,194,299
JBrowse link
G Timm10 translocase of inner mitochondrial membrane 10 decreases expression EXP tolcapone results in decreased expression of TIMM10 mRNA CTD PMID:24136188 NCBI chr 3:72,226,563...72,230,087
Ensembl chr 3:72,226,613...72,230,084
JBrowse link
G Timm44 translocase of inner mitochondrial membrane 44 affects binding EXP tolcapone binds to TIMM44 protein CTD PMID:19783845 NCBI chr12:2,517,006...2,533,707
Ensembl chr12:2,517,006...2,533,706
JBrowse link
G Timm8b translocase of inner mitochondrial membrane 8 homolog B decreases expression EXP tolcapone results in decreased expression of TIMM8B mRNA CTD PMID:24136188 NCBI chr 8:55,037,750...55,039,130
Ensembl chr 8:55,037,750...55,039,128
JBrowse link
G Tk2 thymidine kinase 2 affects binding EXP tolcapone binds to TK2 protein CTD PMID:19783845 NCBI chr19:917,203...939,236
Ensembl chr19:917,203...939,221
JBrowse link
G Tm2d1 TM2 domain containing 1 decreases expression EXP tolcapone results in decreased expression of TM2D1 mRNA CTD PMID:24136188 NCBI chr 5:116,992,405...117,038,882
Ensembl chr 5:116,996,652...117,038,882
JBrowse link
G Tmed10 transmembrane p24 trafficking protein 10 affects binding EXP tolcapone binds to TMED10 protein CTD PMID:19783845 NCBI chr 6:109,169,739...109,205,004
Ensembl chr 6:109,169,741...109,205,004
JBrowse link
G Tmed4 transmembrane p24 trafficking protein 4 affects binding EXP tolcapone binds to TMED4 protein CTD PMID:19783845 NCBI chr14:86,390,327...86,395,151
Ensembl chr14:86,390,338...86,395,135
JBrowse link
G Tmed9 transmembrane p24 trafficking protein 9 affects binding EXP tolcapone binds to TMED9 protein CTD PMID:19783845 NCBI chr17:9,560,735...9,565,249
Ensembl chr17:9,560,761...9,565,249
JBrowse link
G Tmem126a transmembrane protein 126A decreases expression EXP tolcapone results in decreased expression of TMEM126A mRNA CTD PMID:24136188 NCBI chr 1:156,283,105...156,291,057
Ensembl chr 1:156,283,128...156,291,052
JBrowse link
G Tmem126b transmembrane protein 126B decreases expression EXP tolcapone results in decreased expression of TMEM126B mRNA CTD PMID:24136188 NCBI chr 1:156,262,220...156,274,207
Ensembl chr 1:156,262,031...156,275,002
JBrowse link
G Tmem128 transmembrane protein 128 decreases expression EXP tolcapone results in decreased expression of TMEM128 mRNA CTD PMID:24136188 NCBI chr14:77,270,794...77,279,979
Ensembl chr14:77,270,811...77,279,831
JBrowse link
G Tmem203 transmembrane protein 203 decreases expression EXP tolcapone results in decreased expression of TMEM203 mRNA CTD PMID:24136188 NCBI chr 3:2,474,972...2,475,800
Ensembl chr 3:2,474,972...2,475,800
JBrowse link
G Tmem238 transmembrane protein 238 decreases expression EXP tolcapone results in decreased expression of TMEM238 mRNA CTD PMID:24136188 NCBI chr 1:72,623,409...72,629,606 JBrowse link
G Tmem256 transmembrane protein 256 decreases expression EXP tolcapone results in decreased expression of TMEM256 mRNA CTD PMID:24136188 NCBI chr10:56,446,022...56,447,138
Ensembl chr10:56,445,647...56,447,138
JBrowse link
G Tmsb4x thymosin beta 4, X-linked decreases expression EXP tolcapone results in decreased expression of TMSB4X mRNA CTD PMID:24136188 NCBI chr  X:28,593,405...28,617,267
Ensembl chr  X:28,593,405...28,595,395
JBrowse link
G Tnfaip8 TNF alpha induced protein 8 affects binding EXP tolcapone binds to TNFAIP8 protein CTD PMID:19783845 NCBI chr18:44,664,310...44,779,914
Ensembl chr18:44,716,226...44,779,914
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression EXP tolcapone results in increased expression of TNFRSF1A mRNA CTD PMID:24136188 NCBI chr 4:157,864,905...157,877,634
Ensembl chr 4:157,864,969...157,877,633
JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 affects binding EXP tolcapone binds to TOMM20 protein CTD PMID:19783845 NCBI chr19:59,863,421...59,873,411
Ensembl chr19:59,863,421...59,873,411
JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 affects binding EXP tolcapone binds to TOMM40 protein CTD PMID:19783845 NCBI chr 1:80,617,749...80,630,253
Ensembl chr 1:80,618,154...80,630,038
JBrowse link
G Tomm7 translocase of outer mitochondrial membrane 7 affects binding EXP tolcapone binds to TOMM7 protein CTD PMID:19783845 NCBI chr 4:7,835,949...7,842,790
Ensembl chr 4:7,835,949...7,842,789
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 decreases expression EXP tolcapone results in decreased expression of TP53I3 mRNA CTD PMID:24136188 NCBI chr13:75,101,759...75,145,967
Ensembl chr13:75,105,615...75,143,441
JBrowse link
G Trappc2l trafficking protein particle complex subunit 2L decreases expression EXP tolcapone results in decreased expression of TRAPPC2L mRNA CTD PMID:24136188 NCBI chr19:55,423,350...55,428,551
Ensembl chr19:55,423,350...55,427,036
JBrowse link
G Tspan6 tetraspanin 6 decreases expression EXP tolcapone results in decreased expression of TSPAN6 mRNA CTD PMID:24136188 NCBI chr  X:104,719,930...104,729,606
Ensembl chr  X:104,719,940...104,726,816
JBrowse link
G Tubb6 tubulin, beta 6 class V affects binding EXP tolcapone binds to TUBB6 protein CTD PMID:19783845 NCBI chr18:63,130,542...63,140,181
Ensembl chr18:63,130,542...63,140,181
JBrowse link
G Txndc17 thioredoxin domain containing 17 decreases expression EXP tolcapone results in decreased expression of TXNDC17 mRNA CTD PMID:24136188 NCBI chr10:58,776,792...58,779,764
Ensembl chr10:58,776,792...58,779,764
JBrowse link
G Uchl3-ps1 ubiquitin carboxyl-terminal esterase L3, pseudogene 1 decreases expression EXP tolcapone results in decreased expression of UCHL3-PS1 mRNA CTD PMID:24136188 NCBI chr 3:171,092,806...171,134,704 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 decreases glucuronidation
increases glucuronidation
ISO UGT1A9 protein mutant form results in decreased glucuronidation of tolcapone
UGT1A9 protein results in increased glucuronidation of tolcapone
CTD PMID:16344532 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 affects binding EXP tolcapone binds to UQCRC2 protein CTD PMID:19783845 NCBI chr 1:190,555,177...190,585,741
Ensembl chr 1:190,555,177...190,585,734
JBrowse link
G Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 affects binding EXP tolcapone binds to UQCRFS1 protein CTD PMID:19783845 NCBI chr17:35,677,984...35,682,262
Ensembl chr17:35,677,984...35,682,259
JBrowse link
G Uvrag UV radiation resistance associated increases expression EXP tolcapone results in increased expression of UVRAG mRNA CTD PMID:24136188 NCBI chr 1:163,844,804...164,101,568
Ensembl chr 1:163,844,818...164,101,578
JBrowse link
G Vdac2 voltage-dependent anion channel 2 affects binding EXP tolcapone binds to VDAC2 protein CTD PMID:19783845 NCBI chr15:2,634,622...2,648,548
Ensembl chr15:2,634,624...2,648,551
JBrowse link
G Vdac3 voltage-dependent anion channel 3 affects binding EXP tolcapone binds to VDAC3 protein CTD PMID:19783845 NCBI chr16:74,292,466...74,308,910
Ensembl chr16:74,292,438...74,308,903
JBrowse link
G Vsnl1 visinin-like 1 affects binding EXP tolcapone binds to VSNL1 protein CTD PMID:19783845 NCBI chr 6:37,001,360...37,121,969
Ensembl chr 6:37,001,356...37,122,023
JBrowse link
G Washc3 WASH complex subunit 3 decreases expression EXP tolcapone results in decreased expression of WASHC3 mRNA CTD PMID:24136188 NCBI chr 7:28,762,417...28,809,286
Ensembl chr 7:28,762,417...28,809,280
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein affects binding EXP tolcapone binds to WFS1 protein CTD PMID:19783845 NCBI chr14:78,640,707...78,665,224
Ensembl chr14:78,640,620...78,665,966
JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 increases expression EXP Tolcapone results in increased expression of YARS1 mRNA CTD PMID:24136188 NCBI chr 5:147,375,350...147,403,578
Ensembl chr 5:147,375,350...147,403,571
JBrowse link
G Yeats4 YEATS domain containing 4 decreases expression EXP tolcapone results in decreased expression of YEATS4 mRNA CTD PMID:24136188 NCBI chr 7:60,287,477...60,294,618
Ensembl chr 7:60,287,531...60,294,796
JBrowse link
G Znrf1 zinc and ring finger 1 increases expression EXP tolcapone results in increased expression of ZNRF1 mRNA CTD PMID:24136188 NCBI chr19:43,750,205...43,834,962
Ensembl chr19:43,750,278...43,832,878
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      application 19406
        pharmaceutical 19304
          drug 19304
            antidyskinesia agent 1145
              antiparkinson drug 860
                tolcapone 344
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic group 18599
                              organic divalent group 18590
                                organodiyl group 18590
                                  carbonyl group 18505
                                    carbonyl compound 18505
                                      ketone 16829
                                        aromatic ketone 12096
                                          benzophenones 1182
                                            tolcapone 344
paths to the root