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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tizanidine
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Accession:CHEBI:63629 term browser browse the term
Definition:2,1,3-Benzothiadiazole substituted at C-4 by a Delta(1)-imidazolin-2-ylamino group and at C-4 by a chloro group. It is an agonist at alpha2-adrenergic receptor sites.
Synonyms:exact_synonym: 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine
 related_synonym: 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole;   Formula=C9H8ClN5S;   InChI=1S/C9H8ClN5S/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9/h1-2H,3-4H2,(H2,11,12,13);   InChIKey=XFYDIVBRZNQMJC-UHFFFAOYSA-N;   SMILES=Clc1ccc2nsnc2c1NC1=NCCN1;   tizanidina;   tizanidinum
 alt_id: CHEBI:9608
 xref: Beilstein:618691;   CAS:51322-75-9;   DrugBank:DB00697;   Drug_Central:2683;   KEGG:C07452;   KEGG:D08611;   LINCS:LSM-5242
 xref_mesh: MESH:C023754
 xref: PMID:21317414;   PMID:21733633;   PMID:21982341;   PMID:22196407;   PMID:22223284;   Patent:US3843668;   Reaxys:618691;   Wikipedia:Tizanidine



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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
multiple interactions
increases metabolic processing
ISO CYP1A2 protein affects the metabolism of tizanidine
[[Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of CYP1A2 protein] which results in decreased metabolism of tizanidine; Ciprofloxacin inhibits the reaction [CYP1A2 protein affects the metabolism of tizanidine]; rofecoxib inhibits the reaction [CYP1A2 protein results in increased metabolism of tizanidine]
CTD PMID:15592331 PMID:15834531 PMID:16198659 PMID:16934051 PMID:17618427 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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  CHEBI ontology 19800
    role 19751
      application 19498
        pharmaceutical 19356
          drug 19356
            neuromuscular agent 1315
              muscle relaxant 1310
                tizanidine 1
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  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  heteroarene 16542
                                    monocyclic heteroarene 13505
                                      azole 12710
                                        diazole 8598
                                          imidazoles 7695
                                            tizanidine 1
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