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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tenofovir (anhydrous)
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Accession:CHEBI:63625 term browser browse the term
Definition:A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.
Synonyms:exact_synonym: ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonic acid
 related_synonym: (R)-PMPA;   Formula=C9H14N5O4P;   InChI=1S/C9H14N5O4P/c1-6(18-5-19(15,16)17)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H2,10,11,12)(H2,15,16,17)/t6-/m1/s1;   InChIKey=SGOIRFVFHAKUTI-ZCFIWIBFSA-N;   SMILES=C[C@H](Cn1cnc2c(N)ncnc12)OCP(O)(O)=O;   anh. tenofovir;   tenofovir
 xref: CAS:147127-20-6;   DrugBank:DB00300;   HMDB:HMDB0014445;   KEGG:D06074;   LINCS:LSM-5340;   PMID:11777298;   PMID:25017682;   PMID:28166217;   PMID:28503983;   Reaxys:7415378;   Wikipedia:Tenofovir
 cyclic_relationship: is_conjugate_acid_of CHEBI:134504

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tenofovir disoproxil fumarate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Tenofovir results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Acacb acetyl-CoA carboxylase beta affects expression ISO Tenofovir affects the expression of ACACB mRNA CTD PMID:20032539 NCBI chr12:48,127,149...48,238,969
Ensembl chr12:48,127,149...48,238,887 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression ISO Tenofovir results in increased expression of BNIP3L protein CTD PMID:23640862 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression
multiple interactions		 ISO Tenofovir results in increased expression of CCL20 mRNA
Tenofovir results in increased expression of and results in increased secretion of CCL20 protein		 CTD PMID:24205323 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO [Emtricitabine co-treated with Tenofovir] results in increased expression of CDKN1A protein
Tenofovir results in increased expression of CDKN1A protein		 CTD PMID:31545371 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Tenofovir results in decreased activity of CYP2E1 protein CTD PMID:17162464 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Edn1 endothelin 1 increases secretion
multiple interactions		 ISO Tenofovir results in increased secretion of EDN1 protein
coenzyme Q10 inhibits the reaction [Tenofovir results in increased secretion of EDN1 protein]		 CTD PMID:23640862 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha affects phosphorylation ISO Tenofovir affects the phosphorylation of EIF2S1 protein CTD PMID:27041070 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases secretion
multiple interactions		 ISO Tenofovir results in increased secretion of HAVCR1 protein
Tenofovir inhibits the reaction [cidofovir results in increased secretion of HAVCR1 protein]		 CTD PMID:29738843 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 affects expression ISO Tenofovir affects the expression of HSD11B1 mRNA CTD PMID:20032539 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 affects expression ISO Tenofovir affects the expression of HSPD1 protein CTD PMID:27041070 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
G Lipe lipase E, hormone sensitive type affects expression ISO Tenofovir affects the expression of LIPE mRNA CTD PMID:20032539 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727 		JBrowse link
G Lonp1 lon peptidase 1, mitochondrial affects expression ISO Tenofovir affects the expression of LONP1 protein CTD PMID:27041070 NCBI chr 9:10,428,853...10,441,180
Ensembl chr 9:10,428,853...10,441,177 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 affects phosphorylation ISO Tenofovir affects the phosphorylation of MAPK8 protein CTD PMID:27041070 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO Tenofovir promotes the reaction [Didanosine results in decreased expression of COX2 mRNA] CTD PMID:16940060 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression EXP Tenofovir results in decreased expression of NFKBIA protein CTD PMID:27899301 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Tenofovir results in increased expression of NOS2 mRNA; Tenofovir results in increased expression of NOS2 protein CTD PMID:27899301 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases phosphorylation		 ISO coenzyme Q10 inhibits the reaction [Tenofovir results in decreased phosphorylation of NOS3 protein] CTD PMID:23640862 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects expression ISO Tenofovir affects the expression of NR3C1 mRNA CTD PMID:20032539 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression ISO Tenofovir results in increased expression of NT5E mRNA CTD PMID:24205323 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696 		JBrowse link
G Nt5m 5',3'-nucleotidase, mitochondrial decreases expression ISO Tenofovir results in decreased expression of NT5M mRNA CTD PMID:24205323 NCBI chr10:46,216,494...46,244,478
Ensembl chr10:46,216,884...46,243,077 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO Tenofovir affects the expression of PPARG mRNA CTD PMID:20032539 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO [Emtricitabine co-treated with Tenofovir] results in decreased expression of PRKN protein CTD PMID:31545371 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Tenofovir results in increased expression of PTGS2 mRNA; Tenofovir results in increased expression of PTGS2 protein CTD PMID:27899301 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
increases expression		 EXP Melatonin inhibits the reaction [Tenofovir affects the localization of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of and results in increased activity of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of RELA mRNA]; Tenofovir results in increased expression of and results in increased activity of RELA protein CTD PMID:27899301 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sirt3 sirtuin 3 increases expression ISO Tenofovir results in increased expression of SIRT3 protein CTD PMID:27041070 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases response to substance
increases import
multiple interactions		 ISO SLC22A6 protein results in increased susceptibility to Tenofovir
SLC22A6 protein results in increased import of Tenofovir
Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to Tenofovir]; SLC22A6 protein results in increased uptake of and results in increased susceptibility to Tenofovir; Tenofovir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]		 CTD PMID:23856525 PMID:25448811 PMID:29738843 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases response to substance
increases import		 ISO SLC22A8 protein results in increased susceptibility to Tenofovir
SLC22A8 protein results in increased import of Tenofovir		 CTD PMID:25448811 PMID:29738843 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482 		JBrowse link
G Tnf tumor necrosis factor decreases expression
increases expression		 ISO
EXP		 Tenofovir results in decreased expression of TNF mRNA
Tenofovir results in increased expression of TNF mRNA; Tenofovir results in increased expression of TNF protein		 CTD PMID:24205323 PMID:27899301 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO [Emtricitabine co-treated with Tenofovir] results in increased expression of TP53 protein
Tenofovir results in increased expression of TP53 protein		 CTD PMID:31545371 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      biological role 19711
        antimicrobial agent 17369
          antiviral agent 10271
            antiviral drug 1849
              tenofovir (anhydrous) 30
                tenofovir disoproxil + 30
                tenofovir hydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19569
                        carbon atom 19559
                          organic molecular entity 19559
                            heteroorganic entity 19195
                              organochalcogen compound 18941
                                organooxygen compound 18868
                                  carbohydrates and carbohydrate derivatives 12260
                                    carbohydrate 12260
                                      carbohydrate derivative 11888
                                        glycosyl compound 10962
                                          N-glycosyl compound 5484
                                            nucleoside analogue 710
                                              tenofovir (anhydrous) 30
                                                tenofovir disoproxil + 30
                                                tenofovir hydrate 0
paths to the root