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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:rasagiline
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Accession:CHEBI:63620 term browser browse the term
Definition:An indane that consists of 1-aminoindane bearing an N-propargyl substituent. A selective, irreversible monoamine oxidase-B inhibitor.
Synonyms:exact_synonym: (1R)-N-(prop-2-yn-1-yl)indan-1-amine
 related_synonym: (1R)-N-propargylindan-1-amine;   (R)-N-2-Propynyl-1-indanamine;   (R)-indan-1-yl-prop-2-ynyl-amine;   Formula=C12H13N;   InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1;   InChIKey=RUOKEQAAGRXIBM-GFCCVEGCSA-N;   RAS;   SMILES=C#CCN[C@@H]1CCc2ccccc12
 xref: CAS:136236-51-6;   DrugBank:DB01367;   KEGG:D08469
 xref_mesh: MESH:C031967
 xref: PMID:20577110;   PMID:21482191;   PMID:21500280;   PMID:21628600;   PMID:21671840;   PMID:21819487;   PMID:21864207;   PMID:21878836;   PMID:21895884;   PMID:21946113;   PMID:21953831;   PMID:21971006;   PMID:21971007;   PMID:22045282;   PMID:22065207;   Reaxys:9194207;   Wikipedia:Rasagiline


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rasagiline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GDNF glial cell derived neurotrophic factor multiple interactions
increases expression		 EXP Sulfasalazine inhibits the reaction [rasagiline results in increased expression of GDNF protein]
rasagiline results in increased expression of GDNF mRNA; rasagiline results in increased expression of GDNF protein		 CTD PMID:14687604 NCBI chr 5:37,812,677...37,840,041
Ensembl chr 5:37,812,677...37,840,041 		JBrowse link
G MAOB monoamine oxidase B decreases activity EXP rasagiline results in decreased activity of MAOB protein CTD PMID:21923181 NCBI chr  X:43,766,610...43,882,450
Ensembl chr  X:43,766,610...43,882,450 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP rasagiline results in increased localization of and results in increased activity of RELA protein; Sulfasalazine inhibits the reaction [rasagiline results in increased localization of and results in increased activity of RELA protein] CTD PMID:14687604 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      application 25172
        pharmaceutical 24558
          drug 24544
            protective agent 20758
              neuroprotective agent 17678
                rasagiline 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    main group molecular entity 25834
                      s-block molecular entity 25166
                        hydrogen molecular entity 24765
                          hydrides 22965
                            inorganic hydride 20483
                              pnictogen hydride 20424
                                nitrogen hydride 20200
                                  azane 19942
                                    ammonia 19941
                                      organic amino compound 19941
                                        secondary amino compound 6948
                                          secondary amine 1827
                                            rasagiline 3
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