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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:rasagiline
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Accession:CHEBI:63620 term browser browse the term
Definition:An indane that consists of 1-aminoindane bearing an N-propargyl substituent. A selective, irreversible monoamine oxidase-B inhibitor.
Synonyms:exact_synonym: (1R)-N-(prop-2-yn-1-yl)indan-1-amine
 related_synonym: (1R)-N-propargylindan-1-amine;   (R)-N-2-Propynyl-1-indanamine;   (R)-indan-1-yl-prop-2-ynyl-amine;   Formula=C12H13N;   InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1;   InChIKey=RUOKEQAAGRXIBM-GFCCVEGCSA-N;   RAS;   SMILES=C#CCN[C@@H]1CCc2ccccc12
 xref: CAS:136236-51-6;   DrugBank:DB01367;   KEGG:D08469
 xref_mesh: MESH:C031967
 xref: PMID:20577110;   PMID:21482191;   PMID:21500280;   PMID:21628600;   PMID:21671840;   PMID:21819487;   PMID:21864207;   PMID:21878836;   PMID:21895884;   PMID:21946113;   PMID:21953831;   PMID:21971006;   PMID:21971007;   PMID:22045282;   PMID:22065207;   Reaxys:9194207;   Wikipedia:Rasagiline


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rasagiline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gdnf glial cell derived neurotrophic factor multiple interactions
increases expression
ISO Sulfasalazine inhibits the reaction [rasagiline results in increased expression of GDNF protein]
rasagiline results in increased expression of GDNF mRNA; rasagiline results in increased expression of GDNF protein
CTD PMID:14687604 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Maob monoamine oxidase B decreases activity ISO rasagiline results in decreased activity of MAOB protein CTD PMID:21923181 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO rasagiline results in increased localization of and results in increased activity of RELA protein; Sulfasalazine inhibits the reaction [rasagiline results in increased localization of and results in increased activity of RELA protein] CTD PMID:14687604 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      application 19423
        pharmaceutical 19321
          drug 19321
            protective agent 16498
              neuroprotective agent 15506
                rasagiline 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    main group molecular entity 19675
                      s-block molecular entity 19443
                        hydrogen molecular entity 19439
                          hydrides 18763
                            inorganic hydride 17484
                              pnictogen hydride 17461
                                nitrogen hydride 17315
                                  azane 17021
                                    ammonia 17020
                                      organic amino compound 17019
                                        secondary amino compound 6585
                                          secondary amine 1722
                                            rasagiline 3
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