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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:rasagiline
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Accession:CHEBI:63620 term browser browse the term
Definition:An indane that consists of 1-aminoindane bearing an N-propargyl substituent. A selective, irreversible monoamine oxidase-B inhibitor.
Synonyms:exact_synonym: (1R)-N-(prop-2-yn-1-yl)indan-1-amine
 related_synonym: (1R)-N-propargylindan-1-amine;   (R)-N-2-Propynyl-1-indanamine;   (R)-indan-1-yl-prop-2-ynyl-amine;   Formula=C12H13N;   InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1;   InChIKey=RUOKEQAAGRXIBM-GFCCVEGCSA-N;   RAS;   SMILES=C#CCN[C@@H]1CCc2ccccc12
 xref: CAS:136236-51-6;   DrugBank:DB01367;   KEGG:D08469
 xref_mesh: MESH:C031967
 xref: PMID:20577110;   PMID:21482191;   PMID:21500280;   PMID:21628600;   PMID:21671840;   PMID:21819487;   PMID:21864207;   PMID:21878836;   PMID:21895884;   PMID:21946113;   PMID:21953831;   PMID:21971006;   PMID:21971007;   PMID:22045282;   PMID:22065207;   Reaxys:9194207;   Wikipedia:Rasagiline


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rasagiline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gdnf glial cell derived neurotrophic factor multiple interactions
increases expression		 ISO Sulfasalazine inhibits the reaction [rasagiline results in increased expression of GDNF protein]
rasagiline results in increased expression of GDNF mRNA; rasagiline results in increased expression of GDNF protein		 CTD PMID:14687604 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Maob monoamine oxidase B decreases activity ISO rasagiline results in decreased activity of MAOB protein CTD PMID:21923181 NCBI chr  X:5,907,327...6,010,996
Ensembl chr  X:5,907,266...6,011,003 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO rasagiline results in increased localization of and results in increased activity of RELA protein; Sulfasalazine inhibits the reaction [rasagiline results in increased localization of and results in increased activity of RELA protein] CTD PMID:14687604 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19911
    role 19854
      application 19722
        pharmaceutical 19556
          drug 19556
            protective agent 18263
              neuroprotective agent 15712
                rasagiline 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19911
    subatomic particle 19909
      composite particle 19909
        hadron 19880
          baryon 19880
            nucleon 19909
              atomic nucleus 19880
                atom 19909
                  main group element atom 19849
                    main group molecular entity 19849
                      s-block molecular entity 19681
                        hydrogen molecular entity 19662
                          hydrides 19167
                            inorganic hydride 18182
                              pnictogen hydride 18172
                                nitrogen hydride 18085
                                  azane 17866
                                    ammonia 17865
                                      organic amino compound 17888
                                        secondary amino compound 6958
                                          secondary amine 1849
                                            rasagiline 3
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