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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:propafenone
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Accession:CHEBI:63619 term browser browse the term
Definition:An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.
Synonyms:exact_synonym: 1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one
 related_synonym: 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone;   2-(2'-hydroxy-3'-propylaminopropoxy)-omega-phenylpropiophenone;   Formula=C21H27NO3;   InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3;   InChIKey=JWHAUXFOSRPERK-UHFFFAOYSA-N;   SMILES=CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1;   propafenona;   propafenonum
 alt_id: CHEBI:8465
 xref: CAS:54063-53-5;   DrugBank:DB01182;   Drug_Central:2291;   KEGG:C07381;   KEGG:D08435;   LINCS:LSM-1416
 xref_mesh: MESH:D011405
 xref: PMID:8777484;   Patent:DE2001431;   Reaxys:2175182;   Wikipedia:Propafenone
 cyclic_relationship: is_conjugate_base_of CHEBI:63650


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propafenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 multiple interactions ISO Propafenone binds to and results in decreased activity of ADRB1 protein CTD PMID:6141285 NCBI chr 1:277,537,585...277,538,985
Ensembl chr 1:277,537,585...277,538,985
JBrowse link
G Adrb2 adrenoceptor beta 2 multiple interactions ISO Propafenone binds to and results in decreased activity of ADRB2 protein CTD PMID:6141285 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Casp3 caspase 3 increases activity ISO Propafenone results in increased activity of CASP3 protein CTD PMID:22700542 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity ISO Propafenone results in increased activity of CASP7 protein CTD PMID:22700542 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects response to substance ISO CYP2D6 protein mutant form affects the susceptibility to Propafenone CTD PMID:12421483 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
affects activity
ISO Propafenone analog binds to and results in decreased activity of KCNH2 protein; Propafenone binds to and results in decreased activity of KCNH2 protein; Propafenone inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Propafenone results in decreased activity of KCNH2 protein
Propafenone affects the activity of KCNH2 protein
CTD PMID:16278312, PMID:18724381, PMID:21158687, PMID:21175572, PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnk18 potassium two pore domain channel subfamily K member 18 multiple interactions ISO Propafenone inhibits the reaction [KCNK18 protein results in increased transport of Potassium] CTD PMID:12754259 NCBI chr 1:280,383,579...280,397,784
Ensembl chr 1:280,383,579...280,397,784
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Propafenone inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Propafenone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:21641380 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Propafenone inhibits the reaction [SLC22A4 protein results in increased uptake of Tetraethylammonium] CTD PMID:21641380 NCBI chr10:39,334,972...39,373,508 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            cardiovascular drug 7613
              anti-arrhythmia drug 908
                propafenone 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    main group molecular entity 19670
                      s-block molecular entity 19428
                        hydrogen molecular entity 19418
                          hydrides 18685
                            inorganic hydride 17409
                              pnictogen hydride 17381
                                nitrogen hydride 17223
                                  azane 16940
                                    ammonia 16939
                                      organic amino compound 16938
                                        secondary amino compound 6515
                                          propafenone 10
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