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ONTOLOGY REPORT - ANNOTATIONS


Term:propafenone
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Accession:CHEBI:63619 term browser browse the term
Definition:An aromatic ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias.
Synonyms:exact_synonym: 1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one
 related_synonym: 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone;   2-(2'-hydroxy-3'-propylaminopropoxy)-omega-phenylpropiophenone;   Formula=C21H27NO3;   InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3;   InChIKey=JWHAUXFOSRPERK-UHFFFAOYSA-N;   SMILES=CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1;   propafenona;   propafenonum
 alt_id: CHEBI:8465
 xref: CAS:54063-53-5 "ChemIDplus";   CAS:54063-53-5 "KEGG COMPOUND";   DrugBank:DB01182;   Drug_Central:2291 "DrugCentral";   KEGG:C07381;   KEGG:D08435;   LINCS:LSM-1416
 xref_mesh: MESH:D011405
 xref: PMID:8777484 "Europe PMC";   Patent:DE2001431;   Reaxys:2175182 "Reaxys";   Wikipedia:Propafenone
 cyclic_relationship: is_conjugate_base_of CHEBI:63650


show annotations for term's descendants       view all columns           Sort by:
 
propafenone term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adrb1 adrenoceptor beta 1 JBrowse link 1 277,537,585 277,538,985 RGD:6480464
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp7 caspase 7 JBrowse link 1 277,190,557 277,242,779 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Kcnk18 potassium two pore domain channel subfamily K member 18 JBrowse link 1 280,383,579 280,397,784 RGD:6480464
G Slc22a1 solute carrier family 22 member 1 JBrowse link 1 48,273,639 48,300,645 RGD:6480464
G Slc22a3 solute carrier family 22 member 3 JBrowse link 1 48,433,079 48,521,261 RGD:6480464
G Slc22a4 solute carrier family 22 member 4 JBrowse link 10 39,334,972 39,373,508 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      application 19232
        pharmaceutical 19094
          drug 19094
            cardiovascular drug 7560
              anti-arrhythmia drug 874
                propafenone 10
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    main group molecular entity 19539
                      s-block molecular entity 19322
                        hydrogen molecular entity 19312
                          hydrides 18241
                            inorganic hydride 17110
                              pnictogen hydride 17068
                                nitrogen hydride 16889
                                  azane 16565
                                    ammonia 16562
                                      organic amino compound 16561
                                        secondary amino compound 6371
                                          propafenone 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.