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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pravastatin
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Accession:CHEBI:63618 term browser browse the term
Definition:A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.
Synonyms:exact_synonym: (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid
 related_synonym: (+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid;   Formula=C23H36O7;   InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22-/m0/s1;   InChIKey=TUZYXOIXSAXUGO-PZAWKZKUSA-N;   SMILES=[H][C@]12[C@H](C[C@H](O)C=C1C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(O)=O)OC(=O)[C@@H](C)CC;   pravastatin acid;   pravastatina;   pravastatine;   pravastatinum
 alt_id: CHEBI:8360
 xref: CAS:81093-37-0;   DrugBank:DB00175;   Drug_Central:2239;   HMDB:HMDB0005022;   KEGG:C01844;   KEGG:D08410;   KNApSAcK:C00000565;   LINCS:LSM-3347
 xref_mesh: MESH:D017035
 xref: PMID:21749370;   PMID:21851379;   PMID:25264019;   Reaxys:4825538;   Wikipedia:Pravastatin
 cyclic_relationship: is_conjugate_acid_of CHEBI:63660


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pravastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression
decreases expression
EXP
ISO
[[colestimide co-treated with Pravastatin] results in increased expression of ABCA1 protein] which results in decreased abundance of Cholesterol; [colestimide co-treated with Pravastatin] affects the expression of ABCA1 mRNA; [colestimide co-treated with Pravastatin] affects the expression of ABCA1 protein
cotreatment with pravastatin and colestimide increases expression of abca1 mRNA and protein in rat liver; and decreases expression of abca1 mRNA and protein in rat small intestine
Pravastatin results in decreased expression of ABCA1
CTD PMID:17526932, PMID:19461118, PMID:17526932 RGD:2308820 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
affects import
ISO Pravastatin inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]
ABCB11 protein affects the import of Pravastatin
CTD PMID:15901796 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases transport ISO ABCB1 protein results in increased transport of Pravastatin; ABCB1 protein results in increased transport of Pravastatin analog CTD PMID:15616150 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression EXP Pravastatin results in increased expression of ABCB4 mRNA CTD PMID:15242490 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 affects export
increases expression
multiple interactions
affects transport
ISO
EXP
ABCC2 protein affects the export of Pravastatin
Pravastatin results in increased expression of ABCC2 protein
ABCC2 protein binds to and results in increased uptake of Pravastatin analog; Pravastatin analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Pravastatin promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC2 protein affects the transport of Pravastatin
CTD PMID:15901800, PMID:15955871, PMID:23562342, PMID:24909372 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Pravastatin results in increased expression of ABCC3 protein CTD PMID:24909372 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases transport ISO ABCC4 protein results in increased transport of Pravastatin CTD PMID:17939016 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 decreases expression ISO Pravastatin results in decreased expression of ABCD3 mRNA CTD PMID:27225895 NCBI chr 2:225,335,708...225,389,120
Ensembl chr 2:225,335,718...225,389,120
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 affects export
increases activity
ISO ABCG2 protein affects the export of Pravastatin
Pravastatin results in increased activity of ABCG2 protein
CTD PMID:15901800, PMID:27475308 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP Pravastatin results in increased expression of ABCG5 mRNA CTD PMID:15242490 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression EXP Pravastatin results in increased expression of ABCG8 mRNA CTD PMID:15242490 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Acaa1b acetyl-Coenzyme A acyltransferase 1B decreases expression ISO Pravastatin results in decreased expression of ACAA1B mRNA CTD PMID:27225895 NCBI chr 8:127,836,235...127,845,296 JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 decreases expression EXP
ISO
Pravastatin results in decreased expression of ACAA2 mRNA CTD PMID:27225895 NCBI chr18:70,733,872...70,762,395
Ensembl chr18:70,733,872...70,762,395
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases expression ISO
EXP
Pravastatin results in decreased expression of ACAT1 mRNA CTD PMID:27225895 NCBI chr 8:58,166,990...58,195,884
Ensembl chr 8:58,166,990...58,195,884
JBrowse link
G Acot1 acyl-CoA thioesterase 1 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of ACOT1 mRNA
Pravastatin results in decreased expression of ACOT1 mRNA
CTD PMID:27225895 NCBI chr 6:107,485,088...107,493,082
Ensembl chr 6:107,485,249...107,493,798
JBrowse link
G Acot12 acyl-CoA thioesterase 12 decreases expression ISO
EXP
Pravastatin results in decreased expression of ACOT12 mRNA CTD PMID:27225895 NCBI chr 2:20,857,056...20,901,656
Ensembl chr 2:20,857,202...20,901,659
JBrowse link
G Acot2 acyl-CoA thioesterase 2 affects expression ISO Pravastatin affects the expression of ACOT2 mRNA CTD PMID:27225895 NCBI chr 6:107,460,596...107,468,324
Ensembl chr 6:107,460,668...107,467,487
JBrowse link
G Acot3 acyl-CoA thioesterase 3 decreases expression ISO Pravastatin results in decreased expression of ACOT3 mRNA CTD PMID:27225895 NCBI chr 6:107,531,508...107,537,446
Ensembl chr 6:107,531,528...107,536,789
JBrowse link
G Acot4 acyl-CoA thioesterase 4 decreases expression ISO Pravastatin results in decreased expression of ACOT4 mRNA CTD PMID:27225895 NCBI chr 6:107,517,668...107,522,952
Ensembl chr 6:107,517,668...107,522,952
JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression ISO
EXP
Pravastatin results in decreased expression of ACOX1 mRNA CTD PMID:27225895 NCBI chr10:104,724,534...104,748,003
Ensembl chr10:104,722,958...104,748,050
JBrowse link
G Acsf2 acyl-CoA synthetase family member 2 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of ACSF2 mRNA
Pravastatin results in decreased expression of ACSF2 mRNA
CTD PMID:27225895 NCBI chr10:82,284,719...82,326,771
Ensembl chr10:82,284,720...82,326,771
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression ISO Pravastatin results in decreased expression of ACSL1 mRNA CTD PMID:27225895 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle decreases expression EXP
ISO
Pravastatin results in decreased expression of ACTA1 mRNA CTD PMID:27225895 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
JBrowse link
G Adamdec1 ADAM-like, decysin 1 increases expression ISO
EXP
Pravastatin results in increased expression of ADAMDEC1 mRNA CTD PMID:27225895 NCBI chr15:49,485,604...49,521,638
Ensembl chr15:49,485,611...49,505,553
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) decreases expression ISO
EXP
Pravastatin results in decreased expression of ADH1 mRNA CTD PMID:27225895 NCBI chr 2:243,550,655...243,562,243
Ensembl chr 2:243,550,627...243,687,857
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide decreases expression EXP
ISO
Pravastatin results in decreased expression of ADH7 mRNA CTD PMID:27225895 NCBI chr 2:243,500,540...243,516,865
Ensembl chr 2:243,502,073...243,516,532
JBrowse link
G Agt angiotensinogen decreases expression EXP
ISO
Pravastatin results in decreased expression of AGT mRNA CTD PMID:27225895 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Aif1 allograft inflammatory factor 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of AIF1 mRNA CTD PMID:27225895 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 decreases expression ISO
EXP
Pravastatin results in decreased expression of AKR1C18 mRNA
Pravastatin results in decreased expression of AKR1C3 mRNA
CTD PMID:27225895 NCBI chr17:69,761,126...69,778,021
Ensembl chr17:69,761,118...69,778,021
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
Pravastatin inhibits the reaction [Carboplatin results in increased activity of and results in increased phosphorylation of AKT1 protein]
[Pravastatin co-treated with olmesartan] results in increased phosphorylation of AKT1 protein; [resveratrol co-treated with Pravastatin] results in increased phosphorylation of AKT1 protein
Pravastatin results in increased phosphorylation of AKT1 protein
CTD PMID:17170375, PMID:17188708, PMID:18483861 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression ISO
EXP
Pravastatin results in decreased expression of ALDH1A1 mRNA CTD PMID:16763553, PMID:27225895 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 multiple interactions
decreases expression
ISO Cholesterol, Dietary inhibits the reaction [Pravastatin results in decreased expression of ALDH1A2 mRNA] CTD PMID:16763553 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 affects expression EXP
ISO
Pravastatin affects the expression of ALDH1A3 mRNA CTD PMID:27225895 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882
JBrowse link
G Aldoart2 aldolase 1 A retrogene 2 increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of ALDOART2 mRNA
Pravastatin results in decreased expression of ALDOART2 mRNA
CTD PMID:27225895 NCBI chr 6:76,349,362...76,351,052
Ensembl chr 6:76,349,362...76,351,051
JBrowse link
G Ampd3 adenosine monophosphate deaminase 3 increases expression EXP
ISO
Pravastatin results in increased expression of AMPD3 mRNA CTD PMID:27225895 NCBI chr 1:175,585,301...175,630,479
Ensembl chr 1:175,586,097...175,630,467
JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression ISO
EXP
Pravastatin results in decreased expression of ANGPTL3 mRNA CTD PMID:27225895 NCBI chr 5:117,698,590...117,706,729
Ensembl chr 5:117,698,764...117,705,808
JBrowse link
G Ank2 ankyrin 2 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of ANK2 mRNA
Pravastatin results in decreased expression of ANK2 mRNA
CTD PMID:27225895 NCBI chr 2:231,224,643...231,522,655
Ensembl chr 2:231,226,949...231,648,122
JBrowse link
G Anks6 ankyrin repeat and sterile alpha motif domain containing 6 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of ANKS6 mRNA
Pravastatin results in decreased expression of ANKS6 mRNA
CTD PMID:27225895 NCBI chr 5:62,642,974...62,684,387
Ensembl chr 5:62,640,645...62,683,964
JBrowse link
G Apoa1 apolipoprotein A1 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of APOA1 mRNA
Pravastatin results in decreased expression of APOA1 mRNA
CTD PMID:27225895 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G App amyloid beta precursor protein increases expression ISO Pravastatin results in increased expression of APP CTD PMID:19461118 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arg2 arginase 2 increases expression ISO Pravastatin results in increased expression of ARG2 mRNA CTD PMID:27225895 NCBI chr 6:102,311,097...102,338,406
Ensembl chr 6:102,311,116...102,338,520
JBrowse link
G Arhgap11a Rho GTPase activating protein 11A decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of ARHGAP11A mRNA
Pravastatin affects the expression of ARHGAP11A mRNA
CTD PMID:27225895 NCBI chr 3:105,281,827...105,298,108
Ensembl chr 3:105,281,827...105,298,108
JBrowse link
G Arntl2 aryl hydrocarbon receptor nuclear translocator-like 2 increases expression
affects expression
ISO
EXP
Pravastatin results in increased expression of ARNTL2 mRNA
Pravastatin affects the expression of ARNTL2 mRNA
CTD PMID:27225895 NCBI chr 4:181,103,774...181,158,415
Ensembl chr 4:181,103,774...181,214,994
JBrowse link
G Arrdc3 arrestin domain containing 3 decreases expression EXP
ISO
Pravastatin results in decreased expression of ARRDC3 mRNA CTD PMID:27225895 NCBI chr 2:8,732,907...8,745,445
Ensembl chr 2:8,732,932...8,743,069
JBrowse link
G Atp4a ATPase H+/K+ transporting subunit alpha decreases expression ISO
EXP
Pravastatin results in decreased expression of ATP4A mRNA CTD PMID:27225895 NCBI chr 1:89,162,700...89,175,504
Ensembl chr 1:89,162,639...89,175,811
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of ATP6V0D2 mRNA
Pravastatin results in decreased expression of ATP6V0D2 mRNA
CTD PMID:27225895 NCBI chr 5:33,843,591...33,892,446
Ensembl chr 5:33,843,519...33,892,462
JBrowse link
G Axin2 axin 2 decreases expression EXP
ISO
Pravastatin results in decreased expression of AXIN2 mRNA CTD PMID:27225895 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
JBrowse link
G Bard1 BRCA1 associated RING domain 1 decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of BARD1 mRNA
Pravastatin affects the expression of BARD1 mRNA
CTD PMID:27225895 NCBI chr 9:78,297,723...78,368,777
Ensembl chr 9:78,294,834...78,369,031
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [LDLR gene mutant form results in increased susceptibility to Pravastatin] which affects the expression of BAX protein CTD PMID:26875785 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [LDLR gene mutant form results in increased susceptibility to Pravastatin] which affects the expression of BCL2 protein CTD PMID:26875785 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bhlha15 basic helix-loop-helix family, member a15 decreases expression EXP
ISO
Pravastatin results in decreased expression of BHLHA15 mRNA CTD PMID:27225895 NCBI chr12:12,403,385...12,409,103
Ensembl chr12:12,403,385...12,407,561
JBrowse link
G Bmper BMP-binding endothelial regulator affects expression
increases expression
EXP
ISO
Pravastatin affects the expression of BMPER mRNA
Pravastatin results in increased expression of BMPER mRNA
CTD PMID:27225895 NCBI chr 8:24,369,916...24,615,484
Ensembl chr 8:24,369,916...24,615,479
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of BUB1B mRNA
Pravastatin results in decreased expression of BUB1B mRNA
CTD PMID:27225895 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G C1qb complement C1q B chain decreases expression ISO
EXP
Pravastatin results in decreased expression of C1QB mRNA CTD PMID:27225895 NCBI chr 5:155,246,444...155,251,995
Ensembl chr 5:155,246,447...155,252,003
JBrowse link
G C1qc complement C1q C chain decreases expression EXP
ISO
Pravastatin results in decreased expression of C1QC mRNA CTD PMID:27225895 NCBI chr 5:155,255,013...155,258,631
Ensembl chr 5:155,255,005...155,258,392
JBrowse link
G C5ar1 complement C5a receptor 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of C5AR1 mRNA CTD PMID:27225895 NCBI chr 1:78,186,777...78,195,132
Ensembl chr 1:78,186,776...78,195,328
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO
EXP
[LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in increased cleavage of CASP3 protein; Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]
Pravastatin results in increased cleavage of CASP3 protein
Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP3 protein]; Pravastatin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]
CTD PMID:18483861, PMID:20368269, PMID:26875785 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions EXP Pravastatin inhibits the reaction [Carboplatin results in increased expression of CASP9 protein] CTD PMID:18483861 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases activity ISO Pravastatin results in increased activity of CAT protein CTD PMID:17479860 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl12 chemokine (C-C motif) ligand 12 decreases expression ISO
EXP
Pravastatin results in decreased expression of CCL12 mRNA CTD PMID:27225895 NCBI chr10:69,476,866...69,478,416
Ensembl chr10:69,476,775...69,478,462
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]; Pravastatin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
Pravastatin inhibits the reaction [lopinavir-ritonavir drug combination results in increased secretion of CCL2 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of CCL2 protein]
CTD PMID:18323514, PMID:20884875 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl6 chemokine (C-C motif) ligand 6 decreases expression EXP
ISO
Pravastatin results in decreased expression of CCL6 mRNA CTD PMID:27225895 NCBI chr10:70,798,118...70,802,750
Ensembl chr10:70,797,124...70,802,782
JBrowse link
G Cd209 CD209 molecule decreases expression EXP Pravastatin results in decreased expression of CD209 mRNA CTD PMID:27225895 NCBI chr12:2,406,879...2,413,324
Ensembl chr12:2,406,879...2,413,324
JBrowse link
G Cd209a CD209a antigen decreases expression ISO Pravastatin results in decreased expression of CD209 mRNA CTD PMID:27225895 NCBI chr12:2,341,960...2,347,543
Ensembl chr12:2,341,960...2,347,543
JBrowse link
G Cd28 Cd28 molecule decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of CD28 mRNA
Pravastatin affects the expression of CD28 mRNA
CTD PMID:27225895 NCBI chr 9:67,546,408...67,573,858
Ensembl chr 9:67,546,408...67,571,871
JBrowse link
G Cd40 CD40 molecule affects expression EXP
ISO
Pravastatin affects the expression of CD40 mRNA CTD PMID:27225895 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd7 Cd7 molecule decreases expression EXP
ISO
Pravastatin results in decreased expression of CD7 mRNA CTD PMID:27225895 NCBI chr10:110,229,931...110,232,812
Ensembl chr10:110,229,922...110,232,843
JBrowse link
G Cdc27 cell division cycle 27 affects expression
increases expression
EXP
ISO
Pravastatin affects the expression of CDC27 mRNA
Pravastatin results in increased expression of CDC27 mRNA
CTD PMID:27225895 NCBI chr10:92,551,754...92,602,214
Ensembl chr10:92,554,081...92,602,082
JBrowse link
G Cdc6 cell division cycle 6 decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of CDC6 mRNA
Pravastatin affects the expression of CDC6 mRNA
CTD PMID:27225895 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Cdca7l cell division cycle associated 7 like affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of CDCA7L mRNA
Pravastatin results in decreased expression of CDCA7L mRNA
CTD PMID:27225895 NCBI chr 6:145,739,570...145,785,607
Ensembl chr 6:145,740,035...145,785,606
JBrowse link
G Cdhr5 cadherin-related family member 5 decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of CDHR5 mRNA
Pravastatin results in increased expression of CDHR5 mRNA
CTD PMID:27225895 NCBI chr 1:214,255,118...214,263,848
Ensembl chr 1:214,255,110...214,263,581
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Pravastatin inhibits the reaction [Benzo(a)pyrene results in decreased degradation of CDKN1A protein]; Pravastatin inhibits the reaction [Fluorouracil results in decreased degradation of CDKN1A protein] CTD PMID:15625077 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cds1 CDP-diacylglycerol synthase 1 increases expression ISO
EXP
Pravastatin results in increased expression of CDS1 mRNA CTD PMID:27225895 NCBI chr14:9,396,511...9,456,964
Ensembl chr14:9,396,512...9,456,990
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression ISO Pravastatin results in increased expression of CEBPD mRNA CTD PMID:27225895 NCBI chr11:89,008,008...89,009,146
Ensembl chr11:89,008,008...89,009,146
JBrowse link
G Cers6 ceramide synthase 6 decreases expression ISO Pravastatin results in decreased expression of CERS6 mRNA CTD PMID:27225895 NCBI chr 3:55,094,240...55,338,370
Ensembl chr 3:55,094,637...55,338,445
JBrowse link
G Cesl1 carboxylesterase-like 1 decreases expression EXP Pravastatin results in decreased expression of CESL1 mRNA CTD PMID:27225895 Ensembl chr19:15,081,158...15,335,002 JBrowse link
G Cip2a cellular inhibitor of PP2A decreases expression EXP Pravastatin results in decreased expression of CIP2A mRNA CTD PMID:27225895 NCBI chr11:54,373,794...54,404,704
Ensembl chr11:54,377,374...54,404,612
JBrowse link
G Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of CITED1 mRNA
Pravastatin results in increased expression of CITED1 mRNA
CTD PMID:27225895 NCBI chr  X:72,128,996...72,133,692
Ensembl chr  X:72,128,994...72,133,692
JBrowse link
G Clcn6 chloride voltage-gated channel 6 increases expression ISO
EXP
Pravastatin results in increased expression of CLCN6 mRNA CTD PMID:27225895 NCBI chr 5:164,811,815...164,844,554
Ensembl chr 5:164,811,816...164,844,586
JBrowse link
G Clec4f C-type lectin domain family 4, member F decreases expression EXP
ISO
Pravastatin results in decreased expression of CLEC4F mRNA CTD PMID:27225895 NCBI chr 4:115,322,300...115,332,021
Ensembl chr 4:115,322,291...115,332,052
JBrowse link
G Clstn3 calsyntenin 3 decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of CLSTN3 mRNA
Pravastatin affects the expression of CLSTN3 mRNA
CTD PMID:27225895 NCBI chr 4:157,044,736...157,078,013
Ensembl chr 4:157,043,925...157,078,130
JBrowse link
G Cnn1 calponin 1 decreases expression ISO
EXP
Pravastatin results in decreased expression of CNN1 mRNA CTD PMID:27225895 NCBI chr 8:23,113,083...23,121,748
Ensembl chr 8:23,113,048...23,121,761
JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of CPT1B mRNA
Pravastatin affects the expression of CPT1B mRNA
CTD PMID:27225895 NCBI chr 7:130,395,211...130,404,731
Ensembl chr 7:130,395,194...130,405,347
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO Pravastatin results in decreased expression of CPT2 mRNA CTD PMID:27225895 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
JBrowse link
G Crat carnitine O-acetyltransferase increases expression
affects expression
EXP
ISO
Pravastatin results in increased expression of CRAT mRNA
Pravastatin affects the expression of CRAT mRNA
CTD PMID:27225895 NCBI chr 3:8,967,984...8,981,959
Ensembl chr 3:8,968,417...8,981,362
JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of CREB3L3 mRNA
Pravastatin affects the expression of CREB3L3 mRNA
CTD PMID:27225895 NCBI chr 7:11,490,852...11,499,287
Ensembl chr 7:11,490,852...11,499,282
JBrowse link
G Crp C-reactive protein decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of CRP mRNA
Pravastatin results in increased expression of CRP mRNA
CTD PMID:27225895 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Csad cysteine sulfinic acid decarboxylase decreases expression EXP
ISO
Pravastatin results in decreased expression of CSAD mRNA CTD PMID:27225895 NCBI chr 7:143,781,520...143,810,880
Ensembl chr 7:143,781,702...143,793,970
JBrowse link
G Csf1r colony stimulating factor 1 receptor decreases expression EXP
ISO
Pravastatin results in decreased expression of CSF1R mRNA CTD PMID:27225895 NCBI chr18:56,414,493...56,458,300
Ensembl chr18:56,414,488...56,458,300
JBrowse link
G Csmd1 CUB and Sushi multiple domains 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of CSMD1 mRNA CTD PMID:27225895 NCBI chr16:77,152,823...78,850,222
Ensembl chr16:78,539,489...78,850,222
JBrowse link
G Ctnnb1 catenin beta 1 affects localization
multiple interactions
EXP Pravastatin affects the localization of CTNNB1 protein
[resveratrol co-treated with Pravastatin] affects the localization of CTNNB1 protein
CTD PMID:17188708 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 affects expression
increases expression
EXP
ISO
Pravastatin affects the expression of CXCL2 mRNA
Pravastatin results in increased expression of CXCL2 mRNA
CTD PMID:27225895 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression EXP Pravastatin results in decreased expression of CYBA protein CTD PMID:17170375 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP Pravastatin inhibits the reaction [Carboplatin results in increased expression of CYCS protein] CTD PMID:18483861 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression EXP
ISO
Pravastatin results in decreased expression of CYP1A2 mRNA CTD PMID:27225895 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 affects expression
increases expression
EXP
ISO
Pravastatin affects the expression of CYP1B1 mRNA
Pravastatin results in increased expression of CYP1B1 mRNA
CTD PMID:27225895 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 affects expression ISO Pravastatin affects the expression of CYP2B10 mRNA CTD PMID:27225895 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b21 cytochrome P450, family 2, subfamily b, polypeptide 21 decreases expression EXP Pravastatin results in decreased expression of CYP2B21 mRNA CTD PMID:27225895 NCBI chr 1:83,389,783...83,418,613
Ensembl chr 1:83,389,788...83,418,777
JBrowse link
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 decreases expression ISO Pravastatin results in decreased expression of CYP2D10 mRNA CTD PMID:27225895 NCBI chr 7:123,625,641...123,630,045
Ensembl chr 7:123,625,590...123,638,765
JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 decreases expression EXP Pravastatin results in decreased expression of CYP2D3 mRNA CTD PMID:27225895 NCBI chr 7:123,634,400...123,638,757
Ensembl chr 7:123,625,590...123,638,765
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 decreases expression EXP Pravastatin results in decreased expression of CYP2J4 mRNA CTD PMID:27225895 NCBI chr 5:119,546,458...119,564,843
Ensembl chr 5:119,546,461...119,564,846
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP Pravastatin results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:27225895 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 decreases expression EXP Pravastatin results in decreased expression of CYP4A1 mRNA CTD PMID:27225895 NCBI chr 5:134,492,734...134,507,158
Ensembl chr 5:134,492,756...134,507,154
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 affects expression EXP Pravastatin affects the expression of CYP4A2 mRNA CTD PMID:27225895 NCBI chr 5:134,196,910...134,207,888
Ensembl chr 5:134,196,912...134,207,863
JBrowse link
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 decreases expression EXP Pravastatin results in decreased expression of CYP4A3 mRNA CTD PMID:27225895 NCBI chr 5:134,468,666...134,484,851
Ensembl chr 5:134,469,270...134,484,839
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP
ISO
Pravastatin results in increased expression of CYP51 mRNA CTD PMID:27225895 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of DECR1 mRNA CTD PMID:27225895 NCBI chr 5:29,573,893...29,601,731
Ensembl chr 5:29,573,898...29,601,748
JBrowse link
G Depdc1b DEP domain containing 1B decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of DEPDC1B mRNA
Pravastatin affects the expression of DEPDC1B mRNA
CTD PMID:27225895 NCBI chr 2:39,980,796...40,069,982
Ensembl chr 2:40,000,313...40,069,975
JBrowse link
G Derl3 derlin 3 decreases expression EXP
ISO
Pravastatin results in decreased expression of DERL3 mRNA CTD PMID:27225895 NCBI chr20:13,692,102...13,707,645
Ensembl chr20:13,704,314...13,706,205
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases expression ISO
EXP
Pravastatin results in decreased expression of DIO3 mRNA CTD PMID:27225895 NCBI chr 6:134,627,278...134,629,139
Ensembl chr 6:134,627,278...134,629,138
JBrowse link
G Dlgap1 DLG associated protein 1 increases expression EXP
ISO
Pravastatin results in increased expression of DLGAP1 mRNA CTD PMID:27225895 NCBI chr 9:118,277,046...119,159,807
Ensembl chr 9:118,586,179...119,158,196
JBrowse link
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 affects farnesylation ISO Pravastatin affects the farnesylation of DNAJA1 protein CTD PMID:20884875 NCBI chr 5:57,028,467...57,039,378
Ensembl chr 5:57,028,467...57,039,378
JBrowse link
G Dnase2b deoxyribonuclease 2 beta increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of DNASE2B mRNA
Pravastatin results in decreased expression of DNASE2B mRNA
CTD PMID:27225895 NCBI chr 2:252,436,363...252,475,506
Ensembl chr 2:252,436,332...252,451,999
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression EXP
ISO
Pravastatin results in increased expression of DPYSL2 mRNA CTD PMID:27225895 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog decreases expression
affects expression
EXP
ISO
Pravastatin results in decreased expression of DTL mRNA
Pravastatin affects the expression of DTL mRNA
CTD PMID:27225895 NCBI chr13:110,219,276...110,257,345
Ensembl chr13:110,220,283...110,257,367
JBrowse link
G Ech1 enoyl-CoA hydratase 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of ECH1 mRNA CTD PMID:27225895 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Edn1 endothelin 1 decreases expression ISO
EXP
Pravastatin results in decreased expression of EDN1 protein
Pravastatin results in decreased expression of EDN1 mRNA; Pravastatin results in decreased expression of EDN1 protein
CTD PMID:12105140, PMID:19812503 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Efhb EF hand domain family, member B increases expression ISO
EXP
Pravastatin results in increased expression of EFHB mRNA CTD PMID:27225895 NCBI chr 9:47,988...120,800
Ensembl chr 9:47,724...120,799
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase decreases expression EXP
ISO
Pravastatin results in decreased expression of EHHADH mRNA CTD PMID:27225895 NCBI chr11:82,945,104...82,978,364
Ensembl chr11:82,945,104...82,978,364
JBrowse link
G Enpp5 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 affects expression
decreases expression
EXP
ISO
Pravastatin affects the expression of ENPP5 mRNA
Pravastatin results in decreased expression of ENPP5 mRNA
CTD PMID:27225895 NCBI chr 9:19,469,276...19,476,684
Ensembl chr 9:19,469,706...19,476,646
JBrowse link
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of ENTPD2 mRNA
Pravastatin results in increased expression of ENTPD2 mRNA
CTD PMID:27225895 NCBI chr 3:2,617,795...2,623,818
Ensembl chr 3:2,617,805...2,623,445
JBrowse link
G Ephx2 epoxide hydrolase 2 decreases expression ISO
EXP
Pravastatin results in decreased expression of EPHX2 mRNA CTD PMID:27225895 NCBI chr15:42,757,241...42,794,211
Ensembl chr15:42,757,235...42,794,279
JBrowse link
G Ephx4 epoxide hydrolase 4 increases expression
affects expression
EXP
ISO
Pravastatin results in increased expression of EPHX4 mRNA
Pravastatin affects the expression of EPHX4 mRNA
CTD PMID:27225895 NCBI chr14:3,360,680...3,389,996
Ensembl chr14:3,360,712...3,389,943
JBrowse link
G Evi2a ecotropic viral integration site 2A decreases expression ISO
EXP
Pravastatin results in decreased expression of EVI2A mRNA CTD PMID:27225895 NCBI chr10:66,870,048...66,873,948
Ensembl chr10:66,870,067...66,873,948
JBrowse link
G F13a1 coagulation factor XIII A1 chain decreases expression ISO
EXP
Pravastatin results in decreased expression of F13A1 mRNA CTD PMID:27225895 NCBI chr17:28,504,650...28,680,015
Ensembl chr17:28,504,623...28,680,362
JBrowse link
G Fabp1 fatty acid binding protein 1 decreases expression ISO Pravastatin results in decreased expression of FABP1 mRNA CTD PMID:27225895 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fabp2 fatty acid binding protein 2 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of FABP2 mRNA
Pravastatin results in decreased expression of FABP2 mRNA
CTD PMID:27225895 NCBI chr 2:227,080,912...227,083,654
Ensembl chr 2:227,080,924...227,083,501
JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression ISO
EXP
Pravastatin results in increased expression of FABP5 mRNA CTD PMID:27225895 NCBI chr 2:93,981,662...93,985,322
Ensembl chr 2:93,981,656...93,985,378
JBrowse link
G Far1 fatty acyl CoA reductase 1 increases expression EXP
ISO
Pravastatin results in increased expression of FAR1 mRNA CTD PMID:27225895 NCBI chr 1:178,351,674...178,412,838
Ensembl chr 1:178,351,680...178,431,395
JBrowse link
G Fbn1 fibrillin 1 increases expression ISO Pravastatin results in increased expression of FBN1 mRNA CTD PMID:27225895 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Fbp2 fructose-bisphosphatase 2 affects expression EXP Pravastatin affects the expression of FBP2 mRNA CTD PMID:27225895 NCBI chr17:372,554...389,918
Ensembl chr17:372,551...389,967
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 affects activity ISO Pravastatin affects the activity of FDFT1 protein CTD PMID:8517861 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Fgd2 FYVE, RhoGEF and PH domain containing 2 decreases expression ISO
EXP
Pravastatin results in decreased expression of FGD2 mRNA CTD PMID:27225895 NCBI chr20:6,973,356...6,990,026
Ensembl chr20:6,973,398...6,990,023
JBrowse link
G Fgf13 fibroblast growth factor 13 affects expression
increases expression
EXP
ISO
Pravastatin affects the expression of FGF13 mRNA
Pravastatin results in increased expression of FGF13 mRNA
CTD PMID:27225895 NCBI chr  X:142,053,648...142,589,274
Ensembl chr  X:142,053,654...142,248,369
JBrowse link
G Flacc1 flagellum associated containing coiled-coil domains 1 increases expression EXP
ISO
Pravastatin results in increased expression of FLACC1 mRNA CTD PMID:27225895 NCBI chr 9:65,665,663...65,693,822
Ensembl chr 9:65,665,664...65,693,822
JBrowse link
G Flot1 flotillin 1 decreases expression ISO Pravastatin results in decreased expression of FLOT1 protein CTD PMID:12628479 NCBI chr20:3,427,890...3,438,418
Ensembl chr20:3,427,880...3,438,396
JBrowse link
G Folr2 folate receptor beta decreases expression EXP
ISO
Pravastatin results in decreased expression of FOLR2 mRNA CTD PMID:27225895 NCBI chr 1:166,915,045...166,933,377
Ensembl chr 1:166,915,045...166,919,302
JBrowse link
G Gck glucokinase decreases expression EXP Pravastatin results in decreased expression of GCK mRNA CTD PMID:27225895 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of GCLC mRNA
Pravastatin results in decreased expression of GCLC mRNA
CTD PMID:27225895 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 (I blood group) increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of GCNT2 mRNA
Pravastatin results in decreased expression of GCNT2 mRNA
CTD PMID:27225895 NCBI chr17:21,634,546...21,677,477
Ensembl chr17:21,634,551...21,739,408
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO Pravastatin inhibits the reaction [lopinavir-ritonavir drug combination results in increased activity of GLB1 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased activity of GLB1 protein] CTD PMID:20884875 NCBI chr 8:122,439,328...122,511,939
Ensembl chr 8:122,439,328...122,511,939
JBrowse link
G Gldc glycine decarboxylase decreases expression ISO
EXP
Pravastatin results in decreased expression of GLDC mRNA CTD PMID:27225895 NCBI chr 1:248,295,140...248,377,122
Ensembl chr 1:248,297,331...248,377,093
JBrowse link
G Gls2 glutaminase 2 decreases expression ISO
EXP
Pravastatin results in decreased expression of GLS2 mRNA CTD PMID:27225895 NCBI chr 7:2,605,679...2,621,853
Ensembl chr 7:2,605,719...2,621,852
JBrowse link
G Gpr85 G protein-coupled receptor 85 increases expression EXP
ISO
Pravastatin results in increased expression of GPR85 mRNA CTD PMID:27225895 NCBI chr 4:40,377,705...40,387,147
Ensembl chr 4:40,381,685...40,385,349
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of GSTK1 mRNA CTD PMID:27225895 NCBI chr 4:71,621,777...71,626,096
Ensembl chr 4:71,621,729...71,626,107
JBrowse link
G Hadh hydroxyacyl-CoA dehydrogenase decreases expression ISO
EXP
Pravastatin results in decreased expression of HADH mRNA CTD PMID:27225895 NCBI chr 2:236,353,445...236,395,067
Ensembl chr 2:236,353,445...236,395,067
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha decreases expression EXP
ISO
Pravastatin results in decreased expression of HADHA mRNA CTD PMID:27225895 NCBI chr 6:27,589,840...27,628,921
Ensembl chr 6:27,589,657...27,629,175
JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta decreases expression EXP
ISO
Pravastatin results in decreased expression of HADHB mRNA CTD PMID:27225895 NCBI chr 6:27,555,408...27,589,539
Ensembl chr 6:27,555,412...27,582,995
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression EXP
ISO
Pravastatin results in increased expression of HAMP mRNA CTD PMID:27225895 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Hax1 HCLS1 associated protein X-1 multiple interactions EXP Pravastatin inhibits the reaction [Carboplatin results in decreased expression of HAX1 protein] CTD PMID:18483861 NCBI chr 2:189,330,900...189,333,305
Ensembl chr 2:189,330,902...189,333,322
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases response to substance
increases expression
decreases activity
affects expression
ISO
EXP
HMGCR gene SNP results in decreased susceptibility to Pravastatin
Pravastatin results in increased expression of HMGCR mRNA
Pravastatin results in decreased activity of HMGCR protein
Pravastatin affects the expression of HMGCR mRNA
CTD PMID:8517861, PMID:8593127, PMID:15199031, PMID:27225895, PMID:29969672 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Pravastatin results in increased expression of HMGCS1 mRNA CTD PMID:27225895 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
EXP
ISO
[[Pravastatin co-treated with pirinixic acid] co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA; [Pravastatin co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA; [Pravastatin co-treated with pirinixic acid] results in increased expression of HMOX1 mRNA; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Pravastatin results in increased expression of HMOX1 protein]; Pravastatin promotes the reaction [PPARA protein binds to HMOX1 promoter] CTD PMID:20368269 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hopx HOP homeobox decreases expression ISO
EXP
Pravastatin results in decreased expression of HOPX mRNA CTD PMID:27225895 NCBI chr14:33,354,803...33,362,547
Ensembl chr14:33,354,807...33,362,551
JBrowse link
G Hrg histidine-rich glycoprotein decreases expression ISO
EXP
Pravastatin results in decreased expression of HRG mRNA CTD PMID:27225895 NCBI chr11:81,621,274...81,639,938
Ensembl chr11:81,621,283...81,639,952
JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 increases expression ISO
EXP
Pravastatin results in increased expression of HSD17B7 mRNA CTD PMID:27225895 NCBI chr13:88,288,116...88,308,019
Ensembl chr13:88,288,046...88,307,988
JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of HSDL2 mRNA
Pravastatin results in increased expression of HSDL2 mRNA
CTD PMID:27225895 NCBI chr 5:76,812,881...76,848,853
Ensembl chr 5:76,812,931...76,848,101
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP
ISO
Pravastatin results in increased expression of IDI1 mRNA CTD PMID:27225895 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Pravastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; Pravastatin inhibits the reaction [Palmitic Acid results in increased expression of IFNB1 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA] CTD PMID:18323514 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Il1b interleukin 1 beta decreases expression
increases expression
EXP
ISO
Pravastatin results in decreased expression of IL1B mRNA
Pravastatin results in increased expression of IL1B mRNA
CTD PMID:27225895 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]; Pravastatin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Pravastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Pravastatin inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA]; Pravastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]
Pravastatin inhibits the reaction [lopinavir-ritonavir drug combination results in increased secretion of IL6 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased secretion of IL6 protein]
Pravastatin results in decreased expression of IL6 protein
CTD PMID:17729120, PMID:18323514, PMID:19330073, PMID:20884875 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO Pravastatin inhibits the reaction [Palmitic Acid results in increased phosphorylation of IRF3 protein] CTD PMID:18323514 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions EXP
ISO
geranylgeraniol inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein] CTD PMID:12500026 NCBI chr 2:46,996,904...47,097,011
Ensembl chr 2:47,000,323...47,096,961
JBrowse link
G Itgb1 integrin subunit beta 1 multiple interactions EXP
ISO
geranylgeraniol inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Mevalonic Acid inhibits the reaction [Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein]]; Pravastatin results in increased expression of [ITGA2 protein binds to ITGB1 protein] CTD PMID:12500026 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Itgb6 integrin subunit beta 6 affects expression ISO Pravastatin affects the expression of ITGB6 mRNA CTD PMID:27225895 NCBI chr 3:46,652,624...46,775,362
Ensembl chr 3:46,652,623...46,726,958
JBrowse link
G Kcns3 potassium voltage-gated channel, modifier subfamily S, member 3 increases expression ISO
EXP
Pravastatin results in increased expression of KCNS3 mRNA CTD PMID:27225895 NCBI chr 6:36,764,040...36,819,810
Ensembl chr 6:36,764,044...36,819,821
JBrowse link
G Kctd12 potassium channel tetramerization domain containing 12 decreases expression ISO
EXP
Pravastatin results in decreased expression of KCTD12 mRNA CTD PMID:27225895 NCBI chr15:87,384,632...87,390,627 JBrowse link
G Kif20a kinesin family member 20A affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of KIF20A mRNA
Pravastatin results in decreased expression of KIF20A mRNA
CTD PMID:27225895 NCBI chr18:27,424,328...27,432,814
Ensembl chr18:27,424,328...27,432,814
JBrowse link
G Kif20b kinesin family member 20B affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of KIF20B mRNA
Pravastatin results in decreased expression of KIF20B mRNA
CTD PMID:27225895 NCBI chr 1:253,220,038...253,275,523
Ensembl chr 1:253,221,812...253,275,490
JBrowse link
G Kif23 kinesin family member 23 affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of KIF23 mRNA
Pravastatin results in decreased expression of KIF23 mRNA
CTD PMID:27225895 NCBI chr 8:66,866,043...66,893,241
Ensembl chr 8:66,866,082...66,893,196
JBrowse link
G Kitlg KIT ligand increases expression
affects expression
EXP
ISO
Pravastatin results in increased expression of KITLG mRNA
Pravastatin affects the expression of KITL mRNA
CTD PMID:27225895 NCBI chr 7:42,269,784...42,351,054
Ensembl chr 7:42,269,784...42,351,054
JBrowse link
G Klb klotho beta decreases expression ISO
EXP
Pravastatin results in decreased expression of KLB mRNA CTD PMID:27225895 NCBI chr14:44,529,523...44,614,093 JBrowse link
G Krt23 keratin 23 decreases expression EXP
ISO
Pravastatin results in decreased expression of KRT23 mRNA CTD PMID:27225895 NCBI chr10:87,391,623...87,407,634
Ensembl chr10:87,391,623...87,407,634
JBrowse link
G Ldlr low density lipoprotein receptor increases activity
increases response to substance
multiple interactions
ISO Pravastatin results in increased activity of LDLR protein
[LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in increased susceptibility to INS1 protein; LDLR gene mutant form results in increased susceptibility to Pravastatin
[LDLR gene mutant form results in increased susceptibility to Pravastatin] inhibits the reaction [Glucose results in increased secretion of INS1 protein]; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which affects the expression of BAX protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which affects the expression of BCL2 protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of INS1 protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of SNAP25 protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of STX1A protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of VAMP2 protein; [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in increased cleavage of CASP3 protein
CTD PMID:8593127, PMID:26875785 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lep leptin multiple interactions ISO Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of CCL2 mRNA]; Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of IL6 mRNA]; Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA] CTD PMID:18323514 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lgals4 galectin 4 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of LGALS4 mRNA
Pravastatin results in decreased expression of LGALS4 mRNA
CTD PMID:27225895 NCBI chr 1:87,019,598...87,027,720
Ensembl chr 1:87,019,975...87,027,691
JBrowse link
G Lgi2 leucine-rich repeat LGI family, member 2 increases expression EXP
ISO
Pravastatin results in increased expression of LGI2 mRNA CTD PMID:27225895 NCBI chr14:60,764,325...60,791,809
Ensembl chr14:60,764,409...60,796,116
JBrowse link
G Lmna lamin A/C increases expression ISO Pravastatin results in increased expression of LMNA protein CTD PMID:20884875 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G LOC100910526 sulfotransferase 1C2-like decreases expression ISO Pravastatin results in decreased expression of SULT1C2 mRNA CTD PMID:27225895 NCBI chr 9:4,820,678...4,834,271
Ensembl chr 9:4,807,717...4,834,335
JBrowse link
G Lpl lipoprotein lipase decreases expression EXP
ISO
Pravastatin results in decreased expression of LPL mRNA CTD PMID:27225895 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lrmda leucine rich melanocyte differentiation associated decreases expression ISO Pravastatin results in decreased expression of LRMDA mRNA CTD PMID:27225895 NCBI chr15:1,269,869...2,346,246 JBrowse link
G Lss lanosterol synthase increases expression EXP
ISO
Pravastatin results in increased expression of LSS mRNA CTD PMID:27225895 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Ltbp2 latent transforming growth factor beta binding protein 2 increases expression EXP
ISO
Pravastatin results in increased expression of LTBP2 mRNA CTD PMID:27225895 NCBI chr 6:108,500,114...108,596,653
Ensembl chr 6:108,500,112...108,596,569
JBrowse link
G Ly86 lymphocyte antigen 86 decreases expression ISO
EXP
Pravastatin results in decreased expression of LY86 mRNA CTD PMID:27225895 NCBI chr17:28,104,535...28,191,447
Ensembl chr17:28,104,589...28,191,436
JBrowse link
G Mapt microtubule-associated protein tau affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of MAPT
Pravastatin results in decreased expression of MAPT mRNA
CTD PMID:19461118, PMID:27225895 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mastl microtubule associated serine/threonine kinase-like affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of MASTL mRNA
Pravastatin results in decreased expression of MASTL mRNA
CTD PMID:27225895 NCBI chr17:89,839,562...89,875,855
Ensembl chr17:89,742,140...89,876,825
JBrowse link
G Mdm2 MDM2 proto-oncogene increases phosphorylation
increases expression
multiple interactions
ISO
EXP
Pravastatin results in increased phosphorylation of MDM2 protein
Pravastatin results in increased expression of MDM2 protein
[Pravastatin results in increased phosphorylation of MDM2 protein] which results in increased degradation of TP53 protein; Sirolimus inhibits the reaction [Pravastatin results in increased phosphorylation of MDM2 protein]; U 0126 inhibits the reaction [Pravastatin results in increased phosphorylation of MDM2 protein]
CTD PMID:15625077 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Meiob meiosis specific with OB-fold decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of MEIOB mRNA
Pravastatin results in increased expression of MEIOB mRNA
CTD PMID:27225895 NCBI chr10:14,174,645...14,206,026
Ensembl chr10:14,174,732...14,206,025
JBrowse link
G Mgll monoglyceride lipase decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of MGLL mRNA
Pravastatin affects the expression of MGLL mRNA
CTD PMID:27225895 NCBI chr 4:120,671,436...120,773,458
Ensembl chr 4:120,671,489...120,771,088
JBrowse link
G Miox myo-inositol oxygenase decreases expression ISO Pravastatin results in decreased expression of MIOX mRNA CTD PMID:27225895 NCBI chr 7:130,308,707...130,311,205
Ensembl chr 7:130,308,532...130,313,727
JBrowse link
G Mis18a MIS18 kinetochore protein A increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of MIS18A mRNA
Pravastatin results in decreased expression of MIS18A mRNA
CTD PMID:27225895 NCBI chr11:30,880,231...30,893,262
Ensembl chr11:30,879,887...30,893,310
JBrowse link
G Mlycd malonyl-CoA decarboxylase decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of MLYCD mRNA
Pravastatin affects the expression of MLYCD mRNA
CTD PMID:27225895 NCBI chr19:52,032,950...52,048,773
Ensembl chr19:52,032,886...52,048,753
JBrowse link
G Mme membrane metallo-endopeptidase affects expression
decreases expression
EXP
ISO
Pravastatin affects the expression of MME mRNA
Pravastatin results in decreased expression of MME mRNA
CTD PMID:27225895 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Mmp14 matrix metallopeptidase 14 decreases expression EXP Pravastatin results in decreased expression of MMP14 mRNA CTD PMID:16935385 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases activity
decreases expression
EXP Pravastatin results in decreased activity of MMP2 protein
Pravastatin results in decreased expression of MMP2 mRNA
CTD PMID:16935385 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 affects response to substance ISO MMP3 promoter polymorphism affects the susceptibility to Pravastatin CTD PMID:8662692 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases activity
decreases expression
EXP Pravastatin results in decreased activity of MMP9 protein
Pravastatin results in decreased expression of MMP9 mRNA
CTD PMID:16935385 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mss51 MSS51 mitochondrial translational activator decreases expression
increases expression
EXP
ISO
Pravastatin results in decreased expression of MSS51 mRNA
Pravastatin results in increased expression of MSS51 mRNA
CTD PMID:27225895 NCBI chr15:4,240,203...4,252,072
Ensembl chr15:4,240,203...4,252,072
JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation ISO Pravastatin results in increased phosphorylation of MTOR protein CTD PMID:15625077 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Mvd mevalonate diphosphate decarboxylase increases expression EXP
ISO
Pravastatin results in increased expression of MVD mRNA CTD PMID:27225895 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
JBrowse link
G Nfe2 nuclear factor, erythroid 2 increases expression EXP
ISO
Pravastatin results in increased expression of NFE2 mRNA CTD PMID:27225895 NCBI chr 7:144,872,739...144,880,092
Ensembl chr 7:144,872,747...144,880,092
JBrowse link
G Nnmt nicotinamide N-methyltransferase increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of NNMT mRNA
Pravastatin results in decreased expression of NNMT mRNA
CTD PMID:27225895 NCBI chr 8:52,918,437...52,938,172
Ensembl chr 8:52,925,175...52,937,972
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Pravastatin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Pravastatin inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA] CTD PMID:18323514 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases phosphorylation
EXP [Resveratrol co-treated with Pravastatin] results in increased phosphorylation of NOS3 protein; Pravastatin promotes the reaction [NOS3 protein binds to NOS3 protein]; Pravastatin promotes the reaction [olmesartan results in increased activity of and results in increased phosphorylation of NOS3 protein]; Pravastatin results in increased activity of and results in increased phosphorylation of NOS3 protein
Pravastatin results in increased phosphorylation of NOS3 protein
CTD PMID:17170375, PMID:17188708 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO
EXP
Pravastatin results in decreased expression of NR0B2 mRNA CTD PMID:27225895 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like increases expression EXP
ISO
Pravastatin results in increased expression of NSDHL mRNA CTD PMID:27225895 NCBI chr  X:152,933,118...152,964,399
Ensembl chr  X:152,933,069...152,964,390
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO Pravastatin results in increased expression of OLR1 mRNA CTD PMID:27225895 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Orc1 origin recognition complex, subunit 1 affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of ORC1 mRNA
Pravastatin results in decreased expression of ORC1 mRNA
CTD PMID:27225895 NCBI chr 5:128,186,651...128,212,901
Ensembl chr 5:128,190,708...128,210,445
JBrowse link
G Pcdhb5 protocadherin beta 5 increases expression EXP Pravastatin results in increased expression of PCDHB4 mRNA CTD PMID:27225895 NCBI chr18:30,398,113...30,400,695
Ensembl chr18:30,398,113...30,400,695
JBrowse link
G Pcdhb8 protocadherin beta 8 increases expression ISO Pravastatin results in increased expression of PCDHB4 mRNA CTD PMID:27225895 NCBI chr18:30,435,119...30,437,458
Ensembl chr18:30,435,119...30,437,458
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression EXP
ISO
Pravastatin results in increased expression of PCSK9 mRNA CTD PMID:27225895 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
JBrowse link
G Pctp phosphatidylcholine transfer protein decreases expression ISO Pravastatin results in decreased expression of PCTP mRNA CTD PMID:27225895 NCBI chr10:77,491,445...77,537,268
Ensembl chr10:77,491,454...77,512,032
JBrowse link
G Pde4a phosphodiesterase 4A decreases expression
increases expression
ISO
EXP
Pravastatin results in decreased expression of PDE4A mRNA
Pravastatin results in increased expression of PDE4A mRNA
CTD PMID:27225895 NCBI chr 8:22,189,533...22,234,036
Ensembl chr 8:22,189,600...22,233,748
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 affects expression
increases expression
EXP
ISO
Pravastatin affects the expression of PDK4 mRNA
Pravastatin results in increased expression of PDK4 mRNA
CTD PMID:27225895 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase decreases expression EXP
ISO
Pravastatin results in decreased expression of PEMT mRNA CTD PMID:27225895 NCBI chr10:46,339,821...46,404,640
Ensembl chr10:46,339,821...46,404,642
JBrowse link
G Pex11a peroxisomal biogenesis factor 11 alpha decreases expression EXP
ISO
Pravastatin results in decreased expression of PEX11A mRNA CTD PMID:27225895 NCBI chr 1:141,474,189...141,481,270
Ensembl chr 1:141,474,180...141,481,315
JBrowse link
G Pf4 platelet factor 4 decreases expression EXP
ISO
Pravastatin results in decreased expression of PF4 mRNA CTD PMID:27225895 NCBI chr14:18,848,549...18,849,258
Ensembl chr14:18,848,549...18,849,258
JBrowse link
G Pla2r1 phospholipase A2 receptor 1 increases expression EXP
ISO
Pravastatin results in increased expression of PLA2R1 mRNA CTD PMID:27225895 NCBI chr 3:46,488,963...46,621,873
Ensembl chr 3:46,488,186...46,621,873
JBrowse link
G Plppr1 phospholipid phosphatase related 1 decreases expression ISO
EXP
Pravastatin results in decreased expression of PLPPR1 mRNA CTD PMID:27225895 NCBI chr 5:67,852,817...67,985,310
Ensembl chr 5:67,852,180...68,139,199
JBrowse link
G Pmvk phosphomevalonate kinase increases expression EXP
ISO
Pravastatin results in increased expression of PMVK mRNA CTD PMID:27225895 NCBI chr 2:188,784,329...188,793,890
Ensembl chr 2:188,784,222...188,793,895
JBrowse link
G Pnpla7 patatin-like phospholipase domain containing 7 decreases expression EXP
ISO
Pravastatin results in decreased expression of PNPLA7 mRNA CTD PMID:27225895 NCBI chr 3:2,182,191...2,261,890
Ensembl chr 3:2,182,957...2,261,878
JBrowse link
G Pole2 DNA polymerase epsilon 2, accessory subunit affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of POLE2 mRNA
Pravastatin results in decreased expression of POLE2 mRNA
CTD PMID:27225895 NCBI chr 6:91,494,348...91,532,355
Ensembl chr 6:91,494,393...91,518,996
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases expression
multiple interactions
affects localization
ISO
EXP
Pravastatin results in increased expression of PPARA protein
Pravastatin promotes the reaction [Glucose inhibits the reaction [Palmitoyl Coenzyme A analog binds to PPARA protein]]
Pravastatin affects the localization of PPARA protein
[[Pravastatin co-treated with pirinixic acid] co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA; [Pravastatin co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Pravastatin affects the localization of PPARA protein]; Pravastatin promotes the reaction [PPARA protein binds to HMOX1 promoter]
CTD PMID:18812576, PMID:20368269 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Pravastatin inhibits the reaction [[troglitazone binds to and results in increased activity of PPARG protein] which results in increased abundance of Cholesterol] CTD PMID:12044893 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppm1j protein phosphatase, Mg2+/Mn2+ dependent, 1J decreases expression
increases expression
EXP
ISO
Pravastatin results in decreased expression of PPM1J mRNA
Pravastatin results in increased expression of PPM1J mRNA
CTD PMID:27225895 NCBI chr 2:207,263,307...207,268,601
Ensembl chr 2:207,262,934...207,268,609
JBrowse link
G Prnd prion like protein doppel decreases expression EXP
ISO
Pravastatin results in decreased expression of PRND mRNA CTD PMID:27225895 NCBI chr 3:124,543,227...124,548,548
Ensembl chr 3:124,545,364...124,545,900
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Pravastatin results in increased expression of PTGS2 protein CTD PMID:20368269 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptprn protein tyrosine phosphatase, receptor type, N increases expression
affects expression
ISO
EXP
Pravastatin results in increased expression of PTPRN mRNA
Pravastatin affects the expression of PTPRN mRNA
CTD PMID:27225895 NCBI chr 9:82,446,626...82,462,314
Ensembl chr 9:82,446,633...82,461,903
JBrowse link
G Rdh11 retinol dehydrogenase 11 increases expression ISO
EXP
Pravastatin results in increased expression of RDH11 mRNA CTD PMID:27225895 NCBI chr 6:102,356,498...102,372,618
Ensembl chr 6:102,356,492...102,372,611
JBrowse link
G Reep1 receptor accessory protein 1 affects expression
increases expression
EXP
ISO
Pravastatin affects the expression of REEP1 mRNA
Pravastatin results in increased expression of REEP1 mRNA
CTD PMID:27225895 NCBI chr 4:99,618,622...99,735,329
Ensembl chr 4:99,618,622...99,735,319
JBrowse link
G Retsat retinol saturase decreases expression EXP
ISO
Pravastatin results in decreased expression of RETSAT mRNA CTD PMID:27225895 NCBI chr 4:100,465,365...100,474,128
Ensembl chr 4:100,465,170...100,474,301
JBrowse link
G RGD1560455 similar to RIKEN cDNA A630033H20 gene affects expression EXP Pravastatin affects the expression of RGD1560455 mRNA CTD PMID:27225895 NCBI chr  X:78,258,495...78,284,180
Ensembl chr  X:78,259,409...78,284,180
JBrowse link
G RGD1564308 similar to LOC495042 protein increases expression EXP Pravastatin results in increased expression of RGD1564308 mRNA CTD PMID:27225895 NCBI chr16:49,485,022...49,509,756
Ensembl chr16:49,485,256...49,509,767
JBrowse link
G Rgs16 regulator of G-protein signaling 16 decreases expression EXP
ISO
Pravastatin results in decreased expression of RGS16 mRNA CTD PMID:27225895 NCBI chr13:71,163,411...71,185,147
Ensembl chr13:71,179,910...71,185,216
JBrowse link
G Rnf186 ring finger protein 186 decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of RNF186 mRNA
Pravastatin affects the expression of RNF186 mRNA
CTD PMID:27225895 NCBI chr 5:157,416,897...157,418,121
Ensembl chr 5:157,416,897...157,418,121
JBrowse link
G Rragd Ras-related GTP binding D decreases expression ISO Pravastatin results in decreased expression of RRAGD mRNA CTD PMID:27225895 NCBI chr 5:48,224,994...48,260,691
Ensembl chr 5:48,224,994...48,260,685
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions EXP [[Pravastatin co-treated with pirinixic acid] co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA; [Pravastatin co-treated with [RXRA protein co-treated with PPARA protein]] results in increased expression of HMOX1 mRNA CTD PMID:20368269 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G S100a4 S100 calcium-binding protein A4 affects expression
increases expression
EXP
ISO
Pravastatin affects the expression of S100A4 mRNA
Pravastatin results in increased expression of S100A4 mRNA
CTD PMID:27225895 NCBI chr 2:189,997,278...189,999,587
Ensembl chr 2:189,997,129...189,999,604
JBrowse link
G S100g S100 calcium binding protein G decreases expression ISO
EXP
Pravastatin results in decreased expression of S100G mRNA CTD PMID:27225895 NCBI chr  X:33,442,820...33,445,714
Ensembl chr  X:33,443,186...33,445,709
JBrowse link
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 decreases expression ISO
EXP
Pravastatin results in decreased expression of SAT2 mRNA CTD PMID:27225895 NCBI chr10:56,227,703...56,229,796
Ensembl chr10:56,227,692...56,229,850
JBrowse link
G Scd stearoyl-CoA desaturase increases expression EXP Pravastatin results in increased expression of SCD mRNA CTD PMID:27225895 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 increases expression ISO Pravastatin results in increased expression of SCD2 mRNA CTD PMID:27225895 NCBI chr 1:264,059,374...264,072,433
Ensembl chr 1:264,059,374...264,072,433
JBrowse link
G Selp selectin P decreases expression ISO Pravastatin results in decreased expression of SELP protein CTD PMID:11189483 NCBI chr13:82,428,914...82,464,629
Ensembl chr13:82,429,063...82,464,628
JBrowse link
G Serpinb1a serpin family B member 1A decreases expression ISO
EXP
Pravastatin results in decreased expression of SERPINB1A mRNA CTD PMID:27225895 NCBI chr17:32,903,089...32,911,498
Ensembl chr17:32,904,119...32,911,495
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 increases expression ISO Pravastatin results in increased expression of SFRP1 mRNA CTD PMID:27225895 NCBI chr16:73,372,007...73,410,777
Ensembl chr16:73,372,007...73,410,777
JBrowse link
G Shisa4 shisa family member 4 increases expression EXP
ISO
Pravastatin results in increased expression of SHISA4 mRNA CTD PMID:27225895 NCBI chr13:52,193,989...52,197,205
Ensembl chr13:52,193,989...52,197,205
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of SLC10A1 mRNA CTD PMID:27225895 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc13a3 solute carrier family 13 member 3 decreases expression ISO Pravastatin results in decreased expression of SLC13A3 mRNA CTD PMID:27225895 NCBI chr 3:162,084,336...162,147,398
Ensembl chr 3:162,084,315...162,147,393
JBrowse link
G Slc15a3 solute carrier family 15 member 3 decreases expression ISO
EXP
Pravastatin results in decreased expression of SLC15A3 mRNA CTD PMID:27225895 NCBI chr 1:226,896,387...226,912,644
Ensembl chr 1:226,897,625...226,912,708
JBrowse link
G Slc16a5 solute carrier family 16 member 5 decreases expression
affects expression
ISO
EXP
Pravastatin results in decreased expression of SLC16A5 mRNA
Pravastatin affects the expression of SLC16A5 mRNA
CTD PMID:27225895 NCBI chr10:104,019,888...104,035,735
Ensembl chr10:104,019,888...104,034,595
JBrowse link
G Slc17a1 solute carrier family 17 member 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of SLC17A1 mRNA CTD PMID:27225895 NCBI chr17:43,473,048...43,504,645 JBrowse link
G Slc17a3 solute carrier family 17 member 3 decreases expression ISO
EXP
Pravastatin results in decreased expression of SLC17A3 mRNA CTD PMID:27225895 NCBI chr17:43,518,760...43,545,160
Ensembl chr17:43,518,655...43,543,185
JBrowse link
G Slc22a5 solute carrier family 22 member 5 affects expression
decreases expression
EXP
ISO
Pravastatin affects the expression of SLC22A5 mRNA
Pravastatin results in decreased expression of SLC22A5 mRNA
CTD PMID:27225895 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
G Slc23a1 solute carrier family 23 member 1 decreases expression ISO
EXP
Pravastatin results in decreased expression of SLC23A1 mRNA CTD PMID:27225895 NCBI chr18:28,413,910...28,428,133
Ensembl chr18:28,414,009...28,428,117
JBrowse link
G Slc25a20 solute carrier family 25 member 20 decreases expression ISO Pravastatin results in decreased expression of SLC25A20 mRNA CTD PMID:27225895 NCBI chr 8:117,455,308...117,476,762
Ensembl chr 8:117,455,262...117,476,734
JBrowse link
G Slc25a34 solute carrier family 25, member 34 affects expression EXP Pravastatin affects the expression of SLC25A34 mRNA CTD PMID:27225895 NCBI chr 5:160,175,206...160,179,978
Ensembl chr 5:160,176,124...160,179,978
JBrowse link
G Slc25a42 solute carrier family 25, member 42 decreases expression EXP
ISO
Pravastatin results in decreased expression of SLC25A42 mRNA CTD PMID:27225895 NCBI chr16:20,962,144...21,000,191
Ensembl chr16:20,962,227...20,985,225
JBrowse link
G Slc27a2 solute carrier family 27 member 2 decreases expression EXP
ISO
Pravastatin results in decreased expression of SLC27A2 mRNA CTD PMID:27225895 NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression ISO
EXP
Pravastatin results in decreased expression of SLC2A4 mRNA CTD PMID:27225895 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Slc34a2 solute carrier family 34 member 2 decreases expression ISO
EXP
Pravastatin results in decreased expression of SLC34A2 mRNA CTD PMID:27225895 NCBI chr14:60,257,211...60,276,516
Ensembl chr14:60,256,712...60,276,794
JBrowse link
G Slc9b2 solute carrier family 9 member B2 affects expression
increases expression
EXP
ISO
Pravastatin affects the expression of SLC9B2 mRNA
Pravastatin results in increased expression of SLC9B2 mRNA
CTD PMID:27225895 NCBI chr 2:240,485,254...240,519,166
Ensembl chr 2:240,495,371...240,519,141
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects transport
decreases expression
ISO
EXP
SLCO1A4 protein affects the transport of Pravastatin
Pravastatin results in decreased expression of SLCO1A4 protein
CTD PMID:19833843, PMID:24909372 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Slco1a5 solute carrier organic anion transporter family, member 1A5 increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of SLCO1A5 mRNA
Pravastatin results in decreased expression of SLCO1A5 mRNA
CTD PMID:27225895 NCBI chr 4:176,445,856...176,528,117
Ensembl chr 4:176,445,858...176,528,110
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Mesalamine]; Pravastatin inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein] CTD PMID:21430235 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Pravastatin inhibits the reaction [SLCO2B1 protein results in increased uptake of Mesalamine]; Pravastatin inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein] CTD PMID:21430235 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 increases expression EXP
ISO
Pravastatin results in increased expression of SLCO4A1 mRNA CTD PMID:27225895 NCBI chr 3:175,838,994...175,857,985
Ensembl chr 3:175,838,994...175,857,983
JBrowse link
G Smim3 small integral membrane protein 3 increases expression ISO Pravastatin results in increased expression of SMIM3 mRNA CTD PMID:27225895 NCBI chr18:55,744,809...55,797,186
Ensembl chr18:55,744,810...55,771,730
JBrowse link
G Snap25 synaptosome associated protein 25 multiple interactions ISO [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of SNAP25 protein CTD PMID:26875785 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Pravastatin results in increased expression of SOCS3 protein CTD PMID:19330073 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Spag5 sperm associated antigen 5 affects expression
decreases expression
ISO
EXP
Pravastatin affects the expression of SPAG5 mRNA
Pravastatin results in decreased expression of SPAG5 mRNA
CTD PMID:27225895 NCBI chr10:65,552,780...65,585,773
Ensembl chr10:65,566,171...65,585,760
Ensembl chr10:65,566,171...65,585,760
JBrowse link
G Spic Spi-C transcription factor decreases expression
increases expression
EXP
ISO
Pravastatin results in decreased expression of SPIC mRNA
Pravastatin results in increased expression of SPIC mRNA
CTD PMID:27225895 NCBI chr 7:29,225,721...29,233,452
Ensembl chr 7:29,225,727...29,233,392
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression ISO Pravastatin results in decreased expression of SRD5A2 mRNA CTD PMID:27225895 NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511
JBrowse link
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 decreases expression EXP
ISO
Pravastatin results in decreased expression of ST8SIA3 mRNA CTD PMID:27225895 NCBI chr18:59,748,766...59,755,257
Ensembl chr18:59,748,444...59,755,226
JBrowse link
G Stard4 StAR-related lipid transfer domain containing 4 increases expression ISO
EXP
Pravastatin results in increased expression of STARD4 mRNA CTD PMID:27225895 NCBI chr18:25,982,210...25,997,555
Ensembl chr18:25,984,638...25,997,555
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Pravastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:18323514 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Pravastatin results in decreased phosphorylation of STAT3 protein CTD PMID:19330073 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stx1a syntaxin 1A multiple interactions ISO [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of STX1A protein CTD PMID:26875785 NCBI chr12:24,682,050...24,710,002
Ensembl chr12:24,682,041...24,710,019
JBrowse link
G Sult1c2a sulfotransferase family, cytosolic, 1C, member 2a affects expression EXP Pravastatin affects the expression of SULT1C2 mRNA CTD PMID:27225895 NCBI chr 9:4,152,588...4,168,355
Ensembl chr 9:4,152,589...4,168,221
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases expression ISO Pravastatin results in decreased expression of SULT1E1 mRNA CTD PMID:27225895 NCBI chr14:22,070,861...22,089,264
Ensembl chr14:22,072,024...22,089,248
JBrowse link
G Sult2a1 sulfotransferase family 2A member 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of SULT2A1 mRNA CTD PMID:27225895 NCBI chr 1:76,558,721...76,614,315
Ensembl chr 1:76,252,329...76,780,230
JBrowse link
G Tex12 testis expressed 12 decreases expression EXP
ISO
Pravastatin results in decreased expression of TEX12 mRNA CTD PMID:27225895 NCBI chr 8:54,991,501...54,999,454
Ensembl chr 8:54,992,841...54,994,871
JBrowse link
G Thbd thrombomodulin affects expression
increases expression
EXP
ISO
Pravastatin affects the expression of THBD mRNA
Pravastatin results in increased expression of THBD mRNA
CTD PMID:27225895 NCBI chr 3:142,748,673...142,752,325
Ensembl chr 3:142,748,674...142,752,325
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 decreases expression EXP Pravastatin results in decreased expression of TIMP1 mRNA CTD PMID:16935385 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression EXP Pravastatin results in decreased expression of TIMP2 mRNA CTD PMID:16935385 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tlcd4 TLC domain containing 4 decreases expression ISO Pravastatin results in decreased expression of TLCD4 mRNA CTD PMID:27225895 NCBI chr 2:224,768,034...224,843,198
Ensembl chr 2:224,772,893...224,802,997
JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 increases expression EXP
ISO
Pravastatin results in increased expression of TM7SF2 mRNA CTD PMID:27225895 NCBI chr 1:221,426,017...221,430,340
Ensembl chr 1:221,425,987...221,431,713
JBrowse link
G Tmem139 transmembrane protein 139 increases expression
decreases expression
EXP
ISO
Pravastatin results in increased expression of TMEM139 mRNA
Pravastatin results in decreased expression of TMEM139 mRNA
CTD PMID:27225895 NCBI chr 4:71,648,705...71,651,861
Ensembl chr 4:71,650,575...71,651,438
JBrowse link
G Tmem164 transmembrane protein 164 decreases expression
increases expression
EXP
ISO
Pravastatin results in decreased expression of TMEM164 mRNA
Pravastatin results in increased expression of TMEM164 mRNA
CTD PMID:27225895 NCBI chr  X:113,947,355...114,110,064
Ensembl chr  X:113,948,654...114,110,062
JBrowse link
G Tmem205 transmembrane protein 205 decreases expression ISO
EXP
Pravastatin results in decreased expression of TMEM205 mRNA CTD PMID:27225895 NCBI chr 8:22,932,175...22,937,953
Ensembl chr 8:22,932,175...22,937,909
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO Pravastatin inhibits the reaction [LEP gene mutant form results in increased expression of TNF mRNA]; Pravastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Pravastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]; Pravastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]
Pravastatin results in increased expression of TNF mRNA
CTD PMID:17729120, PMID:18323514, PMID:27225895 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfsf18 TNF superfamily member 18 affects expression ISO
EXP
Pravastatin affects the expression of TNFSF18 mRNA CTD PMID:27225895 NCBI chr13:79,378,412...79,388,687
Ensembl chr13:79,378,733...79,388,498
JBrowse link
G Tnnt2 troponin T2, cardiac type increases expression ISO Pravastatin results in increased expression of TNNT2 mRNA CTD PMID:27225895 NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO
EXP
[Pravastatin results in increased phosphorylation of MDM2 protein] which results in increased degradation of TP53 protein; Pravastatin inhibits the reaction [Fluorouracil results in decreased degradation of TP53 protein]; Pravastatin inhibits the reaction [leptomycin B results in decreased degradation of TP53 protein]; Pravastatin inhibits the reaction [lopinavir-ritonavir drug combination results in increased expression of TP53 protein]; Pravastatin inhibits the reaction [Ritonavir results in increased expression of TP53 protein]
Pravastatin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]
CTD PMID:15625077, PMID:20650967, PMID:20884875 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tspan13 tetraspanin 13 increases expression EXP
ISO
Pravastatin results in increased expression of TSPAN13 mRNA CTD PMID:27225895 NCBI chr 6:55,497,659...55,524,415
Ensembl chr 6:55,497,658...55,524,436
JBrowse link
G Tuba1a tubulin, alpha 1A increases expression EXP
ISO
Pravastatin results in increased expression of TUBA1A mRNA CTD PMID:27225895 NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 decreases expression ISO
EXP
Pravastatin results in decreased expression of UGT2B1 mRNA CTD PMID:27225895 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Uroc1 urocanate hydratase 1 decreases expression EXP
ISO
Pravastatin results in decreased expression of UROC1 mRNA CTD PMID:27225895 NCBI chr 4:122,244,744...122,276,357
Ensembl chr 4:122,244,711...122,276,361
JBrowse link
G Vamp2 vesicle-associated membrane protein 2 multiple interactions ISO [LDLR gene mutant form results in increased susceptibility to Pravastatin] which results in decreased expression of VAMP2 protein CTD PMID:26875785 NCBI chr10:55,675,171...55,679,405
Ensembl chr10:55,675,575...55,679,450
JBrowse link
G Vnn1 vanin 1 decreases expression ISO Pravastatin results in decreased expression of VNN1 mRNA CTD PMID:27225895 NCBI chr 1:22,614,832...22,625,134
Ensembl chr 1:22,614,783...22,625,204
JBrowse link
G Zc3h12a zinc finger CCCH type containing 12A increases expression
decreases expression
ISO
EXP
Pravastatin results in increased expression of ZC3H12A mRNA
Pravastatin results in decreased expression of ZC3H12A mRNA
CTD PMID:27225895 NCBI chr 5:143,111,342...143,120,131
Ensembl chr 5:143,111,074...143,120,165
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        xenobiotic 18381
          pravastatin 299
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        monocarboxylic acid 17407
                                          fatty acid 15845
                                            short-chain fatty acid 15500
                                              fatty acid 4:0 7011
                                                butyric acid 5292
                                                  methylbutyric acid 980
                                                    2-methylbutyric acid 921
                                                      (S)-2-methylbutyric acid 921
                                                        pravastatin 299
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.