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ONTOLOGY REPORT - ANNOTATIONS


Term:pravastatin
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Accession:CHEBI:63618 term browser browse the term
Definition:A carboxylic ester resulting from the formal condensation of (S)-2-methylbutyric acid with the hydroxy group adjacent to the ring junction of (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6,8-dihydroxy-2-methyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid. Derived from microbial transformation of mevastatin, pravastatin is a reversible inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA). The sodium salt is used for lowering cholesterol and preventing cardiovascular disease. It is one of the lower potency statins, but has the advantage of fewer side effects compared with lovastatin and simvastatin.
Synonyms:exact_synonym: (3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid
 related_synonym: (+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid;   Formula=C23H36O7;   InChI=1S/C23H36O7/c1-4-13(2)23(29)30-20-11-17(25)9-15-6-5-14(3)19(22(15)20)8-7-16(24)10-18(26)12-21(27)28/h5-6,9,13-14,16-20,22,24-26H,4,7-8,10-12H2,1-3H3,(H,27,28)/t13-,14-,16+,17+,18+,19-,20-,22-/m0/s1;   InChIKey=TUZYXOIXSAXUGO-PZAWKZKUSA-N;   SMILES=[H][C@]12[C@H](C[C@H](O)C=C1C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC(O)=O)OC(=O)[C@@H](C)CC;   pravastatin acid;   pravastatina;   pravastatine;   pravastatinum
 alt_id: CHEBI:8360
 xref: CAS:81093-37-0 "ChemIDplus";   CAS:81093-37-0 "KEGG COMPOUND";   DrugBank:DB00175;   Drug_Central:2239 "DrugCentral";   HMDB:HMDB0005022;   KEGG:C01844;   KEGG:D08410;   KNApSAcK:C00000565;   LINCS:LSM-3347
 xref_mesh: MESH:D017035
 xref: PMID:21749370 "Europe PMC";   PMID:21851379 "Europe PMC";   PMID:25264019 "Europe PMC";   Reaxys:4825538 "Reaxys";   Wikipedia:Pravastatin
 cyclic_relationship: is_conjugate_acid_of CHEBI:63660


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pravastatin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca1 ATP binding cassette subfamily A member 1 JBrowse link 5 69,857,717 69,983,042 RGD:6480464
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:6480464
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:6480464
G Abcc4 ATP binding cassette subfamily C member 4 JBrowse link 15 103,695,415 103,927,980 RGD:6480464
G Abcd3 ATP binding cassette subfamily D member 3 JBrowse link 2 225,335,708 225,389,120 RGD:6480464
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Abcg5 ATP binding cassette subfamily G member 5 JBrowse link 6 7,935,771 7,961,207 RGD:6480464
G Abcg8 ATP binding cassette subfamily G member 8 JBrowse link 6 7,961,413 7,980,708 RGD:6480464
G Acaa1b acetyl-Coenzyme A acyltransferase 1B JBrowse link 8 127,836,235 127,845,296 RGD:6480464
G Acaa2 acetyl-CoA acyltransferase 2 JBrowse link 18 70,733,872 70,762,395 RGD:6480464
G Acat1 acetyl-CoA acetyltransferase 1 JBrowse link 8 58,166,990 58,195,884 RGD:6480464
G Acot1 acyl-CoA thioesterase 1 JBrowse link 6 107,485,088 107,493,082 RGD:6480464
G Acot12 acyl-CoA thioesterase 12 JBrowse link 2 20,857,056 20,901,656 RGD:6480464
G Acot2 acyl-CoA thioesterase 2 JBrowse link 6 107,460,596 107,468,324 RGD:6480464
G Acot3 acyl-CoA thioesterase 3 JBrowse link 6 107,531,508 107,537,446 RGD:6480464
G Acot4 acyl-CoA thioesterase 4 JBrowse link 6 107,517,668 107,522,952 RGD:6480464
G Acox1 acyl-CoA oxidase 1 JBrowse link 10 104,724,534 104,748,003 RGD:6480464
G Acsf2 acyl-CoA synthetase family member 2 JBrowse link 10 82,284,719 82,326,771 RGD:6480464
G Acsl1 acyl-CoA synthetase long-chain family member 1 JBrowse link 16 48,937,456 49,003,898 RGD:6480464
G Acta1 actin, alpha 1, skeletal muscle JBrowse link 19 56,674,072 56,677,084 RGD:6480464
G Adamdec1 ADAM-like, decysin 1 JBrowse link 15 49,485,604 49,521,638 RGD:6480464
G Adh1 alcohol dehydrogenase 1 (class I) JBrowse link 2 243,550,655 243,562,243 RGD:6480464
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide JBrowse link 2 243,500,540 243,516,865 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Aif1 allograft inflammatory factor 1 JBrowse link 20 5,161,350 5,167,176 RGD:6480464
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 JBrowse link 1 238,222,689 238,264,381 RGD:6480464
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 JBrowse link 8 77,640,234 77,719,488 RGD:6480464
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 JBrowse link 1 127,302,920 127,337,828 RGD:6480464
G Aldoart2 aldolase 1 A retrogene 2 JBrowse link 6 76,349,362 76,351,052 RGD:6480464
G Ampd3 adenosine monophosphate deaminase 3 JBrowse link 1 175,585,301 175,630,479 RGD:6480464
G Angptl3 angiopoietin-like 3 JBrowse link 5 117,698,590 117,706,729 RGD:6480464
G Ank2 ankyrin 2 JBrowse link 2 231,224,643 231,522,655 RGD:6480464
G Anks6 ankyrin repeat and sterile alpha motif domain containing 6 JBrowse link 5 62,642,974 62,684,387 RGD:6480464
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:6480464
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:6480464
G Arg2 arginase 2 JBrowse link 6 102,311,097 102,338,406 RGD:6480464
G Arhgap11a Rho GTPase activating protein 11A JBrowse link 3 105,281,827 105,298,108 RGD:6480464
G Arntl2 aryl hydrocarbon receptor nuclear translocator-like 2 JBrowse link 4 181,103,774 181,158,415 RGD:6480464
G Arrdc3 arrestin domain containing 3 JBrowse link 2 8,732,907 8,745,445 RGD:6480464
G Atp4a ATPase H+/K+ transporting subunit alpha JBrowse link 1 89,162,700 89,175,504 RGD:6480464
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 JBrowse link 5 33,843,591 33,892,446 RGD:6480464
G Axin2 axin 2 JBrowse link 10 97,212,483 97,238,824 RGD:6480464
G Bard1 BRCA1 associated RING domain 1 JBrowse link 9 78,297,723 78,368,777 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bhlha15 basic helix-loop-helix family, member a15 JBrowse link 12 12,403,385 12,409,103 RGD:6480464
G Bmper BMP-binding endothelial regulator JBrowse link 8 24,369,916 24,615,484 RGD:6480464
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B JBrowse link 3 110,367,949 110,420,471 RGD:6480464
G C1qb complement C1q B chain JBrowse link 5 155,246,444 155,251,995 RGD:6480464
G C1qc complement C1q C chain JBrowse link 5 155,255,013 155,258,631 RGD:6480464
G C5ar1 complement C5a receptor 1 JBrowse link 1 78,186,777 78,195,132 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:6480464
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:6480464
G Ccl12 chemokine (C-C motif) ligand 12 JBrowse link 10 69,476,866 69,478,416 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccl6 chemokine (C-C motif) ligand 6 JBrowse link 10 70,798,118 70,802,750 RGD:6480464
G Cd209 CD209 molecule JBrowse link 12 2,406,879 2,413,324 RGD:6480464
G Cd209a CD209a antigen JBrowse link 12 2,341,960 2,347,543 RGD:6480464
G Cd28 Cd28 molecule JBrowse link 9 67,546,408 67,573,858 RGD:6480464
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:6480464
G Cd7 Cd7 molecule JBrowse link 10 110,229,931 110,232,812 RGD:6480464
G Cdc27 cell division cycle 27 JBrowse link 10 92,551,754 92,602,214 RGD:6480464
G Cdc6 cell division cycle 6 JBrowse link 10 86,819,477 86,833,301 RGD:6480464
G Cdca7l cell division cycle associated 7 like JBrowse link 6 145,739,570 145,785,607 RGD:6480464
G Cdhr5 cadherin-related family member 5 JBrowse link 1 214,255,118 214,263,848 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Cds1 CDP-diacylglycerol synthase 1 JBrowse link 14 9,396,511 9,456,964 RGD:6480464
G Cebpd CCAAT/enhancer binding protein delta JBrowse link 11 89,008,008 89,009,146 RGD:6480464
G Cers6 ceramide synthase 6 JBrowse link 3 55,094,240 55,338,370 RGD:6480464
G Cesl1 carboxylesterase-like 1 RGD:6480464
G Cip2a cell proliferation regulating inhibitor of protein phosphatase 2A JBrowse link 11 54,373,794 54,404,704 RGD:6480464
G Cited1 Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1 JBrowse link X 72,128,996 72,133,692 RGD:6480464
G Clcn6 chloride voltage-gated channel 6 JBrowse link 5 164,811,815 164,844,554 RGD:6480464
G Clec4f C-type lectin domain family 4, member F JBrowse link 4 115,322,300 115,332,021 RGD:6480464
G Clstn3 calsyntenin 3 JBrowse link 4 157,044,736 157,078,013 RGD:6480464
G Cnn1 calponin 1 JBrowse link 8 23,113,083 23,121,748 RGD:6480464
G Cpt1b carnitine palmitoyltransferase 1B JBrowse link 7 130,395,211 130,404,731 RGD:6480464
G Cpt2 carnitine palmitoyltransferase 2 JBrowse link 5 127,505,646 127,523,016 RGD:6480464
G Crat carnitine O-acetyltransferase JBrowse link 3 8,967,984 8,981,959 RGD:6480464
G Creb3l3 cAMP responsive element binding protein 3-like 3 JBrowse link 7 11,490,852 11,499,287 RGD:6480464
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:6480464
G Csad cysteine sulfinic acid decarboxylase JBrowse link 7 143,781,520 143,810,880 RGD:6480464
G Csf1r colony stimulating factor 1 receptor JBrowse link 18 56,414,493 56,458,300 RGD:6480464
G Csmd1 CUB and Sushi multiple domains 1 JBrowse link 16 77,152,823 78,850,222 RGD:6480464
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:6480464
G Cxcl2 C-X-C motif chemokine ligand 2 JBrowse link 14 18,731,346 18,733,391 RGD:6480464
G Cyba cytochrome b-245 alpha chain JBrowse link 19 55,249,634 55,257,824 RGD:6480464
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:6480464
G Cyp2b21 cytochrome P450, family 2, subfamily b, polypeptide 21 JBrowse link 1 83,389,783 83,418,613 RGD:6480464
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 JBrowse link 7 123,625,641 123,630,045 RGD:6480464
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 JBrowse link 7 123,634,400 123,638,757 RGD:6480464
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 JBrowse link 5 119,546,458 119,564,843 RGD:6480464
G Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 JBrowse link 12 11,053,888 11,082,742 RGD:6480464
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 JBrowse link 5 134,492,734 134,507,158 RGD:6480464
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 JBrowse link 5 134,196,910 134,207,888 RGD:6480464
G Cyp4a3 cytochrome P450, family 4, subfamily a, polypeptide 3 JBrowse link 5 134,468,666 134,484,851 RGD:6480464
G Cyp51 cytochrome P450, family 51 JBrowse link 4 27,175,564 27,194,018 RGD:6480464
G Decr1 2,4-dienoyl-CoA reductase 1 JBrowse link 5 29,573,893 29,601,731 RGD:6480464
G Depdc1b DEP domain containing 1B JBrowse link 2 39,980,796 40,069,982 RGD:6480464
G Derl3 derlin 3 JBrowse link 20 13,692,102 13,707,645 RGD:6480464
G Dio3 iodothyronine deiodinase 3 JBrowse link 6 134,627,278 134,629,139 RGD:6480464
G Dlgap1 DLG associated protein 1 JBrowse link 9 118,277,046 119,159,807 RGD:6480464
G Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 JBrowse link 5 57,028,467 57,039,378 RGD:6480464
G Dnase2b deoxyribonuclease 2 beta JBrowse link 2 252,436,363 252,475,506 RGD:6480464
G Dpysl2 dihydropyrimidinase-like 2 JBrowse link 15 43,475,640 43,581,725 RGD:6480464
G Dtl denticleless E3 ubiquitin protein ligase homolog JBrowse link 13 110,219,276 110,257,345 RGD:6480464
G Ech1 enoyl-CoA hydratase 1 JBrowse link 1 87,009,798 87,015,996 RGD:6480464
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:6480464
G Efhb EF hand domain family, member B JBrowse link 9 47,988 120,800 RGD:6480464
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase JBrowse link 11 82,945,104 82,978,364 RGD:6480464
G Enpp5 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 JBrowse link 9 19,469,276 19,476,684 RGD:6480464
G Entpd2 ectonucleoside triphosphate diphosphohydrolase 2 JBrowse link 3 2,617,795 2,623,818 RGD:6480464
G Ephx2 epoxide hydrolase 2 JBrowse link 15 42,757,241 42,794,211 RGD:6480464
G Ephx4 epoxide hydrolase 4 JBrowse link 14 3,360,680 3,389,996 RGD:6480464
G Evi2a ecotropic viral integration site 2A JBrowse link 10 66,870,048 66,873,948 RGD:6480464
G F13a1 coagulation factor XIII A1 chain JBrowse link 17 28,504,650 28,680,015 RGD:6480464
G Fabp1 fatty acid binding protein 1 JBrowse link 4 99,063,181 99,066,957 RGD:6480464
G Fabp2 fatty acid binding protein 2 JBrowse link 2 227,080,912 227,083,654 RGD:6480464
G Fabp5 fatty acid binding protein 5 JBrowse link 2 93,981,662 93,985,322 RGD:6480464
G Far1 fatty acyl CoA reductase 1 JBrowse link 1 178,351,674 178,412,838 RGD:6480464
G Fbn1 fibrillin 1 JBrowse link 3 117,569,708 117,766,160 RGD:6480464
G Fbp2 fructose-bisphosphatase 2 JBrowse link 17 372,554 389,918 RGD:6480464
G Fdft1 farnesyl diphosphate farnesyl transferase 1 JBrowse link 15 46,339,248 46,367,302 RGD:6480464
G Fgd2 FYVE, RhoGEF and PH domain containing 2 JBrowse link 20 6,973,356 6,990,026 RGD:6480464
G Fgf13 fibroblast growth factor 13 JBrowse link X 142,053,648 142,589,274 RGD:6480464
G Flacc1 flagellum associated containing coiled-coil domains 1 JBrowse link 9 65,665,663 65,693,822 RGD:6480464
G Flot1 flotillin 1 JBrowse link 20 3,427,890 3,438,418 RGD:6480464
G Folr2 folate receptor beta JBrowse link 1 166,915,045 166,933,377 RGD:6480464
G Gck glucokinase JBrowse link 14 86,149,146 86,191,589 RGD:6480464
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:6480464
G Gcnt2 glucosaminyl (N-acetyl) transferase 2 (I blood group) JBrowse link 17 21,634,546 21,677,477 RGD:6480464
G Glb1 galactosidase, beta 1 JBrowse link 8 122,439,328 122,511,939 RGD:6480464
G Gldc glycine decarboxylase JBrowse link 1 248,295,140 248,377,122 RGD:6480464
G Gls2 glutaminase 2 JBrowse link 7 2,605,679 2,621,853 RGD:6480464
G Gpr85 G protein-coupled receptor 85 JBrowse link 4 40,377,705 40,387,147 RGD:6480464
G Gstk1 glutathione S-transferase kappa 1 JBrowse link 4 71,621,777 71,626,096 RGD:6480464
G Hadh hydroxyacyl-CoA dehydrogenase JBrowse link 2 236,353,445 236,395,067 RGD:6480464
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha JBrowse link 6 27,589,840 27,628,921 RGD:6480464
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta JBrowse link 6 27,555,408 27,589,539 RGD:6480464
G Hamp hepcidin antimicrobial peptide JBrowse link 1 89,368,021 89,369,960 RGD:6480464
G Hax1 HCLS1 associated protein X-1 JBrowse link 2 189,330,900 189,333,305 RGD:6480464
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:6480464
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 JBrowse link 2 52,427,351 52,445,082 RGD:6480464
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:6480464
G Hopx HOP homeobox JBrowse link 14 33,354,803 33,362,547 RGD:6480464
G Hrg histidine-rich glycoprotein JBrowse link 11 81,621,274 81,639,938 RGD:6480464
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 JBrowse link 13 88,288,116 88,308,019 RGD:6480464
G Hsdl2 hydroxysteroid dehydrogenase like 2 JBrowse link 5 76,812,881 76,848,853 RGD:6480464
G Idi1 isopentenyl-diphosphate delta isomerase 1 JBrowse link 17 57,976,266 57,984,036 RGD:6480464
G Ifnb1 interferon beta 1 JBrowse link 5 106,865,192 106,865,746 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Irf3 interferon regulatory factor 3 JBrowse link 1 100,992,244 100,997,202 RGD:6480464
G Itga2 integrin subunit alpha 2 JBrowse link 2 46,996,904 47,097,011 RGD:6480464
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:6480464
G Itgb6 integrin subunit beta 6 JBrowse link 3 46,652,624 46,775,362 RGD:6480464
G Kcns3 potassium voltage-gated channel, modifier subfamily S, member 3 JBrowse link 6 36,764,040 36,819,810 RGD:6480464
G Kctd12 potassium channel tetramerization domain containing 12 JBrowse link 15 87,384,632 87,390,627 RGD:6480464
G Kif20a kinesin family member 20A JBrowse link 18 27,424,328 27,432,814 RGD:6480464
G Kif20b kinesin family member 20B JBrowse link 1 253,220,038 253,275,523 RGD:6480464
G Kif23 kinesin family member 23 JBrowse link 8 66,866,043 66,893,241 RGD:6480464
G Kitlg KIT ligand JBrowse link 7 42,269,784 42,351,054 RGD:6480464
G Klb klotho beta JBrowse link 14 44,529,523 44,614,093 RGD:6480464
G Krt23 keratin 23 JBrowse link 10 87,391,623 87,407,634 RGD:6480464
G Ldlr low density lipoprotein receptor JBrowse link 8 22,750,425 22,773,305 RGD:6480464
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:6480464
G Lgals4 galectin 4 JBrowse link 1 87,019,598 87,027,720 RGD:6480464
G Lgi2 leucine-rich repeat LGI family, member 2 JBrowse link 14 60,764,325 60,791,809 RGD:6480464
G Lmna lamin A/C JBrowse link 2 187,842,884 187,863,552 RGD:6480464
G LOC100910526 sulfotransferase 1C2-like JBrowse link 9 4,820,678 4,834,271 RGD:6480464
G Lpl lipoprotein lipase JBrowse link 16 22,537,687 22,561,487 RGD:6480464
G Lrmda leucine rich melanocyte differentiation associated JBrowse link 15 1,269,869 2,346,246 RGD:6480464
G Lss lanosterol synthase JBrowse link 20 12,844,522 12,870,474 RGD:6480464
G Ltbp2 latent transforming growth factor beta binding protein 2 JBrowse link 6 108,500,114 108,596,653 RGD:6480464
G Ly86 lymphocyte antigen 86 JBrowse link 17 28,104,535 28,191,447 RGD:6480464
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:6480464
G Mastl microtubule associated serine/threonine kinase-like JBrowse link 17 89,839,562 89,875,855 RGD:6480464
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:6480464
G Meiob meiosis specific with OB-fold JBrowse link 10 14,174,645 14,206,026 RGD:6480464
G Mgll monoglyceride lipase JBrowse link 4 120,671,436 120,773,458 RGD:6480464
G Miox myo-inositol oxygenase JBrowse link 7 130,308,707 130,311,205 RGD:6480464
G Mis18a MIS18 kinetochore protein A JBrowse link 11 30,880,231 30,893,262 RGD:6480464
G Mlycd malonyl-CoA decarboxylase JBrowse link 19 52,032,950 52,048,773 RGD:6480464
G Mme membrane metallo-endopeptidase JBrowse link 2 153,799,203 153,880,910 RGD:6480464
G Mmp14 matrix metallopeptidase 14 JBrowse link 15 33,074,441 33,083,666 RGD:6480464
G Mmp2 matrix metallopeptidase 2 JBrowse link 19 15,542,771 15,570,589 RGD:6480464
G Mmp3 matrix metallopeptidase 3 JBrowse link 8 5,676,608 5,698,579 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Mss51 MSS51 mitochondrial translational activator JBrowse link 15 4,240,203 4,252,072 RGD:6480464
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6480464
G Mvd mevalonate diphosphate decarboxylase JBrowse link 19 55,258,910 55,268,933 RGD:6480464
G Nfe2 nuclear factor, erythroid 2 JBrowse link 7 144,872,739 144,880,092 RGD:6480464
G Nnmt nicotinamide N-methyltransferase JBrowse link 8 52,918,437 52,938,172 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 JBrowse link 5 151,776,004 151,779,319 RGD:6480464
G Nsdhl NAD(P) dependent steroid dehydrogenase-like JBrowse link X 152,933,118 152,964,399 RGD:6480464
G Olr1 oxidized low density lipoprotein receptor 1 JBrowse link 4 163,239,853 163,261,937 RGD:6480464
G Orc1 origin recognition complex, subunit 1 JBrowse link 5 128,186,651 128,212,901 RGD:6480464
G Pcdhb5 protocadherin beta 5 JBrowse link 18 30,398,113 30,400,695 RGD:6480464
G Pcsk9 proprotein convertase subtilisin/kexin type 9 JBrowse link 5 126,031,368 126,053,726 RGD:6480464
G Pctp phosphatidylcholine transfer protein JBrowse link 10 77,491,445 77,537,268 RGD:6480464
G Pde4a phosphodiesterase 4A JBrowse link 8 22,189,533 22,234,036 RGD:6480464
G Pdk4 pyruvate dehydrogenase kinase 4 JBrowse link 4 30,546,772 30,556,774 RGD:6480464
G Pemt phosphatidylethanolamine N-methyltransferase JBrowse link 10 46,339,821 46,404,640 RGD:6480464
G Pex11a peroxisomal biogenesis factor 11 alpha JBrowse link 1 141,474,189 141,481,270 RGD:6480464
G Pf4 platelet factor 4 JBrowse link 14 18,848,549 18,849,258 RGD:6480464
G Pla2r1 phospholipase A2 receptor 1 JBrowse link 3 46,488,963 46,621,873 RGD:6480464
G Plppr1 phospholipid phosphatase related 1 JBrowse link 5 67,852,817 67,985,310 RGD:6480464
G Pmvk phosphomevalonate kinase JBrowse link 2 188,784,329 188,793,890 RGD:6480464
G Pnpla7 patatin-like phospholipase domain containing 7 JBrowse link 3 2,182,191 2,261,890 RGD:6480464
G Pole2 DNA polymerase epsilon 2, accessory subunit JBrowse link 6 91,494,348 91,532,355 RGD:6480464
G Ppara peroxisome proliferator activated receptor alpha JBrowse link 7 126,618,872 126,687,282 RGD:6480464
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:6480464
G Ppm1j protein phosphatase, Mg2+/Mn2+ dependent, 1J JBrowse link 2 207,263,307 207,268,601 RGD:6480464
G Prnd prion like protein doppel JBrowse link 3 124,543,227 124,548,548 RGD:6480464
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:6480464
G Ptprn protein tyrosine phosphatase, receptor type, N JBrowse link 9 82,446,626 82,462,314 RGD:6480464
G Rdh11 retinol dehydrogenase 11 JBrowse link 6 102,356,498 102,372,618 RGD:6480464
G Reep1 receptor accessory protein 1 JBrowse link 4 99,618,622 99,735,329 RGD:6480464
G Retsat retinol saturase JBrowse link 4 100,465,365 100,474,128 RGD:6480464
G RGD1560455 similar to RIKEN cDNA A630033H20 gene JBrowse link X 78,258,495 78,284,180 RGD:6480464
G RGD1564308 similar to LOC495042 protein JBrowse link 16 49,485,022 49,509,756 RGD:6480464
G Rgs16 regulator of G-protein signaling 16 JBrowse link 13 71,163,411 71,185,147 RGD:6480464
G Rnf186 ring finger protein 186 JBrowse link 5 157,416,897 157,418,121 RGD:6480464
G Rragd Ras-related GTP binding D JBrowse link 5 48,224,994 48,260,691 RGD:6480464
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:6480464
G S100a4 S100 calcium-binding protein A4 JBrowse link 2 189,997,278 189,999,587 RGD:6480464
G S100g S100 calcium binding protein G JBrowse link X 33,442,820 33,445,714 RGD:6480464
G Sat2 spermidine/spermine N1-acetyltransferase family member 2 JBrowse link 10 56,227,703 56,229,796 RGD:6480464
G Scd stearoyl-CoA desaturase JBrowse link 1 264,159,966 264,173,061 RGD:6480464
G Scd2 stearoyl-Coenzyme A desaturase 2 JBrowse link 1 264,059,374 264,072,433 RGD:6480464
G Selp selectin P JBrowse link 13 82,428,914 82,464,629 RGD:6480464
G Serpinb1a serpin family B member 1A JBrowse link 17 32,903,089 32,911,498 RGD:6480464
G Sfrp1 secreted frizzled-related protein 1 JBrowse link 16 73,372,007 73,410,777 RGD:6480464
G Shisa4 shisa family member 4 JBrowse link 13 52,193,989 52,197,205 RGD:6480464
G Slc10a1 solute carrier family 10 member 1 JBrowse link 6 104,617,730 104,631,355 RGD:6480464
G Slc13a3 solute carrier family 13 member 3 JBrowse link 3 162,084,336 162,147,398 RGD:6480464
G Slc15a3 solute carrier family 15 member 3 JBrowse link 1 226,896,387 226,912,644 RGD:6480464
G Slc16a5 solute carrier family 16 member 5 JBrowse link 10 104,019,888 104,035,735 RGD:6480464
G Slc17a1 solute carrier family 17 member 1 JBrowse link 17 43,473,048 43,504,645 RGD:6480464
G Slc17a3 solute carrier family 17 member 3 JBrowse link 17 43,518,760 43,545,160 RGD:6480464
G Slc22a5 solute carrier family 22 member 5 JBrowse link 10 39,201,101 39,228,090 RGD:6480464
G Slc23a1 solute carrier family 23 member 1 JBrowse link 18 28,413,910 28,428,133 RGD:6480464
G Slc25a20 solute carrier family 25 member 20 JBrowse link 8 117,455,308 117,476,762 RGD:6480464
G Slc25a34 solute carrier family 25, member 34 JBrowse link 5 160,175,206 160,179,978 RGD:6480464
G Slc25a42 solute carrier family 25, member 42 JBrowse link 16 20,962,144 21,000,191 RGD:6480464
G Slc27a2 solute carrier family 27 member 2 JBrowse link 3 119,014,620 119,052,531 RGD:6480464
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:6480464
G Slc34a2 solute carrier family 34 member 2 JBrowse link 14 60,257,211 60,276,516 RGD:6480464
G Slc9b2 solute carrier family 9 member B2 JBrowse link 2 240,485,254 240,519,166 RGD:6480464
G Slco1a4 solute carrier organic anion transporter family, member 1a4 JBrowse link 4 175,969,549 176,026,227 RGD:6480464
G Slco1b2 solute carrier organic anion transporter family, member 1B2 JBrowse link 4 175,814,118 175,881,775 RGD:6480464
G Slco2b1 solute carrier organic anion transporter family, member 2b1 JBrowse link 1 164,623,313 164,671,612 RGD:6480464
G Slco4a1 solute carrier organic anion transporter family, member 4a1 JBrowse link 3 175,838,994 175,857,985 RGD:6480464
G Smim3 small integral membrane protein 3 JBrowse link 18 55,744,809 55,797,186 RGD:6480464
G Snap25 synaptosome associated protein 25 JBrowse link 3 129,697,408 129,788,417 RGD:6480464
G Socs3 suppressor of cytokine signaling 3 JBrowse link 10 106,973,863 106,976,969 RGD:6480464
G Spag5 sperm associated antigen 5 JBrowse link 10 65,552,780 65,585,773 RGD:6480464
G Spic Spi-C transcription factor JBrowse link 7 29,225,721 29,233,452 RGD:6480464
G Srd5a2 steroid 5 alpha-reductase 2 JBrowse link 6 25,279,635 25,315,501 RGD:6480464
G St8sia3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 JBrowse link 18 59,748,766 59,755,257 RGD:6480464
G Stard4 StAR-related lipid transfer domain containing 4 JBrowse link 18 25,982,210 25,997,555 RGD:6480464
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:6480464
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:6480464
G Stx1a syntaxin 1A JBrowse link 12 24,682,050 24,710,002 RGD:6480464
G Sult1c2a sulfotransferase family, cytosolic, 1C, member 2a JBrowse link 9 4,152,588 4,168,355 RGD:6480464
G Sult1e1 sulfotransferase family 1E member 1 JBrowse link 14 22,070,861 22,089,264 RGD:6480464
G Sult2a1 sulfotransferase family 2A member 1 JBrowse link 1 76,558,721 76,614,315 RGD:6480464
G Tex12 testis expressed 12 JBrowse link 8 54,991,501 54,999,454 RGD:6480464
G Thbd thrombomodulin JBrowse link 3 142,748,673 142,752,325 RGD:6480464
G Timp1 TIMP metallopeptidase inhibitor 1 JBrowse link X 1,364,771 1,369,451 RGD:6480464
G Timp2 TIMP metallopeptidase inhibitor 2 JBrowse link 10 107,338,465 107,386,072 RGD:6480464
G Tlcd4 TLC domain containing 4 JBrowse link 2 224,768,034 224,843,198 RGD:6480464
G Tm7sf2 transmembrane 7 superfamily member 2 JBrowse link 1 221,426,017 221,430,340 RGD:6480464
G Tmem139 transmembrane protein 139 JBrowse link 4 71,648,705 71,651,861 RGD:6480464
G Tmem164 transmembrane protein 164 JBrowse link X 113,947,355 114,110,064 RGD:6480464
G Tmem205 transmembrane protein 205 JBrowse link 8 22,932,175 22,937,953 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfsf18 TNF superfamily member 18 JBrowse link 13 79,378,412 79,388,687 RGD:6480464
G Tnnt2 troponin T2, cardiac type JBrowse link 13 52,662,974 52,680,992 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Tspan13 tetraspanin 13 JBrowse link 6 55,497,659 55,524,415 RGD:6480464
G Tuba1a tubulin, alpha 1A JBrowse link 7 140,637,287 140,640,953 RGD:6480464
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 JBrowse link 14 22,724,399 22,736,148 RGD:6480464
G Uroc1 urocanate hydratase 1 JBrowse link 4 122,244,744 122,276,357 RGD:6480464
G Vamp2 vesicle-associated membrane protein 2 JBrowse link 10 55,675,171 55,679,405 RGD:6480464
G Vnn1 vanin 1 JBrowse link 1 22,614,832 22,625,134 RGD:6480464
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        xenobiotic 18178
          pravastatin 299
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        monocarboxylic acid 17256
                                          fatty acid 15814
                                            short-chain fatty acid 15510
                                              fatty acid 4:0 6996
                                                butyric acid 5267
                                                  methylbutyric acid 971
                                                    2-methylbutyric acid 918
                                                      (S)-2-methylbutyric acid 918
                                                        pravastatin 299
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.