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ONTOLOGY REPORT - ANNOTATIONS


Term:pergolide
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Accession:CHEBI:63617 term browser browse the term
Definition:A diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.
Synonyms:exact_synonym: (8beta)-8-[(methylsulfanyl)methyl]-6-propylergoline
 related_synonym: Formula=C19H26N2S;   InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1;   InChIKey=YEHCICAEULNIGD-MZMPZRCHSA-N;   SMILES=[H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@@H](CSC)CN2CCC;   pergolida;   pergolidum
 alt_id: CHEBI:8020
 xref: CAS:66104-22-1 "ChemIDplus";   CAS:66104-22-1 "KEGG COMPOUND";   DrugBank:DB01186;   Drug_Central:2105 "DrugCentral";   HMDB:HMDB0015317;   KEGG:C07425;   KEGG:D08339;   LINCS:LSM-3352
 xref_mesh: MESH:D010479
 xref: PMID:11852289 "Europe PMC";   PMID:15180134 "Europe PMC";   PMID:16845152 "Europe PMC";   PMID:18071034 "Europe PMC";   PMID:2012117 "Europe PMC";   Patent:US4166182;   Reaxys:5091461 "Reaxys";   Wikipedia:Pergolide
 cyclic_relationship: is_conjugate_base_of CHEBI:63706


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pergolide term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Drd1 dopamine receptor D1 JBrowse link 17 11,099,736 11,104,352 RGD:6480464
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:6480464
G Gdnf glial cell derived neurotrophic factor JBrowse link 2 56,884,181 56,912,964 RGD:6480464
G Kcna5 potassium voltage-gated channel subfamily A member 5 JBrowse link 4 159,077,195 159,079,003 RGD:6480464
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 JBrowse link 15 344,204 1,048,849 RGD:6480464
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:6480464
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G Slc22a2 solute carrier family 22 member 2 JBrowse link 1 48,318,025 48,360,219 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19728
    role 19675
      application 19328
        pharmaceutical 19202
          drug 19202
            antidyskinesia agent 1132
              antiparkinson drug 849
                pergolide 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19728
    subatomic particle 19724
      composite particle 19724
        hadron 19724
          baryon 19724
            nucleon 19724
              atomic nucleus 19724
                atom 19724
                  main group element atom 19610
                    main group molecular entity 19610
                      s-block molecular entity 19378
                        hydrogen molecular entity 19367
                          hydrides 18278
                            inorganic hydride 17205
                              pnictogen hydride 17167
                                nitrogen hydride 17003
                                  azane 16694
                                    ammonia 16691
                                      organic amino compound 16690
                                        polyamine 8072
                                          diamine 7999
                                            pergolide 13
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.