Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pergolide
go back to main search page
Accession:CHEBI:63617 term browser browse the term
Definition:A diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.
Synonyms:exact_synonym: (8beta)-8-[(methylsulfanyl)methyl]-6-propylergoline
 related_synonym: Formula=C19H26N2S;   InChI=1S/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s1;   InChIKey=YEHCICAEULNIGD-MZMPZRCHSA-N;   SMILES=[H][C@@]12Cc3c[nH]c4cccc(c34)[C@@]1([H])C[C@@H](CSC)CN2CCC;   pergolida;   pergolidum
 alt_id: CHEBI:8020
 xref: CAS:66104-22-1;   DrugBank:DB01186;   Drug_Central:2105;   HMDB:HMDB0015317;   KEGG:C07425;   KEGG:D08339;   LINCS:LSM-3352
 xref_mesh: MESH:D010479
 xref: PMID:11852289;   PMID:15180134;   PMID:16845152;   PMID:18071034;   PMID:2012117;   Patent:US4166182;   Reaxys:5091461;   Wikipedia:Pergolide
 cyclic_relationship: is_conjugate_base_of CHEBI:63706


show annotations for term's descendants           Sort by:
 
pergolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of BAX protein]
Pergolide inhibits the reaction [Levodopa results in increased expression of BAX protein]
CTD PMID:15081873 PMID:15672541 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of CDKN1A protein] CTD PMID:15081873 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Drd1 dopamine receptor D1 increases activity ISO Pergolide results in increased activity of DRD1 protein CTD PMID:16129789 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 increases activity ISO Pergolide results in increased activity of DRD2 protein CTD PMID:16129789 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Gdnf glial cell derived neurotrophic factor increases expression
increases secretion
ISO Pergolide results in increased expression of GDNF mRNA
Pergolide results in increased secretion of GDNF protein
CTD PMID:12770616 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 decreases activity ISO Pergolide results in decreased activity of KCNA5 protein CTD PMID:16129789 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 decreases activity EXP Pergolide results in decreased activity of KCNMA1 protein CTD PMID:16129789 NCBI chr15:344,204...1,048,849
Ensembl chr15:344,360...1,047,956
JBrowse link
G Msh2 mutS homolog 2 multiple interactions ISO Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of MSH2 protein] CTD PMID:15081873 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Pergolide inhibits the reaction [Hydrogen Peroxide affects the localization of NFKB1 protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of NFKB1 protein] CTD PMID:15081873 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Ngf nerve growth factor increases expression
increases secretion
ISO Pergolide results in increased expression of NGF mRNA
Pergolide results in increased secretion of NGF protein
CTD PMID:12770616 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Pergolide inhibits the reaction [Hydrogen Peroxide affects the localization of RELA protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of RELA protein] CTD PMID:15081873 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Pergolide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of BAX protein]; Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of CDKN1A protein]; Pergolide inhibits the reaction [[Hydrogen Peroxide results in increased expression of TP53 protein] which results in increased expression of MSH2 protein]; Pergolide inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 protein]
Pergolide inhibits the reaction [Levodopa results in increased expression of TRP53 protein]
CTD PMID:15081873 PMID:15672541 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      application 19411
        pharmaceutical 19299
          drug 19299
            antidyskinesia agent 1145
              antiparkinson drug 860
                pergolide 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    main group molecular entity 19662
                      s-block molecular entity 19429
                        hydrogen molecular entity 19423
                          hydrides 18758
                            inorganic hydride 17453
                              pnictogen hydride 17428
                                nitrogen hydride 17272
                                  azane 17003
                                    ammonia 17002
                                      organic amino compound 17001
                                        polyamine 8259
                                          diamine 8186
                                            pergolide 13
paths to the root