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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:linezolid
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Accession:CHEBI:63607 term browser browse the term
Definition:An organofluorine compound that consists of 1,3-oxazolidin-2-one bearing an N-3-fluoro-4-(morpholin-4-yl)phenyl group as well as an acetamidomethyl group at position 5. A synthetic antibacterial agent that inhibits bacterial protein synthesis by binding to a site on 23S ribosomal RNA of the 50S subunit and prevents further formation of a functional 70S initiation complex.
Synonyms:exact_synonym: N-({(5S)-3-[3-fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)acetamide
 related_synonym: Formula=C16H20FN3O4;   InChI=1S/C16H20FN3O4/c1-11(21)18-9-13-10-20(16(22)24-13)12-2-3-15(14(17)8-12)19-4-6-23-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1;   InChIKey=TYZROVQLWOKYKF-ZDUSSCGKSA-N;   N-(((S)-3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl)methyl)acetamide;   SMILES=CC(=O)NC[C@H]1CN(C(=O)O1)c1ccc(N2CCOCC2)c(F)c1
 alt_id: CHEBI:6477
 xref: CAS:165800-03-3;   DrugBank:DB00601;   Drug_Central:1584;   KEGG:C08146;   KEGG:D00947;   LINCS:LSM-5750
 xref_mesh: MESH:C098010
 xref: PDBeChem:ZLD;   PMID:21740298;   PMID:21815204;   PMID:21899392;   PMID:22037854;   PMID:22064533;   PMID:22064542;   PMID:22110086;   PMID:22134348;   PMID:22139199;   PMID:22214776;   PMID:22230331;   PMID:22247123;   Patent:US5688792;   Patent:WO957271;   Reaxys:7496939;   Wikipedia:Linezolid


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linezolid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alas2 5'-aminolevulinate synthase 2 decreases expression EXP Linezolid results in decreased expression of ALAS2 mRNA CTD PMID:21296123 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Camkv CaM kinase-like vesicle-associated decreases expression EXP Linezolid results in decreased expression of CAMKV mRNA CTD PMID:21296123 NCBI chr 8:116,715,755...116,730,061
Ensembl chr 8:116,715,755...116,730,061
JBrowse link
G Cdc25b cell division cycle 25B decreases expression EXP Linezolid results in decreased expression of CDC25B mRNA CTD PMID:21296123 NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
JBrowse link
G Cfap77 cilia and flagella associated protein 77 decreases expression EXP Linezolid results in decreased expression of CFAP77 mRNA CTD PMID:21296123 NCBI chr 3:7,508,500...7,632,311
Ensembl chr 3:7,508,496...7,632,345
JBrowse link
G Cib2 calcium and integrin binding family member 2 decreases expression EXP Linezolid results in decreased expression of CIB2 mRNA CTD PMID:21296123 NCBI chr 8:59,123,078...59,139,946
Ensembl chr 8:59,123,079...59,139,946
JBrowse link
G Crym crystallin, mu decreases expression EXP Linezolid results in decreased expression of CRYM mRNA CTD PMID:21296123 NCBI chr 1:189,944,895...189,960,069
Ensembl chr 1:189,944,895...189,960,073
JBrowse link
G Csad cysteine sulfinic acid decarboxylase decreases expression EXP Linezolid results in decreased expression of CSAD mRNA CTD PMID:21296123 NCBI chr 7:143,781,520...143,810,880
Ensembl chr 7:143,781,702...143,793,970
JBrowse link
G Dars2 aspartyl-tRNA synthetase 2 (mitochondrial) decreases expression EXP Linezolid results in decreased expression of DARS2 mRNA CTD PMID:21296123 NCBI chr13:78,857,638...78,885,464
Ensembl chr13:78,857,638...78,885,464
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 decreases expression EXP Linezolid results in decreased expression of HBA-A2 mRNA CTD PMID:21296123 NCBI chr10:15,589,364...15,590,207
Ensembl chr10:15,589,364...15,590,220
JBrowse link
G Hbb hemoglobin subunit beta decreases expression EXP Linezolid results in decreased expression of HBB mRNA CTD PMID:21296123 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G IgG-2a gamma-2a immunoglobulin heavy chain decreases expression EXP Linezolid results in decreased expression of IGG-2A mRNA CTD PMID:21296123
G Kifc1 kinesin family member C1 decreases expression EXP Linezolid results in decreased expression of KIFC1 mRNA CTD PMID:21296123 NCBI chr20:5,509,059...5,526,175
Ensembl chr20:5,509,059...5,526,175
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression EXP Linezolid results in decreased expression of MKI67 mRNA CTD PMID:21296123 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mlc1 modulator of VRAC current 1 decreases expression EXP Linezolid results in decreased expression of MLC1 mRNA CTD PMID:21296123 NCBI chr 7:129,949,984...129,970,314
Ensembl chr 7:129,949,967...129,970,550
JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 decreases expression EXP Linezolid results in decreased expression of PHLDA3 mRNA CTD PMID:21296123 NCBI chr13:52,588,917...52,592,002
Ensembl chr13:52,588,917...52,592,001
JBrowse link
G Prcp prolylcarboxypeptidase decreases expression EXP Linezolid results in decreased expression of PRCP mRNA CTD PMID:21296123 NCBI chr 1:157,701,089...157,750,177
Ensembl chr 1:157,701,089...157,750,169
JBrowse link
G Prtg protogenin decreases expression EXP Linezolid results in decreased expression of PRTG mRNA CTD PMID:21296123 NCBI chr 8:79,489,790...79,593,806
Ensembl chr 8:79,489,790...79,593,806
JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases expression EXP Linezolid results in decreased expression of SLC22A8 mRNA CTD PMID:21296123 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Stac3 SH3 and cysteine rich domain 3 decreases expression EXP Linezolid results in decreased expression of STAC3 mRNA CTD PMID:21296123 NCBI chr 7:70,807,427...70,815,271
Ensembl chr 7:70,807,867...70,815,270
JBrowse link
G Trip13 thyroid hormone receptor interactor 13 decreases expression EXP Linezolid results in decreased expression of TRIP13 mRNA CTD PMID:21296123 NCBI chr 1:31,967,980...32,012,923
Ensembl chr 1:31,967,978...32,012,919
JBrowse link
G Zfyve19 zinc finger FYVE-type containing 19 decreases expression EXP Linezolid results in decreased expression of ZFYVE19 mRNA CTD PMID:21296123 NCBI chr 3:111,013,856...111,021,841
Ensembl chr 3:111,013,856...111,021,841
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19781
    role 19726
      biological role 19726
        antimicrobial agent 17379
          antibacterial agent 13452
            antibacterial drug 3187
              linezolid 21
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    p-block element atom 19669
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic group 18620
                              organic divalent group 18611
                                organodiyl group 18611
                                  carbonyl group 18526
                                    carbonyl compound 18526
                                      carboxylic acid 18202
                                        carboacyl group 17418
                                          univalent carboacyl group 17418
                                            carbamoyl group 17216
                                              carboxamide 17216
                                                acetamides 12403
                                                  linezolid 21
paths to the root