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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fludarabine phosphate
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Accession:CHEBI:63599 term browser browse the term
Definition:A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Once incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas.
Synonyms:exact_synonym: 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl)-9H-purin-6-amine
 related_synonym: 2-Fluoro-ARA AMP;   2-Fluoroadenine arabinoside 5'-monophosphate;   2F-ara-AMP;   9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate;   9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-(dihydrogen phosphate);   9-beta-D-Arabinofuranosyl-2-fluoroadenine 5'-monophosphate;   FAMP;   Fludara;   Fludarabine 5'-monophosphate;   Fludarabine monophosphate;   Formula=C10H13FN5O7P;   InChI=1S/C10H13FN5O7P/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(18)5(17)3(23-9)1-22-24(19,20)21/h2-3,5-6,9,17-18H,1H2,(H2,12,14,15)(H2,19,20,21)/t3-,5-,6+,9-/m1/s1;   InChIKey=GIUYCYHIANZCFB-FJFJXFQQSA-N;   SMILES=Nc1nc(F)nc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O
 alt_id: CHEBI:31616
 xref: CAS:75607-67-9;   DrugBank:DB01073;   Drug_Central:1189;   KEGG:D01907;   PMID:10720130;   PMID:19283354;   PMID:19567212;   PMID:19862681;   PMID:19915381;   PMID:20215092;   PMID:20467451;   PMID:20514405;   PMID:20686506;   PMID:21296675;   PMID:21725721;   PMID:21736869;   PMID:21909959;   PMID:8204523;   PMID:8528057;   PMID:8651523;   Patent:WO2010046917;   Patent:WO2010133629;   Reaxys:8167686;   Wikipedia:Fludarabine



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Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    role 19810
      biological role 19808
        antimicrobial agent 18202
          antiviral agent 11072
            fludarabine phosphate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19782
                    p-block element atom 19782
                      chalcogen 19533
                        oxygen atom 19530
                          oxygen molecular entity 19506
                            hydroxides 19312
                              oxoacid 18748
                                pnictogen oxoacid 14885
                                  phosphorus oxoacid 14476
                                    phosphoric acids 13916
                                      phosphoric acid 13916
                                        phosphoric acid derivative 13822
                                          phosphate 13821
                                            organic phosphate 13821
                                              nucleoside phosphate 1856
                                                nucleoside 5'-monophosphate 358
                                                  purine nucleoside monophosphate 346
                                                    purine arabinonucleoside monophosphate 0
                                                      fludarabine phosphate 0
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