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G |
Actn2 |
actinin alpha 2 |
decreases expression |
ISO |
Ribavirin results in decreased expression of ACTN2 protein |
CTD |
PMID:32112805 |
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NCBI chr17:66,304,530...66,397,647
Ensembl chr17:66,304,501...66,397,653
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation |
ISO |
Ribavirin results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:29112301 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO |
Ribavirin results in increased activity of CASP3 protein Ribavirin promotes the reaction [FAS protein results in increased activity of CASP3 protein] |
CTD |
PMID:12760867 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp7 |
caspase 7 |
multiple interactions |
ISO |
Ribavirin promotes the reaction [FAS protein results in increased activity of CASP7 protein] |
CTD |
PMID:12760867 |
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NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
Ribavirin promotes the reaction [FAS protein results in increased activity of CASP8 protein] |
CTD |
PMID:12760867 |
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NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
Ribavirin results in decreased expression of CCND1 protein |
CTD |
PMID:29112301 |
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NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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G |
Eif4e |
eukaryotic translation initiation factor 4E |
multiple interactions decreases phosphorylation |
ISO |
Ribavirin inhibits the reaction [Doxorubicin results in increased phosphorylation of EIF4E protein] Ribavirin results in decreased phosphorylation of EIF4E protein |
CTD |
PMID:29112301 |
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NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
decreases phosphorylation |
ISO |
Ribavirin results in decreased phosphorylation of EIF4EBP1 protein |
CTD |
PMID:29112301 |
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NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
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G |
Epo |
erythropoietin |
multiple interactions increases expression |
ISO |
[peginterferon alfa-2b co-treated with Ribavirin] affects the expression of EPO protein; [Ribavirin co-treated with Interferons] results in increased expression of EPO protein Ribavirin results in increased expression of EPO |
CTD |
PMID:12713065 PMID:15232364 PMID:20009130 |
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NCBI chr12:22,274,828...22,278,268
Ensembl chr12:22,274,828...22,278,266
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G |
Fas |
Fas cell surface death receptor |
multiple interactions |
ISO |
Ribavirin promotes the reaction [FAS protein results in increased activity of CASP3 protein]; Ribavirin promotes the reaction [FAS protein results in increased activity of CASP7 protein]; Ribavirin promotes the reaction [FAS protein results in increased activity of CASP8 protein] |
CTD |
PMID:12760867 |
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NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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G |
Gas5 |
growth arrest specific 5 |
increases expression |
ISO |
Ribavirin results in increased expression of GAS5 mRNA |
CTD |
PMID:32112805 |
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NCBI chr13:78,852,523...78,855,844
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G |
Gata4 |
GATA binding protein 4 |
decreases expression |
ISO |
Ribavirin results in decreased expression of GATA4 mRNA |
CTD |
PMID:32112805 |
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NCBI chr15:46,386,703...46,458,679
Ensembl chr15:46,386,712...46,432,965
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G |
H2ax |
H2A.X variant histone |
increases expression |
ISO |
Ribavirin results in increased expression of H2AX protein modified form |
CTD |
PMID:32112805 |
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NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
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G |
Icam1 |
intercellular adhesion molecule 1 |
decreases expression |
ISO |
Ribavirin results in decreased expression of ICAM1 protein modified form |
CTD |
PMID:12853993 |
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NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
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G |
Ifng |
interferon gamma |
multiple interactions increases expression decreases expression |
ISO |
[Ribavirin co-treated with IFNA2 protein] affects the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]; [Ribavirin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IFNG mRNA; Ribavirin inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]; Ribavirin results in increased expression of and results in increased secretion of IFNG protein Ribavirin results in increased expression of IFNG protein Ribavirin results in increased expression of IFNG mRNA; Ribavirin results in increased expression of IFNG protein Ribavirin results in decreased expression of IFNG mRNA |
CTD |
PMID:9722937 PMID:10190717 PMID:10770762 PMID:17210188 PMID:29594315 |
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NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
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G |
Ifnl3 |
interferon, lambda 3 |
multiple interactions |
ISO |
IFNL3 gene polymorphism affects the susceptibility to [Ribavirin co-treated with IFNA2 protein modified form]; IFNL3 gene SNP affects the susceptibility to [peginterferon alfa-2a co-treated with Ribavirin]; IFNL3 protein results in increased susceptibility to [Ribavirin co-treated with IFNA2 protein modified form] |
CTD |
PMID:19749757 PMID:19749758 PMID:22003405 |
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NCBI chr 1:85,236,243...85,237,775
Ensembl chr 1:85,236,243...85,237,775
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G |
Il10 |
interleukin 10 |
multiple interactions decreases expression |
ISO EXP |
[Ribavirin co-treated with IFNA2 protein] affects the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]; Ribavirin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]; Ribavirin results in decreased expression of and results in decreased secretion of IL10 protein [peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of IL10 mRNA; [peginterferon alfa-2a co-treated with Ribavirin] results in increased expression of IL10 mRNA Ribavirin results in decreased expression of IL10 protein Ribavirin results in decreased expression of IL10 mRNA |
CTD |
PMID:9722937 PMID:10190717 PMID:10770762 PMID:17210188 PMID:18007553 |
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NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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G |
Il12a |
interleukin 12A |
multiple interactions |
ISO |
[Ribavirin co-treated with IFNA2 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; Ribavirin promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:9722937 |
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NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
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G |
Il12b |
interleukin 12B |
multiple interactions |
ISO |
[Ribavirin co-treated with IFNA2 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]]; Ribavirin promotes the reaction [Lipopolysaccharides results in increased secretion of [IL12A protein binds to IL12B protein]] |
CTD |
PMID:9722937 |
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NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO |
Ribavirin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] Ribavirin results in increased expression of IL1B mRNA |
CTD |
PMID:9722937 PMID:29594315 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il2 |
interleukin 2 |
multiple interactions increases expression |
ISO |
[Ribavirin co-treated with IFNA2 protein] promotes the reaction [Lipopolysaccharides results in increased secretion of IL2 protein]; [Ribavirin co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA; Ribavirin promotes the reaction [Lipopolysaccharides results in increased secretion of IL2 protein]; Ribavirin results in increased expression of and results in increased secretion of IL2 protein Ribavirin results in increased expression of IL2 mRNA; Ribavirin results in increased expression of IL2 protein |
CTD |
PMID:9722937 PMID:10190717 PMID:10770762 PMID:29594315 |
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NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
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G |
Il4 |
interleukin 4 |
decreases expression multiple interactions |
ISO |
Ribavirin results in decreased expression of IL4 mRNA; Ribavirin results in decreased expression of IL4 protein Ribavirin promotes the reaction [Lipopolysaccharides results in increased secretion of IL4 protein]; Ribavirin results in decreased expression of and results in decreased secretion of IL4 protein |
CTD |
PMID:9722937 PMID:10190717 PMID:10770762 |
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NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
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G |
Il5 |
interleukin 5 |
decreases expression multiple interactions |
ISO |
Ribavirin results in decreased expression of IL5 mRNA; Ribavirin results in decreased expression of IL5 protein Ribavirin results in decreased expression of and results in decreased secretion of IL5 protein |
CTD |
PMID:10190717 PMID:10770762 |
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NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
[peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of IL6 mRNA |
CTD |
PMID:18007553 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Isl1 |
ISL LIM homeobox 1 |
decreases expression |
ISO |
Ribavirin results in decreased expression of ISL1 mRNA |
CTD |
PMID:32112805 |
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NCBI chr 2:48,488,911...48,501,217
Ensembl chr 2:48,487,736...48,501,436
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G |
Itpa |
inosine triphosphatase |
increases response to substance |
ISO |
ITPA 5' UTR SNP results in increased susceptibility to Ribavirin |
CTD |
PMID:20637204 |
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NCBI chr 3:123,209,611...123,221,266
Ensembl chr 3:123,209,608...123,221,269
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G |
Klrc1 |
killer cell lectin like receptor C1 |
affects expression |
ISO |
Ribavirin co-treated with Interferon alfa-2a affects expression of KLRC1 protein in Natural Killer cells |
RGD |
PMID:20550548 |
RGD:40818079 |
NCBI chr 4:163,453,435...163,463,718
Ensembl chr 4:163,458,528...163,463,718
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G |
Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation |
ISO |
Ribavirin results in decreased phosphorylation of MTOR protein |
CTD |
PMID:29112301 |
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NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression |
ISO |
Ribavirin results in decreased expression of MYC protein |
CTD |
PMID:29112301 |
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NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
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G |
Myh6 |
myosin heavy chain 6 |
decreases expression |
ISO |
Ribavirin results in decreased expression of MYH6 mRNA |
CTD |
PMID:32112805 |
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NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
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G |
Oas1a |
2'-5' oligoadenylate synthetase 1A |
multiple interactions |
ISO |
[Ribavirin co-treated with IFNA2 protein] results in increased activity of OAS1 protein |
CTD |
PMID:9722937 |
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NCBI chr12:41,200,680...41,211,393
Ensembl chr12:41,200,718...41,211,909
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G |
Slc29a1 |
solute carrier family 29 member 1 |
increases uptake |
ISO |
SLC29A1 protein results in increased uptake of Ribavirin |
CTD |
PMID:20185188 |
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NCBI chr 9:17,784,468...17,799,008
Ensembl chr 9:17,784,468...17,799,005
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G |
Slc29a3 |
solute carrier family 29 member 3 |
affects transport |
ISO |
SLC29A3 protein affects the transport of Ribavirin |
CTD |
PMID:19164483 |
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NCBI chr20:30,289,527...30,327,343
Ensembl chr20:30,287,424...30,327,361
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G |
Slc6a4 |
solute carrier family 6 member 4 |
multiple interactions increases expression |
ISO |
Ribavirin promotes the reaction [SLC6A4 protein results in increased uptake of Serotonin]; Ribavirin results in increased expression of and results in increased activity of SLC6A4 protein Ribavirin results in increased expression of SLC6A4 mRNA |
CTD |
PMID:16476009 |
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NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
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G |
Tnf |
tumor necrosis factor |
multiple interactions increases expression |
ISO EXP |
Ribavirin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Ribavirin results in increased expression of and results in increased secretion of TNF protein [peginterferon alfa-2a co-treated with Ribavirin co-treated with Danazol] results in decreased expression of TNF mRNA Ribavirin results in increased expression of TNF mRNA; Ribavirin results in increased expression of TNF protein |
CTD |
PMID:9722937 PMID:10190717 PMID:10770762 PMID:18007553 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Tnfsf10 |
TNF superfamily member 10 |
decreases response to substance |
ISO |
Ribavirin results in decreased susceptibility to TNFSF10 protein |
CTD |
PMID:12637521 |
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NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
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G |
Tnnt2 |
troponin T2, cardiac type |
decreases expression |
ISO |
Ribavirin results in decreased expression of TNNT2 protein |
CTD |
PMID:32112805 |
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NCBI chr13:52,662,974...52,680,992
Ensembl chr13:52,662,996...52,680,990
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
Ribavirin results in increased expression of TP53 protein |
CTD |
PMID:32112805 |
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NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Txn1 |
thioredoxin 1 |
decreases expression |
ISO |
Ribavirin results in decreased expression of TXN protein |
CTD |
PMID:16198661 |
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NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
Ribavirin results in decreased expression of VEGFA protein |
CTD |
PMID:29112301 |
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NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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