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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:cabazitaxel
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Accession:CHEBI:63584 term browser browse the term
Definition:A tetracyclic diterpenoid that is 10-deacetylbaccatin III having O-methyl groups attached at positions 7 and 10 as well as an O-(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl group attached at position 13. Acts as a microtubule inhibitor, binds tubulin and promotes microtubule assembly and simultaneously inhibits disassembly.
Synonyms:exact_synonym: (2alpha,5beta,7beta,10beta,13alpha)-4-acetoxy-13-({(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl}oxy)-1-hydroxy-7,10-dimethoxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
 related_synonym: Formula=C45H57NO14;   InChI=1S/C45H57NO14/c1-24-28(57-39(51)33(48)32(26-17-13-11-14-18-26)46-40(52)60-41(3,4)5)22-45(53)37(58-38(50)27-19-15-12-16-20-27)35-43(8,36(49)34(55-10)31(24)42(45,6)7)29(54-9)21-30-44(35,23-56-30)59-25(2)47/h11-20,28-30,32-35,37,48,53H,21-23H2,1-10H3,(H,46,52)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1;   InChIKey=BMQGVNUXMIRLCK-OAGWZNDDSA-N;   SMILES=[H][C@]12[C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C(C)=C([C@@H](OC)C(=O)[C@]1(C)[C@H](C[C@H]1OC[C@@]21OC(C)=O)OC)C3(C)C;   cabazitaxelum
 xref: CAS:183133-96-2;   DrugBank:DB06772;   Drug_Central:4153;   KEGG:D09755
 xref_mesh: MESH:C552428
 xref: PMID:21174534;   PMID:21339064;   PMID:21406025;   PMID:21448449;   PMID:21455038;   PMID:21461278;   PMID:21463139;   PMID:21695098;   PMID:21734586;   PMID:21748753;   PMID:21770474;   PMID:22048000;   PMID:22079047;   PMID:22111007;   PMID:22229405;   Reaxys:14351224;   Wikipedia:Cabazitaxel


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cabazitaxel term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1s1 AKT1 substrate 1 decreases expression ISO cabazitaxel results in decreased expression of AKT1S1 protein CTD PMID:32525019 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677 		JBrowse link
G Foxo3 forkhead box O3 affects expression ISO cabazitaxel affects the expression of FOXO3 protein CTD PMID:32525019 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19757
    role 19730
      application 19563
        pharmaceutical 19440
          drug 19440
            antineoplastic agent 17630
              cabazitaxel 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19757
    subatomic particle 19755
      composite particle 19755
        hadron 19755
          baryon 19755
            nucleon 19755
              atomic nucleus 19755
                atom 19755
                  main group element atom 19703
                    p-block element atom 19703
                      carbon group element atom 19649
                        carbon atom 19645
                          organic molecular entity 19645
                            organic group 18859
                              organic divalent group 18845
                                organodiyl group 18845
                                  carbonyl group 18809
                                    carbonyl compound 18809
                                      ketone 17107
                                        oxyketone 8796
                                          alpha-oxyketone 8796
                                            alpha-hydroxy ketone 8796
                                              secondary alpha-hydroxy ketone 994
                                                10-deacetylbaccatin III 2
                                                  cabazitaxel 2
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