CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: iopromide
Accession: CHEBI:63578
browse the term
Definition: A dicarboxylic acid diamide that consists of N-methylisophthalamide bearing three iodo substituents at positions 2, 4 and 6, a methoxyacetyl substituent at position 5 and two 2,3-dihydroxypropyl groups attached to the amide nitrogens. A water soluble x-ray contrast agent for intravascular administration.
Synonyms: exact_synonym: N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-[(methoxyacetyl)amino]-N-methylisophthalamide
related_synonym: Formula=C18H24I3N3O8; InChI=1S/C18H24I3N3O8/c1-24(4-9(28)6-26)18(31)12-13(19)11(17(30)22-3-8(27)5-25)14(20)16(15(12)21)23-10(29)7-32-2/h8-9,25-28H,3-7H2,1-2H3,(H,22,30)(H,23,29); InChIKey=DGAIEPBNLOQYER-UHFFFAOYSA-N; N,N'-Bis(2,3-dihydroxypropyl)-2,4,6-triiodo-5-(2-methoxyacetamido)-N-methylisophthalamide; SMILES=COCC(=O)Nc1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)N(C)CC(O)CO)c1I; Ultravist; iopromida; iopromidum
alt_id: CHEBI:31712
xref: Beilstein:7085608; CAS:73334-07-3; Drug_Central:1468; HMDB:HMDB0041910; KEGG:D01893; LINCS:LSM-5134
xref_mesh: MESH:C038192
xref: PMID:20412314; PMID:20890877; PMID:20921088; PMID:21039317; PMID:21141818; PMID:21159465; PMID:21529272; PMID:21545991; PMID:21623210; PMID:21877755; PMID:21943940; PMID:22028567; PMID:22178894; Patent:DE2909439; Patent:US4364921; Reaxys:7085608; Wikipedia:Iopromide
G
Edn1
endothelin 1
increases expression
EXP
iopromide results in increased expression of EDN1 protein
CTD
PMID:21354280
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
G
Hexb
hexosaminidase subunit beta
increases secretion
ISO
iopromide results in increased secretion of HEXB protein
CTD
PMID:34774977
NCBI chr 2:28,483,997...28,504,165
Ensembl chr 2:28,484,012...28,504,223
G
Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
iopromide results in decreased phosphorylation of MAPK1 protein
CTD
PMID:34774977
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
iopromide results in decreased phosphorylation of MAPK3 protein
CTD
PMID:34774977
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Mr1
major histocompatibility complex, class I-related
affects expression
ISO
iopromide affects the expression of MR1 mRNA
CTD
PMID:25811541
NCBI chr13:67,298,362...67,317,985
Ensembl chr13:67,299,585...67,317,970
G
Nos2
nitric oxide synthase 2
decreases expression
EXP
iopromide results in decreased expression of NOS2 protein
CTD
PMID:21354280
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
G
RT1-Da
RT1 class II, locus Da
affects expression
ISO
iopromide affects the expression of HLA-DRA mRNA
CTD
PMID:25811541
NCBI chr20:4,513,464...4,518,457
Ensembl chr20:4,512,911...4,518,455
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all