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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gonadotropin releasing hormone agonist
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Accession:CHEBI:63533 term browser browse the term
Definition:Any drug which binds to gonadotropin-releasing hormone receptors and triggers a response.
Synonyms:related_synonym: GnRH agonist;   GnRH agonists;   GnRH-A;   gonadotrophin releasing hormone agonist;   gonadotrophin releasing hormone agonists;   gonadotropin releasing hormone agonists
 xref: Wikipedia:Gonadotropin-releasing_hormone_agonist



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gonadorelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Esr1 estrogen receptor 1 multiple interactions ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Gonadotropin-Releasing Hormone results in decreased expression of ESR1 protein]; Gonadotropin-Releasing Hormone results in increased ubiquitination of and results in increased degradation of and results in decreased expression of ESR1 protein CTD PMID:16055746 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 increases expression ISO Gonadotropin-Releasing Hormone results in increased expression of UBE2D2 mRNA; Gonadotropin-Releasing Hormone results in increased expression of UBE2D2 protein CTD PMID:16055746 NCBI chr18:27,364,665...27,405,589
Ensembl chr18:27,364,303...27,406,181
JBrowse link
leuprolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Leuprolide inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:17143537 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Leuprolide results in increased expression of BAX protein CTD PMID:15965100 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP Leuprolide results in increased expression of BCL2 mRNA CTD PMID:18829022 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases expression ISO Leuprolide results in increased expression of CASP3 protein CTD PMID:15965100 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases expression ISO Leuprolide results in increased expression of CASP9 protein CTD PMID:15965100 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cldn4 claudin 4 decreases expression ISO Leuprolide results in decreased expression of CLDN4 protein CTD PMID:21761342 NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436
JBrowse link
G Cldn8 claudin 8 decreases expression ISO Leuprolide results in decreased expression of CLDN8 protein CTD PMID:21761342 NCBI chr11:27,875,857...27,878,106
Ensembl chr11:27,875,692...27,878,513
JBrowse link
G Cycs cytochrome c, somatic affects localization
increases expression
ISO
EXP
Leuprolide affects the localization of CYCS protein
Leuprolide results in increased expression of CYCS mRNA
CTD PMID:15965100 PMID:18829022 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO [Leuprolide co-treated with Testosterone] results in decreased expression of CYP19A1 mRNA CTD PMID:16032706 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Fshr follicle stimulating hormone receptor multiple interactions ISO [Leuprolide co-treated with Testosterone] results in decreased expression of FSHR mRNA CTD PMID:16032706 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Leuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]; Leuprolide inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein] CTD PMID:17143537 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO Leuprolide results in decreased expression of and results in decreased phosphorylation of IGF1R protein CTD PMID:17143537 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
EXP Leuprolide inhibits the reaction [resveratrol results in decreased expression of IL6 protein]; resveratrol inhibits the reaction [Leuprolide results in decreased expression of IL6 protein] CTD PMID:25462211 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itga5 integrin subunit alpha 5 multiple interactions ISO Leuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]] CTD PMID:17143537 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO Leuprolide inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]] CTD PMID:17143537 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression ISO Leuprolide results in decreased expression of LHB protein CTD PMID:10221860 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor multiple interactions
decreases expression
ISO [Leuprolide co-treated with Testosterone] results in decreased expression of LHCGR mRNA
Leuprolide results in decreased expression of LHCGR mRNA
CTD PMID:16032706 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
EXP Leuprolide inhibits the reaction [Resveratrol results in decreased expression of MMP2 protein]; Resveratrol inhibits the reaction [Leuprolide results in decreased expression of MMP2 protein] CTD PMID:25462211 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
EXP Leuprolide results in decreased expression of MMP9 protein
Leuprolide inhibits the reaction [Resveratrol results in decreased expression of MMP9 protein]; Resveratrol inhibits the reaction [Leuprolide results in decreased expression of MMP9 protein]
CTD PMID:25462211 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Leuprolide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP Leuprolide inhibits the reaction [resveratrol results in decreased expression of TNF protein]; resveratrol inhibits the reaction [Leuprolide results in decreased expression of TNF protein] CTD PMID:25462211 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions
EXP Leuprolide results in decreased expression of VEGFA protein
Leuprolide inhibits the reaction [resveratrol results in decreased expression of VEGFA protein]; resveratrol inhibits the reaction [Leuprolide results in decreased expression of VEGFA protein]
CTD PMID:25462211 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
triptorelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gnrhr gonadotropin releasing hormone receptor multiple interactions
affects expression
ISO [Estradiol co-treated with Progesterone] inhibits the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA]; Estradiol inhibits the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA]; Progesterone promotes the reaction [Triptorelin Pamoate affects the expression of GNRHR mRNA] CTD PMID:17185802 NCBI chr14:21,856,871...21,874,861
Ensembl chr14:21,856,871...21,874,861
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression
increases expression
EXP Triptorelin Pamoate results in decreased expression of LHB protein
Triptorelin Pamoate results in increased expression of LHB protein
CTD PMID:3158510 PMID:20463352 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP testosterone enanthate inhibits the reaction [Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]]; testosterone enanthate inhibits the reaction [Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 protein]]; Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]; Triptorelin Pamoate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 protein] CTD PMID:20463352 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pde5a phosphodiesterase 5A multiple interactions EXP [testosterone enanthate co-treated with Triptorelin Pamoate] results in increased expression of PDE5A mRNA; [testosterone enanthate co-treated with Triptorelin Pamoate] results in increased expression of PDE5A protein CTD PMID:20463352 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
JBrowse link
G Pde6d phosphodiesterase 6D decreases expression EXP Triptorelin Pamoate results in decreased expression of PDE6D mRNA CTD PMID:20463352 NCBI chr 9:87,192,991...87,237,926
Ensembl chr 9:87,192,983...87,237,969
JBrowse link
G Pde9a phosphodiesterase 9A decreases expression EXP Triptorelin Pamoate results in decreased expression of PDE9A mRNA CTD PMID:20463352 NCBI chr20:9,469,809...9,562,949
Ensembl chr20:9,469,848...9,562,948
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 decreases expression
multiple interactions
EXP Triptorelin Pamoate results in decreased expression of PRKG1 mRNA; Triptorelin Pamoate results in decreased expression of PRKG1 protein
testosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 mRNA]; testosterone enanthate promotes the reaction [Triptorelin Pamoate results in decreased expression of PRKG1 protein]
CTD PMID:20463352 NCBI chr 1:228,409,883...229,638,794 JBrowse link
G Prl prolactin multiple interactions ISO
EXP
Triptorelin Pamoate inhibits the reaction [Sulpiride results in increased abundance of PRL protein]
Triptorelin Pamoate inhibits the reaction [Haloperidol results in increased expression of PRL protein]
CTD PMID:2954994 PMID:3158510 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        pharmacological role 18852
          agonist 18262
            hormone agonist 2761
              gonadotropin releasing hormone agonist 31
                gonadorelin 2
                histrelin + 0
                histrelin acetate 0
                leuprolide + 22
                leuprolide acetate 0
                nafarelin + 0
                nafarelin acetate + 0
                nafarelin acetate hydrate 0
                triptorelin 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      application 19486
        pharmaceutical 19335
          drug 19335
            receptor modulator 18886
              hormone receptor modulator 18875
                hormone agonist 2761
                  gonadotropin releasing hormone agonist 31
                    gonadorelin 2
                    histrelin + 0
                    histrelin acetate 0
                    leuprolide + 22
                    leuprolide acetate 0
                    nafarelin + 0
                    nafarelin acetate + 0
                    nafarelin acetate hydrate 0
                    triptorelin 8
paths to the root