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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:oleandrigenin
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Accession:CHEBI:63508 term browser browse the term
Definition:A steroid ester that is the 16-acetyl derivative of gitoxigenin.
Synonyms:exact_synonym: (3beta,5beta,16beta)-16-acetoxy-3,14-dihydroxycard-20(22)-enolide
 related_synonym: 16-Acetylgitoxigenin;   16-O-acetylgitoxigenin;   16beta-acetoxy-3beta,14-dihydroxy-5beta,14beta-card-20(22)-enolide;   3beta,14,16beta-Trihydroxy-5-betacard-20(22)-enolide 16-acetate;   Formula=C25H36O6;   Gitoxigenin 16-acetate;   InChI=1S/C25H36O6/c1-14(26)31-20-12-25(29)19-5-4-16-11-17(27)6-8-23(16,2)18(19)7-9-24(25,3)22(20)15-10-21(28)30-13-15/h10,16-20,22,27,29H,4-9,11-13H2,1-3H3/t16-,17+,18+,19-,20+,22+,23+,24-,25+/m1/s1;   InChIKey=IWCNCUVTGOMGKG-YOVVEKLRSA-N;   Oleandrisenin;   SMILES=[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@H]([C@H](C[C@]34O)OC(C)=O)C3=CC(=O)OC3)[C@@]1(C)CC[C@H](O)C2
 xref: CAS:465-15-6;   PMID:10952541;   PMID:12054363;   PMID:12416031;   PMID:19274509;   PMID:7739045;   PMID:8855150;   PMID:9263390;   Reaxys:98733


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oleandrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO oleandrin results in increased activity of CASP3 protein CTD PMID:24172227 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp8 caspase 8 increases activity ISO oleandrin results in increased activity of CASP8 protein CTD PMID:24172227 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 increases expression ISO oleandrin results in increased expression of CXCR1 mRNA; oleandrin results in increased expression of CXCR1 protein CTD PMID:24172227 NCBI chr 1:74,228,862...74,233,867
Ensembl chr 1:74,230,944...74,233,790 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 increases expression ISO oleandrin results in increased expression of CXCR2 mRNA; oleandrin results in increased expression of CXCR2 protein CTD PMID:24172227 NCBI chr 1:74,193,153...74,200,405
Ensembl chr 1:74,193,150...74,200,405 		JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression ISO oleandrin results in increased expression of CXCR4 mRNA CTD PMID:24172227 NCBI chr 1:128,515,936...128,520,036
Ensembl chr 1:128,515,936...128,520,030 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      biological role 22162
        biochemical role 21431
          metabolite 21379
            oleandrigenin 5
              oleandrin 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  ester 18216
                                    carboxylic ester 17229
                                      lactone 13001
                                        steroid lactone 469
                                          cardanolide 50
                                            5beta-cardanolide 50
                                              gitoxigenin 5
                                                oleandrigenin 5
                                                  oleandrin 5
paths to the root