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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:AZD4547
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Accession:CHEBI:63453 term browser browse the term
Definition:A member of the class of benzamides that is a carboxamide resulting from the formal condensation of the carboxy group of 4-(cis-3,5-dimethylpiperazin-1-yl)benzoic acid with the amino substituent of 5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-amine. It is an inhibitor of the fibroblast growth factor receptor (FGFR).
Synonyms:exact_synonym: N-{5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl}-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide
 related_synonym: AZD-4547;   Formula=C26H33N5O3;   InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+;   InChIKey=VRQMAABPASPXMW-HDICACEKSA-N;   N-{5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl}-4-(cis-3,5-dimethylpiperazin-1-yl)benzamide;   SMILES=COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1
 xref: LINCS:LSM-6308
 xref_mesh: MESH:C572463


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AZD4547 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO AZD4547 results in decreased phosphorylation of AKT1 protein CTD PMID:26853465 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt1s1 AKT1 substrate 1 decreases phosphorylation ISO AZD4547 results in decreased phosphorylation of AKT1S1 protein CTD PMID:26853465 NCBI chr 1:100,845,443...100,851,961
Ensembl chr 1:100,845,563...100,851,960
JBrowse link
G Frs2 fibroblast growth factor receptor substrate 2 increases phosphorylation ISO AZD4547 results in increased phosphorylation of FRS2 protein CTD PMID:26853465 NCBI chr 7:60,128,506...60,210,482
Ensembl chr 7:60,128,508...60,210,518
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta affects expression
multiple interactions
ISO AZD4547 affects the expression of MAP1LC3B protein modified form
bafilomycin A1 affects the reaction [AZD4547 affects the expression of MAP1LC3B protein modified form]
CTD PMID:26853465 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO AZD4547 results in decreased phosphorylation of RPS6 protein CTD PMID:26853465 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO AZD4547 results in decreased expression of SREBF1 protein CTD PMID:26853465 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      biological role 19723
        pharmacological role 18833
          antagonist 16278
            fibroblast growth factor receptor antagonist 25
              AZD4547 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic group 18603
                              organic divalent group 18594
                                organodiyl group 18594
                                  carbonyl group 18507
                                    carbonyl compound 18507
                                      carboxylic acid 18159
                                        carboacyl group 17415
                                          univalent carboacyl group 17415
                                            carbamoyl group 17211
                                              carboxamide 17211
                                                monocarboxylic acid amide 14599
                                                  arenecarboxamide 6539
                                                    benzamides 6539
                                                      AZD4547 6
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