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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:AZD4547
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Accession:CHEBI:63453 term browser browse the term
Definition:A member of the class of benzamides that is a carboxamide resulting from the formal condensation of the carboxy group of 4-(cis-3,5-dimethylpiperazin-1-yl)benzoic acid with the amino substituent of 5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-amine. It is an inhibitor of the fibroblast growth factor receptor (FGFR).
Synonyms:exact_synonym: N-{5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl}-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide
 related_synonym: AZD-4547;   Formula=C26H33N5O3;   InChI=1S/C26H33N5O3/c1-17-15-31(16-18(2)27-17)22-9-6-20(7-10-22)26(32)28-25-13-21(29-30-25)8-5-19-11-23(33-3)14-24(12-19)34-4/h6-7,9-14,17-18,27H,5,8,15-16H2,1-4H3,(H2,28,29,30,32)/t17-,18+;   InChIKey=VRQMAABPASPXMW-HDICACEKSA-N;   N-{5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl}-4-(cis-3,5-dimethylpiperazin-1-yl)benzamide;   SMILES=COc1cc(CCc2cc(NC(=O)c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n[nH]2)cc(OC)c1
 xref: LINCS:LSM-6308
 xref_mesh: MESH:C572463



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AZD4547 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO AZD4547 results in decreased phosphorylation of AKT1 protein CTD PMID:26853465 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt1s1 AKT1 substrate 1 decreases phosphorylation ISO AZD4547 results in decreased phosphorylation of AKT1S1 protein CTD PMID:26853465 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677
JBrowse link
G Frs2 fibroblast growth factor receptor substrate 2 increases phosphorylation ISO AZD4547 results in increased phosphorylation of FRS2 protein CTD PMID:26853465 NCBI chr 7:52,711,255...52,792,758
Ensembl chr 7:52,711,257...52,792,743
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta affects expression
multiple interactions
ISO AZD4547 affects the expression of MAP1LC3B protein modified form
bafilomycin A1 affects the reaction [AZD4547 affects the expression of MAP1LC3B protein modified form]
CTD PMID:26853465 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation ISO AZD4547 results in decreased phosphorylation of RPS6 protein CTD PMID:26853465 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression ISO AZD4547 results in decreased expression of SREBF1 protein CTD PMID:26853465 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19703
    role 19678
      biological role 19677
        pharmacological role 18937
          antagonist 16619
            fibroblast growth factor receptor antagonist 43
              AZD4547 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19703
    subatomic particle 19702
      composite particle 19702
        hadron 19702
          baryon 19702
            nucleon 19702
              atomic nucleus 19702
                atom 19702
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19595
                        carbon atom 19592
                          organic molecular entity 19592
                            organic group 18784
                              organic divalent group 18769
                                organodiyl group 18769
                                  carbonyl group 18735
                                    carbonyl compound 18735
                                      carboxylic acid 18440
                                        carboacyl group 17598
                                          univalent carboacyl group 17598
                                            carbamoyl group 17435
                                              carboxamide 17435
                                                monocarboxylic acid amide 15549
                                                  arenecarboxamide 7312
                                                    benzamides 7312
                                                      AZD4547 6
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