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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:midostaurin
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Accession:CHEBI:63452 term browser browse the term
Definition:An organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine.
Synonyms:exact_synonym: N-[(5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-yl]-N-methylbenzamide
 related_synonym: 4'-N-benzoylstaurosporine;   CGP-41251;   Formula=C35H30N4O4;   InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1;   InChIKey=BMGQWWVMWDBQGC-IIFHNQTCSA-N;   PKC 412;   PKC412;   SMILES=CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1;   benzoylstaurosporine
 xref: CAS:120685-11-2;   KEGG:D05029;   LINCS:LSM-2287
 xref_mesh: MESH:C059539
 xref: PMID:20980353;   Reaxys:7345336;   Wikipedia:Midostaurin



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midostaurin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO midostaurin results in decreased activity of ABCB1 protein CTD PMID:11836167 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Agt angiotensinogen multiple interactions EXP midostaurin inhibits the reaction [AGT protein results in increased abundance of Epoprostenol] CTD PMID:14613874 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
decreases activity
ISO midostaurin inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Daunorubicin]; midostaurin inhibits the reaction [AKR1C3 protein results in increased metabolism of Daunorubicin]
midostaurin results in decreased activity of AKR1C3 protein
CTD PMID:33025066 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Casp3 caspase 3 multiple interactions ISO midostaurin promotes the reaction [Loratadine results in increased activity of CASP3 protein]; midostaurin promotes the reaction [Terfenadine results in increased activity of CASP3 protein] CTD PMID:20570632 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Egf epidermal growth factor multiple interactions ISO midostaurin inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]] CTD PMID:15542774 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases activity ISO midostaurin results in decreased activity of FGFR3 protein CTD PMID:16091734 NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases response to substance
decreases activity
ISO FLT3 protein results in decreased susceptibility to midostaurin
midostaurin results in decreased activity of FLT3 protein
CTD PMID:21980431 NCBI chr12:7,623,658...7,699,474
Ensembl chr12:7,623,930...7,699,474
JBrowse link
G Gypa glycophorin A decreases expression ISO midostaurin results in decreased expression of GYPA protein CTD PMID:19573588 NCBI chr19:27,450,311...27,465,940
Ensembl chr19:27,450,308...27,465,822
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO midostaurin inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein] CTD PMID:17420286 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO midostaurin results in increased expression of and results in increased localization of ITGB3 protein CTD PMID:19573588 NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO midostaurin inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein] CTD PMID:17420286 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO midostaurin affects the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein] CTD PMID:15542774 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO midostaurin affects the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein] CTD PMID:15542774 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor increases expression ISO midostaurin results in increased expression of MPL protein CTD PMID:19573588 NCBI chr 5:131,973,897...131,987,472
Ensembl chr 5:131,973,895...131,986,797
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP midostaurin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:14613874 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO midostaurin affects the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]; midostaurin inhibits the reaction [EGF protein inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]] CTD PMID:15542774 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19715
    role 19690
      biological role 19688
        biochemical role 19395
          apoptosis inducer 13443
            staurosporine 156
              midostaurin 16
Path 2
Term Annotations click to browse term
  CHEBI ontology 19715
    subatomic particle 19713
      composite particle 19713
        hadron 19713
          baryon 19713
            nucleon 19713
              atomic nucleus 19713
                atom 19713
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19606
                        carbon atom 19603
                          organic molecular entity 19603
                            organic group 18792
                              organic divalent group 18777
                                organodiyl group 18777
                                  carbonyl group 18743
                                    carbonyl compound 18743
                                      carboxylic acid 18443
                                        carboacyl group 17599
                                          univalent carboacyl group 17599
                                            carbamoyl group 17435
                                              carboxamide 17435
                                                monocarboxylic acid amide 15545
                                                  arenecarboxamide 7311
                                                    benzamides 7311
                                                      midostaurin 16
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