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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:midostaurin
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Accession:CHEBI:63452 term browser browse the term
Definition:An organic heterooctacyclic compound that is the N-benzoyl derivative of staurosporine.
Synonyms:exact_synonym: N-[(5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-yl]-N-methylbenzamide
 related_synonym: 4'-N-benzoylstaurosporine;   CGP-41251;   Formula=C35H30N4O4;   InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)/t25-,26-,32-,35+/m1/s1;   InChIKey=BMGQWWVMWDBQGC-IIFHNQTCSA-N;   PKC 412;   PKC412;   SMILES=CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1;   benzoylstaurosporine
 xref: CAS:120685-11-2;   KEGG:D05029;   LINCS:LSM-2287
 xref_mesh: MESH:C059539
 xref: PMID:20980353;   Reaxys:7345336;   Wikipedia:Midostaurin


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midostaurin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO midostaurin results in decreased activity of ABCB1 protein CTD PMID:11836167 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Agt angiotensinogen multiple interactions EXP midostaurin inhibits the reaction [AGT protein results in increased abundance of Epoprostenol] CTD PMID:14613874 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Casp3 caspase 3 multiple interactions ISO midostaurin promotes the reaction [Loratadine results in increased activity of CASP3 protein]; midostaurin promotes the reaction [Terfenadine results in increased activity of CASP3 protein] CTD PMID:20570632 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Egf epidermal growth factor multiple interactions ISO midostaurin inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]] CTD PMID:15542774 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Fgfr3 fibroblast growth factor receptor 3 decreases activity ISO midostaurin results in decreased activity of FGFR3 protein CTD PMID:16091734 NCBI chr14:82,272,322...82,287,739
Ensembl chr14:82,273,070...82,287,706
JBrowse link
G Flt3 Fms related receptor tyrosine kinase 3 decreases response to substance
decreases activity
ISO FLT3 protein results in decreased susceptibility to midostaurin
midostaurin results in decreased activity of FLT3 protein
CTD PMID:21980431 NCBI chr12:9,360,439...9,437,004
Ensembl chr12:9,360,672...9,436,570
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO midostaurin inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein] CTD PMID:17420286 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Itgb3 integrin subunit beta 3 multiple interactions ISO midostaurin results in increased expression of and results in increased localization of ITGB3 protein CTD PMID:19573588 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions ISO midostaurin inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein] CTD PMID:17420286 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO midostaurin affects the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK1 protein] CTD PMID:15542774 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO midostaurin affects the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of MAPK3 protein] CTD PMID:15542774 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mpl MPL proto-oncogene, thrombopoietin receptor increases expression ISO midostaurin results in increased expression of MPL protein CTD PMID:19573588 NCBI chr 5:137,268,412...137,282,032
Ensembl chr 5:137,269,480...137,281,298
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP midostaurin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:14613874 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO midostaurin affects the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]; midostaurin inhibits the reaction [EGF protein inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]] CTD PMID:15542774 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            antineoplastic agent 16985
              midostaurin 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic group 18495
                              organic divalent group 18488
                                organodiyl group 18488
                                  carbonyl group 18391
                                    carbonyl compound 18391
                                      carboxylic acid 18061
                                        carboacyl group 17348
                                          univalent carboacyl group 17348
                                            carbamoyl group 17134
                                              carboxamide 17134
                                                monocarboxylic acid amide 14553
                                                  arenecarboxamide 6508
                                                    benzamides 6508
                                                      midostaurin 14
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