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G
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Cyp3a2
|
cytochrome P450, family 3, subfamily a, polypeptide 2
|
multiple interactions
|
ISO
|
[CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam] which results in increased abundance of 1-hydroxymethylmidazolam glucuronide
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CTD |
PMID:27485346 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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|
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G
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Abca8
|
ATP binding cassette subfamily A member 8
|
increases uptake multiple interactions
|
ISO
|
ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide Adenosine Triphosphate affects the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Digoxin inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; dofequidar inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; ochratoxin A inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Probenecid inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; Verapamil inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide]
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CTD |
PMID:12379217 |
|
NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988
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G
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Abcb11
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ATP binding cassette subfamily B member 11
|
decreases activity decreases secretion affects localization multiple interactions
|
EXP
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estradiol-17 beta-glucuronide results in decreased activity of ABCB11 protein estradiol-17 beta-glucuronide results in decreased secretion of ABCB11 protein estradiol-17 beta-glucuronide affects the localization of ABCB11 protein estradiol-17 beta-glucuronide affects the localization of and affects the activity of ABCB11 protein; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]
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CTD |
PMID:10869290 PMID:12702498 PMID:12893835 PMID:15763547 PMID:18972403 PMID:20815017 PMID:29090346 More...
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G
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Abcb1a
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ATP binding cassette subfamily B member 1A
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affects response to substance multiple interactions increases transport
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ISO EXP
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ABCB1 affects the susceptibility to estradiol-17 beta-glucuronide Daunorubicin inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]; estriol 17-glucuronide inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]; estriol-16 alpha-(beta-D-glucuronide) inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]
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CTD |
PMID:9794924 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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G
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Abcb4
|
ATP binding cassette subfamily B member 4
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affects export
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ISO
|
ABCB4 protein affects the export of estradiol-17 beta-glucuronide
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CTD |
PMID:11302927 |
|
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G
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Abcc1
|
ATP binding cassette subfamily C member 1
|
affects transport increases export multiple interactions increases uptake increases transport
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ISO
|
ABCC1 protein affects the transport of estradiol-17 beta-glucuronide ABCC1 protein results in increased export of estradiol-17 beta-glucuronide [Glutathione co-treated with Apigenin] affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; [Glutathione co-treated with naringenin] inhibits the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of estradiol-17 beta-glucuronide]; BAY u9773 inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; BAY u9773 inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]; estradiol-17 beta-glucuronide inhibits the reaction [ABCC1 protein affects the transport of Leukotriene C4]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein mutant form]; estradiol-17 beta-glucuronide inhibits the reaction [Adenosine Diphosphate binds to ABCC1 protein]; estradiol-17 beta-glucuronide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; kaempferol affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Quercetin affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; S-decylglutathione inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; S-decylglutathione inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide] ABCC1 protein mutant form results in increased transport of estradiol-17 beta-glucuronide; ABCC1 protein results in increased transport of estradiol-17 beta-glucuronide
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CTD |
PMID:11278867 PMID:11306701 PMID:15459206 PMID:18336795 PMID:21918036 PMID:27297967 More...
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G
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Abcc2
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ATP binding cassette subfamily C member 2
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affects export multiple interactions affects transport affects response to substance increases transport affects localization decreases secretion
|
ISO EXP
|
ABCC2 protein affects the export of estradiol-17 beta-glucuronide [Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; [SLCO1B1 protein co-treated with ABCC2 protein] results in increased transport of estradiol-17 beta-glucuronide; [SLCO1B1 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; Bile Acids and Salts promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; estradiol-17 beta-glucuronide promotes the reaction [ABCC2 protein affects the transport of Bile Acids and Salts]; estradiol-17 beta-glucuronide results in decreased activity of and affects the localization of ABCC2 protein; Ethinyl Estradiol metabolite promotes the reaction [ABCC2 protein results in increased uptake of estradiol-17 beta-glucuronide]; Furosemide promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Indomethacin promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Pantoprazole promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Penicillin G promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; sulfanitran promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; verlukast inhibits the reaction [[Adenosine Triphosphate co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide] ABCC2 protein affects the susceptibility to estradiol-17 beta-glucuronide ABCC2 protein modified form results in increased transport of estradiol-17 beta-glucuronide; ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide abietic acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide]; AG 1879 inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; Bucladesine inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; CL 387785 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; EGF protein inhibits the reaction [Fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]]; EGFR protein promotes the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein; Fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; Glycyrrhetinic Acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide]; Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Protein Kinase Inhibitors inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein] estradiol-17 beta-glucuronide results in decreased secretion of ABCC2 protein
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CTD |
PMID:11500505 PMID:12029626 PMID:12642476 PMID:12702498 PMID:12702717 PMID:12704183 PMID:12893835 PMID:14722317 PMID:15652233 PMID:15846474 PMID:15901800 PMID:15904671 PMID:17463180 PMID:18180276 PMID:18436619 PMID:18972403 PMID:19628752 PMID:20815017 PMID:25813982 PMID:29052767 PMID:29090346 PMID:32003934 More...
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NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G
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Abcc3
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ATP binding cassette subfamily C member 3
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affects transport multiple interactions increases transport increases activity
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ISO
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ABCC3 protein affects the transport of estradiol-17 beta-glucuronide Bile Acids and Salts inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Ethinyl Estradiol metabolite promotes the reaction [ABCC3 protein results in increased uptake of estradiol-17 beta-glucuronide]; Furosemide inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Indomethacin inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide]; resveratrol metabolite promotes the reaction [ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide]; resveratrol-4'-O-glucuronide inhibits the reaction [ABCC3 protein results in increased transport of estradiol-17 beta-glucuronide] estradiol-17 beta-glucuronide results in increased activity of ABCC3 protein
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CTD |
PMID:12704183 PMID:14722317 PMID:17569508 PMID:19114588 |
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NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G
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Abcc4
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ATP binding cassette subfamily C member 4
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increases transport affects export increases export
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ISO
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ABCC4 protein results in increased transport of estradiol-17 beta-glucuronide ABCC4 gene SNP affects the export of estradiol-17 beta-glucuronide ABCC4 protein results in increased export of estradiol-17 beta-glucuronide
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CTD |
PMID:11856762 PMID:27659809 |
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NCBI chr15:101,948,387...102,182,912
Ensembl chr15:95,542,315...95,774,283
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G
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Abcg2
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ATP binding cassette subfamily G member 2
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increases transport multiple interactions
|
ISO
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ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide Glycyrrhetinic Acid inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide]; lapatinib inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide]
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CTD |
PMID:18436619 PMID:18829547 |
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NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
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G
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Akt1
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AKT serine/threonine kinase 1
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increases phosphorylation multiple interactions
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EXP
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estradiol-17 beta-glucuronide results in increased phosphorylation of AKT1 protein tyrphostin AG 1024 inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of AKT1 protein]
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CTD |
PMID:29090346 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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G
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Aqp8
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aquaporin 8
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decreases expression
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EXP
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estradiol-17 beta-glucuronide results in decreased expression of AQP8 protein
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CTD |
PMID:17110522 |
|
NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158
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G
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Egf
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epidermal growth factor
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multiple interactions
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EXP
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EGF protein inhibits the reaction [fulvestrant inhibits the reaction [estradiol-17 beta-glucuronide results in decreased activity of ABCC2 protein]]
|
CTD |
PMID:25813982 |
|
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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G
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Egfr
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epidermal growth factor receptor
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multiple interactions
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EXP
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EGFR protein promotes the reaction [estradiol-17 beta-glucuronide affects the localization of and results in decreased activity of ABCC2 protein]; estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of EGFR protein; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of EGFR protein]
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CTD |
PMID:25813982 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G
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Esr1
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estrogen receptor 1
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multiple interactions
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EXP
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estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of ESR1 protein
|
CTD |
PMID:25813982 |
|
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
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G
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Hgf
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hepatocyte growth factor
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multiple interactions increases uptake
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EXP
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[HGF protein results in increased expression of SLCO1A1 protein] which results in increased uptake of estradiol-17 beta-glucuronide; ochratoxin A inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; SLCO1A1 protein affects the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]; Sulfobromophthalein inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]
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CTD |
PMID:18031729 |
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NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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G
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Igf1r
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insulin-like growth factor 1 receptor
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multiple interactions increases phosphorylation
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EXP
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4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of IGF1R protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]; IGF1R protein affects the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]
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CTD |
PMID:29090346 |
|
NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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G
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Ocln
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occludin
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affects localization
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EXP
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estradiol-17 beta-glucuronide affects the localization of OCLN protein
|
CTD |
PMID:17463180 |
|
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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G
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Prkca
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protein kinase C, alpha
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multiple interactions affects localization
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EXP
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Go 6976 inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of PRKCA protein]
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CTD |
PMID:18972403 |
|
NCBI chr10:93,388,991...93,787,617
Ensembl chr10:92,894,012...93,288,012
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G
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Slc22a8
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solute carrier family 22 member 8
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multiple interactions affects transport
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EXP ISO
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estradiol-17 beta-glucuronide inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine] SLC22A8 protein affects the transport of estradiol-17 beta-glucuronide
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CTD |
PMID:11306713 PMID:15319347 |
|
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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G
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Slco1a1
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solute carrier organic anion transporter family, member 1a1
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increases import increases uptake multiple interactions
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EXP
|
SLCO1A1 protein results in increased import of estradiol-17 beta-glucuronide SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide [HGF protein results in increased expression of SLCO1A1 protein] which results in increased uptake of estradiol-17 beta-glucuronide; Desoxycorticosterone inhibits the reaction [SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide]; hexadecafluoro-nonanoic acid inhibits the reaction [SLCO1A1 protein results in increased import of estradiol-17 beta-glucuronide]; Ibuprofen inhibits the reaction [SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Indomethacin inhibits the reaction [SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Ketoprofen inhibits the reaction [SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Naproxen inhibits the reaction [SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide]; perfluorodecanoic acid inhibits the reaction [SLCO1A1 protein results in increased import of estradiol-17 beta-glucuronide]; perfluoroundecanoic acid inhibits the reaction [SLCO1A1 protein results in increased import of estradiol-17 beta-glucuronide]; Quinidine inhibits the reaction [SLCO1A1 protein results in increased uptake of estradiol-17 beta-glucuronide]; SLCO1A1 protein affects the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide]
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CTD |
PMID:11883641 PMID:18031729 PMID:19915082 PMID:34619012 |
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NCBI chr 4:174,877,045...174,950,900
Ensembl chr 4:174,876,593...174,950,873
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G
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Slco1a4
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solute carrier organic anion transporter family, member 1a4
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affects uptake increases uptake multiple interactions
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ISO EXP
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SLCO1A4 protein affects the uptake of estradiol-17 beta-glucuronide SLCO1A2 protein results in increased uptake of estradiol-17 beta-glucuronide Bile Acids and Salts inhibits the reaction [SLCO1A2 protein results in increased uptake of estradiol-17 beta-glucuronide]
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CTD |
PMID:19464309 PMID:21561886 |
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NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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G
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Slco1b2
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solute carrier organic anion transporter family member 1B2
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increases uptake increases import multiple interactions affects response to substance
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EXP ISO
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SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide SLCO1B3 protein results in increased import of estradiol-17 beta-glucuronide; SLCO1B3 results in increased import of estradiol-17 beta-glucuronide 2,2',4,4',5,6'-hexabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; 2,2',4,4'-tetrabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; [SLCO1B3 protein co-treated with ABCC2 protein] results in increased uptake of estradiol-17 beta-glucuronide; darolutamide inhibits the reaction [SLCO1B3 protein results in increased import of estradiol-17 beta-glucuronide]; darolutamide metabolite inhibits the reaction [SLCO1B3 protein results in increased import of estradiol-17 beta-glucuronide]; pentabromodiphenyl ether inhibits the reaction [SLCO1B3 results in increased import of estradiol-17 beta-glucuronide]; Rifampin inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide] SLCO1B2 protein affects the susceptibility to estradiol-17 beta-glucuronide Bile Acids and Salts inhibits the reaction [SLCO1B3 protein results in increased uptake of estradiol-17 beta-glucuronide]
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CTD |
PMID:18180276 PMID:18296417 PMID:19464309 PMID:20176623 PMID:32003934 PMID:32305507 PMID:34619012 PMID:38491867 More...
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NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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G
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Src
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SRC proto-oncogene, non-receptor tyrosine kinase
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multiple interactions
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EXP
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estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein; Protein Kinase Inhibitors inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein]; RTKI cpd inhibits the reaction [estradiol-17 beta-glucuronide results in increased phosphorylation of and results in increased activity of SRC protein]
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CTD |
PMID:25813982 |
|
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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G
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Tjp1
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tight junction protein 1
|
affects localization
|
EXP
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estradiol-17 beta-glucuronide affects the localization of TJP1 protein
|
CTD |
PMID:17463180 |
|
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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|
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G
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Abcb11
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ATP binding cassette subfamily B member 11
|
decreases activity
|
EXP
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estradiol-3-glucuronide results in decreased activity of ABCB11 protein
|
CTD |
PMID:10869290 |
|
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G
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Kl
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Klotho
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multiple interactions increases hydrolysis
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ISO
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estradiol-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] KL protein results in increased hydrolysis of estradiol-3-glucuronide
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CTD |
PMID:14701853 |
|
NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
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|
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G
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Arf6
|
ARF GTPase 6
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multiple interactions
|
ISO
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2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]
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CTD |
PMID:10931844 |
|
NCBI chr 6:87,853,742...87,854,890
Ensembl chr 6:87,840,142...87,874,114
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G
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Bglap
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bone gamma-carboxyglutamate protein
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decreases activity
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ISO
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2,3-Diphosphoglycerate results in decreased activity of BGLAP protein
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CTD |
PMID:16857255 |
|
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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G
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Pld1
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phospholipase D1
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decreases activity
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ISO
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2,3-Diphosphoglycerate results in decreased activity of PLD1 protein
|
CTD |
PMID:16857255 |
|
NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
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G
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Sts
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steroid sulfatase
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multiple interactions
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ISO
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2,3-Diphosphoglycerate inhibits the reaction [Tretinoin results in increased activity of STS protein]
|
CTD |
PMID:16178010 |
|
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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|
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G
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Arf6
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ARF GTPase 6
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multiple interactions
|
ISO
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2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein affects the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]; 2,3-Diphosphoglycerate inhibits the reaction [ARF6 protein mutant form promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased abundance of Superoxides]]
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CTD |
PMID:10931844 |
|
NCBI chr 6:87,853,742...87,854,890
Ensembl chr 6:87,840,142...87,874,114
|
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G
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Bglap
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bone gamma-carboxyglutamate protein
|
decreases activity
|
ISO
|
2,3-Diphosphoglycerate results in decreased activity of BGLAP protein
|
CTD |
PMID:16857255 |
|
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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G
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Pld1
|
phospholipase D1
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decreases activity
|
ISO
|
2,3-Diphosphoglycerate results in decreased activity of PLD1 protein
|
CTD |
PMID:16857255 |
|
NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
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G
|
Sts
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steroid sulfatase
|
multiple interactions
|
ISO
|
2,3-Diphosphoglycerate inhibits the reaction [Tretinoin results in increased activity of STS protein]
|
CTD |
PMID:16178010 |
|
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
|
|
|
G
|
Gapdh
|
glyceraldehyde-3-phosphate dehydrogenase
|
multiple interactions
|
EXP
|
[GAPDH protein co-treated with 3-phosphoglycerate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with 3-phosphoglycerate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with 3-phosphoglycerate co-treated with NAD] results in increased reduction of sodium arsenate analog]
|
CTD |
PMID:15788719 |
|
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
|
|
G
|
Idh2
|
isocitrate dehydrogenase (NADP(+)) 2
|
multiple interactions increases abundance
|
ISO
|
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of 3-phosphoglycerate]
|
CTD |
PMID:27469509 |
|
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
|
|
G
|
Mapt
|
microtubule-associated protein tau
|
multiple interactions
|
ISO
|
[amyloid beta-protein (1-42) binds to MAPT protein] which results in decreased abundance of 3-phosphoglycerate; PF-06840003 inhibits the reaction [[amyloid beta-protein (1-42) binds to MAPT protein] which results in decreased abundance of 3-phosphoglycerate]
|
CTD |
PMID:39172838 |
|
NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129
|
|
|
G
|
Ugt1a1
|
UDP glucuronosyltransferase family 1 member A1
|
multiple interactions
|
ISO
|
[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [[UGT1A1 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A1 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
|
CTD |
PMID:31812603 PMID:33290829 |
|
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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|
G
|
Ugt1a2
|
UDP glucuronosyltransferase 1 family, polypeptide A2
|
multiple interactions
|
ISO
|
[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [[UGT1A3 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A3 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
|
CTD |
PMID:31812603 PMID:33290829 |
|
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G
|
Ugt1a6
|
UDP glucuronosyltransferase family 1 member A6
|
multiple interactions
|
ISO
|
[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; belinostat inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; Diclofenac inhibits the reaction [[UGT1A6 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A6 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
|
CTD |
PMID:31812603 PMID:33290829 |
|
NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
|
|
G
|
Ugt1a9
|
UDP glucuronosyltransferase family 1 member A9
|
multiple interactions
|
ISO
|
[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Diclofenac inhibits the reaction [[UGT1A9 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT1A9 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
|
CTD |
PMID:31812603 PMID:33290829 |
|
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
|
|
G
|
Ugt2b1
|
UDP glucuronosyltransferase 2 family, polypeptide B1
|
multiple interactions
|
ISO
|
[UGT2B17 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide
|
CTD |
PMID:33290829 |
|
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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|
G
|
Ugt2b7
|
UDP glucuronosyltransferase family 2 member B7
|
multiple interactions
|
ISO
|
[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; [UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide; Androsterone inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; belinostat inhibits the reaction [[UGT2B7 protein results in increased glucuronidation of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]; pterostilbene inhibits the reaction [[UGT2B7 protein results in increased metabolism of Hymecromone] which results in increased chemical synthesis of 4-methylumbelliferyl glucuronide]
|
CTD |
PMID:31812603 PMID:33290829 |
|
NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
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|
|
G
|
Abcc4
|
ATP binding cassette subfamily C member 4
|
multiple interactions
|
ISO
|
4-nitrophenylglucuronide inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate]
|
CTD |
PMID:11856762 |
|
NCBI chr15:101,948,387...102,182,912
Ensembl chr15:95,542,315...95,774,283
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|
|
G
|
Ugt2b15
|
UDP glucuronosyltransferase family 2 member B15
|
increases abundance
|
EXP
|
UGT2B15 protein results in increased abundance of 7-hydroxycoumarin glucuronide
|
CTD |
PMID:7574722 |
|
NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
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|
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G
|
Abcc3
|
ATP binding cassette subfamily C member 3
|
increases activity multiple interactions affects export
|
ISO EXP
|
acetaminophen glucuronide results in increased activity of ABCC3 protein Ethinyl Estradiol promotes the reaction [ABCC3 protein results in increased secretion of acetaminophen glucuronide] ABCC3 protein affects the export of acetaminophen glucuronide
|
CTD |
PMID:16250050 PMID:16554369 PMID:17569508 |
|
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G
|
Ins2
|
insulin 2
|
increases abundance
|
ISO
|
INS protein results in increased abundance of acetaminophen glucuronide
|
CTD |
PMID:26739624 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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|
G
|
Ogt
|
O-linked N-acetylglucosamine (GlcNAc) transferase
|
multiple interactions
|
ISO
|
OGT gene mutant form inhibits the reaction [Acetaminophen results in increased abundance of acetaminophen glucuronide]
|
CTD |
PMID:29325178 |
|
NCBI chr X:66,771,278...66,816,148
Ensembl chr X:66,771,349...66,816,146
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|
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G
|
Ugt2b7
|
UDP glucuronosyltransferase family 2 member B7
|
multiple interactions increases chemical synthesis
|
ISO
|
alclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Anti-Inflammatory Agents, Non-Steroidal inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; cicloprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Diclofenac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Diflunisal inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Fenoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ibuprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Indomethacin inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ketoprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Ketorolac inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Meclofenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Mefenamic Acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; Naproxen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; pirprofen inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]; tiaprofenic acid inhibits the reaction [UGT2B7 protein results in increased chemical synthesis of aldosterone 18-glucuronide]
|
CTD |
PMID:19740398 |
|
NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
|
|
|
G
|
Abcc4
|
ATP binding cassette subfamily C member 4
|
multiple interactions
|
ISO
|
naphthyl glucuronide inhibits the reaction [ABCC4 protein results in increased transport of Methotrexate]
|
CTD |
PMID:11856762 |
|
NCBI chr15:101,948,387...102,182,912
Ensembl chr15:95,542,315...95,774,283
|
|
|
G
|
Kl
|
Klotho
|
multiple interactions
|
ISO
|
androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
|
CTD |
PMID:14701853 |
|
NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
|
|
|
G
|
Ache
|
acetylcholinesterase
|
multiple interactions increases expression
|
EXP
|
baicalin results in increased expression of and results in increased activity of ACHE protein baicalin results in increased expression of ACHE mRNA
|
CTD |
PMID:27019979 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
|
|
G
|
Ahr
|
aryl hydrocarbon receptor
|
increases activity
|
ISO
|
baicalin results in increased activity of AHR protein
|
CTD |
PMID:17869316 PMID:26204831 |
|
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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|
G
|
Aif1
|
allograft inflammatory factor 1
|
multiple interactions
|
ISO
|
baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of AIF1 protein]
|
CTD |
PMID:38016618 |
|
NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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|
G
|
Alb
|
albumin
|
multiple interactions
|
ISO
|
baicalin inhibits the reaction [Arsenic Trioxide results in decreased expression of ALB protein]
|
CTD |
PMID:35088608 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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|
G
|
Alox5
|
arachidonate 5-lipoxygenase
|
multiple interactions
|
EXP
|
baicalin inhibits the reaction [Hydrogen Peroxide affects the localization of and results in increased activity of ALOX5 protein]
|
CTD |
PMID:20139896 |
|
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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|
G
|
Angpt1
|
angiopoietin 1
|
multiple interactions
|
EXP
|
baicalin inhibits the reaction [Streptozocin results in decreased expression of ANGPT1 mRNA]
|
CTD |
PMID:34414639 |
|
NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
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|
G
|
Atf2
|
activating transcription factor 2
|
multiple interactions
|
EXP
|
baicalin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of ATF2 protein]
|
CTD |
PMID:24312512 |
|
NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:58,718,332...58,795,236
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
increases expression multiple interactions
|
ISO EXP
|
baicalin results in increased expression of BAX protein baicalin affects the reaction [Rotenone results in increased expression of BAX mRNA]; baicalin inhibits the reaction [Rotenone results in increased expression of BAX protein] baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; baicalin inhibits the reaction [Gentamicins results in increased expression of BAX mRNA]; baicalin inhibits the reaction [Gentamicins results in increased expression of BAX protein] baicalin inhibits the reaction [Rotenone affects the expression of BAX protein]
|
CTD |
PMID:21457722 PMID:25423838 PMID:31021006 PMID:34333357 PMID:35088608 PMID:36446982 More...
|
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
multiple interactions decreases expression
|
EXP ISO
|
baicalin inhibits the reaction [Rotenone affects the expression of BCL2 protein] baicalin results in decreased expression of BCL2 protein baicalin affects the reaction [Rotenone results in decreased expression of BCL2 mRNA]; baicalin inhibits the reaction [Rotenone results in decreased expression of BCL2 protein] baicalin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]; baicalin inhibits the reaction [Gentamicins results in decreased expression of BCL2 mRNA]; baicalin inhibits the reaction [Gentamicins results in decreased expression of BCL2 protein]
|
CTD |
PMID:25423838 PMID:31021006 PMID:34333357 PMID:35088608 PMID:36446982 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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|
G
|
Casp1
|
caspase 1
|
multiple interactions
|
ISO
|
baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of CASP1 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]]
|
CTD |
PMID:38016618 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions
|
EXP ISO
|
baicalin inhibits the reaction [Rotenone affects the expression of CASP3 protein] baicalin affects the reaction [Rotenone results in decreased activity of CASP3 protein] baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; baicalin inhibits the reaction [Gentamicins results in increased cleavage of CASP3 protein]
|
CTD |
PMID:25423838 PMID:31021006 PMID:34333357 PMID:35088608 PMID:36446982 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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|
G
|
Cat
|
catalase
|
multiple interactions
|
ISO
|
baicalin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]
|
CTD |
PMID:34333357 PMID:35088608 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
|
|
G
|
Ccna2
|
cyclin A2
|
decreases expression
|
ISO
|
baicalin results in decreased expression of CCNA2 protein
|
CTD |
PMID:21457722 |
|
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
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|
G
|
Ccnd1
|
cyclin D1
|
increases expression decreases expression multiple interactions
|
ISO
|
baicalin results in increased expression of CCND1 mRNA baicalin results in decreased expression of CCND1 protein N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of CCND1 mRNA]
|
CTD |
PMID:19160421 PMID:21457722 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
|
|
G
|
Col1a2
|
collagen type I alpha 2 chain
|
multiple interactions
|
EXP
|
baicalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]
|
CTD |
PMID:19474275 |
|
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
|
|
G
|
Cyp1a1
|
cytochrome P450, family 1, subfamily a, polypeptide 1
|
multiple interactions increases expression
|
ISO
|
3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A1 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A1 protein]; baicalin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] baicalin results in increased expression of CYP1A1 mRNA; baicalin results in increased expression of CYP1A1 protein
|
CTD |
PMID:18451504 PMID:26204831 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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|
G
|
Cyp1a2
|
cytochrome P450, family 1, subfamily a, polypeptide 2
|
multiple interactions increases expression
|
ISO
|
3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A2 mRNA]; 3',4'-dimethoxyflavone inhibits the reaction [baicalin results in increased expression of CYP1A2 protein] resveratrol inhibits the reaction [baicalin results in increased expression of CYP1A2 mRNA]; resveratrol inhibits the reaction [baicalin results in increased expression of CYP1A2 protein] baicalin results in increased expression of CYP1A2 mRNA; baicalin results in increased expression of CYP1A2 protein
|
CTD |
PMID:26204831 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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|
G
|
Egf
|
epidermal growth factor
|
multiple interactions
|
ISO
|
baicalin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; baicalin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]
|
CTD |
PMID:25625231 |
|
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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|
G
|
Egfr
|
epidermal growth factor receptor
|
multiple interactions
|
ISO
|
baicalin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]
|
CTD |
PMID:25625231 |
|
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
|
|
G
|
Elk1
|
ETS transcription factor ELK1
|
multiple interactions
|
ISO
|
baicalin inhibits the reaction [EGF protein results in increased phosphorylation of ELK1 protein]
|
CTD |
PMID:25625231 |
|
NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713
|
|
G
|
Ern1
|
endoplasmic reticulum to nucleus signaling 1
|
multiple interactions
|
ISO
|
baicalin inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]
|
CTD |
PMID:29031535 |
|
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
|
|
G
|
Foxa2
|
forkhead box A2
|
decreases expression
|
ISO
|
baicalin results in decreased expression of FOXA2 mRNA; baicalin results in decreased expression of FOXA2 protein
|
CTD |
PMID:32687838 |
|
NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
|
|
G
|
Got1
|
glutamic-oxaloacetic transaminase 1
|
multiple interactions
|
EXP
|
baicalin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GOT1 protein]
|
CTD |
PMID:15645217 |
|
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
|
|
G
|
Gpt
|
glutamic--pyruvic transaminase
|
multiple interactions
|
EXP ISO
|
baicalin inhibits the reaction [tert-Butylhydroperoxide results in increased activity of GPT protein] baicalin inhibits the reaction [Arsenic Trioxide results in increased activity of GPT protein]
|
CTD |
PMID:15645217 PMID:35088608 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G
|
Hes1
|
hes family bHLH transcription factor 1
|
increases expression multiple interactions
|
ISO
|
baicalin results in increased expression of HES1 mRNA N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HES1 mRNA]
|
CTD |
PMID:19160421 |
|
NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
|
|
G
|
Hey1
|
hes-related family bHLH transcription factor with YRPW motif 1
|
increases expression multiple interactions
|
ISO
|
baicalin results in increased expression of HEY1 mRNA N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY1 mRNA]
|
CTD |
PMID:19160421 |
|
NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312
|
|
G
|
Hey2
|
hes-related family bHLH transcription factor with YRPW motif 2
|
multiple interactions increases expression
|
ISO
|
N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalin results in increased expression of HEY2 mRNA]
|
CTD |
PMID:19160421 |
|
NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
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G
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Hmox1
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heme oxygenase 1
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multiple interactions increases expression
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ISO EXP
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[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein; baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of HMOX1 protein]; baicalin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; baicalin promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein] baicalin results in increased expression of HMOX1 mRNA; baicalin results in increased expression of HMOX1 protein
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CTD |
PMID:16824337 PMID:18187930 PMID:38016618 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G
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Hnf1a
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HNF1 homeobox A
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multiple interactions decreases expression
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ISO
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baicalin inhibits the reaction [HNF4A protein binds to HNF1A promoter]; HNF1A protein promotes the reaction [baicalin results in decreased secretion of Hepatitis B Surface Antigens]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A mRNA]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A protein] baicalin results in decreased expression of HNF1A mRNA; baicalin results in decreased expression of HNF1A protein
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CTD |
PMID:32687838 |
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NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
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G
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Hnf4a
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hepatocyte nuclear factor 4, alpha
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decreases expression multiple interactions
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ISO
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baicalin results in decreased expression of HNF4A protein baicalin inhibits the reaction [HNF4A protein binds to HNF1A promoter]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A mRNA]; HNF4A protein promotes the reaction [baicalin results in decreased expression of HNF1A protein]; HNF4A protein promotes the reaction [baicalin results in decreased secretion of Hepatitis B Surface Antigens] baicalin results in decreased expression of HNF4A mRNA; baicalin results in decreased expression of HNF4A protein
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CTD |
PMID:32687838 |
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NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
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G
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Hspb1
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heat shock protein family B (small) member 1
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multiple interactions
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EXP
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baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of HSPB1 protein]
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CTD |
PMID:34414639 |
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NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
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G
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Il1b
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interleukin 1 beta
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multiple interactions
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ISO
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baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B mRNA]; baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of IL1B protein]; baicalin inhibits the reaction [Palmitic Acid results in increased secretion of IL1B protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]] baicalin inhibits the reaction [Rotenone results in increased expression of IL1B protein]
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CTD |
PMID:29031535 PMID:35088608 PMID:36446982 PMID:38016618 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G
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Il6
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interleukin 6
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decreases expression multiple interactions
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EXP ISO
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baicalin results in decreased expression of IL6 mRNA; baicalin results in decreased expression of IL6 protein baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL6 mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL6 mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 protein]; baicalin inhibits the reaction [Palmitic Acid results in increased secretion of IL6 protein]
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CTD |
PMID:22019745 PMID:29031535 PMID:34333357 PMID:35088608 PMID:38016618 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G
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Ins1
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insulin 1
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multiple interactions
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EXP
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baicalin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]
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CTD |
PMID:34414639 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G
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Itga4
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integrin subunit alpha 4
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multiple interactions
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EXP
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baicalin inhibits the reaction [ITGA4 protein results in increased expression of KDR protein]; baicalin inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein]
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CTD |
PMID:36731809 |
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NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
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G
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Jak2
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Janus kinase 2
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multiple interactions
|
ISO
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baicalin promotes the reaction [Arsenic Trioxide results in increased phosphorylation of JAK2 protein]
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CTD |
PMID:35088608 |
|
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G
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Kdr
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kinase insert domain receptor
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multiple interactions
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EXP
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baicalin inhibits the reaction [ITGA4 protein results in increased expression of KDR protein]
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CTD |
PMID:36731809 |
|
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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G
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Keap1
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Kelch-like ECH-associated protein 1
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multiple interactions
|
ISO
|
baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of KEAP1 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in decreased expression of KEAP1 protein]
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CTD |
PMID:38016618 |
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NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G
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Mapk1
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mitogen activated protein kinase 1
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multiple interactions
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EXP
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baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]
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CTD |
PMID:34414639 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G
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Mapk3
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mitogen activated protein kinase 3
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multiple interactions
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EXP
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baicalin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]
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CTD |
PMID:34414639 |
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NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G
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Myd88
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MYD88, innate immune signal transduction adaptor
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decreases expression
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EXP
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baicalin results in decreased expression of MYD88 protein
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CTD |
PMID:22019745 |
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NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415
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G
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Nfe2l2
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NFE2 like bZIP transcription factor 2
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multiple interactions
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ISO
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[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] affects the localization of NFE2L2 protein; baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NFE2L2 protein]; baicalin inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased ubiquitination of NFE2L2 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; baicalin promotes the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]]
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CTD |
PMID:38016618 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G
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Nfkbia
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NFKB inhibitor alpha
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increases expression
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EXP
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baicalin results in increased expression of NFKBIA protein
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CTD |
PMID:22019745 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
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G
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Nlrp3
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NLR family, pyrin domain containing 3
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multiple interactions
|
ISO
|
baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of NLRP3 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]; baicalin inhibits the reaction [Palmitic Acid results in increased expression of NLRP3 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]]
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CTD |
PMID:29031535 PMID:38016618 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G
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Nos2
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nitric oxide synthase 2
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multiple interactions decreases expression
|
EXP ISO
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baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; mifobate inhibits the reaction [baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]] baicalin results in decreased expression of NOS2 mRNA; baicalin results in decreased expression of NOS2 protein baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]
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CTD |
PMID:18187930 PMID:22019745 PMID:24312512 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G
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Notch1
|
notch receptor 1
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increases activity increases expression
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ISO
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baicalin results in increased activity of NOTCH1 protein baicalin results in increased expression of NOTCH1 mRNA
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CTD |
PMID:19160421 |
|
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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G
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Nr1h3
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nuclear receptor subfamily 1, group H, member 3
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increases expression
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ISO
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Baicalin increases expression of NR1H3 mRNA and protein in foam cells
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RGD |
PMID:27389392 |
RGD:401842390 |
NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
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G
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Pkm
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pyruvate kinase M1/2
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increases activity
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ISO
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baicalin results in increased activity of PKM protein
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CTD |
PMID:25388478 |
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NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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G
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Pparg
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peroxisome proliferator-activated receptor gamma
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multiple interactions
|
EXP
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baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of and results in decreased activity of PPARG protein]
|
CTD |
PMID:24312512 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G
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Prima1
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proline rich membrane anchor 1
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increases expression
|
EXP
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baicalin results in increased expression of PRIMA1 mRNA
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CTD |
PMID:27019979 |
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NCBI chr 6:122,338,365...122,390,955
Ensembl chr 6:122,338,370...122,389,921
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G
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Ptgs2
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prostaglandin-endoperoxide synthase 2
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decreases expression
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EXP
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baicalin results in decreased expression of PTGS2 mRNA; baicalin results in decreased expression of PTGS2 protein
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CTD |
PMID:22019745 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G
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Pycard
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PYD and CARD domain containing
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multiple interactions
|
ISO
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baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of PYCARD protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]]
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CTD |
PMID:38016618 |
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NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
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G
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Rela
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RELA proto-oncogene, NF-kB subunit
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multiple interactions
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EXP ISO
|
baicalin affects the localization of and results in decreased expression of RELA protein baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased phosphorylation of RELA protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of and results in increased phosphorylation of RELA protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]]
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CTD |
PMID:22019745 PMID:34333357 PMID:38016618 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G
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Snca
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synuclein alpha
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multiple interactions
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ISO
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[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] affects the localization of NFE2L2 protein; [baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL6 mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of TNF mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]; baicalin inhibits the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased ubiquitination of NFE2L2 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in decreased expression of KEAP1 protein]; baicalin promotes the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; baicalin promotes the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [[baicalin co-treated with 1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of CASP1 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of IL1B protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of NLRP3 protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of PYCARD protein]]; NFE2L2 protein affects the reaction [baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased phosphorylation of RELA protein]]
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CTD |
PMID:38016618 |
|
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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G
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Stat3
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signal transducer and activator of transcription 3
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multiple interactions
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ISO
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baicalin promotes the reaction [Arsenic Trioxide results in increased phosphorylation of STAT3 protein]
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CTD |
PMID:35088608 |
|
NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
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G
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Tek
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TEK receptor tyrosine kinase
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multiple interactions
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EXP
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baicalin inhibits the reaction [Streptozocin results in decreased expression of TEK mRNA]
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CTD |
PMID:34414639 |
|
NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
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G
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Tfam
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transcription factor A, mitochondrial
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decreases expression multiple interactions
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ISO
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baicalin results in decreased expression of TFAM mRNA baicalin inhibits the reaction [Rotenone results in decreased expression of TFAM mRNA]
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CTD |
PMID:36446982 |
|
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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G
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Tgfb1
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transforming growth factor, beta 1
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multiple interactions
|
EXP
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baicalin inhibits the reaction [Streptozocin results in decreased expression of TGFB1 mRNA]; baicalin inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]
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CTD |
PMID:19474275 PMID:34414639 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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G
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Th
|
tyrosine hydroxylase
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multiple interactions
|
ISO
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baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TH protein]
|
CTD |
PMID:38016618 |
|
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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G
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Tlr4
|
toll-like receptor 4
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decreases expression multiple interactions
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EXP ISO
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baicalin results in decreased expression of TLR4 protein baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of TLR4 protein] baicalin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]
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CTD |
PMID:22019745 PMID:24312512 PMID:34333357 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G
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Tnf
|
tumor necrosis factor
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multiple interactions decreases expression
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ISO EXP
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baicalin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF mRNA]; baicalin inhibits the reaction [[1-Methyl-4-phenylpyridinium co-treated with SNCA protein] results in increased expression of TNF mRNA]; baicalin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF protein]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; baicalin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein] baicalin results in decreased expression of TNF mRNA; baicalin results in decreased expression of TNF protein baicalin inhibits the reaction [Paraquat results in increased expression of TNF protein]
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CTD |
PMID:16824337 PMID:18187930 PMID:22019745 PMID:34333357 PMID:35088608 PMID:38016618 More...
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G
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Tp53
|
tumor protein p53
|
increases expression
|
ISO
|
baicalin results in increased expression of TP53 protein
|
CTD |
PMID:21457722 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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G
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Txnip
|
thioredoxin interacting protein
|
multiple interactions
|
ISO
|
baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]; dorsomorphin inhibits the reaction [baicalin inhibits the reaction [Palmitic Acid results in increased expression of TXNIP protein]]
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CTD |
PMID:29031535 |
|
NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:184,092,991...184,096,886
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G
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Usp27x
|
ubiquitin specific peptidase 27, X-linked
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multiple interactions
|
EXP
|
baicalin inhibits the reaction [Streptozocin results in increased expression of USP27X protein]
|
CTD |
PMID:34414639 |
|
NCBI chr X:15,123,620...15,126,855
Ensembl chr X:15,124,596...15,125,912
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G
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Vegfa
|
vascular endothelial growth factor A
|
multiple interactions
|
EXP
|
baicalin inhibits the reaction [ITGA4 protein results in increased expression of VEGFA protein]
|
CTD |
PMID:36731809 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G
|
Vegfc
|
vascular endothelial growth factor C
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multiple interactions
|
EXP
|
baicalin inhibits the reaction [Streptozocin results in decreased expression of VEGFC mRNA]
|
CTD |
PMID:34414639 |
|
NCBI chr16:44,445,293...44,560,887
Ensembl chr16:37,712,262...37,827,848
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G
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Xdh
|
xanthine dehydrogenase
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multiple interactions
|
ISO
|
baicalin inhibits the reaction [[Biological Products co-treated with potassium oxonate] results in increased activity of XDH protein]
|
CTD |
PMID:34044073 |
|
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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|
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G
|
Abcb1a
|
ATP binding cassette subfamily B member 1A
|
multiple interactions
|
EXP
|
estriol-16 alpha-(beta-D-glucuronide) inhibits the reaction [ABCB1 results in increased transport of estradiol-17 beta-glucuronide]
|
CTD |
PMID:9794924 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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|
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G
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Kl
|
Klotho
|
multiple interactions increases hydrolysis
|
ISO
|
estriol 3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] KL protein results in increased hydrolysis of estriol 3-glucuronide
|
CTD |
PMID:14701853 |
|
NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
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|
|
G
|
Kl
|
Klotho
|
increases hydrolysis multiple interactions
|
ISO
|
KL protein results in increased hydrolysis of estrone-3-glucuronide estrone-3-glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
|
CTD |
PMID:14701853 |
|
NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
|
|
|
G
|
Abcb11
|
ATP binding cassette subfamily B member 11
|
multiple interactions decreases activity
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Glycyrrhizic Acid results in decreased activity of ABCB11 protein
|
CTD |
PMID:24014644 |
|
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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|
G
|
Abcc3
|
ATP binding cassette subfamily C member 3
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ABCC3 mRNA]
|
CTD |
PMID:28549656 |
|
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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|
G
|
Acaca
|
acetyl-CoA carboxylase alpha
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of ACACA mRNA]
|
CTD |
PMID:31918260 |
|
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
|
|
G
|
Acat2
|
acetyl-CoA acetyltransferase 2
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ACAT2 mRNA]
|
CTD |
PMID:28549656 |
|
NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:47,695,788...47,752,821
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G
|
Ache
|
acetylcholinesterase
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of ACHE protein]
|
CTD |
PMID:31150628 |
|
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G
|
Acta2
|
actin alpha 2, smooth muscle
|
decreases expression multiple interactions
|
ISO EXP
|
Glycyrrhizic Acid results in decreased expression of ACTA2 protein Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of ACTA2 protein]
|
CTD |
PMID:33030083 PMID:33522686 |
|
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
|
|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]
|
CTD |
PMID:32525084 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
|
|
G
|
Alb
|
albumin
|
multiple interactions
|
ISO EXP
|
ALB protein binds to and affects the transport of Glycyrrhizic Acid Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased secretion of ALB protein]
|
CTD |
PMID:8831264 PMID:19558898 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
|
|
G
|
Aqp2
|
aquaporin 2
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Gentamicins results in decreased expression of AQP2 protein]
|
CTD |
PMID:12969435 |
|
NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
|
|
G
|
Aqp5
|
aquaporin 5
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [Histamine results in decreased expression of AQP5 protein]
|
CTD |
PMID:29452068 |
|
NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
|
|
G
|
Ar
|
androgen receptor
|
multiple interactions affects localization
|
ISO
|
Glycyrrhizic Acid binds to and results in increased activity of AR protein Glycyrrhizic Acid affects the localization of AR protein
|
CTD |
PMID:28478275 |
|
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925
|
|
G
|
Bad
|
BCL2-associated agonist of cell death
|
increases expression
|
ISO
|
Glycyrrhizic Acid results in increased expression of BAD mRNA
|
CTD |
PMID:35844403 |
|
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
increases expression
|
ISO
|
Glycyrrhizic Acid results in increased expression of BAX mRNA
|
CTD |
PMID:35844403 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
decreases expression multiple interactions
|
ISO
|
Glycyrrhizic Acid results in decreased expression of BCL2 mRNA [Glycyrrhizic Acid co-treated with Cisplatin] results in decreased expression of BCL2 mRNA
|
CTD |
PMID:35844403 PMID:37659683 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G
|
Bdnf
|
brain-derived neurotrophic factor
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of BDNF protein]
|
CTD |
PMID:31150628 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
|
|
G
|
Casp2
|
caspase 2
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP2 protein]
|
CTD |
PMID:22051199 |
|
NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions increases activity
|
EXP ISO
|
Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP3 protein]; Glycyrrhizic Acid inhibits the reaction [Fusaric Acid results in decreased expression of CASP3 protein] [Glycyrrhizic Acid co-treated with Cisplatin] results in increased expression of CASP3 mRNA Glycyrrhizic Acid results in increased activity of CASP3 protein
|
CTD |
PMID:22051199 PMID:31150628 PMID:35844403 PMID:37659683 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
|
|
G
|
Casp6
|
caspase 6
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP6 protein]
|
CTD |
PMID:22051199 |
|
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
|
|
G
|
Casp8
|
caspase 8
|
multiple interactions increases activity
|
EXP ISO
|
Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP8 protein] [Glycyrrhizic Acid co-treated with Cisplatin] results in increased expression of CASP8 mRNA Glycyrrhizic Acid results in increased activity of CASP8 protein
|
CTD |
PMID:22051199 PMID:35844403 PMID:37659683 |
|
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
|
|
G
|
Casp9
|
caspase 9
|
multiple interactions increases activity
|
EXP ISO
|
Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in increased activity of CASP9 protein] [Glycyrrhizic Acid co-treated with Cisplatin] results in increased expression of CASP9 mRNA Glycyrrhizic Acid results in increased activity of CASP9 protein
|
CTD |
PMID:22051199 PMID:35844403 PMID:37659683 |
|
Ensembl chr 5:154,109,046...154,126,626
|
|
G
|
Ccl2
|
C-C motif chemokine ligand 2
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [Cyclosporine results in increased expression of CCL2 mRNA]
|
CTD |
PMID:27585667 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
|
|
G
|
Ccn2
|
cellular communication network factor 2
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased secretion of CCN2 protein]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of CCN2 mRNA]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of CCN2 protein]
|
CTD |
PMID:19558898 |
|
NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
|
|
G
|
Ccnd1
|
cyclin D1
|
decreases expression
|
ISO
|
Glycyrrhizic Acid results in decreased expression of CCND1 mRNA
|
CTD |
PMID:35844403 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
|
|
G
|
Cd68
|
Cd68 molecule
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of CD68 protein]
|
CTD |
PMID:33030083 |
|
NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
|
|
G
|
Cdh1
|
cadherin 1
|
increases expression
|
ISO
|
Glycyrrhizic Acid results in increased expression of CDH1 protein
|
CTD |
PMID:33522686 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
|
|
G
|
Cdk4
|
cyclin-dependent kinase 4
|
decreases expression
|
ISO
|
Glycyrrhizic Acid results in decreased expression of CDK4 mRNA
|
CTD |
PMID:35844403 |
|
NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403
|
|
G
|
Cdkn1a
|
cyclin-dependent kinase inhibitor 1A
|
increases expression
|
ISO
|
Glycyrrhizic Acid results in increased expression of CDKN1A mRNA
|
CTD |
PMID:35844403 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
|
|
G
|
Cebpa
|
CCAAT/enhancer binding protein alpha
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA]
|
CTD |
PMID:34302803 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
|
|
G
|
Cebpb
|
CCAAT/enhancer binding protein beta
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPB mRNA]
|
CTD |
PMID:34302803 |
|
NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
|
|
G
|
Cebpd
|
CCAAT/enhancer binding protein delta
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPD mRNA]
|
CTD |
PMID:34302803 |
|
NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
|
|
G
|
Col4a1
|
collagen type IV alpha 1 chain
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased secretion of COL4A1 protein]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of COL4A1 protein]
|
CTD |
PMID:19558898 |
|
NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
|
|
G
|
Cpt1a
|
carnitine palmitoyltransferase 1A
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of CPT1A mRNA]
|
CTD |
PMID:31918260 |
|
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055
|
|
G
|
Creb1
|
cAMP responsive element binding protein 1
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [Histamine results in decreased phosphorylation of CREB1 protein]
|
CTD |
PMID:29452068 |
|
NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816
|
|
G
|
Cyp11b3
|
cytochrome P450, family 11, subfamily b, polypeptide 3
|
decreases expression
|
EXP
|
Glycyrrhizic Acid results in decreased expression of CYP11B2 mRNA
|
CTD |
PMID:10474021 PMID:11798659 |
|
NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048
|
|
G
|
Cyp3a2
|
cytochrome P450, family 3, subfamily a, polypeptide 2
|
multiple interactions increases expression
|
ISO
|
NR1I2 protein affects the reaction [Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA] Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA; Glycyrrhizic Acid results in increased expression of CYP3A4 protein
|
CTD |
PMID:22982774 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
|
|
G
|
Cyp7a1
|
cytochrome P450 family 7 subfamily A member 1
|
decreases expression multiple interactions
|
ISO
|
Glycyrrhizic Acid results in decreased expression of CYP7A1 mRNA Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]
|
CTD |
PMID:22982774 PMID:28549656 |
|
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
|
|
G
|
Ephx2
|
epoxide hydrolase 2
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene results in decreased activity of EPHX2 protein]
|
CTD |
PMID:22051199 |
|
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
|
|
G
|
Fabp4
|
fatty acid binding protein 4
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]
|
CTD |
PMID:34302803 |
|
NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578
|
|
G
|
Fn1
|
fibronectin 1
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased secretion of FN1 protein]
|
CTD |
PMID:19558898 |
|
NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678
|
|
G
|
Got1
|
glutamic-oxaloacetic transaminase 1
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased secretion of GOT1 protein]
|
CTD |
PMID:31918260 |
|
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
|
|
G
|
Gpt
|
glutamic--pyruvic transaminase
|
multiple interactions
|
EXP ISO
|
Glycyrrhizic Acid inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with BCG Vaccine] results in increased activity of GPT protein]; Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased secretion of GPT protein] Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; Glycyrrhizic Acid inhibits the reaction [diosbulbin B results in increased activity of GPT protein]
|
CTD |
PMID:19196740 PMID:28549656 PMID:31918260 PMID:37794747 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
|
|
G
|
Hes1
|
hes family bHLH transcription factor 1
|
decreases expression
|
ISO
|
Glycyrrhizic Acid results in decreased expression of HES1 mRNA
|
CTD |
PMID:35844403 |
|
NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192
|
|
G
|
Hmgb1
|
high mobility group box 1
|
decreases secretion multiple interactions decreases activity
|
ISO EXP
|
Glycyrrhizic Acid results in decreased secretion of HMGB1 protein Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of HMGB1 protein] Glycyrrhizic Acid results in decreased activity of HMGB1 protein
|
CTD |
PMID:27585667 PMID:27689324 PMID:27783111 PMID:32525084 |
|
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
|
|
G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; Glycyrrhizic Acid promotes the reaction [Carbon Tetrachloride results in increased expression of HMOX1 protein]
|
CTD |
PMID:17917259 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G
|
Hsd11b2
|
hydroxysteroid 11-beta dehydrogenase 2
|
decreases expression
|
EXP
|
Glycyrrhizic Acid results in decreased expression of HSD11B2 mRNA
|
CTD |
PMID:10474021 PMID:11798659 |
|
NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
|
|
G
|
Ifng
|
interferon gamma
|
affects expression
|
ISO
|
Glycyrrhizic Acid affects the expression of IFNG mRNA
|
CTD |
PMID:16945185 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
|
G
|
Il12a
|
interleukin 12A
|
multiple interactions
|
ISO
|
[Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]; [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of IL12A mRNA
|
CTD |
PMID:11412311 |
|
NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
|
|
G
|
Il12b
|
interleukin 12B
|
multiple interactions
|
ISO
|
[Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of [IL12A protein binds to IL12B protein]; [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of IL12B mRNA; [Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased expression of IL12B protein
|
CTD |
PMID:11412311 |
|
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of IL1B protein]
|
CTD |
PMID:33030083 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
ISO EXP
|
Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein] Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of IL6 mRNA]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of IL6 protein] Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased expression of IL6 mRNA]; Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased expression of IL6 protein]
|
CTD |
PMID:21644799 PMID:26524701 PMID:29452068 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G
|
Ins1
|
insulin 1
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPA mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPB mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CEBPD mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SCD1 mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC2A4 mRNA]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein]; Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein]
|
CTD |
PMID:34302803 |
|
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
|
|
G
|
Jag1
|
jagged canonical Notch ligand 1
|
decreases expression
|
ISO
|
Glycyrrhizic Acid results in decreased expression of JAG1 mRNA
|
CTD |
PMID:35844403 |
|
NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209
|
|
G
|
Lpl
|
lipoprotein lipase
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of LPL mRNA]
|
CTD |
PMID:34302803 |
|
NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
|
|
G
|
Map1lc3b
|
microtubule-associated protein 1 light chain 3 beta
|
multiple interactions
|
EXP
|
[Glycyrrhizic Acid co-treated with bafilomycin A1] results in increased lipidation of MAP1LC3B protein; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased lipidation of MAP1LC3B protein]
|
CTD |
PMID:32525084 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK1 protein]
|
CTD |
PMID:34302803 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased phosphorylation of MAPK3 protein]
|
CTD |
PMID:34302803 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
|
|
G
|
Mmp2
|
matrix metallopeptidase 2
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [Picryl Chloride results in increased secretion of MMP2 protein] [Glycyrrhizic Acid co-treated with Cisplatin] results in decreased expression of MMP2 mRNA
|
CTD |
PMID:16945185 PMID:37659683 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
|
|
G
|
Mmp9
|
matrix metallopeptidase 9
|
multiple interactions
|
ISO
|
[Glycyrrhizic Acid co-treated with Cisplatin] results in decreased expression of MMP9 mRNA
|
CTD |
PMID:37659683 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G
|
Mpo
|
myeloperoxidase
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [diosbulbin B results in increased activity of MPO protein]
|
CTD |
PMID:37794747 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
|
|
G
|
Mtor
|
mechanistic target of rapamycin kinase
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased phosphorylation of MTOR protein]
|
CTD |
PMID:32525084 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
|
|
G
|
Mttp
|
microsomal triglyceride transfer protein
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of MTTP mRNA]
|
CTD |
PMID:28549656 |
|
NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
|
|
G
|
Muc5ac
|
mucin 5AC, oligomeric mucus/gel-forming
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [Histamine results in increased expression of MUC5AC mRNA]; Glycyrrhizic Acid inhibits the reaction [Histamine results in increased secretion of MUC5AC protein]
|
CTD |
PMID:29452068 |
|
NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
|
|
G
|
Nfkb1
|
nuclear factor kappa B subunit 1
|
multiple interactions
|
ISO
|
[Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased activity of [NFKB1 protein binds to RELA protein]
|
CTD |
PMID:11412311 |
|
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
|
|
G
|
Nfkbia
|
NFKB inhibitor alpha
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [Histamine results in increased phosphorylation of NFKBIA protein]
|
CTD |
PMID:29452068 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]
|
CTD |
PMID:17917259 PMID:21644799 PMID:23373965 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G
|
Notch1
|
notch receptor 1
|
decreases expression
|
ISO
|
Glycyrrhizic Acid results in decreased expression of NOTCH1 mRNA
|
CTD |
PMID:35844403 |
|
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
|
|
G
|
Npc1l1
|
NPC1 like intracellular cholesterol transporter 1
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of NPC1L1 mRNA]
|
CTD |
PMID:28549656 |
|
NCBI chr14:81,071,448...81,091,113
Ensembl chr14:81,071,451...81,091,113
|
|
G
|
Nr0b2
|
nuclear receptor subfamily 0, group B, member 2
|
increases expression
|
ISO
|
Glycyrrhizic Acid results in increased expression of NR0B2 mRNA
|
CTD |
PMID:22982774 |
|
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
|
|
G
|
Nr1i2
|
nuclear receptor subfamily 1, group I, member 2
|
increases activity multiple interactions
|
ISO
|
Glycyrrhizic Acid results in increased activity of NR1I2 protein NR1I2 protein affects the reaction [Glycyrrhizic Acid results in increased expression of CYP3A4 mRNA]
|
CTD |
PMID:22982774 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
|
|
G
|
Pik3cd
|
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
|
decreases activity
|
ISO
|
Glycyrrhizic Acid results in decreased activity of PIK3CD protein
|
CTD |
PMID:21644799 |
|
NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:160,094,952...160,120,930
|
|
G
|
Pik3cg
|
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
|
decreases activity
|
ISO
|
Glycyrrhizic Acid results in decreased activity of PIK3CG protein
|
CTD |
PMID:21644799 |
|
NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043
|
|
G
|
Ppara
|
peroxisome proliferator activated receptor alpha
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PPARA mRNA]
|
CTD |
PMID:31918260 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
|
|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARG mRNA]
|
CTD |
PMID:34302803 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
|
|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]
|
CTD |
PMID:17917259 PMID:21644799 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G
|
Rad21
|
RAD21 cohesin complex component
|
decreases binding
|
ISO
|
Glycyrrhizinic acid decreases binding of RAD21 protein to SMC3 protein in lymphoma cells
|
RGD |
PMID:21880767 |
RGD:243065267 |
NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
ISO EXP
|
[Glycyrrhizic Acid co-treated with Lipopolysaccharides] results in increased activity of [NFKB1 protein binds to RELA protein] Glycyrrhizic Acid inhibits the reaction [Histamine results in increased phosphorylation of RELA protein] Glycyrrhizic Acid inhibits the reaction [Benzo(a)pyrene affects the localization of RELA protein]; Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased phosphorylation of RELA protein]
|
CTD |
PMID:11412311 PMID:22051199 PMID:26524701 PMID:29452068 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G
|
Ren
|
renin
|
decreases activity
|
ISO
|
Glycyrrhizic Acid results in decreased activity of REN protein
|
CTD |
PMID:20460744 |
|
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
|
|
G
|
Scd
|
stearoyl-CoA desaturase
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SCD1 mRNA]
|
CTD |
PMID:34302803 |
|
NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
|
|
G
|
Sirt1
|
sirtuin 1
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]
|
CTD |
PMID:25162824 |
|
NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
|
|
G
|
Slc22a2
|
solute carrier family 22 member 2
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
|
CTD |
PMID:21599003 |
|
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
|
|
G
|
Slc2a4
|
solute carrier family 2 member 4
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SLC2A4 mRNA]
|
CTD |
PMID:34302803 |
|
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
|
|
G
|
Slc51b
|
SLC51 subunit beta
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLC51B mRNA]
|
CTD |
PMID:28549656 |
|
NCBI chr 8:65,931,891...65,939,953
Ensembl chr 8:65,931,890...65,940,145
|
|
G
|
Slco1a4
|
solute carrier organic anion transporter family, member 1a4
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLCO1A4 mRNA]
|
CTD |
PMID:28549656 |
|
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
|
|
G
|
Smad4
|
SMAD family member 4
|
decreases expression
|
ISO
|
Glycyrrhizic Acid results in decreased expression of SMAD4 protein
|
CTD |
PMID:33522686 |
|
NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
|
|
G
|
Smad7
|
SMAD family member 7
|
increases expression
|
ISO
|
Glycyrrhizic Acid results in increased expression of SMAD7 protein
|
CTD |
PMID:33522686 |
|
NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765
|
|
G
|
Sod1
|
superoxide dismutase 1
|
increases activity
|
ISO
|
Glycyrrhizic Acid results in increased activity of SOD1 protein
|
CTD |
PMID:37659683 |
|
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
|
|
G
|
Sod2
|
superoxide dismutase 2
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of SOD2 protein]
|
CTD |
PMID:25162824 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
|
|
G
|
Sqstm1
|
sequestosome 1
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid affects the reaction [Doxorubicin results in increased expression of SQSTM1 protein]
|
CTD |
PMID:32525084 |
|
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
|
|
G
|
Srebf1
|
sterol regulatory element binding transcription factor 1
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of SREBF1 mRNA]
|
CTD |
PMID:31918260 |
|
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
|
|
G
|
Tgfb1
|
transforming growth factor, beta 1
|
multiple interactions
|
EXP
|
Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of and results in increased secretion of TGFB1 protein]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of TGFB1 mRNA]; Glycyrrhizic Acid inhibits the reaction [Doxorubicin results in increased expression of TGFB1 protein]; Glycyrrhizic Acid inhibits the reaction [Glucose results in increased expression of TGFB1 protein]; Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of TGFB1 protein]
|
CTD |
PMID:19558898 PMID:25162824 PMID:33030083 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
|
|
G
|
Tgfbr1
|
transforming growth factor, beta receptor 1
|
decreases expression
|
ISO
|
Glycyrrhizic Acid results in decreased expression of TGFBR1 protein
|
CTD |
PMID:33522686 |
|
NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
|
|
G
|
Tgfbr2
|
transforming growth factor, beta receptor 2
|
decreases expression
|
ISO
|
Glycyrrhizic Acid results in decreased expression of TGFBR2 protein
|
CTD |
PMID:33522686 |
|
NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228
|
|
G
|
Tjp1
|
tight junction protein 1
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of TJP1 protein]; Glycyrrhizic Acid inhibits the reaction [Palmitic Acid results in decreased expression of TJP1 protein]
|
CTD |
PMID:27689324 PMID:27783111 |
|
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
|
|
G
|
Tjp2
|
tight junction protein 2
|
multiple interactions
|
ISO
|
Glycyrrhizic Acid inhibits the reaction [Glucose results in decreased expression of TJP2 protein]; Glycyrrhizic Acid inhibits the reaction [Palmitic Acid results in decreased expression of TJP2 protein]
|
CTD |
PMID:27689324 PMID:27783111 |
|
NCBI chr 1:221,709,745...221,838,291
Ensembl chr 1:221,709,745...221,838,295
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
ISO EXP
|
Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Glycyrrhizic Acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Glycyrrhizic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein] Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased expression of TNF mRNA]; Glycyrrhizic Acid inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Glycyrrhizic Acid inhibits the reaction [Sodium Nitrite results in increased expression of TNF protein]
|
CTD |
PMID:17917259 PMID:21644799 PMID:26524701 PMID:33030083 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G
|
Tp53
|
tumor protein p53
|
increases expression
|
ISO
|
Glycyrrhizic Acid results in increased expression of TP53 mRNA
|
CTD |
PMID:35844403 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
|
|
|
G
|
Acadm
|
acyl-CoA dehydrogenase medium chain
|
multiple interactions
|
EXP
|
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of ACADM mRNA]
|
CTD |
PMID:26190035 |
|
NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
|
|
G
|
Adrb2
|
adrenoceptor beta 2
|
multiple interactions
|
ISO
|
quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine binds to ADRB2 protein]
|
CTD |
PMID:24929186 |
|
NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
|
|
G
|
Agt
|
angiotensinogen
|
multiple interactions
|
ISO
|
quercetin 3-O-glucuronide analog inhibits the reaction [AGT protein results in increased phosphorylation of JUN protein]
|
CTD |
PMID:12054679 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
|
|
G
|
Alox5
|
arachidonate 5-lipoxygenase
|
multiple interactions
|
ISO
|
quercetin 3-O-glucuronide inhibits the reaction [ALOX5 protein results in increased chemical synthesis of Leukotriene B4]
|
CTD |
PMID:18096136 |
|
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
|
|
G
|
App
|
amyloid beta precursor protein
|
multiple interactions decreases expression
|
ISO
|
quercetin 3-O-glucuronide inhibits the reaction [APP protein binds to APP protein modified form] quercetin 3-O-glucuronide results in decreased expression of APP protein
|
CTD |
PMID:23097297 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
|
|
G
|
Cat
|
catalase
|
multiple interactions
|
EXP
|
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT protein
|
CTD |
PMID:25716194 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
|
|
G
|
Cav1
|
caveolin 1
|
multiple interactions
|
ISO
|
quercetin 3-O-glucuronide inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA]
|
CTD |
PMID:27257344 |
|
NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
|
|
G
|
Cd36
|
CD36 molecule
|
decreases expression
|
ISO
|
quercetin 3-O-glucuronide results in decreased expression of CD36 mRNA
|
CTD |
PMID:18199750 |
|
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
|
|
G
|
Cpt1a
|
carnitine palmitoyltransferase 1A
|
multiple interactions
|
EXP
|
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of CPT1A mRNA]
|
CTD |
PMID:26190035 |
|
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055
|
|
G
|
Fas
|
Fas cell surface death receptor
|
multiple interactions
|
EXP
|
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of FAS mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]
|
CTD |
PMID:26190035 |
|
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
|
|
G
|
Gclc
|
glutamate-cysteine ligase, catalytic subunit
|
multiple interactions
|
EXP
|
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein
|
CTD |
PMID:25716194 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
|
|
G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions
|
ISO EXP
|
quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of HMOX1 mRNA] [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 protein
|
CTD |
PMID:24929186 PMID:25716194 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G
|
Icam1
|
intercellular adhesion molecule 1
|
multiple interactions
|
ISO
|
quercetin 3-O-glucuronide inhibits the reaction [Lysophosphatidylcholines results in increased expression of ICAM1 mRNA]
|
CTD |
PMID:27257344 |
|
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
|
|
G
|
Ikbkb
|
inhibitor of nuclear factor kappa B kinase subunit beta
|
multiple interactions
|
ISO
|
quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IKBKB protein]
|
CTD |
PMID:23504962 |
|
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
EXP
|
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of IL1B protein]
|
CTD |
PMID:26190035 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
ISO
|
quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased secretion of IL6 protein]
|
CTD |
PMID:23504962 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G
|
Ins2
|
insulin 2
|
multiple interactions
|
ISO
|
quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased chemical synthesis of Nitric Oxide]]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]]
|
CTD |
PMID:23504962 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
|
|
G
|
Irs1
|
insulin receptor substrate 1
|
multiple interactions
|
ISO
|
quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of IRS1 protein]]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of IRS1 protein]
|
CTD |
PMID:23504962 |
|
NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
|
|
G
|
Jun
|
Jun proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
ISO
|
quercetin 3-O-glucuronide analog inhibits the reaction [AGT protein results in increased phosphorylation of JUN protein]
|
CTD |
PMID:12054679 |
|
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
|
|
G
|
Mmp2
|
matrix metallopeptidase 2
|
multiple interactions
|
ISO
|
quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA]
|
CTD |
PMID:24929186 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
|
|
G
|
Mmp9
|
matrix metallopeptidase 9
|
multiple interactions
|
ISO
|
quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased activity of MMP9 protein]; quercetin 3-O-glucuronide inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]
|
CTD |
PMID:24929186 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
|
|
G
|
Msr1
|
macrophage scavenger receptor 1
|
decreases expression
|
ISO
|
quercetin 3-O-glucuronide results in decreased expression of MSR1 mRNA
|
CTD |
PMID:18199750 |
|
NCBI chr16:52,717,775...52,803,602
Ensembl chr16:52,717,732...52,799,676
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
ISO
|
quercetin 3-O-glucuronide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]
|
CTD |
PMID:27257013 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G
|
Nos3
|
nitric oxide synthase 3
|
multiple interactions
|
ISO
|
quercetin 3-O-glucuronide inhibits the reaction [Palmitates inhibits the reaction [INS protein results in increased phosphorylation of NOS3 protein]]
|
CTD |
PMID:23504962 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
|
|
G
|
Ppara
|
peroxisome proliferator activated receptor alpha
|
multiple interactions
|
EXP
|
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA mRNA]; quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in decreased expression of PPARA protein]; quercetin 3-O-glucuronide inhibits the reaction [Dietary Fats results in decreased expression of PPARA protein]
|
CTD |
PMID:26190035 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
|
|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
increases expression
|
ISO
|
quercetin 3-O-glucuronide results in increased expression of PPARG mRNA
|
CTD |
PMID:25765892 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
|
|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
multiple interactions
|
ISO
|
quercetin 3-O-glucuronide inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]
|
CTD |
PMID:27257013 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
ISO
|
quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased phosphorylation of RELA protein]
|
CTD |
PMID:23504962 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
|
|
G
|
Slc22a8
|
solute carrier family 22 member 8
|
multiple interactions increases uptake
|
ISO
|
quercetin 3-O-glucuronide analog inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein]; quercetin 3-O-glucuronide inhibits the reaction [SLC22A8 protein results in increased transport of 4-carboxyfluorescein] SLC22A8 protein results in increased uptake of quercetin 3-O-glucuronide analog
|
CTD |
PMID:21244849 |
|
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
|
|
G
|
Srebf1
|
sterol regulatory element binding transcription factor 1
|
multiple interactions
|
EXP
|
quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of SREBF1 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]
|
CTD |
PMID:26190035 |
|
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
ISO EXP
|
quercetin 3-O-glucuronide inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with TNF protein] results in increased expression of VCAM1 protein]; quercetin 3-O-glucuronide inhibits the reaction [Palmitates results in increased secretion of TNF protein] quercetin 3-O-glucuronide inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of TNF protein]
|
CTD |
PMID:17880982 PMID:23504962 PMID:26190035 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
|
G
|
Tnfsf11
|
TNF superfamily member 11
|
decreases activity
|
ISO
|
quercetin 3-O-glucuronide results in decreased activity of TNFSF11 protein
|
CTD |
PMID:19495926 |
|
NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
|
|
G
|
Vcam1
|
vascular cell adhesion molecule 1
|
multiple interactions
|
ISO
|
quercetin 3-O-glucuronide inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with TNF protein] results in increased expression of VCAM1 protein]
|
CTD |
PMID:17880982 |
|
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
|
|
|
G
|
Ugt1a9
|
UDP glucuronosyltransferase family 1 member A9
|
increases abundance
|
ISO
|
UGT1A9 protein results in increased abundance of oxazepam glucuronide
|
CTD |
PMID:12386133 |
|
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
|
|
G
|
Ugt2b7
|
UDP glucuronosyltransferase family 2 member B7
|
increases abundance increases chemical synthesis
|
ISO
|
UGT2B7 protein results in increased abundance of oxazepam glucuronide UGT2B7 protein results in increased chemical synthesis of oxazepam glucuronide
|
CTD |
PMID:7773302 PMID:12386133 |
|
NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
|
|
|
G
|
App
|
amyloid beta precursor protein
|
multiple interactions
|
EXP
|
scutellarin inhibits the reaction [APP protein binds to APP protein]
|
CTD |
PMID:17323972 |
|
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
multiple interactions
|
ISO
|
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of BAX mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of BAX protein]
|
CTD |
PMID:34610774 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
multiple interactions
|
ISO
|
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of BCL2 mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of BCL2 protein]
|
CTD |
PMID:34610774 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G
|
Bcl2l1
|
Bcl2-like 1
|
multiple interactions
|
EXP
|
scutellarin inhibits the reaction [cobaltous chloride results in decreased expression of BCL2L1 mRNA]
|
CTD |
PMID:18442013 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
|
|
G
|
Casp1
|
caspase 1
|
multiple interactions
|
EXP
|
scutellarin inhibits the reaction [Streptozocin results in increased expression of CASP1 mRNA]
|
CTD |
PMID:37081038 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions
|
EXP ISO
|
scutellarin inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein] scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CASP3 mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CASP3 protein]; scutellarin inhibits the reaction [Zearalenone results in increased cleavage of CASP3 protein]
|
CTD |
PMID:18442013 PMID:34610774 PMID:36252740 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
|
|
G
|
Casp9
|
caspase 9
|
multiple interactions
|
ISO
|
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CASP9 mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CASP9 protein]
|
CTD |
PMID:34610774 |
|
Ensembl chr 5:154,109,046...154,126,626
|
|
G
|
Ep300
|
E1A binding protein p300
|
multiple interactions
|
ISO
|
scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]]
|
CTD |
PMID:25192544 |
|
NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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|
G
|
Fgf2
|
fibroblast growth factor 2
|
decreases expression
|
EXP
|
scutellarin results in decreased expression of FGF2 protein
|
CTD |
PMID:16297343 |
|
NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221
|
|
G
|
Gsdmd
|
gasdermin D
|
multiple interactions
|
EXP
|
scutellarin inhibits the reaction [Streptozocin results in increased expression of GSDMD protein]
|
CTD |
PMID:37081038 |
|
NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
|
|
G
|
Hif1a
|
hypoxia inducible factor 1 subunit alpha
|
multiple interactions decreases expression
|
ISO
|
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; epoxomicin inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; epoxomicin inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; MG 262 inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; MG 262 inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose co-treated with Cycloheximide] results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of and results in decreased ubiquitination of HIF1A protein]; scutellarin promotes the reaction [Cycloheximide inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]
|
CTD |
PMID:25192544 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
|
|
G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions
|
ISO
|
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 mRNA]
|
CTD |
PMID:34610774 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G
|
Ikbkb
|
inhibitor of nuclear factor kappa B kinase subunit beta
|
multiple interactions
|
ISO
|
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of IKBKB protein]
|
CTD |
PMID:34610774 |
|
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
|
|
G
|
Il18
|
interleukin 18
|
multiple interactions
|
EXP
|
scutellarin inhibits the reaction [Streptozocin results in increased expression of IL18 protein]
|
CTD |
PMID:37081038 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
ISO
|
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 mRNA]
|
CTD |
PMID:34610774 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G
|
Jun
|
Jun proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
ISO
|
scutellarin inhibits the reaction [Zearalenone results in increased expression of JUN protein]
|
CTD |
PMID:36252740 |
|
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
|
|
G
|
Keap1
|
Kelch-like ECH-associated protein 1
|
multiple interactions
|
ISO
|
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of KEAP1 mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of KEAP1 protein]
|
CTD |
PMID:34610774 |
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
|
|
G
|
Map2k4
|
mitogen activated protein kinase kinase 4
|
multiple interactions
|
ISO
|
scutellarin inhibits the reaction [Zearalenone results in increased expression of MAP2K4 protein]
|
CTD |
PMID:36252740 |
|
NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
|
|
G
|
Mki67
|
marker of proliferation Ki-67
|
multiple interactions
|
ISO
|
scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 protein]
|
CTD |
PMID:25192544 |
|
NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
|
|
G
|
Myd88
|
MYD88, innate immune signal transduction adaptor
|
multiple interactions
|
ISO
|
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of MYD88 mRNA]
|
CTD |
PMID:34610774 |
|
NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415
|
|
G
|
Nfe2l2
|
NFE2 like bZIP transcription factor 2
|
multiple interactions
|
ISO
|
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]
|
CTD |
PMID:34610774 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G
|
Nfkb1
|
nuclear factor kappa B subunit 1
|
multiple interactions
|
ISO
|
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 mRNA]
|
CTD |
PMID:34610774 |
|
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
|
|
G
|
Nfkbib
|
NFKB inhibitor beta
|
multiple interactions
|
ISO
|
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFKBIB mRNA]
|
CTD |
PMID:34610774 |
|
NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
|
|
G
|
Nlrp3
|
NLR family, pyrin domain containing 3
|
multiple interactions
|
EXP
|
scutellarin inhibits the reaction [Streptozocin results in increased expression of NLRP3 protein]
|
CTD |
PMID:37081038 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G
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Nos2
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nitric oxide synthase 2
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decreases expression
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EXP
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scutellarin results in decreased expression of NOS2 protein
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CTD |
PMID:16297343 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G
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Nos3
|
nitric oxide synthase 3
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increases expression
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EXP
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scutellarin results in increased expression of NOS3 protein
|
CTD |
PMID:16297343 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G
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Nppb
|
natriuretic peptide B
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multiple interactions
|
ISO
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scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NPPB protein]
|
CTD |
PMID:34610774 |
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NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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G
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Nqo1
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NAD(P)H quinone dehydrogenase 1
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multiple interactions
|
ISO
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scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NQO1 mRNA]
|
CTD |
PMID:34610774 |
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NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
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G
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Parp1
|
poly (ADP-ribose) polymerase 1
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multiple interactions
|
ISO
|
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of PARP1 mRNA]
|
CTD |
PMID:34610774 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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G
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Pcna
|
proliferating cell nuclear antigen
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multiple interactions
|
ISO
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scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of PCNA mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of PCNA protein]
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CTD |
PMID:25192544 |
|
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
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G
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Pkm
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pyruvate kinase M1/2
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increases activity
|
ISO
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scutellarin results in increased activity of PKM protein
|
CTD |
PMID:25388478 |
|
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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G
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Pla2g2a
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phospholipase A2 group IIA
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affects activity
|
ISO
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scutellarin affects the activity of PLA2G2A protein
|
CTD |
PMID:8190018 |
|
NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014
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G
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Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
ISO
|
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of RELA protein]
|
CTD |
PMID:34610774 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G
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Ripk1
|
receptor interacting serine/threonine kinase 1
|
multiple interactions
|
ISO
|
scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 mRNA]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 protein]
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CTD |
PMID:36252740 |
|
NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
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G
|
Tlr4
|
toll-like receptor 4
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multiple interactions
|
ISO
|
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TLR4 mRNA]
|
CTD |
PMID:34610774 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
ISO
|
scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF mRNA]; scutellarin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF protein]
|
CTD |
PMID:34610774 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
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G
|
Vegfa
|
vascular endothelial growth factor A
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decreases expression multiple interactions
|
EXP ISO
|
scutellarin results in decreased expression of VEGFA protein scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA protein]
|
CTD |
PMID:16297343 PMID:25192544 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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|
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G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
ISO
|
soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
|
CTD |
PMID:20923188 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G
|
Il6
|
interleukin 6
|
multiple interactions
|
ISO
|
soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
|
CTD |
PMID:20923188 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G
|
Nfkbia
|
NFKB inhibitor alpha
|
multiple interactions
|
ISO
|
soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased degradation of and results in increased phosphorylation of NFKBIA protein]
|
CTD |
PMID:20923188 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
|
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G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
ISO
|
soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased secretion of NOS2 protein]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]
|
CTD |
PMID:20923188 PMID:21397503 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
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G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
multiple interactions
|
ISO
|
soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]
|
CTD |
PMID:20923188 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
ISO
|
soyasaponin I inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]
|
CTD |
PMID:20923188 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G
|
Ren
|
renin
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decreases activity
|
ISO
|
soyasaponin I results in decreased activity of REN protein
|
CTD |
PMID:19060406 PMID:20460744 |
|
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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G
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St3gal4
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ST3 beta-galactoside alpha-2,3-sialyltransferase 4
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decreases expression
|
ISO
|
soyasaponin I results in decreased expression of ST3GAL4 mRNA
|
CTD |
PMID:15661230 |
|
NCBI chr 8:33,415,666...33,465,319
Ensembl chr 8:33,415,671...33,524,389
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G
|
Tnf
|
tumor necrosis factor
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multiple interactions
|
ISO
|
soyasaponin I inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
|
CTD |
PMID:20923188 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
|
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G
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Kl
|
Klotho
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multiple interactions
|
ISO
|
testosterone glucuronate inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides]
|
CTD |
PMID:14701853 |
|
NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080
|
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|
G
|
Alb
|
albumin
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affects binding
|
ISO
|
tolmetin glucuronide binds to ALB protein
|
CTD |
PMID:8027947 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
|
|
G
|
Ccl2
|
C-C motif chemokine ligand 2
|
increases expression
|
ISO
|
tolmetin glucuronide analog results in increased expression of CCL2 mRNA
|
CTD |
PMID:24104198 |
|
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G
|
Cd69
|
Cd69 molecule
|
increases expression
|
ISO
|
tolmetin glucuronide results in increased expression of CD69 mRNA
|
CTD |
PMID:26528891 |
|
NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
|
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G
|
Cxcr1
|
C-X-C motif chemokine receptor 1
|
increases expression
|
ISO
|
tolmetin glucuronide results in increased expression of CXCR1 mRNA
|
CTD |
PMID:26528891 |
|
NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084
|
|
G
|
Ifng
|
interferon gamma
|
increases expression
|
ISO
|
tolmetin glucuronide results in increased expression of IFNG mRNA
|
CTD |
PMID:26528891 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
|
|
G
|
Il1a
|
interleukin 1 alpha
|
increases expression
|
ISO
|
tolmetin glucuronide results in increased expression of IL1A mRNA
|
CTD |
PMID:26528891 |
|
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
|
|
G
|
Il6
|
interleukin 6
|
increases expression
|
ISO
|
tolmetin glucuronide results in increased expression of IL6 mRNA
|
CTD |
PMID:26528891 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G
|
Lcp2
|
lymphocyte cytosolic protein 2
|
increases expression
|
ISO
|
tolmetin glucuronide results in increased expression of LCP2 mRNA
|
CTD |
PMID:26528891 |
|
NCBI chr10:18,642,600...18,689,562
Ensembl chr10:18,642,658...18,689,559
|
|
G
|
Mgst1
|
microsomal glutathione S-transferase 1
|
increases expression
|
ISO
|
tolmetin glucuronide results in increased expression of MGST1 mRNA
|
CTD |
PMID:26528891 |
|
NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892
|
|
G
|
Mt1-ps3
|
metallothionein 1, pseudogene 3
|
increases expression
|
ISO
|
tolmetin glucuronide results in increased expression of MT1E mRNA
|
CTD |
PMID:26528891 |
|
NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135
|
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G
|
Mt2
|
metallothionein 2
|
increases expression
|
ISO
|
tolmetin glucuronide results in increased expression of MT2A mRNA
|
CTD |
PMID:26528891 |
|
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
|
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G
|
Nampt
|
nicotinamide phosphoribosyltransferase
|
increases expression
|
ISO
|
tolmetin glucuronide results in increased expression of NAMPT mRNA
|
CTD |
PMID:26528891 |
|
NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
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|
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G
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Apeh
|
acylaminoacyl-peptide hydrolase
|
multiple interactions increases metabolic processing
|
ISO
|
Carbapenems inhibits the reaction [APEH protein results in increased metabolism of valproic acid glucuronide]
|
CTD |
PMID:20551238 |
|
NCBI chr 8:108,773,791...108,782,903
Ensembl chr 8:108,773,794...108,782,933
|
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