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ONTOLOGY REPORT - ANNOTATIONS


Term:labetalol
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Accession:CHEBI:6343 term browser browse the term
Definition:A secondary amino compound formally derived from ammonia by replacing two of the hydrogens by 2-(3-carbamoyl-4-hydroxyphenyl)-2-hydroxyethyl and 4-phenylbutan-2-yl groups. It is an adrenergic antagonist used to treat high blood pressure.
Synonyms:exact_synonym: 2-hydroxy-5-{1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl}benzamide
 related_synonym: 3-Carboxamido-4-hydroxy-alpha-((1-methyl-3-phenylpropylamino)methyl)benzyl alcohol;   5-(1-Hydroxy-2-(1-methyl-3-phenylpropylamino)ethyl)salicylamide;   Formula=C19H24N2O3;   InChI=1S/C19H24N2O3/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24);   InChIKey=SGUAFYQXFOLMHL-UHFFFAOYSA-N;   SMILES=CC(CCc1ccccc1)NCC(O)c1ccc(O)c(c1)C(N)=O;   kabetalol;   labetalolum
 xref: Beilstein:2948416 "Beilstein";   CAS:36894-69-6 "ChemIDplus";   DrugBank:DB00598;   Drug_Central:1531 "DrugCentral";   HMDB:HMDB0014736;   KEGG:C07063;   KEGG:D08106;   LINCS:LSM-1282
 xref_mesh: MESH:D007741
 xref: PMID:21908132 "Europe PMC";   PMID:22300487 "Europe PMC";   PMID:22528277 "Europe PMC";   PMID:23055089 "Europe PMC";   PMID:28166217 "Europe PMC";   Patent:DE2032642;   Patent:US4012444;   Reaxys:2948416 "Reaxys";   Wikipedia:Labetalol


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labetalol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb4 ATP binding cassette subfamily B member 4 JBrowse link 4 22,133,984 22,192,687 RGD:6480464
G Adrb1 adrenoceptor beta 1 JBrowse link 1 277,537,585 277,538,985 RGD:6480464
G Adrb2 adrenoceptor beta 2 JBrowse link 18 57,513,792 57,515,834 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Avp arginine vasopressin JBrowse link 3 123,117,482 123,119,460 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Nppa natriuretic peptide A JBrowse link 5 164,808,407 164,809,716 RGD:6480464
G Prl prolactin JBrowse link 17 39,814,236 39,824,299 RGD:6480464
G Ren renin JBrowse link 13 50,502,724 50,513,953 RGD:6480464
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:6480464
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 JBrowse link 14 22,597,103 22,619,968 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19657
    role 19601
      application 19225
        pharmaceutical 19089
          drug 19089
            cardiovascular drug 7552
              antihypertensive agent 1637
                labetalol 12
Path 2
Term Annotations click to browse term
  CHEBI ontology 19657
    subatomic particle 19653
      composite particle 19653
        hadron 19653
          baryon 19653
            nucleon 19653
              atomic nucleus 19653
                atom 19653
                  main group element atom 19534
                    p-block element atom 19534
                      carbon group element atom 19417
                        carbon atom 19409
                          organic molecular entity 19409
                            organic group 18338
                              organic divalent group 18329
                                organodiyl group 18329
                                  carbonyl group 18218
                                    carbonyl compound 18218
                                      carboxylic acid 17918
                                        carboacyl group 16941
                                          univalent carboacyl group 16941
                                            carbamoyl group 16621
                                              carboxamide 16621
                                                monocarboxylic acid amide 13181
                                                  arenecarboxamide 6406
                                                    benzamides 6406
                                                      labetalol 12
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