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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:etoricoxib
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Accession:CHEBI:6339 term browser browse the term
Definition:A member of the class of bipyridines that is 2,3'-bipyridine which is substituted at the 3, 5, and 6' positions by 4-(methylsulfonyl)phenyl, chlorine, and methyl groups, respectively.
Synonyms:exact_synonym: 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine
 related_synonym: 5-Chloro-3-(4-methanesulfonyl-phenyl)-6'-methyl-[2,3']bipyridinyl;   5-chloro-2-(6-methylpyridin-3-yl)-3-(4-(methylsulfonyl)phenyl)pyridine;   5-chloro-6'-methyl-3-(p-(methylsulfonyl)phenyl)-2,3'-bipyridine;   Formula=C18H15ClN2O2S;   InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-13)24(2,22)23/h3-11H,1-2H3;   InChIKey=MNJVRJDLRVPLFE-UHFFFAOYSA-N;   L791456;   SMILES=Cc1ccc(cn1)-c1ncc(Cl)cc1-c1ccc(cc1)S(C)(=O)=O;   etoricoxibum
 alt_id: CHEBI:106706
 xref: CAS:202409-33-4;   DrugBank:DB01628;   Drug_Central:1113;   KEGG:C11718;   KEGG:D03710;   LINCS:LSM-5650
 xref_mesh: MESH:C422649
 xref: PDBeChem:5CH;   PMID:11327589;   PMID:14761182;   PMID:15239665;   PMID:15454242;   PMID:15916445;   Wikipedia:Etoricoxib


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etoricoxib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO etoricoxib results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Etoricoxib inhibits the reaction [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in increased activity of AHR protein] CTD PMID:37890551 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression		 ISO 2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester promotes the reaction [Etoricoxib results in increased expression of CYP1A1 protein]
Etoricoxib results in increased expression of CYP1A1 mRNA; Etoricoxib results in increased expression of CYP1A1 protein		 CTD PMID:37890551 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO etoricoxib results in decreased activity of CYP1A2 protein CTD PMID:18816299 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing ISO CYP3A4 protein results in increased metabolism of Etoricoxib CTD PMID:18084859 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO etoricoxib results in decreased expression of ICAM1 mRNA; etoricoxib results in decreased expression of ICAM1 protein CTD PMID:17931847 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity		 EXP
ISO		 etoricoxib inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein]
etoricoxib results in decreased activity of PTGS2 protein; etoricoxib results in decreased activity of PTGS2 protein mutant form		 CTD PMID:17164136 PMID:17638016 PMID:22245433 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19831
    role 19807
      application 19650
        anti-inflammatory agent 16605
          anti-inflammatory drug 14947
            non-steroidal anti-inflammatory drug 14262
              etoricoxib 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19831
    subatomic particle 19829
      composite particle 19829
        hadron 19829
          baryon 19829
            nucleon 19829
              atomic nucleus 19829
                atom 19829
                  main group element atom 19779
                    p-block element atom 19779
                      carbon group element atom 19728
                        carbon atom 19724
                          organic molecular entity 19724
                            organic molecule 19677
                              organic cyclic compound 19490
                                organic heterocyclic compound 18852
                                  organonitrogen heterocyclic compound 18148
                                    bipyridines 4250
                                      etoricoxib 7
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