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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hexose derivative
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Accession:CHEBI:63385 term browser browse the term
Definition:A monosaccharide derivative that is formally obtained from a hexose.
Synonyms:related_synonym: hexose derivatives


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3-O-methyl-D-glucose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a1 solute carrier family 2 member 1 multiple interactions
increases uptake
decreases transport
ISO Pentobarbital inhibits the reaction [SLC2A1 protein results in increased uptake of 3-O-Methylglucose]; Pentobarbital promotes the reaction [SLC2A1 gene polymorphism results in decreased uptake of 3-O-Methylglucose]; Phenobarbital inhibits the reaction [SLC2A1 protein results in increased uptake of 3-O-Methylglucose]; Phenobarbital promotes the reaction [SLC2A1 gene polymorphism results in decreased uptake of 3-O-Methylglucose]
SLC2A1 protein mutant form results in decreased transport of 3-O-Methylglucose
CTD PMID:10590023, PMID:11603379 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a2 solute carrier family 2 member 2 multiple interactions
increases uptake
ISO
EXP
Fluorouracil promotes the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]; Phloretin inhibits the reaction [Fluorouracil promotes the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]]; Phloretin inhibits the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]
Cytochalasin B inhibits the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]; Mercuric Chloride inhibits the reaction [SLC2A2 protein results in increased uptake of 3-O-Methylglucose]
CTD PMID:10825458, PMID:15986457 NCBI chr 2:114,413,427...114,445,418
Ensembl chr 2:114,413,410...114,445,395
JBrowse link
alpha-D-galactose 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Galk1 galactokinase 1 multiple interactions ISO [Enzyme Inhibitors binds to and results in decreased activity of GALK1 protein] which results in decreased abundance of galactose-1-phosphate; [GALK1 protein results in increased metabolism of Galactose] which results in increased abundance of galactose-1-phosphate CTD PMID:20696150 NCBI chr10:104,560,322...104,564,499
Ensembl chr10:104,560,303...104,564,480
JBrowse link
alpha-D-glucose 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of glucose-1-phosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of glucose-1-phosphate]
CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
beta-D-fructofuranose 1,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] CTD PMID:15788719 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate]
CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22227475 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22227475 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases degradation
ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA
CTD PMID:22227475 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
beta-D-fructofuranose 2,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pfkm phosphofructokinase, muscle multiple interactions ISO fructose 2,6-diphosphate inhibits the reaction [resveratrol results in decreased activity of PFKM protein] CTD PMID:23454376 NCBI chr 7:139,702,066...139,722,132
Ensembl chr 7:139,685,573...139,722,132
JBrowse link
D-fructofuranose 1,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] CTD PMID:15788719 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate]
CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22227475 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22227475 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases degradation
ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA
CTD PMID:22227475 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
D-galactopyranose 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Galk1 galactokinase 1 multiple interactions ISO [Enzyme Inhibitors binds to and results in decreased activity of GALK1 protein] which results in decreased abundance of galactose-1-phosphate; [GALK1 protein results in increased metabolism of Galactose] which results in increased abundance of galactose-1-phosphate CTD PMID:20696150 NCBI chr10:104,560,322...104,564,499
Ensembl chr10:104,560,303...104,564,480
JBrowse link
D-glucopyranose 6-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G G6pc2 glucose-6-phosphatase catalytic subunit 2 increases hydrolysis ISO G6PC2 protein results in increased hydrolysis of Glucose-6-Phosphate CTD PMID:14722102 NCBI chr 3:55,464,528...55,467,170 JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO [Glycerol co-treated with Succinic Acid co-treated with Glucose-6-Phosphate co-treated with Pantothenic Acid co-treated with Niacinamide] results in increased expression of NR4A1 mRNA CTD PMID:20505214 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
D-mannopyranose 6-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO mannose-6-phosphate affects the reaction [GUSB protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]] CTD PMID:26438400 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO mannose-6-phosphate affects the reaction [GUSB protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]] CTD PMID:26438400 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
D-mannose 6-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO mannose-6-phosphate affects the reaction [GUSB protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]] CTD PMID:26438400 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Gusb glucuronidase, beta multiple interactions ISO mannose-6-phosphate affects the reaction [GUSB protein affects the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]] CTD PMID:26438400 NCBI chr12:30,202,066...30,215,583
Ensembl chr12:30,198,822...30,227,771
JBrowse link
keto-D-fructose 1,6-bisphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased chemical synthesis of sodium arsenite; [GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog; heptelidic acid inhibits the reaction [[GAPDH protein co-treated with fructose-1,6-diphosphate co-treated with NAD] results in increased reduction of sodium arsenate analog] CTD PMID:15788719 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of fructose-1,6-diphosphate] CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:22227475 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:22227475 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases degradation
ISO fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; fructose-1,6-diphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
fructose-1,6-diphosphate results in decreased degradation of NOS2 mRNA
CTD PMID:22227475 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
phosphoramidon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen multiple interactions EXP phosphoramidon inhibits the reaction [AGT protein results in increased expression of EDNRA protein] CTD PMID:15007106 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein] CTD PMID:15177934 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ece1 endothelin converting enzyme 1 multiple interactions EXP EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]]; phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]; phosphoramidon inhibits the reaction [Indomethacin results in increased expression of ECE1 protein] CTD PMID:11145282, PMID:16280098 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
G Edn1 endothelin 1 decreases expression
multiple interactions
EXP phosphoramidon results in decreased expression of EDN1 protein
EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased activity of ECE1 protein]]; EDN1 protein inhibits the reaction [phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]]; phosphoramidon inhibits the reaction [Indomethacin results in increased expression of EDN1 protein]
CTD PMID:11145282, PMID:16280098, PMID:16391412 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednra endothelin receptor type A multiple interactions EXP phosphoramidon inhibits the reaction [AGT protein results in increased expression of EDNRA protein]; phosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein] CTD PMID:15007106 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G Ednrb endothelin receptor type B increases expression EXP phosphoramidon results in increased expression of EDNRB protein CTD PMID:15007106 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein] CTD PMID:15177934 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP phosphoramidon inhibits the reaction [Morphine results in decreased expression of ICAM1 protein alternative form] CTD PMID:10070497 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Kel Kell metallo-endopeptidase (Kell blood group) multiple interactions ISO KEL protein alternative form binds to and affects the metabolism of phosphoramidon CTD PMID:15769748 NCBI chr 4:70,979,504...70,996,920
Ensembl chr 4:70,979,504...70,996,395
JBrowse link
G Lep leptin decreases expression EXP phosphoramidon results in decreased expression of LEP protein CTD PMID:16391412 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:15177934 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:15177934 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions EXP phosphoramidon inhibits the reaction [Morphine results in increased activity of MME protein] CTD PMID:10070497 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Nts neurotensin multiple interactions ISO phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; phosphoramidon inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:15177934 NCBI chr 7:44,111,594...44,120,998
Ensembl chr 7:44,111,151...44,121,130
JBrowse link
G Sell selectin L multiple interactions EXP phosphoramidon inhibits the reaction [Morphine results in decreased expression of SELL protein alternative form] CTD PMID:10070497 NCBI chr13:82,369,820...82,387,774
Ensembl chr13:82,369,493...82,387,631
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP [TAC1 protein co-treated with phosphoramidon] results in increased uptake of Oxygen CTD PMID:9808699 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
topiramate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
EXP Amino Acids, Peptides, and Proteins inhibits the reaction [topiramate results in increased expression of ABCB1 protein] CTD PMID:18473823 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression EXP topiramate results in increased expression of ABCC1 protein CTD PMID:18473823 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP topiramate results in increased expression of ABCC2 protein CTD PMID:18473823 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Acadsb acyl-CoA dehydrogenase, short/branched chain increases expression EXP topiramate results in increased expression of ACADSB mRNA CTD PMID:16979414 NCBI chr 1:201,981,362...202,022,771
Ensembl chr 1:201,981,357...202,021,008
JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 decreases expression EXP topiramate results in decreased expression of ACSL4 mRNA CTD PMID:16979414 NCBI chr  X:113,596,247...113,660,024
Ensembl chr  X:113,596,239...113,659,944
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression
increases secretion
ISO topiramate results in increased expression of ADIPOQ mRNA
topiramate results in increased secretion of ADIPOQ protein
CTD PMID:12927809 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adra2a adrenoceptor alpha 2A increases expression ISO topiramate results in increased expression of ADRA2A mRNA CTD PMID:22489711 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Agxt alanine--glyoxylate and serine--pyruvate aminotransferase increases expression EXP topiramate results in increased expression of AGXT mRNA CTD PMID:16979414 NCBI chr 9:100,281,339...100,291,292
Ensembl chr 9:100,281,339...100,291,291
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of AKT1 protein] CTD PMID:29753867 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression EXP topiramate results in decreased expression of ASS1 mRNA CTD PMID:16979414 NCBI chr 3:10,327,411...10,375,847
Ensembl chr 3:10,327,414...10,375,826
JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression EXP topiramate results in decreased expression of AVPR1A mRNA CTD PMID:16979414 NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of BDNF protein] CTD PMID:29753867 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Ca12 carbonic anhydrase 12 decreases activity ISO topiramate results in decreased activity of CA12 protein CTD PMID:21314129 NCBI chr 8:72,405,770...72,461,425
Ensembl chr 8:72,405,748...72,460,240
JBrowse link
G Ca3 carbonic anhydrase 3 multiple interactions ISO topiramate binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP Topiramate inhibits the reaction [Potassium Chloride results in increased secretion of CALCA protein]; Topiramate inhibits the reaction [Protons results in increased secretion of CALCA protein]; Topiramate inhibits the reaction [S-nitro-N-acetylpenicillamine results in increased secretion of CALCA protein] CTD PMID:16942474 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911
JBrowse link
G Capn6 calpain 6 increases expression EXP topiramate results in increased expression of CAPN6 mRNA CTD PMID:16979414 NCBI chr  X:115,049,113...115,073,824
Ensembl chr  X:115,049,154...115,073,890
JBrowse link
G Car1 carbonic anhydrase 1 multiple interactions ISO topiramate binds to and results in decreased activity of CA1 protein CTD PMID:17826101 NCBI chr 2:88,185,204...88,227,486
Ensembl chr 2:88,217,188...88,227,479
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions
decreases activity
ISO topiramate binds to and results in decreased activity of CA2 protein
topiramate results in decreased activity of CA2 protein
CTD PMID:17826101, PMID:21314129 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Casp3 caspase 3 affects expression
multiple interactions
EXP topiramate affects the expression of CASP3 mRNA; topiramate affects the expression of CASP3 protein
topiramate inhibits the reaction [3-nitropropionic acid results in increased activity of CASP3 protein]
CTD PMID:19148780, PMID:29753867 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression EXP topiramate results in decreased expression of CEBPA mRNA CTD PMID:16979414 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Chka choline kinase alpha decreases expression EXP topiramate results in decreased expression of CHKA mRNA CTD PMID:16979414 NCBI chr 1:219,076,618...219,126,221
Ensembl chr 1:219,077,771...219,126,220
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit decreases expression EXP topiramate results in decreased expression of CHRNA7 mRNA CTD PMID:16979414 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression EXP topiramate results in decreased expression of CITED2 mRNA CTD PMID:16979414 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Cnr1 cannabinoid receptor 1 affects expression ISO topiramate affects the expression of CNR1 mRNA CTD PMID:22017514 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of CREB1 protein] CTD PMID:29753867 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases activity ISO topiramate results in decreased activity of CYP17A1 protein CTD PMID:15730543 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Drd2 dopamine receptor D2 increases expression ISO topiramate results in increased expression of DRD2 mRNA CTD PMID:22489711 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression EXP topiramate results in increased expression of DUSP1 mRNA CTD PMID:16979414 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Fabp3 fatty acid binding protein 3 decreases expression EXP topiramate results in decreased expression of FABP3 mRNA CTD PMID:16979414 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions EXP topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate inhibits the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA2 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides]; topiramate promotes the reaction [[gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein co-treated with GABRB2 protein co-treated with GABRG2 protein]] which results in increased transport of Chlorides] CTD PMID:11123204 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Glul glutamate-ammonia ligase decreases activity ISO topiramate results in decreased activity of GLUL protein CTD PMID:10323596 NCBI chr13:71,331,052...71,340,207
Ensembl chr13:71,331,052...71,340,229
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP topiramate results in decreased expression of GNAI2 mRNA CTD PMID:16979414 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 increases expression EXP topiramate results in increased expression of GOT2 mRNA CTD PMID:16979414 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial decreases expression EXP topiramate results in decreased expression of GPAM mRNA CTD PMID:16979414 NCBI chr 1:275,843,823...275,906,880
Ensembl chr 1:275,846,819...275,906,686
JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 increases expression EXP topiramate results in increased expression of GPD2 mRNA CTD PMID:16979414 NCBI chr 3:43,223,892...43,359,069
Ensembl chr 3:43,255,567...43,359,074
JBrowse link
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased expression of GRIA2 mRNA] CTD PMID:29753867 NCBI chr 2:179,584,302...179,704,629
Ensembl chr 2:179,584,308...179,704,629
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 affects response to substance ISO GRIK1 gene SNP affects the susceptibility to topiramate CTD PMID:19331489 NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in decreased phosphorylation of GSK3B protein] CTD PMID:29753867 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gtf2a2 general transcription factor 2A subunit 2 increases expression EXP topiramate results in increased expression of GTF2A2 mRNA CTD PMID:16979414 NCBI chr 8:76,422,341...76,435,587
Ensembl chr 8:76,422,359...76,435,473
JBrowse link
G Gyg1 glycogenin 1 decreases expression EXP topiramate results in decreased expression of GYG1 mRNA CTD PMID:16979414 NCBI chr 2:104,916,734...104,958,219
Ensembl chr 2:104,916,738...104,958,034
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP topiramate results in increased expression of HMGCS1 mRNA CTD PMID:16979414 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 decreases activity ISO topiramate results in decreased activity of HSD3B2 protein CTD PMID:15730543 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP topiramate results in increased expression of IDI1 mRNA CTD PMID:16979414 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Ifi30 IFI30, lysosomal thiol reductase multiple interactions EXP [topiramate co-treated with Trinitrobenzenesulfonic Acid] results in decreased expression of IFI30 mRNA CTD PMID:21849664 NCBI chr16:20,426,566...20,430,772
Ensembl chr16:20,426,566...20,430,752
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression EXP topiramate results in decreased expression of IGF1 mRNA CTD PMID:16979414 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases expression EXP topiramate results in increased expression of ITPR1 mRNA CTD PMID:16979414 NCBI chr 4:140,247,297...140,580,749
Ensembl chr 4:140,247,313...140,580,748
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO topiramate results in decreased activity of KCNH2 protein CTD PMID:15716081 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G LOC100364500 RT1 class I, locus CE11-like affects expression ISO topiramate affects the expression of HLA-A mRNA CTD PMID:25811541 NCBI chr20:2,704,153...2,707,111
Ensembl chr20:2,704,148...2,707,120
JBrowse link
G Me1 malic enzyme 1 decreases expression EXP topiramate results in decreased expression of ME1 mRNA CTD PMID:16979414 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Mvd mevalonate diphosphate decarboxylase increases expression EXP topiramate results in increased expression of MVD mRNA CTD PMID:16979414 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP topiramate results in increased expression of NOS2 protein CTD PMID:14511393 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Npy neuropeptide Y increases expression EXP topiramate results in increased expression of NPY protein CTD PMID:17572454 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO topiramate results in increased activity of NR1I2 protein CTD PMID:14636322 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr2f2 nuclear receptor subfamily 2, group F, member 2 decreases expression EXP topiramate results in decreased expression of NR2F2 mRNA CTD PMID:16979414 NCBI chr 1:131,447,671...131,465,749
Ensembl chr 1:131,448,447...131,460,473
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression EXP topiramate results in decreased expression of NR4A2 mRNA CTD PMID:16979414 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Pde4b phosphodiesterase 4B decreases expression EXP topiramate results in decreased expression of PDE4B mRNA CTD PMID:16979414 NCBI chr 5:121,759,236...122,136,814
Ensembl chr 5:121,952,977...122,136,814
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression EXP topiramate results in decreased expression of PDK4 mRNA CTD PMID:16979414 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pick1 protein interacting with PRKCA 1 multiple interactions EXP topiramate inhibits the reaction [3-nitropropionic acid results in increased expression of PICK1 protein] CTD PMID:29753867 NCBI chr 7:120,465,472...120,484,824
Ensembl chr 7:120,465,130...120,484,840
JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression EXP topiramate results in decreased expression of PLCD4 mRNA CTD PMID:16979414 NCBI chr 9:81,816,395...81,844,364
Ensembl chr 9:81,816,872...81,844,364
JBrowse link
G Pld1 phospholipase D1 increases expression EXP topiramate results in increased expression of PLD1 mRNA CTD PMID:16979414 NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
JBrowse link
G Ppp5c protein phosphatase 5, catalytic subunit increases expression EXP topiramate results in increased expression of PPP5C mRNA CTD PMID:16979414 NCBI chr 1:78,944,054...78,968,361
Ensembl chr 1:78,944,040...78,968,329
JBrowse link
G Prkag1 protein kinase AMP-activated non-catalytic subunit gamma 1 decreases expression EXP topiramate results in decreased expression of PRKAG1 mRNA CTD PMID:16979414 NCBI chr 7:140,489,499...140,506,925
Ensembl chr 7:140,489,492...140,546,908
JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta decreases expression EXP topiramate results in decreased expression of PRKAR2B mRNA CTD PMID:16979414 NCBI chr 6:51,265,509...51,356,383
Ensembl chr 6:51,265,515...51,356,383
JBrowse link
G RT1-DMb RT1 class II, locus DMb affects expression ISO topiramate affects the expression of HLA-DMB mRNA CTD PMID:25811541 NCBI chr20:3,945,383...3,952,838
Ensembl chr20:5,227,045...5,234,290
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP topiramate results in decreased expression of SCD1 mRNA CTD PMID:16979414 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Slc16a1 solute carrier family 16 member 1 increases expression EXP topiramate results in increased expression of SLC16A1 mRNA CTD PMID:16979414 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
JBrowse link
G Slc37a4 solute carrier family 37 member 4 decreases expression EXP topiramate results in decreased expression of SLC37A4 mRNA CTD PMID:16979414 NCBI chr 8:48,716,914...48,723,024
Ensembl chr 8:48,716,939...48,723,024
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO topiramate affects the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc6a6 solute carrier family 6 member 6 decreases expression EXP topiramate results in decreased expression of SLC6A6 mRNA CTD PMID:16979414 NCBI chr 4:123,638,619...123,713,469
Ensembl chr 4:123,642,210...123,713,464
JBrowse link
G Slc7a1 solute carrier family 7 member 1 decreases expression EXP topiramate results in decreased expression of SLC7A1 mRNA CTD PMID:16979414 NCBI chr12:8,032,775...8,108,972
Ensembl chr12:8,032,809...8,108,972
JBrowse link
G Sqle squalene epoxidase decreases expression EXP topiramate results in decreased expression of SQLE mRNA CTD PMID:16979414 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression EXP topiramate results in increased expression of SREBF1 mRNA CTD PMID:16979414 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Th tyrosine hydroxylase affects expression
increases expression
ISO topiramate affects the expression of TH mRNA
topiramate results in increased expression of TH mRNA
CTD PMID:22017514, PMID:22489711 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP topiramate inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TRPV1 mRNA] CTD PMID:21849664 NCBI chr10:59,799,123...59,824,208
Ensembl chr10:59,799,123...59,824,679
JBrowse link
G Ucp3 uncoupling protein 3 decreases expression EXP topiramate results in decreased expression of UCP3 mRNA CTD PMID:16979414 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 affects response to substance ISO UGT2B7 gene SNP affects the susceptibility to topiramate CTD PMID:18686368 NCBI chr14:22,597,103...22,619,968 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      atom 19782
        nonmetal atom 19657
          oxygen atom 19321
            oxygen molecular entity 19321
              organooxygen compound 18777
                carbohydrates and carbohydrate derivatives 12178
                  carbohydrate derivative 11802
                    monosaccharide derivative 2683
                      hexose derivative 105
                        D-hexose derivative + 2
                        aldohexose derivative + 2
                        hexose phosphate + 25
                        ketoaldohexose derivative 0
                        ketohexose derivative + 80
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            heteroorganic entity 19147
                              organochalcogen compound 18855
                                organooxygen compound 18777
                                  carbohydrates and carbohydrate derivatives 12178
                                    carbohydrate 12178
                                      monosaccharide 4022
                                        hexose 2297
                                          hexose derivative 105
                                            D-hexose derivative + 2
                                            aldohexose derivative + 2
                                            hexose phosphate + 25
                                            ketoaldohexose derivative 0
                                            ketohexose derivative + 80
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.