disaccharide derivative - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	disaccharide derivative	go back to main search page
Accession:	CHEBI:63353	browse the term
Definition:	A carbohydrate derivative that is formally obtained from a disaccharide.
Synonyms:	related_synonym:	disaccharide derivatives

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Rat (464) Mouse (462) Human (462) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (4) Green Monkey (0) Naked Mole-rat (0) All
Genes (464)

(R)-amygdalin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

multiple interactions

Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

fibronectin 1

multiple interactions

Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

heparanase

multiple interactions

Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of HPSE protein]
Amygdalin inhibits the reaction [Ovalbumin results in increased expression of HPSE protein]; Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of HPSE protein]

NCBI chr14:8,896,593...8,937,011
Ensembl chr14:8,896,593...8,937,010

G

prostaglandin-endoperoxide synthase 1

multiple interactions

[peoniflorin co-treated with benzoylpaeoniflorin co-treated with Amygdalin] inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS1 mRNA]; Amygdalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS1 mRNA]

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[peoniflorin co-treated with benzoylpaeoniflorin co-treated with Amygdalin] inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Amygdalin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

transforming growth factor, beta 1

multiple interactions

Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of HPSE protein]; Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; Amygdalin inhibits the reaction [TGFB1 protein results in increased secretion of TGFB1 protein]
Amygdalin inhibits the reaction [Ovalbumin results in increased secretion of TGFB1 protein]; Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of FN1 mRNA]; Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of FN1 protein]; Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of HPSE protein]; Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; Amygdalin inhibits the reaction [TGFB1 protein results in increased secretion of TGFB1 protein]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

vimentin

multiple interactions

Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; Amygdalin inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

lac dye inhibits the reaction [Dietary Fats results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

DNA methyltransferase 1

decreases activity

lac dye results in decreased activity of DNMT1 protein

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

enhancer of zeste 2 polycomb repressive complex 2 subunit

multiple interactions

lac dye inhibits the reaction [Dietary Fats results in decreased expression of EZH2 mRNA]

NCBI chr 4:76,624,399...76,687,362
Ensembl chr 4:76,624,399...76,687,362

G

forkhead box O1

multiple interactions

lac dye inhibits the reaction [Dietary Fats results in increased expression of and results in decreased phosphorylation of FOXO1 protein]; lac dye inhibits the reaction [Dietary Fats results in increased expression of FOXO1 mRNA]

NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

lac dye inhibits the reaction [Dietary Fats results in increased expression of G6PC1 mRNA]

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glutamic--pyruvic transaminase

multiple interactions

lac dye inhibits the reaction [Dietary Fats results in increased expression of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glycogen synthase kinase 3 beta

multiple interactions

lac dye inhibits the reaction [Dietary Fats results in decreased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

interleukin 1 beta

multiple interactions

lac dye inhibits the reaction [Dietary Fats results in increased expression of IL1B mRNA]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

lac dye inhibits the reaction [Dietary Fats results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

lac dye inhibits the reaction [Dietary Fats results in increased expression of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

mitogen activated protein kinase 1

multiple interactions

lac dye inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

lac dye inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

phosphoenolpyruvate carboxykinase 1

multiple interactions

lac dye inhibits the reaction [Dietary Fats results in increased expression of PCK1 mRNA]

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

lac dye inhibits the reaction [Dietary Fats results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

tumor necrosis factor

multiple interactions

lac dye inhibits the reaction [Dietary Fats results in increased expression of TNF mRNA]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

acteoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

actin alpha 2, smooth muscle

decreases expression

acteoside results in decreased expression of ACTA2 protein

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

advanced glycosylation end product-specific receptor

decreases expression

acteoside results in decreased expression of AGER protein

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

aryl hydrocarbon receptor

multiple interactions
decreases localization

acteoside promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]
acteoside results in decreased localization of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aryl hydrocarbon receptor nuclear translocator

increases localization

acteoside results in increased localization of ARNT protein

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

C-C motif chemokine ligand 2

decreases expression
multiple interactions
decreases secretion

acteoside results in decreased expression of CCL2 mRNA
acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]
acteoside results in decreased secretion of CCL2 protein

PMID:21756928 PMID:21967610

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin D1

decreases expression

acteoside results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D2

decreases expression

acteoside results in decreased expression of CCND2 protein

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

G

cyclin D3

decreases expression

acteoside results in decreased expression of CCND3 protein

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin E1

decreases expression

acteoside results in decreased expression of CCNE1 protein

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cadherin 1

increases expression

acteoside results in increased expression of CDH1 protein

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cyclin dependent kinase 2

multiple interactions

acteoside results in decreased expression of and results in decreased activity of CDK2 protein

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

decreases activity
multiple interactions

acteoside results in decreased activity of CDK4 protein
acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 6

multiple interactions

acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]; acteoside results in decreased expression of and results in decreased activity of CDK6 protein

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

acteoside results in increased expression of CDKN1A mRNA; acteoside results in increased expression of CDKN1A protein
acteoside promotes the reaction [CDKN1A protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1A protein binds to CDK6 protein]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression
multiple interactions

acteoside results in increased expression of CDKN1B mRNA; acteoside results in increased expression of CDKN1B protein
acteoside promotes the reaction [CDKN1B protein binds to CDK4 protein]; acteoside promotes the reaction [CDKN1B protein binds to CDK6 protein]

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

C-X-C motif chemokine ligand 10

decreases secretion
decreases expression
multiple interactions

acteoside results in decreased secretion of CXCL10 protein
acteoside results in decreased expression of CXCL10 mRNA
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [PD168393 results in increased secretion of CXCL10 protein]; acteoside promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]

PMID:21756928 PMID:21967610

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

acteoside results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

acteoside inhibits the reaction [Carbon Tetrachloride results in increased expression of and results in increased activity of CYP2E1 protein]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

E2F transcription factor 1

multiple interactions

[acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein]

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

G

epidermal growth factor receptor

decreases phosphorylation
multiple interactions

acteoside results in decreased phosphorylation of EGFR protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein]

PMID:21756928 PMID:21967610

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

high mobility group box 1

decreases expression

acteoside results in decreased expression of HMGB1 protein

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

intercellular adhesion molecule 1

decreases expression

acteoside results in decreased expression of ICAM1 mRNA

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

decreases expression
multiple interactions

acteoside results in decreased expression of IFNG mRNA
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]

PMID:21371465 PMID:21756928

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 6

multiple interactions
decreases expression

acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
acteoside results in decreased expression of IL6 mRNA

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit beta 2

multiple interactions

acteoside inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]; acteoside inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ITGB2 protein]

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions
decreases phosphorylation

acteoside results in increased phosphorylation of MAPK1 protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]
acteoside results in decreased phosphorylation of MAPK1 protein

PMID:21756928 PMID:23527233

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

decreases phosphorylation
multiple interactions
increases phosphorylation

acteoside results in decreased phosphorylation of MAPK3 protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]
acteoside results in increased phosphorylation of MAPK3 protein

PMID:21756928 PMID:23527233

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

NADPH oxidase 1

decreases activity

acteoside results in decreased activity of NOX1 protein

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

G

prostaglandin D2 synthase

affects binding

acteoside binds to PTGDS protein

NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[acteoside co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

Rac family small GTPase 1

decreases expression

Verbascoside decreases expression of RAC1 mRNA in colon cancer cells

RGD

NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251

G

RB transcriptional corepressor 1

decreases phosphorylation
multiple interactions

acteoside results in decreased phosphorylation of RB1 protein
[acteoside results in decreased phosphorylation of RB1 protein] promotes the reaction [RB1 protein binds to E2F1 protein]

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RELA proto-oncogene, NF-kB subunit

increases phosphorylation
multiple interactions
decreases phosphorylation

acteoside results in increased phosphorylation of RELA protein
acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
acteoside results in decreased phosphorylation of RELA protein

PMID:21756928 PMID:23527233

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

SMAD family member 2

increases phosphorylation

acteoside results in increased phosphorylation of SMAD2 protein

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 3

increases phosphorylation

acteoside results in increased phosphorylation of SMAD3 protein

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

SMAD family member 7

increases expression

acteoside results in increased expression of SMAD7 protein

NCBI chr18:68,988,429...69,016,774
Ensembl chr18:68,988,429...69,016,765

G

snail family transcriptional repressor 1

decreases expression

acteoside results in decreased expression of SNAI1 protein

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

snail family transcriptional repressor 2

decreases expression

acteoside results in decreased expression of SNAI2 protein

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

superoxide dismutase 2

decreases expression

acteoside results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

transforming growth factor alpha

multiple interactions

[acteoside co-treated with TGFA protein] results in increased expression of CXCL8 mRNA; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein modified form]; acteoside promotes the reaction [TGFA protein affects the localization of EGFR protein]

PMID:21756928 PMID:21967610

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 1

increases expression

acteoside results in increased expression of TGFB1 mRNA

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 1

decreases expression

acteoside results in decreased expression of TGFBR1 protein

NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777

G

transforming growth factor, beta receptor 2

decreases expression

acteoside results in decreased expression of TGFBR2 protein

NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228

G

tumor necrosis factor

multiple interactions

acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of EGFR protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; acteoside inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

vascular cell adhesion molecule 1

decreases expression

acteoside results in decreased expression of VCAM1 mRNA

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

Adenophostin A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

inositol 1,4,5-trisphosphate receptor, type 2

multiple interactions
increases activity

2-aminoethoxydiphenyl borate inhibits the reaction [[adenophostin A results in increased activity of ITPR2 protein] which results in increased transport of Calcium]; [adenophostin A results in increased activity of ITPR2 protein] which results in increased transport of Calcium; xestospongin C inhibits the reaction [[adenophostin A results in increased activity of ITPR2 protein] which results in increased transport of Calcium]

NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164

G

inositol 1,4,5-trisphosphate receptor, type 3

multiple interactions

adenophostin A analog binds to and results in increased activity of ITPR3 protein; adenophostin A binds to and results in increased activity of ITPR3 protein

NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337

crocin-1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acid phosphatase 5, tartrate resistant

multiple interactions

crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]]

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

AKT serine/threonine kinase 2

multiple interactions

crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA]

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

BMP and activin membrane-bound inhibitor

multiple interactions

crocin inhibits the reaction [Cisplatin results in decreased expression of BAMBI mRNA]

NCBI chr17:54,121,251...54,125,816
Ensembl chr17:54,121,255...54,126,060

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; crocin inhibits the reaction [Diazinon results in increased expression of BAX mRNA]; crocin inhibits the reaction [Diazinon results in increased expression of BAX protein]; crocin inhibits the reaction [Malathion results in increased expression of BAX protein]
crocin results in increased expression of BAX mRNA

PMID:23523949 PMID:27353299 PMID:32886819 PMID:32920515 PMID:35274200

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[crocin co-treated with Paraquat] results in decreased expression of BCL2 mRNA
crocin results in decreased expression of BCL2 mRNA
crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]

PMID:31911963 PMID:32886819 PMID:32920515

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

brain-derived neurotrophic factor

increases expression

crocin results in increased expression of BDNF mRNA; crocin results in increased expression of BDNF protein

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

G

baculoviral IAP repeat-containing 5

decreases expression

crocin results in decreased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

caspase 3

multiple interactions
increases activity
increases expression
increases cleavage

crocin affects the reaction [Ethanol results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased cleavage of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased expression of CASP3 protein modified form]; crocin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; crocin inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]
crocin results in increased activity of CASP3 protein
crocin results in increased expression of CASP3 mRNA
crocin inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA]
Acetylcysteine inhibits the reaction [crocin results in increased activity of CASP3 protein]; MIR34A mRNA inhibits the reaction [crocin results in increased activity of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; PTPN4 protein affects the reaction [crocin results in increased activity of CASP3 protein]

PMID:23523949 PMID:25637687 PMID:25899501 PMID:26807765 PMID:27353299 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity

crocin results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases activity

crocin inhibits the reaction [Diazinon results in increased cleavage of CASP9 protein]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]
crocin results in increased activity of CASP9 protein

PMID:27353299 PMID:32886819 PMID:35274200

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
decreases activity
increases activity

crocin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; crocin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; crocin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
crocin results in decreased activity of CAT protein
crocin inhibits the reaction [Patulin results in increased activity of CAT protein]
crocin results in increased activity of CAT protein

PMID:25899501 PMID:26584762 PMID:29409856 PMID:32886819 PMID:32920515

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin D1

decreases expression

crocin results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

creatine kinase, M-type

multiple interactions

crocin inhibits the reaction [Diazinon results in increased activity of CKM protein]

NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720

G

collagen type II alpha 1 chain

multiple interactions

[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]

NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546

G

cAMP responsive element binding protein 1

multiple interactions

crocin results in increased expression of and results in increased phosphorylation of CREB1 protein

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cytochrome c, somatic

multiple interactions

crocin inhibits the reaction [Diazinon affects the localization of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions
decreases activity

crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CYP2E1 protein]
crocin results in decreased activity of CYP2E1 protein

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

forkhead box P2

increases expression

crocin results in increased expression of FOXP2 protein

NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683

G

glyoxalase 1

multiple interactions

crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein]

NCBI chr20:8,663,617...8,681,661
Ensembl chr20:8,662,801...8,681,649

G

glutamic--pyruvic transaminase

multiple interactions

crocin inhibits the reaction [Cisplatin results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

heme oxygenase 1

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of HMOX1 protein]

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 1 like

multiple interactions

crocin inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA]

NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571

G

interleukin 10

multiple interactions

crocin inhibits the reaction [Doxorubicin results in decreased expression of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions

[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]

PMID:24709313 PMID:26807765

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
decreases expression

crocin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; crocin inhibits the reaction [Ethanol results in decreased expression of IL6 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
crocin results in decreased expression of IL6 mRNA

PMID:25637687 PMID:25899501 PMID:29409856 PMID:32886819 PMID:32920515

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

crocin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

Janus kinase 2

multiple interactions

crocin affects the expression of and affects the phosphorylation of JAK2 protein

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Kelch-like ECH-associated protein 1

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of KEAP1 protein]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

low density lipoprotein receptor

multiple interactions

crocin inhibits the reaction [Diazinon results in decreased expression of LDLR mRNA]

NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK1 protein]
crocin results in decreased phosphorylation of MAPK1 protein

PMID:24132704 PMID:28689058 PMID:32886819

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK3 protein]
crocin results in decreased phosphorylation of MAPK3 protein
crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]

PMID:24132704 PMID:28689058 PMID:30580027 PMID:32886819

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microRNA 122

multiple interactions
decreases expression

crocin inhibits the reaction [bisphenol A results in increased expression of MIR122 mRNA]
crocin results in decreased expression of MIR122

PMID:28689058 PMID:36988377

NCBI chr18:58,758,703...58,758,787

G

microRNA 29b-1

increases expression
multiple interactions

crocin results in increased expression of MIR29B1 mRNA
Cisplatin inhibits the reaction [crocin results in increased expression of MIR29B1 mRNA]; crocin inhibits the reaction [Cisplatin results in decreased expression of MIR29B1 mRNA]

NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067

G

microRNA 34a

multiple interactions

MIR34A mRNA inhibits the reaction [crocin results in increased activity of CASP3 protein]; MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein]

NCBI chr 5:160,533,002...160,533,103
Ensembl chr 5:160,533,002...160,533,103

G

myeloperoxidase

multiple interactions

crocin inhibits the reaction [Ethanol results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

MYC proto-oncogene, bHLH transcription factor

decreases expression

crocin results in decreased expression of MYC mRNA

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

MYCN proto-oncogene, bHLH transcription factor

decreases response to substance
multiple interactions
decreases expression

MYCN results in decreased susceptibility to crocin
crocin results in decreased expression of and results in decreased stability of MYCN mRNA; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein]
crocin results in decreased expression of MYCN protein

NCBI chr 6:35,717,764...35,723,590
Ensembl chr 6:35,717,764...35,723,590

G

MYD88, innate immune signal transduction adaptor

multiple interactions

crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 protein]

NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415

G

NFE2 like bZIP transcription factor 2

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 protein]; crocin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 protein]

PMID:32259551 PMID:32920515

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

osteoclastogenesis associated transmembrane protein 1

multiple interactions

[crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA]

NCBI chr20:46,071,657...46,187,049
Ensembl chr20:46,153,075...46,187,023

G

poly (ADP-ribose) polymerase 1

multiple interactions
increases cleavage

MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

prostaglandin-endoperoxide synthase 2

decreases expression

crocin results in decreased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, non-receptor type 4

multiple interactions
increases expression

MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein]; PTPN4 protein affects the reaction [crocin results in increased activity of CASP3 protein]

NCBI chr13:30,772,012...30,952,340
Ensembl chr13:30,776,682...30,952,170

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

crocin inhibits the reaction [Arsenic Trioxide results in increased expression of RELA protein]; crocin inhibits the reaction [Streptozocin results in increased expression of RELA protein]

PMID:29409856 PMID:32920515

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

SMAD family member 2

decreases expression
multiple interactions

crocin results in decreased expression of SMAD2 protein
Cisplatin inhibits the reaction [crocin results in decreased expression of SMAD2 protein]; crocin inhibits the reaction [Cisplatin results in increased expression of SMAD2 protein]

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

synuclein alpha

multiple interactions

crocin inhibits the reaction [Malathion results in increased expression of SNCA mRNA]; crocin inhibits the reaction [Malathion results in increased expression of SNCA protein]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

sprouty RTK signaling antagonist 2

increases expression

crocin results in increased expression of SPRY2 protein

NCBI chr15:82,692,291...82,697,408
Ensembl chr15:82,692,143...82,698,009

G

signal transducer and activator of transcription 3

multiple interactions

crocin affects the expression of and affects the phosphorylation of STAT3 protein

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

transforming growth factor, beta 1

multiple interactions

crocin inhibits the reaction [Cisplatin results in increased expression of TGFB1 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]

PMID:29409856 PMID:32259551

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

transforming growth factor, beta receptor 1

multiple interactions

crocin inhibits the reaction [Cisplatin results in increased expression of TGFBR1 protein]

NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777

G

toll-like receptor 4

multiple interactions

crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TLR4 protein]

PMID:29409856 PMID:32259551

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions
decreases expression

crocin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; crocin inhibits the reaction [Ethanol results in decreased expression of TNF protein]
crocin results in decreased expression of TNF mRNA

PMID:25637687 PMID:25899501 PMID:26807765 PMID:32886819 PMID:32920515

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 11

multiple interactions

[crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein]; crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]]

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

troponin T2, cardiac type

multiple interactions

crocin inhibits the reaction [Doxorubicin results in increased expression of TNNT2 protein]

NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388

G

tumor protein p53

multiple interactions

crocin inhibits the reaction [Paraquat results in increased expression of TRP53 mRNA]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TNF receptor associated factor 6

multiple interactions

crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]

NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507

G

VGF nerve growth factor inducible

increases expression

crocin results in increased expression of VGF protein

NCBI chr12:19,637,313...19,645,123
Ensembl chr12:19,637,320...19,640,341

diosmin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

Diosmin binds to and results in increased activity of AHR protein

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

BCL2-associated agonist of cell death

multiple interactions

Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein]

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

[Diosmin co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]

PMID:21477647 PMID:32061149

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of CASP3 protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]

PMID:21477647 PMID:23665045 PMID:29187079 PMID:32061149

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; Diosmin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]

PMID:22056647 PMID:23665045

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

CEA cell adhesion molecule 1

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of CEACAM1 protein]

NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992

G

cAMP responsive element binding protein 1

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of CREB1 protein]

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein]

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

enolase 2

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of ENO2 protein]

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

G

glutathione peroxidase 1

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of and results in decreased activity of GPX1 protein]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione-disulfide reductase

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSR protein]

PMID:23665045 PMID:32061149

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

interleukin 6

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

marker of proliferation Ki-67

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein]

NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762

G

myeloperoxidase

multiple interactions

Diosmin inhibits the reaction [Acetic Acid results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

nitric oxide synthase 2

multiple interactions

Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

poly (ADP-ribose) polymerase 1

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

proliferating cell nuclear antigen

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

prostaglandin E receptor 2

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGER2 protein]

NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of PTGS2 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]

PMID:23665045 PMID:29187079 PMID:32061149 PMID:35920545

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

tumor necrosis factor

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:21477647 PMID:23665045 PMID:29187079

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions

Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

xanthine dehydrogenase

multiple interactions

Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of XDH protein]

PMID:23665045 PMID:32061149

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

eprinomectin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

decreases activity

eprinomectin results in decreased activity of ABCB1A protein

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

anoctamin 1

decreases activity

eprinomectin results in decreased activity of ANO1 protein

NCBI chr 1:199,751,439...199,900,099
Ensembl chr 1:199,751,439...199,900,069

G

nuclear receptor coactivator 2

multiple interactions

eprinomectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]

NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions

eprinomectin inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

eriocitrin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

increases expression

eriocitrin results in increased expression of BAX protein

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

eriocitrin results in decreased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 7

increases expression

eriocitrin results in increased expression of CASP7 protein

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

increases expression

eriocitrin results in increased expression of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cyclin D1

decreases expression

eriocitrin results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

Janus kinase 2

decreases phosphorylation

eriocitrin results in decreased phosphorylation of JAK2 protein

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

mitogen-activated protein kinase 8

multiple interactions
increases phosphorylation

Acetylcysteine inhibits the reaction [eriocitrin results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

proliferating cell nuclear antigen

decreases expression

eriocitrin results in decreased expression of PCNA protein

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

SRC proto-oncogene, non-receptor tyrosine kinase

decreases phosphorylation

eriocitrin results in decreased phosphorylation of SRC protein

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

signal transducer and activator of transcription 3

decreases phosphorylation

eriocitrin results in decreased phosphorylation of STAT3 protein

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

ginsenoside Rb2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

increases expression

ginsenoside Rb2 results in increased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

lipoprotein lipase

increases secretion
decreases secretion

ginsenoside Rb2 results in increased secretion of LPL protein
ginsenoside Rb2 results in decreased secretion of LPL protein

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

ginsenoside Rc

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier organic anion transporter family member 1B2

multiple interactions

ginsenoside Rc binds to and results in decreased activity of SLCO1B3 protein

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

ginsenoside Re

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

increases transport

ABCB11 protein results in increased transport of ginsenoside Re

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily C member 1

increases transport

ABCC1 protein results in increased transport of ginsenoside Re

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

increases transport

ABCC2 protein results in increased transport of ginsenoside Re

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily G member 2

increases transport

ABCG2 protein results in increased transport of ginsenoside Re

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

adiponectin, C1Q and collagen domain containing

increases expression
multiple interactions

ginsenoside Re results in increased expression of ADIPOQ mRNA
ginsenoside Re results in increased expression of and results in increased secretion of ADIPOQ protein

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

allograft inflammatory factor 1

multiple interactions
decreases expression

3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]]]; ginsenoside Re affects the reaction [GPX1 protein affects the expression of AIF1 protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of AIF1 protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]]
ginsenoside Re results in decreased expression of AIF1 protein

PMID:29467000 PMID:36682417

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation

ginsenoside Re results in increased phosphorylation of and results in increased activity of AKT1 protein
ginsenoside Re results in increased phosphorylation of AKT1 protein

PMID:17878692 PMID:17885204 PMID:24599032

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

androgen receptor

multiple interactions

ginsenoside Re binds to and affects the activity of AR protein

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

BCL2 associated X, apoptosis regulator

decreases expression
multiple interactions

ginsenoside Re results in decreased expression of BAX mRNA; ginsenoside Re results in decreased expression of BAX protein
3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]]]; Acetylcysteine inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BAX protein]]; Cyclosporine inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BAX protein]]; ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of BAX protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of BAX protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]]

PMID:12674765 PMID:15621629 PMID:29467000 PMID:37308051

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

increases expression
multiple interactions

ginsenoside Re results in increased expression of BCL2 mRNA; ginsenoside Re results in increased expression of BCL2 protein
3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]]]; 3-nitropropionic acid inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased expression of BCL2 protein]]; ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased expression of BCL2 protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of BCL2 protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]]

PMID:15621629 PMID:29467000 PMID:37308051

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

3-nitropropionic acid inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased expression of BCL2L1 protein]]; ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased expression of BCL2L1 protein]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

caspase 3

multiple interactions

3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]]]; 3-nitropropionic acid inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased cleavage of CASP3 protein]]; ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased cleavage of CASP3 protein]; ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]; ginsenoside Re results in decreased cleavage of and results in decreased activity of CASP3 protein; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]]

PMID:15621629 PMID:23102375 PMID:25523949 PMID:29467000 PMID:37308051

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of CAT protein]; PRKCD affects the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of CAT protein]]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cyclin-dependent kinase inhibitor 1A

increases expression

ginsenoside Re results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

choline O-acetyltransferase

increases expression
multiple interactions

ginsenoside Re results in increased expression of CHAT mRNA; ginsenoside Re results in increased expression of CHAT protein
staurosporine aglycone inhibits the reaction [ginsenoside Re results in increased expression of CHAT mRNA]; staurosporine aglycone inhibits the reaction [ginsenoside Re results in increased expression of CHAT protein]

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

ginsenoside Re inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

claudin 1

multiple interactions

ginsenoside Re inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of CLDN1 protein]

NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724

G

C-reactive protein

increases expression

ginsenoside Re results in increased expression of CRP protein

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

cytochrome b-245 alpha chain

multiple interactions

ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; ginsenoside Re inhibits the reaction [Phencyclidine results in increased activity of CYBA protein]

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome P450 family 8 subfamily B member 1

increases expression

ginsenoside Re results in increased expression of CYP8B1 mRNA

NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166

G

estrogen receptor 1

multiple interactions

ginsenoside Re binds to and affects the activity of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

fatty acid binding protein 4

increases expression

ginsenoside Re results in increased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

Fas cell surface death receptor

decreases expression
multiple interactions

ginsenoside Re results in decreased expression of FAS mRNA
ginsenoside Re inhibits the reaction [Dietary Fats results in increased expression of FAS mRNA]

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

ginsenoside Re results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

glucose-6-phosphatase catalytic subunit 1

decreases expression

ginsenoside Re results in decreased expression of G6PC1 mRNA

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glycerol-3-phosphate acyltransferase, mitochondrial

multiple interactions

ginsenoside Re inhibits the reaction [Dietary Fats results in increased expression of GPAM mRNA]

NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639

G

glutathione peroxidase 1

multiple interactions

ginsenoside Re affects the reaction [GPX1 protein affects the expression of AIF1 protein]; ginsenoside Re affects the reaction [GPX1 protein affects the expression of and affects the localization of RELA protein]; ginsenoside Re affects the reaction [GPX1 protein affects the expression of PTAFR protein]; ginsenoside Re affects the reaction [GPX1 protein affects the phosphorylation of MAPK1 protein]; ginsenoside Re affects the reaction [GPX1 protein affects the phosphorylation of MAPK3 protein]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of CYBA protein]]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]

PMID:29037473 PMID:36682417

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glycogen synthase kinase 3 beta

increases phosphorylation

ginsenoside Re results in increased phosphorylation of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

heat shock protein family D (Hsp60) member 1

increases expression

ginsenoside Re results in increased expression of HSPD1 protein

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

interferon gamma

decreases expression

ginsenoside Re results in decreased expression of IFNG protein

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 1 beta

multiple interactions

ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; ginsenoside Re metabolite inhibits the reaction [Oxazolone results in increased expression of IL1B mRNA]; ginsenoside Re metabolite inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL1B mRNA]

PMID:16557482 PMID:22494059 PMID:22849695

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

ginsenoside Re inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

ginsenoside Re inhibits the reaction [Dietary Fats inhibits the reaction [INS1 protein results in increased localization of SLC2A4 protein]]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

interleukin-1 receptor-associated kinase 1

multiple interactions

ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK1 protein]; ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRAK1 protein]

NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521

G

interleukin-1 receptor-associated kinase 4

multiple interactions

ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased degradation of IRAK4 protein]

NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837

G

immunity-related GTPase M

decreases expression

ginsenoside Re results in decreased expression of IRGM protein

NCBI chr10:33,233,513...33,241,594
Ensembl chr10:33,233,455...33,241,578

G

insulin receptor substrate 1

multiple interactions
increases expression
increases phosphorylation

ginsenoside Re inhibits the reaction [TNF protein results in increased phosphorylation of IRS1 protein]
ginsenoside Re results in increased expression of IRS1 mRNA
ginsenoside Re results in increased phosphorylation of IRS1 protein

PMID:17885204 PMID:23545455

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

potassium voltage-gated channel subfamily E regulatory subunit 1

increases expression

ginsenoside Re results in increased expression of KCNE1

NCBI chr11:31,580,951...31,594,116
Ensembl chr11:31,580,742...31,593,901

G

lipoprotein lipase

increases secretion

ginsenoside Re results in increased secretion of LPL protein

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

leucine-rich pentatricopeptide repeat containing

increases expression

ginsenoside Re results in increased expression of LRPPRC protein

NCBI chr 6:9,859,816...9,942,294
Ensembl chr 6:9,859,867...9,942,293

G

microtubule-associated protein 2

increases expression

ginsenoside Re results in increased expression of MAP2 mRNA; ginsenoside Re results in increased expression of MAP2 protein

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

ginsenoside Re affects the reaction [GPX1 protein affects the phosphorylation of MAPK1 protein]; ginsenoside Re results in increased phosphorylation of and results in increased activity of MAPK1 protein
ginsenoside Re results in increased phosphorylation of MAPK1 protein

PMID:24599032 PMID:36682417

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

ginsenoside Re affects the reaction [GPX1 protein affects the phosphorylation of MAPK3 protein]; ginsenoside Re results in increased phosphorylation of and results in increased activity of MAPK3 protein
ginsenoside Re results in increased phosphorylation of MAPK3 protein

PMID:24599032 PMID:36682417

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

myeloperoxidase

multiple interactions

ginsenoside Re inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

myosin light chain 9

affects phosphorylation

ginsenoside Re affects the phosphorylation of MYL9 protein

NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333

G

myosin light chain kinase

affects expression

ginsenoside Re affects the expression of MYLK mRNA; ginsenoside Re affects the expression of MYLK protein

NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261

G

neutrophil cytosolic factor 1

multiple interactions

ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine affects the localization of NCF1 protein]]; ginsenoside Re inhibits the reaction [Phencyclidine affects the localization of NCF1 protein]

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

NFKB inhibitor alpha

multiple interactions

ginsenoside Re inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nerve growth factor

increases expression

ginsenoside Re results in increased expression of NGF mRNA

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nerve growth factor receptor

increases expression

ginsenoside Re results in increased expression of NGFR mRNA; ginsenoside Re results in increased expression of NGFR protein

NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518

G

nitric oxide synthase 2

multiple interactions
decreases expression

ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
ginsenoside Re results in decreased expression of NOS2 protein

PMID:15621629 PMID:23102375

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions
increases phosphorylation

2-aminoethoxydiphenyl borate inhibits the reaction [ginsenoside Re results in increased phosphorylation of NOS3 protein]; Calcium deficiency inhibits the reaction [ginsenoside Re results in increased phosphorylation of NOS3 protein]; Mifepristone inhibits the reaction [ginsenoside Re results in increased phosphorylation of NOS3 protein]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

nuclear receptor subfamily 0, group B, member 2

increases expression

ginsenoside Re results in increased expression of NR0B2 mRNA

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions
increases activity

[ginsenoside Re results in increased activity of NR3C1 protein] which results in increased abundance of Nitric Oxide

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

occludin

multiple interactions

ginsenoside Re inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of OCLN protein]

NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150

G

poly (ADP-ribose) polymerase 1

multiple interactions

ginsenoside Re inhibits the reaction [Methamphetamine results in increased cleavage of PARP1 protein]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phosphoenolpyruvate carboxykinase 1

multiple interactions
decreases expression

ginsenoside Re inhibits the reaction [Dietary Fats results in increased expression of PCK1 mRNA]
ginsenoside Re results in decreased expression of PCK1 mRNA

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

prodynorphin

multiple interactions

3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]]]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]]]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]]]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]]]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]]]; ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of PDYN mRNA]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]]

NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334

G

progesterone receptor

multiple interactions
increases expression

ginsenoside Re binds to and affects the activity of PGR protein
ginsenoside Re results in increased expression of PGR protein

PMID:16204943 PMID:16985185

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

peroxisome proliferator-activated receptor gamma

increases expression

ginsenoside Re results in increased expression of PPARG mRNA

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein kinase AMP-activated catalytic subunit alpha 1

increases phosphorylation
multiple interactions

ginsenoside Re results in increased phosphorylation of PRKAA1 protein
ginsenoside Re inhibits the reaction [Dietary Fats results in decreased phosphorylation of PRKAA1 protein]

NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978

G

protein kinase C, delta

multiple interactions
increases response to substance

3-nitropropionic acid inhibits the reaction [ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased cleavage of and results in increased phosphorylation of PRKCD protein]]; ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased cleavage of and results in increased phosphorylation of PRKCD protein]; ginsenoside Re inhibits the reaction [Methamphetamine affects the localization of PRKCD protein]; PRKCD affects the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of CAT protein]]; PRKCD affects the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of SOD1 protein]]
ginsenoside Re inhibits the reaction [Methamphetamine affects the localization of PRKCD protein]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of and results in increased cleavage of PRKCD protein]
PRKCD results in increased susceptibility to ginsenoside Re

PMID:24430743 PMID:25523949 PMID:37308051

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

platelet-activating factor receptor

multiple interactions
decreases expression

ginsenoside Re affects the reaction [GPX1 protein affects the expression of PTAFR protein]
ginsenoside Re results in decreased expression of PTAFR protein

NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; ginsenoside Re metabolite inhibits the reaction [Oxazolone results in increased expression of PTGS2 mRNA]; ginsenoside Re metabolite inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]

PMID:16557482 PMID:23102375

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ginsenoside Re affects the reaction [GPX1 protein affects the expression of and affects the localization of RELA protein]; ginsenoside Re results in decreased expression of and affects the localization of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ribosomal protein S6 kinase B1

increases phosphorylation

ginsenoside Re results in increased phosphorylation of RPS6KB1 protein

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

stearoyl-CoA desaturase

decreases expression
multiple interactions

ginsenoside Re results in decreased expression of SCD mRNA
ginsenoside Re inhibits the reaction [Dietary Fats results in increased expression of SCD1 mRNA]

NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562

G

solute carrier family 18 member A3

increases expression

ginsenoside Re results in increased expression of SLC18A3 mRNA

NCBI chr16:7,713,630...7,716,491

G

solute carrier family 2 member 4

multiple interactions
increases localization

ginsenoside Re inhibits the reaction [Dietary Fats inhibits the reaction [INS1 protein results in increased localization of SLC2A4 protein]]
ginsenoside Re results in increased localization of SLC2A4 protein

PMID:17885204 PMID:22571876 PMID:23545455

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier family 5 member 7

increases expression

ginsenoside Re results in increased expression of SLC5A7 mRNA

NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258

G

solute carrier organic anion transporter family member 1B2

multiple interactions

SLCO1B2 protein binds to and results in increased transport of ginsenoside Re
SLCO1B3 protein binds to and results in increased transport of ginsenoside Re

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

suppressor of cytokine signaling 3

multiple interactions

ginsenoside Re inhibits the reaction [TNF protein results in increased expression of SOCS3 mRNA]

NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787

G

superoxide dismutase 1

multiple interactions
decreases activity

ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in increased activity of SOD1 protein]]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of SOD1 protein]; PRKCD affects the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased activity of SOD1 protein]]
ginsenoside Re results in decreased activity of SOD1 protein

PMID:24430743 PMID:29037473 PMID:36682417

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions

ginsenoside Re inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in decreased activity of SOD2 protein]; ginsenoside Re inhibits the reaction [GPX1 protein affects the reaction [Phencyclidine results in decreased activity of SOD2 protein]]

PMID:29037473 PMID:37308051

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sterol regulatory element binding transcription factor 1

multiple interactions
decreases expression

ginsenoside Re inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]
ginsenoside Re results in decreased expression of SREBF1 mRNA

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

serine/threonine kinase 11

increases phosphorylation

ginsenoside Re results in increased phosphorylation of STK11 protein

NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315

G

tachykinin, precursor 1

multiple interactions

ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of TAC1 mRNA]; ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of TAC1 protein modified form]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of TAC1 mRNA]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [Methamphetamine results in increased expression of TAC1 protein modified form]]

NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178

G

TBC1 domain family, member 4

increases phosphorylation

ginsenoside Re results in increased phosphorylation of TBC1D4 protein

NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265

G

trefoil factor 1

increases expression

ginsenoside Re results in increased expression of TFF1 mRNA

NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597

G

tyrosine hydroxylase

multiple interactions

ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased activity of TH protein]
3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]]]; ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of TH protein]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]]

PMID:25523949 PMID:29467000

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

tight junction protein 1

multiple interactions

ginsenoside Re inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased expression of TJP1 protein]

NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432

G

toll-like receptor 4

multiple interactions

ginsenoside Re inhibits the reaction [Lipopolysaccharides binds to TLR4 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions

ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; ginsenoside Re inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; ginsenoside Re inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; ginsenoside Re inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]; ginsenoside Re inhibits the reaction [TNF protein results in increased expression of SOCS3 mRNA]; ginsenoside Re inhibits the reaction [TNF protein results in increased phosphorylation of CHUK protein]; ginsenoside Re inhibits the reaction [TNF protein results in increased phosphorylation of IRS1 protein]; ginsenoside Re metabolite inhibits the reaction [Oxazolone results in increased expression of TNF mRNA]; ginsenoside Re metabolite inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of TNF mRNA]; ginsenoside Re results in decreased expression of and results in decreased secretion of TNF protein

PMID:16557482 PMID:17885204 PMID:22494059 PMID:22849695 PMID:23545455

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

ginsenoside Rf

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apolipoprotein A1

multiple interactions
decreases expression

ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]; ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 protein]; PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]]
ginsenoside Rf results in decreased expression of APOA1 protein

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein C3

multiple interactions
decreases expression
increases expression

ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]; ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 protein]; PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]]; PPARA protein affects the reaction [ginsenoside Rf results in increased expression of APOC3 mRNA]
ginsenoside Rf results in decreased expression of APOC3 protein

NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583

G

potassium voltage-gated channel subfamily H member 2

affects activity

ginsenoside Rf affects the activity of KCNH2 protein

NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008

G

peroxisome proliferator activated receptor alpha

multiple interactions
decreases expression

ginsenoside Rf binds to and results in decreased activity of PPARA protein; ginsenoside Rf inhibits the reaction [pirinixic acid results in increased activity of PPARA protein]; ginsenoside Rf inhibits the reaction [pirinixic acid results in increased expression of PPARA mRNA]; PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOA1 mRNA]]; PPARA protein affects the reaction [ginsenoside Rf inhibits the reaction [pirinixic acid results in decreased expression of APOC3 mRNA]]; PPARA protein affects the reaction [ginsenoside Rf results in increased expression of APOC3 mRNA]
ginsenoside Rf results in decreased expression of PPARA mRNA

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

ginsenoside Rg2

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

increases expression

ginsenoside Rg2 results in increased expression of ABCC2 mRNA

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

AKT serine/threonine kinase 1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

amyloid beta precursor protein

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of and results in increased cleavage of CASP3 protein]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased expression of BAX protein]

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

BCL2 associated X, apoptosis regulator

multiple interactions

ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

beclin 2

multiple interactions

ginsenoside Rg2 inhibits the reaction [BECN2 protein binds to GPRASP1 protein]

NCBI chr13:87,842,980...87,892,410
Ensembl chr13:87,844,531...87,845,787

G

caspase 3

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]]; ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of and results in increased cleavage of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

CREB regulated transcription coactivator 2

multiple interactions

[ginsenoside Rg2 results in increased activity of NR0B2 protein] which results in decreased activity of CRTC2 protein

NCBI chr 2:175,709,603...175,719,768
Ensembl chr 2:175,709,644...175,719,763

G

glucose 6 phosphatase catalytic subunit 3

decreases expression
multiple interactions

ginsenoside Rg2 results in decreased expression of G6PC3 mRNA
dorsomorphin inhibits the reaction [ginsenoside Rg2 results in decreased expression of G6PC3 mRNA]

NCBI chr10:87,146,987...87,151,223
Ensembl chr10:87,146,901...87,151,221

G

G protein-coupled receptor associated sorting protein 1

multiple interactions

ginsenoside Rg2 inhibits the reaction [BECN2 protein binds to GPRASP1 protein]

NCBI chr X:98,764,853...98,772,685
Ensembl chr X:98,709,841...98,772,851

G

glycogen synthase kinase 3 beta

increases phosphorylation
multiple interactions

ginsenoside Rg2 results in increased phosphorylation of GSK3B protein
[[ginsenoside Rg2 results in increased phosphorylation of GSK3B protein] co-treated with [ginsenoside Rg2 results in increased expression of NR0B2 mRNA]] results in decreased chemical synthesis of Glucose; dorsomorphin inhibits the reaction [ginsenoside Rg2 results in increased phosphorylation of GSK3B protein]

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions
increases expression

bafilomycin A1 promotes the reaction [ginsenoside Rg2 results in increased expression of MAP1LC3B protein modified form]

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

nuclear receptor subfamily 0, group B, member 2

multiple interactions
increases expression
increases activity

[[ginsenoside Rg2 results in increased phosphorylation of GSK3B protein] co-treated with [ginsenoside Rg2 results in increased expression of NR0B2 mRNA]] results in decreased chemical synthesis of Glucose; [ginsenoside Rg2 results in increased activity of NR0B2 protein] which results in decreased activity of CRTC2 protein

NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609

G

phosphoenolpyruvate carboxykinase 1

multiple interactions
decreases expression

dorsomorphin inhibits the reaction [ginsenoside Rg2 results in decreased expression of PCK1 mRNA]

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

PPARG coactivator 1 alpha

multiple interactions
decreases expression

dorsomorphin inhibits the reaction [ginsenoside Rg2 results in decreased expression of PPARGC1A mRNA]

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

sequestosome 1

multiple interactions
decreases expression

bafilomycin A1 promotes the reaction [ginsenoside Rg2 results in decreased expression of SQSTM1 protein]

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

serine/threonine kinase 11

increases phosphorylation
multiple interactions

ginsenoside Rg2 results in increased phosphorylation of STK11 protein
dorsomorphin inhibits the reaction [ginsenoside Rg2 results in increased phosphorylation of STK11 protein]

NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315

gypenoside LXXV

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

increases phosphorylation
multiple interactions

gypenoside LXXV results in increased phosphorylation of AKT1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in increased phosphorylation of AKT1 protein]

PMID:35192202 PMID:36325883

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

C-C motif chemokine ligand 2

multiple interactions

gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of CCL2 protein]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cellular communication network factor 2

multiple interactions
increases expression

gypenoside LXXV results in increased expression of and results in increased secretion of CTGF protein
gypenoside LXXV results in increased expression of CTGF mRNA

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

interleukin 1 beta

multiple interactions

gypenoside LXXV inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL1B protein]

PMID:33050067 PMID:35192202

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin receptor substrate 1

decreases phosphorylation
multiple interactions

gypenoside LXXV results in decreased phosphorylation of IRS1 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of IRS1 protein]; gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of IRS1 protein

PMID:35192202 PMID:36325883

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

leptin receptor

multiple interactions

gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of CCL2 protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL1B protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of IL6 protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of TNF protein]

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

nuclear receptor subfamily 3, group C, member 2

multiple interactions

gypenoside LXXV binds to and affects the localization of NR3C2 protein

NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885

G

peroxisome proliferator-activated receptor gamma

increases expression
multiple interactions

gypenoside LXXV results in increased expression of PPARG protein
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in increased expression of PPARG protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV binds to and results in increased activity of PPARG protein]; gypenoside LXXV binds to and results in increased activity of PPARG protein

PMID:35192202 PMID:36325883

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

gypenoside LXXV results in decreased expression of and results in decreased phosphorylation of RELA protein

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

solute carrier family 2 member 4

affects localization
increases expression
multiple interactions

gypenoside LXXV affects the localization of SLC2A4 protein
gypenoside LXXV results in increased expression of SLC2A4 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gypenoside LXXV affects the localization of SLC2A4 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV affects the localization of SLC2A4 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [gypenoside LXXV results in increased expression of SLC2A4 protein]

PMID:35192202 PMID:36325883

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

transforming growth factor, beta 1

decreases expression

gypenoside LXXV results in decreased expression of TGFB1 protein

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tumor necrosis factor

multiple interactions

gypenoside LXXV inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of TNF protein]; gypenoside LXXV inhibits the reaction [LEPR gene mutant form results in increased expression of TNF protein]; gypenoside LXXV inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]

PMID:33050067 PMID:35192202

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

hesperidin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions

[2,2-bis(4-glycidyloxyphenyl)propane co-treated with Hesperidin] inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein]; Hesperidin inhibits the reaction [[Sodium Fluoride results in increased abundance of Fluorides] which results in increased activity of ACHE protein]

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

alpha-fetoprotein

multiple interactions

Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of AFP protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of AFP protein]

PMID:28935427 PMID:30779474

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

G

AKT serine/threonine kinase 1

multiple interactions

Hesperidin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of AKT1 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in decreased activity of AKT1 protein]

PMID:30779474 PMID:35413380

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

multiple interactions
increases expression

Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of AKT2 mRNA]
Hesperidin results in increased expression of AKT2 mRNA

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

albumin

multiple interactions
increases expression

[Hesperidin co-treated with Doxorubicin] results in increased expression of ALB protein
Hesperidin results in increased expression of ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

activating transcription factor 6

multiple interactions
decreases expression

Hesperidin inhibits the reaction [abamectin results in increased expression of ATF6 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of ATF6 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of ATF6 mRNA]
Hesperidin results in decreased expression of ATF6 mRNA

PMID:34748272 PMID:35413380 PMID:36966900

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[Hesperidin co-treated with Chlorpyrifos] results in increased expression of BAX mRNA; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]; Hesperidin inhibits the reaction [abamectin results in increased expression of BAX mRNA]; Hesperidin inhibits the reaction [abamectin results in increased expression of BAX protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of BAX protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of BAX mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of BAX protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of BAX mRNA]
Doxorubicin promotes the reaction [Hesperidin results in increased expression of BAX mRNA]

PMID:24954035 PMID:29481770 PMID:32050098 PMID:33908150 PMID:34748272 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
decreases expression

[Hesperidin co-treated with Chlorpyrifos] results in decreased expression of BCL2 mRNA; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [abamectin results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of BCL2 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in decreased expression of BCL2 mRNA]
Hesperidin results in decreased expression of BCL2 mRNA
Doxorubicin promotes the reaction [Hesperidin results in decreased expression of BCL2 mRNA]

PMID:22093918 PMID:24954035 PMID:29481770 PMID:30623541 PMID:32050098 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

beclin 1

multiple interactions
decreases expression

Hesperidin inhibits the reaction [abamectin results in increased expression of BECN1 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of BECN1 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of BECN1 protein]
Hesperidin results in decreased expression of BECN1 protein

PMID:33908150 PMID:34748272 PMID:35413380

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

G

bone morphogenetic protein 2

increases expression

Hesperidin results in increased expression of BMP2 mRNA

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

caspase 3

multiple interactions
decreases expression
increases activity
increases expression

[Hesperidin co-treated with Chlorpyrifos] results in increased expression of CASP3 mRNA; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [abamectin results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of CASP3 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of CASP3 protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of CASP3 mRNA]; Hesperidin promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein]
Hesperidin results in decreased expression of CASP3 protein
[Hesperidin co-treated with Doxorubicin] results in increased activity of CASP3 protein; Doxorubicin promotes the reaction [Hesperidin results in increased expression of CASP3 mRNA]
Hesperidin results in increased activity of CASP3 protein

PMID:22093918 PMID:29481770 PMID:30066062 PMID:30623541 PMID:30779474 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

multiple interactions

Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions
decreases activity
increases activity

Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [abamectin results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Acetic Acid results in increased activity of CAT protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Finasteride results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of CAT protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in decreased activity of CAT protein]
Hesperidin results in decreased activity of CAT protein
Hesperidin results in increased activity of CAT protein
Hesperidin inhibits the reaction [Doxorubicin results in increased activity of CAT protein]

PMID:22093918 PMID:29481770 PMID:30066062 PMID:30098279 PMID:30623541 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 3

multiple interactions

Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of CCL3 protein]; Hesperidin inhibits the reaction [Ethanol results in increased expression of CCL3 protein]

PMID:30368987 PMID:30811821

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

cyclin D1

multiple interactions
decreases expression

BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CCND1 mRNA]; BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CCND1 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CCND1 mRNA]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CCND1 protein]
Hesperidin results in decreased expression of CCND1 mRNA; Hesperidin results in decreased expression of CCND1 protein

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin dependent kinase 2

multiple interactions

Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of CDK2 protein]

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

multiple interactions
decreases expression

BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK4 mRNA]; BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK4 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK4 mRNA]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK4 protein]
Hesperidin results in decreased expression of CDK4 mRNA; Hesperidin results in decreased expression of CDK4 protein

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase 6

decreases expression
multiple interactions

Hesperidin results in decreased expression of CDK6 mRNA; Hesperidin results in decreased expression of CDK6 protein
BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK6 mRNA]; BIX 02189 promotes the reaction [Hesperidin results in decreased expression of CDK6 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK6 mRNA]; Hesperidin promotes the reaction [BIX 02189 results in decreased expression of CDK6 protein]

NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1A mRNA]; BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1A protein]
Hesperidin results in increased expression of CDKN1A mRNA; Hesperidin results in increased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions
increases expression

BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1B mRNA]; BIX 02189 promotes the reaction [Hesperidin results in increased expression of CDKN1B protein]
Hesperidin results in increased expression of CDKN1B mRNA; Hesperidin results in increased expression of CDKN1B protein

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

C-X-C motif chemokine ligand 3

multiple interactions

Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL1 protein]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases expression

Hesperidin inhibits the reaction [abamectin results in increased expression of EIF2AK3 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of EIF2AK3 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of EIF2AK3 mRNA]
Hesperidin results in increased expression of EIF2AK3 mRNA

PMID:34748272 PMID:35413380 PMID:36966900

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

Hesperidin inhibits the reaction [abamectin results in increased expression of ERN1 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of ERN1 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of ERN1 mRNA]

PMID:34748272 PMID:35413380 PMID:36966900

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

fatty acid binding protein 9

multiple interactions

Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased secretion of FABP9 protein]

NCBI chr 2:91,591,842...91,595,873
Ensembl chr 2:91,592,298...91,595,873

G

fatty acid synthase

multiple interactions

Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein]

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

glucose 6 phosphatase catalytic subunit 3

multiple interactions

Hesperidin inhibits the reaction [Streptozocin results in decreased activity of G6PC3 protein]

NCBI chr10:87,146,987...87,151,223
Ensembl chr10:87,146,901...87,151,221

G

glucose-6-phosphate dehydrogenase

decreases activity
multiple interactions

Hesperidin results in decreased activity of G6PD protein
Hesperidin inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]
Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]

PMID:16427799 PMID:25130191 PMID:31345080

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

glucokinase

multiple interactions

Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA]

NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995

G

glutamic--pyruvic transaminase

decreases activity
multiple interactions

Hesperidin results in decreased activity of GPT protein
Hesperidin inhibits the reaction [Chlorpyrifos results in increased activity of GPT protein]; Hesperidin inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased activity of GPT protein]
[Doxorubicin co-treated with Hesperidin] results in decreased activity of GPT protein

PMID:29481770 PMID:30066062 PMID:30779474 PMID:33908150

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione-disulfide reductase

multiple interactions

Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Hesperidin inhibits the reaction [Acetaminophen results in decreased activity of GSR protein]

PMID:22093918 PMID:30098279

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

hepatitis A virus cellular receptor 1

multiple interactions

Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of HAVCR1 protein]

PMID:22093918 PMID:30098279

NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698

G

histone deacetylase 1

multiple interactions

Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]]

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein]

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heme oxygenase 1

multiple interactions

Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of HMOX1 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of HMOX1 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HMOX1 protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of HMOX1 mRNA]

PMID:28935427 PMID:32050098 PMID:34748272 PMID:35921949 PMID:36966900

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions

Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of HSD3B1 protein]

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Hesperidin inhibits the reaction [abamectin results in increased expression of HSPA5 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of HSPA5 mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of HSPA5 mRNA]

PMID:34748272 PMID:35413380 PMID:36966900

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

intercellular adhesion molecule 1

multiple interactions

Hesperidin inhibits the reaction [Glucose results in increased expression of ICAM1]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]

PMID:17400256 PMID:22074828

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interleukin 1 beta

multiple interactions

Hesperidin inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]
Hesperidin inhibits the reaction [abamectin results in increased expression of IL1B mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL1B mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of IL1B protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of IL1B protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]

PMID:17400256 PMID:30066062 PMID:33908150 PMID:34748272 PMID:35413380 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

multiple interactions

Hesperidin promotes the reaction [Lipopolysaccharides results in increased expression of IL4 protein]

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
decreases expression

Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
Hesperidin results in decreased expression of IL6 protein
[naringin co-treated with Hesperidin] results in decreased expression of IL6 protein; Hesperidin inhibits the reaction [abamectin results in increased expression of IL6 mRNA]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of IL6 mRNA]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of IL6 protein]

PMID:17400256 PMID:21820093 PMID:30066062 PMID:30623541 PMID:34748272 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

Janus kinase 2

multiple interactions

Hesperidin inhibits the reaction [abamectin results in increased expression of JAK2 mRNA]

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

leptin

decreases expression
multiple interactions

Hesperidin results in decreased expression of LEP protein
[naringin co-treated with Hesperidin] results in decreased expression of LEP protein

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

leptin receptor

multiple interactions

Hesperidin affects the reaction [LEPR protein affects the abundance of Glucose]; Hesperidin affects the reaction [LEPR protein affects the activity of FASN protein]; Hesperidin affects the reaction [LEPR protein affects the activity of G6PD protein]; Hesperidin affects the reaction [LEPR protein affects the activity of HMGCR protein]; Hesperidin affects the reaction [LEPR protein affects the expression of GCK mRNA]; Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]; Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein]

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

microtubule-associated protein 1 light chain 3 alpha

multiple interactions

Hesperidin inhibits the reaction [abamectin results in increased expression of MAP1LC3A mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAP1LC3A mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of MAP1LC3A protein]

PMID:34748272 PMID:35413380 PMID:35921949

NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670

G

microtubule-associated protein 1 light chain 3 beta

multiple interactions

Hesperidin inhibits the reaction [abamectin results in increased expression of MAP1LC3B mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAP1LC3B mRNA]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of MAP1LC3B protein]

PMID:34748272 PMID:35413380 PMID:35921949

NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690

G

mitogen activated protein kinase kinase 5

decreases phosphorylation

Hesperidin results in decreased phosphorylation of MAP2K5 protein

NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983

G

mitogen activated protein kinase 14

multiple interactions

Hesperidin inhibits the reaction [abamectin results in increased expression of MAPK14 mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of MAPK14 protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MAPK14 mRNA]

PMID:33908150 PMID:34748272 PMID:35921949

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen-activated protein kinase 7

multiple interactions

BIX 02189 promotes the reaction [Hesperidin results in decreased phosphorylation of MAPK7 protein]; Hesperidin promotes the reaction [BIX 02189 results in decreased phosphorylation of MAPK7 protein]; Hesperidin results in decreased phosphorylation of and affects the localization of MAPK7 protein

NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267

G

mitogen-activated protein kinase 8

multiple interactions

Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

Hesperidin inhibits the reaction [Acetaldehyde results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

microRNA 126b

multiple interactions

Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of MIR126B mRNA]

NCBI chr 3:9,415,087...9,415,159

G

microRNA 181a-2

multiple interactions

Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MIR181A2 mRNA]

NCBI chr 3:22,615,845...22,615,961
Ensembl chr 3:22,615,845...22,615,961

G

matrix metallopeptidase 2

multiple interactions

Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MMP2 mRNA]

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions
decreases secretion

Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of and results in increased activity of MMP9 protein]; Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of MMP9 mRNA]; Hesperidin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]
Hesperidin inhibits the reaction [Paclitaxel results in increased expression of MMP9 mRNA]
Hesperidin results in decreased secretion of MMP9 protein

PMID:19110045 PMID:20138977 PMID:35921949

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions
decreases activity

Hesperidin inhibits the reaction [Acetic Acid results in increased activity of MPO protein]
Hesperidin results in decreased activity of MPO protein

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mechanistic target of rapamycin kinase

multiple interactions

Hesperidin inhibits the reaction [Sodium Fluoride results in decreased expression of MTOR protein]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of NFE2L2 protein]; Hesperidin inhibits the reaction [abamectin results in decreased expression of NFE2L2 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of NFE2L2 protein]; Hesperidin inhibits the reaction [Paclitaxel results in decreased expression of NFE2L2 mRNA]
Hesperidin results in increased expression of NFE2L2 mRNA

PMID:28935427 PMID:32050098 PMID:34748272 PMID:35921949 PMID:36966900

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions
increases expression

Hesperidin inhibits the reaction [abamectin results in increased expression of NFKB1 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NFKB1 mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of NFKB1 mRNA]
Hesperidin results in increased expression of NFKB1 mRNA

PMID:22093918 PMID:34748272 PMID:35921949 PMID:36966900

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

nitric oxide synthase 2

multiple interactions

Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 mRNA]; Hesperidin inhibits the reaction [Acetaminophen results in increased expression of NOS2 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of NOS2 protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:12512693 PMID:22093918 PMID:33908150

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

poly (ADP-ribose) polymerase 1

multiple interactions

[Hesperidin co-treated with Chlorpyrifos] results in increased expression of PARP1 mRNA; [Hesperidin co-treated with Chlorpyrifos] results in increased expression of PARP1 protein; Hesperidin inhibits the reaction [Ethanol results in increased activity of PARP1 protein]

PMID:30368987 PMID:33908150

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

proliferating cell nuclear antigen

multiple interactions

Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of PCNA protein]

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

Hesperidin inhibits the reaction [Diethylnitrosamine results in increased expression of PIK3R1 protein]

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

peroxisome proliferator-activated receptor gamma

multiple interactions

Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG mRNA]; Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased expression of PPARG protein]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of PPARG protein]; Hesperidin inhibits the reaction [Isoproterenol results in decreased expression of PPARG protein]
Hesperidin affects the reaction [LEPR protein affects the expression of PPARG protein]

PMID:16427799 PMID:24954035 PMID:28935427 PMID:30623541

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

multiple interactions

Hesperidin inhibits the reaction [Dextran Sulfate results in decreased expression of PPARGC1A protein]; Hesperidin inhibits the reaction [Ethanol results in decreased expression of PPARGC1A protein]

PMID:30368987 PMID:30811821

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of PTGS2 protein]
Hesperidin inhibits the reaction [Acetaldehyde results in increased expression of PTGS2 mRNA]

PMID:16101151 PMID:19110045 PMID:30098279 PMID:33908150

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Hesperidin inhibits the reaction [Isoproterenol results in increased expression of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

sphingosine-1-phosphate phosphatase 2

multiple interactions

Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SGPP2 mRNA]

NCBI chr 9:79,762,658...79,884,665
Ensembl chr 9:79,763,284...79,880,457

G

sirtuin 1

multiple interactions

Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SIRT1 protein]

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 1 member 2

multiple interactions

Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of SLC1A2 protein]

NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498

G

solute carrier family 2 member 2

multiple interactions

Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 2 member 4

multiple interactions

Hesperidin affects the reaction [LEPR protein affects the expression of SLC2A4 protein]

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

superoxide dismutase 2

multiple interactions

Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 mRNA]; Hesperidin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SOD2 protein]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

sphingosine kinase 1

multiple interactions

Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein]

NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240

G

signal transducer and activator of transcription 3

multiple interactions

Hesperidin inhibits the reaction [abamectin results in increased expression of STAT3 mRNA]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

transcription factor EB

multiple interactions

Hesperidin inhibits the reaction [Ethanol results in decreased expression of TFEB mRNA]

NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714

G

tenascin C

multiple interactions

Hesperidin inhibits the reaction [Ethanol results in increased expression of TNC protein]

NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624

G

tumor necrosis factor

multiple interactions
decreases expression

Hesperidin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Hesperidin inhibits the reaction [TNF protein co-treated with and results in increased expression of IL1B protein co-treated with and results in increased expression of CXCL8 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Hesperidin results in decreased expression of TNF mRNA
Hesperidin inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in increased expression of TNF protein]; Hesperidin inhibits the reaction [abamectin results in increased expression of TNF mRNA]; Hesperidin inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of TNF mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of TNF protein]; Hesperidin inhibits the reaction [sodium arsenite results in increased expression of TNF protein]; Hesperidin inhibits the reaction [Sodium Fluoride results in increased expression of TNF protein]
Hesperidin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

PMID:17400256 PMID:28935427 PMID:30066062 PMID:30623541 PMID:33908150 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 25

increases expression

Hesperidin results in increased expression of TNFRSF25 mRNA

NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341

G

tumor protein p53

multiple interactions

Hesperidin inhibits the reaction [sodium arsenite results in increased expression of TP53 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

TNFRSF1A-associated via death domain

increases expression

Hesperidin results in increased expression of TRADD mRNA

NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638

G

vascular cell adhesion molecule 1

multiple interactions
decreases expression

Hesperidin inhibits the reaction [IL1B protein results in increased expression of VCAM1 protein]; Hesperidin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
Hesperidin results in decreased expression of VCAM1

PMID:17400256 PMID:30991044

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor A

multiple interactions

[Hesperidin co-treated with Chlorpyrifos] results in increased expression of VEGFA protein

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

YY1 transcription factor

multiple interactions

Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of and affects the localization of YY1 protein]

NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747

josamycin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP citrate lyase

affects response to substance

ACLY protein affects the susceptibility to Josamycin

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

ADP-ribosylation factor 1

affects response to substance

ARF1 protein affects the susceptibility to Josamycin

NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434

G

ATP synthase F1 subunit beta

affects response to substance

ATP5F1B protein affects the susceptibility to Josamycin

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATP synthase peripheral stalk-membrane subunit b

affects response to substance

ATP5F1 protein affects the susceptibility to Josamycin

NCBI chr 2:193,424,138...193,435,418
Ensembl chr 2:193,424,047...193,435,418

G

ATP synthase peripheral stalk subunit d

affects response to substance

ATP5PD protein affects the susceptibility to Josamycin

NCBI chr10:100,657,700...100,662,960
Ensembl chr10:100,657,708...100,663,479

G

ATP synthase peripheral stalk subunit OSCP

affects response to substance

ATP5PO protein affects the susceptibility to Josamycin

NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592

G

ATRX, chromatin remodeler

affects response to substance

ATRX protein affects the susceptibility to Josamycin

NCBI chr X:70,850,981...70,997,330
Ensembl chr X:70,850,981...70,997,330

G

caseinolytic mitochondrial matrix peptidase proteolytic subunit

affects response to substance

CLPP protein affects the susceptibility to Josamycin

NCBI chr 9:1,831,680...1,837,700
Ensembl chr 9:1,830,311...1,837,693

G

caseinolytic mitochondrial matrix peptidase chaperone subunit X

affects response to substance

CLPX protein affects the susceptibility to Josamycin

NCBI chr 8:65,805,460...65,845,643
Ensembl chr 8:65,805,511...65,845,082

G

citrate synthase

affects response to substance

CS protein affects the susceptibility to Josamycin

NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421

G

DAZ associated protein 1

affects response to substance

DAZAP1 protein affects the susceptibility to Josamycin

NCBI chr 7:9,423,673...9,448,116
Ensembl chr 7:9,424,178...9,538,818

G

eukaryotic translation initiation factor 2 alpha kinase 1

affects response to substance

EIF2AK1 protein affects the susceptibility to Josamycin

NCBI chr12:10,710,771...10,744,597
Ensembl chr12:10,705,874...10,744,573

G

eukaryotic translation initiation factor 4 gamma 1

affects response to substance

EIF4G1 protein affects the susceptibility to Josamycin

NCBI chr11:80,221,919...80,241,958
Ensembl chr11:80,221,919...80,241,941

G

F-box protein 11

affects response to substance

FBXO11 protein affects the susceptibility to Josamycin

NCBI chr 6:6,486,761...6,562,664
Ensembl chr 6:6,486,015...6,562,662

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Josamycin results in increased expression of FOS mRNA; Josamycin results in increased expression of FOS protein

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

growth arrest and DNA-damage-inducible, alpha

affects response to substance

GADD45A protein affects the susceptibility to Josamycin

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

GTP dependent ribosome recycling factor mitochondrial 2

affects response to substance

GFM2 protein affects the susceptibility to Josamycin

NCBI chr 2:28,449,452...28,488,200
Ensembl chr 2:28,449,517...28,488,197

G

glucose-6-phosphate isomerase

decreases response to substance

GPI protein results in decreased susceptibility to Josamycin

NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086

G

hexokinase 2

decreases response to substance

HK2 protein results in decreased susceptibility to Josamycin

NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530

G

heterogeneous nuclear ribonucleoprotein A1

affects response to substance

HNRNPA1 protein affects the susceptibility to Josamycin

NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609

G

integrin subunit beta 2

multiple interactions
decreases expression

Ribomunyl inhibits the reaction [Josamycin results in decreased expression of ITGB2 protein]

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

mitogen activated protein kinase kinase 3

affects response to substance

MAP2K3 protein affects the susceptibility to Josamycin

NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492

G

mitogen activated protein kinase kinase kinase 4

decreases response to substance

MAP3K4 protein results in decreased susceptibility to Josamycin

NCBI chr 1:48,431,801...48,519,358
Ensembl chr 1:48,431,830...48,519,358

G

malic enzyme 2

affects response to substance

ME2 protein affects the susceptibility to Josamycin

NCBI chr18:67,350,833...67,400,987
Ensembl chr18:67,355,795...67,400,987

G

mitochondrially encoded cytochrome c oxidase II

decreases expression

Josamycin results in decreased expression of COX2 protein

NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689

G

mitochondrial methionyl-tRNA formyltransferase

decreases response to substance

MTFMT protein results in decreased susceptibility to Josamycin

NCBI chr 8:65,953,787...65,971,841
Ensembl chr 8:65,953,767...65,971,841

G

mitochondrial translational initiation factor 2

decreases response to substance

MTIF2 protein results in decreased susceptibility to Josamycin

NCBI chr14:103,265,808...103,285,733
Ensembl chr14:103,270,039...103,285,728

G

mitochondrial translational initiation factor 3

decreases response to substance

MTIF3 protein results in decreased susceptibility to Josamycin

NCBI chr12:8,126,193...8,140,706
Ensembl chr12:8,126,276...8,140,470

G

NADH:ubiquinone oxidoreductase subunit B8

affects response to substance

NDUFB8 protein affects the susceptibility to Josamycin

NCBI chr 1:243,408,656...243,413,715
Ensembl chr 1:243,408,619...243,413,817

G

nucleophosmin 1

affects response to substance

NPM1 protein affects the susceptibility to Josamycin

NCBI chr10:17,741,512...17,751,626
Ensembl chr10:17,739,941...17,751,645

G

pericentriolar material 1

affects response to substance

PCM1 protein affects the susceptibility to Josamycin

NCBI chr16:51,008,315...51,105,261
Ensembl chr16:51,008,315...51,105,091

G

phosphofructokinase, platelet

decreases response to substance

PFKP protein results in decreased susceptibility to Josamycin

NCBI chr17:63,729,743...63,794,026
Ensembl chr17:63,729,780...63,794,018

G

protein phosphatase 1, regulatory subunit 15B

affects response to substance

PPP1R15B protein affects the susceptibility to Josamycin

NCBI chr13:44,577,840...44,585,737
Ensembl chr13:44,577,932...44,585,737

G

protein phosphatase 2, regulatory subunit B, alpha

affects response to substance

PPP2R2A protein affects the susceptibility to Josamycin

NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924

G

protein kinase, DNA-activated, catalytic subunit

affects response to substance

PRKDC protein affects the susceptibility to Josamycin

NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952

G

RNA transcription, translation and transport factor

affects response to substance

RTRAF protein affects the susceptibility to Josamycin

NCBI chr15:4,447,243...4,457,973
Ensembl chr15:4,442,573...4,457,972

G

solute carrier family 16 member 1

affects response to substance

SLC16A1 protein affects the susceptibility to Josamycin

NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611

G

SMG1, nonsense mediated mRNA decay associated PI3K related kinase

affects response to substance

SMG1 protein affects the susceptibility to Josamycin

NCBI chr 1:172,441,892...172,543,667
Ensembl chr 1:172,444,936...172,543,698

G

SMG7 nonsense mediated mRNA decay factor

affects response to substance

SMG7 protein affects the susceptibility to Josamycin

NCBI chr13:64,986,145...65,050,698
Ensembl chr13:64,987,434...65,050,582

G

serine/threonine kinase receptor associated protein

affects response to substance

STRAP protein affects the susceptibility to Josamycin

NCBI chr 4:170,646,042...170,660,291
Ensembl chr 4:170,646,001...170,660,828

G

TATA-box binding protein associated factor 3

affects response to substance

TAF3 protein affects the susceptibility to Josamycin

NCBI chr17:68,455,389...68,608,367
Ensembl chr17:68,423,909...68,608,367

G

TATA-box binding protein associated factor 4

affects response to substance

TAF4 protein affects the susceptibility to Josamycin

NCBI chr 3:167,017,992...167,083,413
Ensembl chr 3:167,017,993...167,083,356

G

TPX2, microtubule nucleation factor

affects response to substance

TPX2 protein affects the susceptibility to Josamycin

NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468

G

TP53 regulated inhibitor of apoptosis 1

affects response to substance

TRIAP1 protein affects the susceptibility to Josamycin

NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042

G

ubiquitin associated protein 2-like

affects response to substance

UBAP2L protein affects the susceptibility to Josamycin

NCBI chr 2:175,438,703...175,494,085
Ensembl chr 2:175,438,703...175,493,998

G

voltage-dependent anion channel 1

affects response to substance

VDAC1 protein affects the susceptibility to Josamycin

NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640

G

voltage-dependent anion channel 2

affects response to substance

VDAC2 protein affects the susceptibility to Josamycin

NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553

kaempferol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

high mobility group box 1

multiple interactions
decreases response to substance

kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]; kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of SELE protein]; kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein]; kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein]; kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein]; kaempferol 3-O-sophoroside inhibits the reaction [Lipopolysaccharides results in increased secretion of HMGB1 protein]
kaempferol 3-O-sophoroside results in decreased susceptibility to HMGB1 protein

NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

intercellular adhesion molecule 1

multiple interactions

kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of ICAM1 protein]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

selectin E

multiple interactions

kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of SELE protein]

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

toll-like receptor 2

multiple interactions

kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein]

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 4

multiple interactions

kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of TLR4 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

vascular cell adhesion molecule 1

multiple interactions

kaempferol 3-O-sophoroside inhibits the reaction [HMGB1 protein results in increased expression of VCAM1 protein]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

naringin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

multiple interactions

naringin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

acetyl-CoA carboxylase alpha

multiple interactions

[naringin co-treated with Dietary Fats] results in decreased expression of ACACA mRNA

NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457

G

angiotensin I converting enzyme

multiple interactions

naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACE protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]]; naringin inhibits the reaction [bisphenol A results in increased activity of ACE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of ACE protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACE protein]

PMID:32172062 PMID:32810514

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

acetylcholinesterase

multiple interactions

[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of ACHE protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of ACHE protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ACHE protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of ACHE protein]; naringin inhibits the reaction [bisphenol A results in increased activity of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ACHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of ACHE protein]

PMID:32172062 PMID:32428650 PMID:32810514

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

acyl-CoA oxidase 1

multiple interactions

naringin inhibits the reaction [Dietary Fats results in decreased expression of ACOX1 mRNA]

NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232

G

acid phosphatase 5, tartrate resistant

multiple interactions
decreases expression

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]; naringin inhibits the reaction [Polymethyl Methacrylate analog results in increased expression of and results in increased activity of ACP5 protein]
naringin results in decreased expression of ACP5 mRNA

PMID:21835177 PMID:24376342

NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929

G

adenosine deaminase

multiple interactions

naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of ADA protein]; naringin inhibits the reaction [bisphenol A results in increased activity of ADA protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of ADA protein]

PMID:32172062 PMID:32428650 PMID:32810514

NCBI chr 3:152,398,745...152,422,854
Ensembl chr 3:152,398,747...152,447,088

G

adiponectin, C1Q and collagen domain containing

multiple interactions

naringin inhibits the reaction [Dietary Fats results in decreased expression of ADIPOQ protein]

NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564

G

angiotensinogen

multiple interactions

naringin inhibits the reaction [AGT protein results in increased expression of CYP11B2 mRNA]; naringin inhibits the reaction [AGT protein results in increased secretion of Aldosterone]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

aldo-keto reductase family 7, member A2

multiple interactions

naringin inhibits the reaction [Acetaminophen results in decreased expression of AKR7A5 protein]

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]; naringin inhibits the reaction [Methylprednisolone results in decreased phosphorylation of AKT1 protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; plerixafor inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]
naringin inhibits the reaction [Dexamethasone results in decreased phosphorylation of AKT1 protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of AKT1 mRNA]

PMID:19810018 PMID:25773745 PMID:29510123 PMID:30878453

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

angiopoietin 1

affects expression

naringin affects the expression of ANGPT1 mRNA

NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067

G

aquaporin 1

multiple interactions

naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP1 protein]

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

aquaporin 5

multiple interactions

naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of AQP5 protein]

NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209

G

ATPase H+ transporting V0 subunit D2

multiple interactions

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA]

NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354

G

BCL2-associated agonist of cell death

multiple interactions

naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAD mRNA]
naringin inhibits the reaction [Dexamethasone results in increased phosphorylation of BAD protein]

PMID:21945202 PMID:30878453

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

naringin results in increased expression of BAX mRNA
CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of BAX protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of BAX protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]
naringin inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased expression of BAX mRNA]; naringin inhibits the reaction [Acrylamide results in increased expression of BAX protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of BAX mRNA]

PMID:21945202 PMID:22847135 PMID:28422390 PMID:30130594 PMID:30878453 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

butyrylcholinesterase

multiple interactions

naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of BCHE protein]; naringin inhibits the reaction [bisphenol A results in increased activity of BCHE protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of BCHE protein]

PMID:32172062 PMID:32810514

NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148

G

BCL2, apoptosis regulator

multiple interactions

[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in decreased expression of BCL2 mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of BCL2 mRNA]
CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]; naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; naringin inhibits the reaction [Dexamethasone results in decreased expression of BCL2 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]
naringin inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]

PMID:21945202 PMID:28422390 PMID:30130594 PMID:30878453 PMID:35166444 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone gamma-carboxyglutamate protein

increases expression
increases secretion
multiple interactions

naringin results in increased expression of BGLAP mRNA; naringin results in increased expression of BGLAP protein
naringin results in increased secretion of BGLAP protein
fulvestrant inhibits the reaction [naringin results in increased secretion of BGLAP protein]

PMID:18495116 PMID:21741227 PMID:23596885

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

bone morphogenetic protein 2

multiple interactions
decreases expression
increases secretion
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]]; FOS protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; FOS protein affects the reaction [naringin results in increased expression of BMP2 protein]; JUN protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; JUN protein affects the reaction [naringin results in increased expression of BMP2 protein]; naringin promotes the reaction [FOS protein binds to BMP2 promoter]; naringin promotes the reaction [JUN protein binds to BMP2 promoter]
naringin results in decreased expression of BMP2 mRNA
fulvestrant inhibits the reaction [naringin results in increased secretion of BMP2 protein]
naringin results in increased expression of BMP2 mRNA; naringin results in increased expression of BMP2 protein

PMID:18495116 PMID:21820093 PMID:23596885

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

G

bone morphogenetic protein 3

decreases expression

naringin results in decreased expression of BMP3 mRNA

NCBI chr14:10,712,489...10,737,153
Ensembl chr14:10,712,489...10,737,153

G

bone morphogenetic protein 4

increases expression

naringin results in increased expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

calcitonin receptor

multiple interactions

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA]

NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392

G

caspase 3

increases expression
multiple interactions

naringin results in increased expression of CASP3 mRNA
naringin inhibits the reaction [Acetaminophen results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein modified form]; naringin inhibits the reaction [Acetaminophen results in increased expression of CASP3 protein]; naringin inhibits the reaction [Dexamethasone results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of CASP3 protein]
naringin inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased cleavage of CASP3 protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]; naringin inhibits the reaction [Acrylamide results in increased expression of CASP3 protein]; naringin inhibits the reaction [Cisplatin results in increased expression of CASP3 mRNA]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of CASP3 mRNA]; rottlerin inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]

PMID:21945202 PMID:22847135 PMID:25773745 PMID:26612654 PMID:28422390 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases expression
multiple interactions

naringin results in increased expression of CASP9 mRNA
[bisphenol A co-treated with naringin] results in decreased expression of CASP9 protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of CASP9 protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of CASP9 protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP9 protein]; naringin inhibits the reaction [bisphenol A results in increased expression of CASP9 protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CASP9 protein]

PMID:22847135 PMID:25773745 PMID:32172062 PMID:32428650 PMID:32810514

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

naringin inhibits the reaction [Dietary Fats results in decreased activity of CAT protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of CAT protein]; naringin inhibits the reaction [Ferric Compounds results in decreased activity of CAT protein]; naringin inhibits the reaction [Nanotubes, Carbon results in decreased activity of CAT protein]
naringin inhibits the reaction [3-nitropropionic acid results in decreased activity of CAT protein]; naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in decreased activity of CAT protein]; naringin inhibits the reaction [Acrylamide results in decreased activity of CAT protein]; naringin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]; naringin inhibits the reaction [Cisplatin results in increased expression of CAT protein]; naringin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; naringin inhibits the reaction [nickel sulfate results in decreased activity of CAT protein]

PMID:20950607 PMID:21345335 PMID:21945202 PMID:22198281 PMID:25773745 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein]
naringin inhibits the reaction [Cyclophosphamide results in increased expression of CCL2 mRNA]

PMID:22965302 PMID:33992719

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 3

multiple interactions

naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL3 mRNA]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein]

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 5

multiple interactions

naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL5 protein]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cyclin D1

decreases expression
multiple interactions
increases expression

naringin results in decreased expression of CCND1 protein
naringin inhibits the reaction [Dexamethasone results in increased expression of CCND1 mRNA]
naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CCND1 protein]
naringin results in increased expression of CCND1 mRNA

PMID:18296682 PMID:18951945 PMID:24915843 PMID:26482937 PMID:30878453

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin E1

decreases expression

naringin results in decreased expression of CCNE1 protein

PMID:18296682 PMID:18951945

NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101

G

cyclin dependent kinase 2

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in decreased expression of CDK2 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK2 protein]; naringin results in decreased expression of and results in decreased activity of CDK2 protein; RAF1 protein affects the reaction [naringin results in decreased expression of CDK2 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDK2 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]; naringin results in decreased expression of and results in decreased activity of CDK2 protein

PMID:18296682 PMID:18951945

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase 4

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDK4 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; naringin results in decreased expression of and results in decreased activity of CDK4 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in decreased expression of CDK4 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; naringin results in decreased expression of and results in decreased activity of CDK4 protein; RAF1 protein affects the reaction [naringin results in decreased expression of CDK4 protein]

PMID:18296682 PMID:18951945

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDKN1A protein]; HRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]
naringin results in increased expression of CDKN1A mRNA; naringin results in increased expression of CDKN1A protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of CDKN1A protein]; HRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]; naringin promotes the reaction [CDKN1A protein binds to CDK2 protein]; naringin promotes the reaction [CDKN1A protein binds to CDK4 protein]; RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]

PMID:18296682 PMID:18951945

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CF transmembrane conductance regulator

multiple interactions

naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR mRNA]; naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased expression of CFTR protein]

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

ChaC glutathione specific gamma-glutamylcyclotransferase 2

multiple interactions

CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]; CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]; CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]]; naringin inhibits the reaction [Acetaminophen results in decreased expression of CHAC2 protein]

PMID:35166444 PMID:35179299

NCBI chr14:104,720,754...104,728,305
Ensembl chr14:104,720,758...104,728,301

G

collagen type I alpha 1 chain

increases expression

naringin results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

carnitine palmitoyltransferase 1A

multiple interactions

[Dietary Fats co-treated with naringin] results in decreased expression of CPT1A mRNA

NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055

G

colony stimulating factor 1 receptor

multiple interactions

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA]

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

catenin beta 1

increases expression
multiple interactions

naringin results in increased expression of CTNNB1 mRNA
naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of CTNNB1 protein]

PMID:24915843 PMID:26482937

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin B

multiple interactions

naringin inhibits the reaction [Isoproterenol results in decreased activity of CTSB protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of CTSB protein]

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin D

multiple interactions

naringin inhibits the reaction [Isoproterenol results in increased activity of CTSD protein]

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cathepsin K

multiple interactions
decreases expression

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA]
naringin results in decreased expression of CTSK mRNA

PMID:21835177 PMID:24376342

NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550

G

C-X-C motif chemokine ligand 12

increases expression

naringin results in increased expression of CXCL12 protein

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 2

affects expression

naringin affects the expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine receptor 4

increases expression

naringin results in increased expression of CXCR4 protein

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome b-245 alpha chain

multiple interactions

naringin inhibits the reaction [TNF protein results in increased expression of CYBA mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of CYBA protein]

NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721

G

cytochrome c, somatic

multiple interactions

naringin inhibits the reaction [Cadmium Chloride results in increased expression of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 11, subfamily b, polypeptide 3

multiple interactions

naringin inhibits the reaction [AGT protein results in increased expression of CYP11B2 mRNA]

NCBI chr 7:106,808,559...106,814,048
Ensembl chr 7:106,808,559...106,814,048

G

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions

naringin inhibits the reaction [Acrylamide results in decreased expression of CYP17A1 mRNA]

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity

naringin results in decreased activity of CYP1A1 protein

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

naringin results in decreased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

naringin binds to and results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity
multiple interactions

naringin results in decreased activity of CYP3A4 protein
naringin inhibits the reaction [CYP3A4 protein affects the metabolism of Verapamil]

PMID:16013069 PMID:21053930

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

dihydrofolate reductase

decreases activity

naringin results in decreased activity of DHFR protein

NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713

G

dickkopf WNT signaling pathway inhibitor 1

multiple interactions

DKK1 protein inhibits the reaction [naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]]

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

epidermal growth factor

multiple interactions

naringin inhibits the reaction [EGF protein affects the localization of RELA protein]; naringin inhibits the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]; naringin inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

naringin inhibits the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

estrogen receptor 1

multiple interactions
increases expression

fulvestrant inhibits the reaction [naringin results in increased expression of ESR1 mRNA]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions
increases expression

fulvestrant inhibits the reaction [naringin results in increased expression of ESR2 mRNA]

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

fatty acid binding protein 4

multiple interactions

naringin inhibits the reaction [Dietary Fats results in increased expression of FABP4 mRNA]

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

Fas associated via death domain

increases expression

naringin results in increased expression of FADD mRNA

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

Fas cell surface death receptor

increases expression

naringin results in increased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

multiple interactions

naringin affects the reaction [LEPR protein affects the activity of FASN protein]; naringin inhibits the reaction [Dietary Fats results in increased expression of FASN mRNA]

PMID:16427799 PMID:22198281

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

fibroblast growth factor 2

multiple interactions
increases expression

fulvestrant inhibits the reaction [naringin results in increased expression of FGF2 mRNA]

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]; FOS protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; FOS protein affects the reaction [naringin results in increased expression of BMP2 protein]; naringin promotes the reaction [FOS protein binds to BMP2 promoter]
naringin results in increased expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

follicle stimulating hormone subunit beta

multiple interactions

naringin inhibits the reaction [Acrylamide results in decreased expression of FSHB protein]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

glucose-6-phosphatase catalytic subunit 1

multiple interactions

naringin affects the reaction [LEPR protein affects the expression of G6PC1 mRNA]; naringin inhibits the reaction [Dietary Fats results in increased expression of G6PC1 mRNA]

PMID:16427799 PMID:22198281

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

glucose-6-phosphate dehydrogenase

multiple interactions

naringin inhibits the reaction [nickel sulfate results in decreased activity of G6PD protein]
naringin affects the reaction [LEPR protein affects the activity of G6PD protein]

PMID:16427799 PMID:20950607

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

galanin and GMAP prepropeptide

multiple interactions

naringin inhibits the reaction [Isoproterenol results in increased activity of GAL protein]

NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959

G

glucokinase

multiple interactions

naringin affects the reaction [LEPR protein affects the expression of GCK mRNA]

NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
increases expression

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein]; [naringin co-treated with 3-nitropropionic acid] results in increased expression of GCLC mRNA; naringin promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of GCLC protein]; rottlerin inhibits the reaction [naringin results in increased expression of GCLC protein]
naringin results in increased expression of GCLC mRNA; naringin results in increased expression of GCLC protein

PMID:22871521 PMID:25773745

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamic-oxaloacetic transaminase 1

multiple interactions

naringin inhibits the reaction [Acetaminophen results in increased secretion of GOT1 protein]

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

G

glutamic--pyruvic transaminase

multiple interactions

naringin affects the reaction [Cyclophosphamide affects the activity of GPT protein]; naringin inhibits the reaction [sodium arsenite results in increased expression of GPT protein]
naringin inhibits the reaction [Acetaminophen results in increased secretion of GPT protein]; naringin inhibits the reaction [Doxorubicin results in increased expression of GPT protein]

PMID:27174133 PMID:33992719 PMID:35166444 PMID:36811345

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

increases activity

naringin results in increased activity of GPX1 protein

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione-disulfide reductase

multiple interactions

naringin inhibits the reaction [3-nitropropionic acid results in decreased activity of GSR protein]; naringin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]; naringin inhibits the reaction [nickel sulfate results in decreased activity of GSR protein]
naringin inhibits the reaction [Mercuric Chloride results in decreased activity of GSR protein]

PMID:20950607 PMID:21945202 PMID:23650045 PMID:33992719

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase pi 1

increases expression
multiple interactions

naringin results in increased expression of GSTP1 mRNA
[naringin co-treated with 3-nitropropionic acid] results in increased expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

glucuronidase, beta

multiple interactions

naringin inhibits the reaction [Isoproterenol results in decreased activity of GUSB protein]; naringin inhibits the reaction [Isoproterenol results in increased activity of GUSB protein]

NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

naringin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]
naringin affects the reaction [LEPR protein affects the activity of HMGCR protein]

PMID:16427799 PMID:16906524

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heme oxygenase 1

multiple interactions
increases expression
increases activity

CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]; naringin inhibits the reaction [Doxorubicin results in decreased expression of HMOX1 protein]; naringin inhibits the reaction [Paraquat results in decreased expression of HMOX1 mRNA]; naringin inhibits the reaction [Paraquat results in decreased expression of HMOX1 protein]; naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]
naringin results in increased expression of HMOX1 mRNA; naringin results in increased expression of HMOX1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of HMOX1 protein]; [naringin co-treated with 3-nitropropionic acid] results in increased expression of HMOX1 mRNA; naringin inhibits the reaction [sodium arsenite results in decreased expression of HMOX1 mRNA]; naringin promotes the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [naringin results in increased expression of HMOX1 protein]
naringin results in increased activity of HMOX1 protein

PMID:22871521 PMID:23603004 PMID:25773745 PMID:27174133 PMID:35166444 More...

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

HRas proto-oncogene, GTPase

multiple interactions
increases activity

HRAS protein affects the reaction [naringin results in decreased expression of CDK2 protein]; HRAS protein affects the reaction [naringin results in decreased expression of CDK4 protein]; HRAS protein affects the reaction [naringin results in increased expression of CDKN1A protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
naringin results in increased activity of HRAS protein

PMID:18296682 PMID:18951945

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

intercellular adhesion molecule 1

multiple interactions
affects expression

naringin inhibits the reaction [Glucose results in increased expression of ICAM1]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
naringin inhibits the reaction [Acetaminophen results in increased expression of ICAM1 mRNA]
naringin affects the expression of ICAM1 mRNA

PMID:22074828 PMID:25117567 PMID:25391245 PMID:35166444 PMID:35179299

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

interferon, alpha 1

multiple interactions

naringin inhibits the reaction [Cyclophosphamide results in increased expression of IFNA1 mRNA]

NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925

G

interferon gamma

multiple interactions
affects expression

naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] affects the localization of RELA protein]; naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL5 protein]
naringin affects the expression of IFNG mRNA

PMID:16945185 PMID:21500970

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

affects expression
multiple interactions
increases expression

naringin affects the expression of IGF1 mRNA
naringin inhibits the reaction [Dexamethasone results in increased expression of IGF1 mRNA]
naringin results in increased expression of IGF1 mRNA
fulvestrant inhibits the reaction [naringin results in increased expression of IGF1 mRNA]

PMID:23596885 PMID:24880026 PMID:30878453

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

interleukin 10

multiple interactions
affects expression

naringin inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of IL10 protein]
naringin affects the expression of IL10 protein

PMID:22985397 PMID:25117567

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

affects expression
multiple interactions

naringin affects the expression of IL1B mRNA
[bisphenol A co-treated with naringin] results in increased expression of IL1B protein; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of IL1B protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in increased expression of IL1B protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of IL1B protein]; naringin inhibits the reaction [Acrylamide results in increased expression of IL1B protein]; naringin inhibits the reaction [bisphenol A results in increased expression of IL1B protein]; naringin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B mRNA]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of IL1B protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL1B mRNA]
naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B protein]
naringin inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; naringin inhibits the reaction [Doxorubicin results in increased expression of IL1B mRNA]

PMID:24131540 PMID:24880026 PMID:30130594 PMID:32172062 PMID:32428650 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor type 1

multiple interactions

naringin inhibits the reaction [Cyclophosphamide results in increased expression of IL1R1 mRNA]

NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937

G

interleukin 2

affects expression

naringin affects the expression of IL2 protein

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

affects expression

naringin affects the expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

affects expression
multiple interactions
decreases expression

naringin affects the expression of IL6 mRNA
[naringin co-treated with Hesperidin] results in decreased expression of IL6 protein; [naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; naringin inhibits the reaction [Acrylamide results in increased expression of IL6 protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; naringin inhibits the reaction [TNF protein results in increased secretion of IL6 protein]
naringin results in decreased expression of IL6 protein
naringin affects the expression of IL6 protein
naringin inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; naringin inhibits the reaction [Doxorubicin results in increased expression of IL6 mRNA]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 protein]

PMID:16137700 PMID:19810018 PMID:21820093 PMID:24131540 PMID:24880026 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions
affects expression

naringin inhibits the reaction [Nanotubes, Carbon inhibits the reaction [Glucose results in increased secretion of INS1 protein]]; naringin promotes the reaction [Glucose results in increased secretion of INS1 protein]
naringin affects the expression of INS1 protein

PMID:24880026 PMID:29658312

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin receptor substrate 1

multiple interactions

naringin inhibits the reaction [Dietary Fats results in decreased phosphorylation of IRS1 protein]

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]]; CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]; JUN protein affects the reaction [naringin results in increased expression of BMP2 mRNA]; JUN protein affects the reaction [naringin results in increased expression of BMP2 protein]; naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]; naringin promotes the reaction [JUN protein binds to BMP2 promoter]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]
naringin results in increased expression of JUN mRNA

PMID:18495116 PMID:35166444

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

Kelch-like ECH-associated protein 1

multiple interactions

naringin inhibits the reaction [Doxorubicin results in decreased expression of KEAP1 protein]

NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862

G

lecithin cholesterol acyltransferase

multiple interactions

naringin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein]

NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231

G

lactate dehydrogenase A

multiple interactions

naringin inhibits the reaction [Isoproterenol results in increased expression of LDHA protein]

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

lactate dehydrogenase B

multiple interactions

naringin inhibits the reaction [Isoproterenol results in increased expression of LDHB protein]

NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403

G

leptin

multiple interactions

naringin inhibits the reaction [Dietary Fats results in increased expression of LEP protein]
[naringin co-treated with Hesperidin] results in decreased expression of LEP protein; naringin inhibits the reaction [Glucose results in increased expression of LEP protein]

PMID:21820093 PMID:22198281 PMID:24399619

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

leptin receptor

multiple interactions

naringin affects the reaction [LEPR protein affects the abundance of Glucose]; naringin affects the reaction [LEPR protein affects the activity of FASN protein]; naringin affects the reaction [LEPR protein affects the activity of G6PD protein]; naringin affects the reaction [LEPR protein affects the activity of HMGCR protein]; naringin affects the reaction [LEPR protein affects the expression of G6PC1 mRNA]; naringin affects the reaction [LEPR protein affects the expression of GCK mRNA]; naringin affects the reaction [LEPR protein affects the expression of PCK1 mRNA]; naringin affects the reaction [LEPR protein affects the expression of PPARG protein]; naringin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]; naringin affects the reaction [LEPR protein affects the expression of SLC2A4 protein]
naringin inhibits the reaction [Glucose results in increased expression of LEPR protein]

PMID:16427799 PMID:24399619

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

luteinizing hormone subunit beta

multiple interactions

naringin inhibits the reaction [Acrylamide results in decreased expression of LHB protein]

NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972

G

lipoprotein lipase

multiple interactions

naringin inhibits the reaction [Isoproterenol results in decreased activity of LPL protein]

NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249

G

monoamine oxidase A

multiple interactions

[NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in increased expression of MAOA protein; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased activity of MAOA protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of MAOA protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]]; naringin inhibits the reaction [bisphenol A results in increased activity of MAOA protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of MAOA protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of MAOA protein]

PMID:32172062 PMID:32428650 PMID:32810514

NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]
naringin results in decreased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]
naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]

PMID:18296682 PMID:18951945 PMID:21835177 PMID:22198281 PMID:22766066 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 10

multiple interactions

naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK10 protein]

NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201

G

mitogen activated protein kinase 14

multiple interactions

naringin inhibits the reaction [Acrylamide results in increased expression of MAPK14 mRNA]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation
increases phosphorylation

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
naringin results in decreased phosphorylation of MAPK3 protein
naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]

PMID:18296682 PMID:18951945 PMID:21835177 PMID:22198281 PMID:22766066 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

naringin inhibits the reaction [Dietary Fats results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

microRNA 126a

multiple interactions
increases expression

MIR126 mRNA affects the reaction [naringin results in decreased expression of VCAM1 mRNA]
naringin results in increased expression of MIR126 mRNA

NCBI chr 3:9,415,063...9,415,180
Ensembl chr 3:9,415,063...9,415,180

G

matrix metallopeptidase 2

multiple interactions

naringin results in decreased expression of and results in decreased activity of MMP2 protein

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

multiple interactions

naringin inhibits the reaction [Paraquat results in increased expression of MMP9 mRNA]; naringin inhibits the reaction [Paraquat results in increased expression of MMP9 protein]
naringin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; naringin results in decreased expression of and results in decreased activity of MMP9 protein
naringin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; naringin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; naringin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MMP9 protein]

PMID:19810018 PMID:22985397 PMID:23603004 PMID:25866363 PMID:26721195

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

naringin inhibits the reaction [Tobacco Smoke Pollution results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

metallothionein 3

multiple interactions

naringin inhibits the reaction [Cadmium Chloride results in increased expression of MT3 protein]

NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158

G

mechanistic target of rapamycin kinase

multiple interactions

naringin inhibits the reaction [TNF protein results in increased phosphorylation of MTOR protein]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

naringin inhibits the reaction [EGF protein results in increased expression of MUC5AC mRNA]; naringin inhibits the reaction [EGF protein results in increased secretion of MUC5AC protein]
naringin inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased secretion of MUC5AC protein]

PMID:22766066 PMID:31301536

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

NFE2 like bZIP transcription factor 2

multiple interactions
affects localization

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [naringin affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin affects the localization of NFE2L2 protein]; [naringin co-treated with 3-nitropropionic acid] affects the localization of NFE2L2 protein; naringin inhibits the reaction [sodium arsenite results in decreased expression of NFE2L2 mRNA]; naringin promotes the reaction [[Oxygen deficiency co-treated with Oxygen] affects the localization of NFE2L2 protein]; rottlerin inhibits the reaction [naringin affects the localization of NFE2L2 protein]
CHAC2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]]; naringin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]; naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of BAX protein]]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in increased expression of JUN protein]]; NFE2L2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]]; NFE2L2 protein promotes the reaction [naringin promotes the reaction [Acetaminophen results in increased expression of NFE2L2 protein]]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]

PMID:22871521 PMID:25773745 PMID:27174133 PMID:35166444 PMID:35179299 More...

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

naringin inhibits the reaction [Cisplatin results in increased expression of NFKB1 mRNA]

PMID:26120027 PMID:26612654

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

affects degradation
multiple interactions

naringin affects the degradation of NFKBIA protein
naringin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]

PMID:21835177 PMID:25117567

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

affects expression
multiple interactions

naringin affects the expression of NOS2 mRNA
naringin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
naringin inhibits the reaction [3-nitropropionic acid results in increased expression of NOS2 mRNA]; naringin inhibits the reaction [Cisplatin results in increased expression of NOS2 mRNA]

PMID:16137700 PMID:22871521 PMID:25117567 PMID:26612654

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NADPH oxidase 4

multiple interactions

naringin inhibits the reaction [TNF protein results in increased expression of NOX4 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of NOX4 protein]

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

[naringin co-treated with 3-nitropropionic acid] results in increased expression of NQO1 mRNA
naringin results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

oxoglutarate dehydrogenase

multiple interactions

naringin inhibits the reaction [Isoproterenol results in decreased activity of OGDH protein]

NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479

G

phosphoenolpyruvate carboxykinase 1

multiple interactions

naringin affects the reaction [LEPR protein affects the expression of PCK1 mRNA]

NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191

G

phosphodiesterase 5A

multiple interactions

naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased activity of PDE5A protein]; naringin inhibits the reaction [bisphenol A promotes the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]]; naringin inhibits the reaction [bisphenol A results in increased activity of PDE5A protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased activity of PDE5A protein]]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased activity of PDE5A protein]

PMID:32172062 PMID:32428650 PMID:32810514

NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701

G

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha

multiple interactions

naringin inhibits the reaction [Dexamethasone results in increased expression of PIK3CA mRNA]

NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

naringin inhibits the reaction [Dexamethasone results in increased expression of PIK3R1 mRNA]

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

peroxisome proliferator activated receptor alpha

multiple interactions

naringin inhibits the reaction [Dietary Fats results in decreased expression of PPARA mRNA]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

multiple interactions

naringin affects the reaction [LEPR protein affects the expression of PPARG protein]; naringin inhibits the reaction [Dietary Fats results in increased expression of PPARG mRNA]
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]; naringin inhibits the reaction [Quinolinic Acid results in decreased expression of PPARG mRNA]

PMID:16427799 PMID:22198281 PMID:30130594

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

PPARG coactivator 1 alpha

multiple interactions

naringin inhibits the reaction [Ethanol results in increased expression of PPARGC1A mRNA]

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

protein kinase C, delta

increases phosphorylation
multiple interactions

naringin results in increased phosphorylation of PRKCD protein
rottlerin inhibits the reaction [naringin results in increased phosphorylation of PRKCD protein]

NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352

G

prostaglandin-endoperoxide synthase 2

affects expression
multiple interactions

naringin affects the expression of PTGS2 mRNA; naringin affects the expression of PTGS2 protein
naringin inhibits the reaction [Acetaminophen results in increased expression of PTGS2 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of PTGS2 protein]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
naringin inhibits the reaction [3-nitropropionic acid results in increased expression of PTGS2 mRNA]

PMID:16137700 PMID:22871521 PMID:25117567 PMID:35166444 PMID:35179299 More...

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions
increases activity
increases phosphorylation

RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
RAF1 protein affects the reaction [naringin results in decreased expression of CDK2 protein]; RAF1 protein affects the reaction [naringin results in decreased expression of CDK4 protein]; RAF1 protein affects the reaction [naringin results in increased expression of CDKN1A protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK1 protein]; RAF1 protein affects the reaction [naringin results in increased phosphorylation of MAPK3 protein]
naringin results in increased activity of RAF1 protein
naringin results in increased phosphorylation of RAF1 protein

PMID:18296682 PMID:18951945

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] affects the localization of RELA protein]; naringin inhibits the reaction [EGF protein affects the localization of RELA protein]
naringin affects the expression of and affects the activity of RELA protein; naringin inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]

PMID:21500970 PMID:22766066 PMID:22965302 PMID:25117567

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

ribosomal protein S6 kinase B1

multiple interactions

naringin inhibits the reaction [AICA ribonucleotide results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [Okadaic Acid results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]

PMID:15342961 PMID:19810018

NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908

G

RUNX family transcription factor 2

increases expression
multiple interactions

naringin results in increased expression of RUNX2 mRNA
naringin inhibits the reaction [Dexamethasone results in decreased expression of RUNX2 protein]
DKK1 protein inhibits the reaction [naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]]; naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of RUNX2 mRNA]
fulvestrant inhibits the reaction [naringin results in increased expression of RUNX2 mRNA]

PMID:21741227 PMID:23596885 PMID:24915843 PMID:26482937 PMID:30878453

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

sirtuin 1

multiple interactions

naringin inhibits the reaction [Ethanol results in increased expression of SIRT1 mRNA]
naringin inhibits the reaction [Doxorubicin results in decreased expression of SIRT1 protein]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in decreased expression of NFE2L2 protein]]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]

PMID:18793633 PMID:36811345

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

solute carrier family 2 member 2

multiple interactions

naringin affects the reaction [LEPR protein affects the expression of SLC2A2 protein]

NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933

G

solute carrier family 2 member 4

multiple interactions

naringin affects the reaction [LEPR protein affects the expression of SLC2A4 protein]

NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565

G

solute carrier organic anion transporter family, member 1a4

multiple interactions

naringin inhibits the reaction [SLCO1A2 protein alternative form results in increased uptake of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased transport of estrone sulfate]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Quercetin]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Quinine]

PMID:24947867 PMID:25466967 PMID:27504015

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

solute carrier organic anion transporter family member 1B2

multiple interactions

naringin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]; naringin inhibits the reaction [SLCO1B3 protein results in increased uptake of Hydroxyurea]

PMID:21256917 PMID:22394605

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

SMAD family member 3

multiple interactions

naringin inhibits the reaction [sodium arsenite results in increased expression of SMAD3 mRNA]

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

superoxide dismutase 2

multiple interactions

CHAC2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]; naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]; naringin inhibits the reaction [Doxorubicin results in decreased expression of SOD2 protein]; naringin inhibits the reaction [Ferric Compounds results in decreased activity of SOD2 protein]; NFE2L2 protein promotes the reaction [naringin inhibits the reaction [Acetaminophen results in decreased expression of SOD2 protein]]

PMID:21345335 PMID:35166444 PMID:35179299 PMID:36811345

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

Sp7 transcription factor

increases expression
multiple interactions

naringin results in increased expression of SP7 mRNA
naringin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP7 mRNA]
fulvestrant inhibits the reaction [naringin results in increased expression of SP7 mRNA]

PMID:23596885 PMID:26482937

NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847

G

sialophorin

multiple interactions
increases expression
decreases expression

[bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A co-treated with naringin] results in decreased expression of SPN protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of SPN protein; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of SPN protein]; naringin inhibits the reaction [bisphenol A results in increased expression of SPN protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of SPN protein]
naringin results in increased expression of SPN protein
naringin results in decreased expression of SPN protein

PMID:32172062 PMID:32428650

NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628

G

secreted phosphoprotein 1

increases expression
increases secretion
multiple interactions

naringin results in increased expression of SPP1 mRNA; naringin results in increased expression of SPP1 protein
naringin results in increased secretion of SPP1 protein
fulvestrant inhibits the reaction [naringin results in increased secretion of SPP1 protein]

PMID:18495116 PMID:23596885 PMID:24915843

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

sterol regulatory element binding transcription factor 1

multiple interactions

naringin inhibits the reaction [Dietary Fats results in increased expression of SREBF1 mRNA]

NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650

G

steroidogenic acute regulatory protein

multiple interactions

naringin inhibits the reaction [Acrylamide results in decreased expression of STAR mRNA]

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

signal transducer and activator of transcription 3

affects expression

naringin affects the expression of STAT3 mRNA; naringin affects the expression of STAT3 protein

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

transforming growth factor, beta 1

multiple interactions
affects expression

naringin inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]
naringin inhibits the reaction [Cyclophosphamide results in increased expression of TGFB1 mRNA]; naringin inhibits the reaction [sodium arsenite results in increased expression of TGFB1 mRNA]
naringin affects the expression of TGFB1 mRNA

PMID:23603004 PMID:25117567 PMID:27174133 PMID:33992719

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

TIMP metallopeptidase inhibitor 1

multiple interactions

naringin inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]; naringin inhibits the reaction [Paraquat results in increased expression of TIMP1 protein]

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

tumor necrosis factor

multiple interactions
affects expression

naringin inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; naringin inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; naringin inhibits the reaction [Doxorubicin results in increased expression of TNF mRNA]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; naringin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]; naringin inhibits the reaction [Paraquat results in increased expression of TNF mRNA]
[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [3-nitropropionic acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TNF protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TNF protein]; naringin inhibits the reaction [Acrylamide results in increased expression of TNF protein]; naringin inhibits the reaction [bisphenol A results in increased expression of TNF protein]; naringin inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; naringin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TNF protein]; naringin inhibits the reaction [Quinolinic Acid results in increased expression of TNF mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of MMP9 protein]; naringin inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of MTOR protein]; naringin inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]; naringin inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]; naringin inhibits the reaction [TNF protein results in increased secretion of IL6 protein]; naringin inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF protein]
naringin affects the expression of TNF protein
naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF protein]; naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] affects the localization of RELA protein]; naringin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased expression of CCL5 protein]; naringin inhibits the reaction [TNF protein results in increased expression of CYBA mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of CYBA protein]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; naringin inhibits the reaction [TNF protein results in increased expression of NOX4 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of NOX4 protein]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
naringin affects the expression of TNF mRNA

PMID:16137700 PMID:19810018 PMID:21500970 PMID:22198281 PMID:22871521 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 11A

decreases expression

naringin results in decreased expression of TNFRSF11A mRNA

NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695

G

TNF receptor superfamily member 11B

multiple interactions

naringin inhibits the reaction [Dexamethasone results in decreased expression of TNFRSF11B protein]; naringin inhibits the reaction [Dexamethasone results in increased expression of TNFRSF11B protein]

NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538

G

TNF superfamily member 11

multiple interactions

naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ACP5 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of ATP6V0D2 mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CALCR mRNA]; naringin inhibits the reaction [[TNFSF11 protein co-treated with CSF1R protein] results in increased expression of CTSK mRNA]; naringin inhibits the reaction [TNFSF11 protein results in increased degradation of NFKBIA protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK1 protein]; naringin inhibits the reaction [TNFSF11 protein results in increased phosphorylation of MAPK3 protein]

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

troponin T2, cardiac type

multiple interactions

naringin inhibits the reaction [Isoproterenol results in increased expression of TNNT2 protein]

NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388

G

tumor protein p53

increases expression
multiple interactions
decreases expression

naringin results in increased expression of TP53 mRNA
naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]; SIRT1 protein affects the reaction [naringin inhibits the reaction [Doxorubicin results in increased expression of TRP53 protein]]
naringin results in decreased expression of TP53 protein
[bisphenol A co-treated with naringin] results in decreased expression of TP53 protein; [NG-Nitroarginine Methyl Ester co-treated with naringin] results in decreased expression of TP53 protein; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TP53 protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TP53 protein]; naringin inhibits the reaction [Acrylamide results in increased expression of TP53 mRNA]; naringin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; naringin inhibits the reaction [Cisplatin results in increased expression of TP53 mRNA]; naringin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein]

PMID:22847135 PMID:26120027 PMID:26612654 PMID:32172062 PMID:32428650 More...

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

thymic stromal lymphopoietin

multiple interactions

naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TSLP mRNA]; naringin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TSLP protein]

NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548

G

uncoupling protein 2

multiple interactions

naringin inhibits the reaction [Dietary Fats results in increased expression of UCP2 mRNA]

NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611

G

vascular cell adhesion molecule 1

multiple interactions
decreases expression

MIR126 mRNA affects the reaction [naringin results in decreased expression of VCAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; naringin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]
naringin results in decreased expression of VCAM1 mRNA; naringin results in decreased expression of VCAM1 protein

PMID:24975661 PMID:25391245

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor C

affects expression

naringin affects the expression of VEGFC mRNA

NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848

neoeriocitrin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

bone gamma-carboxyglutamate protein

multiple interactions
increases expression

neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of BGLAP mRNA]
neoeriocitrin results in increased expression of BGLAP mRNA

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

collagen type I alpha 1 chain

multiple interactions
increases expression

neoeriocitrin inhibits the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of COL1A1 mRNA]
neoeriocitrin results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

RUNX family transcription factor 2

increases expression

neoeriocitrin results in increased expression of RUNX2 mRNA

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

neohesperidin dihydrochalcone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of CASP8 protein]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

catalase

multiple interactions

neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

glutamic--pyruvic transaminase

multiple interactions

neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

interleukin 6

multiple interactions

neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

nitric oxide synthase 2

multiple interactions

neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

prostaglandin-endoperoxide synthase 2

multiple interactions

neohesperidin dihydrochalcone inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

taste 1 receptor member 2

multiple interactions

lactisole inhibits the reaction [neohesperidin dihydrochalcone results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]; neohesperidin dihydrochalcone results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]

NCBI chr 5:151,909,617...151,925,760
Ensembl chr 5:151,830,701...151,925,345

G

taste 1 receptor member 3

multiple interactions
affects binding

lactisole inhibits the reaction [neohesperidin dihydrochalcone results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]]; neohesperidin dihydrochalcone binds to and results in increased activity of TAS1R3 protein; neohesperidin dihydrochalcone results in increased activity of [TAS1R3 protein binds to TAS1R2 protein]
neohesperidin dihydrochalcone binds to TAS1R3 protein

PMID:17935609 PMID:20173092

NCBI chr 5:166,468,703...166,472,759
Ensembl chr 5:166,469,589...166,472,742

notoginsenoside R1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

increases transport

ABCB11 protein results in increased transport of notoginsenoside R1

NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730

G

ATP binding cassette subfamily B member 1A

increases expression
multiple interactions

notoginsenoside R1 results in increased expression of ABCB1 mRNA
notoginsenoside R1 results in increased expression of ABCB1A mRNA
NR1I2 protein promotes the reaction [notoginsenoside R1 results in increased expression of ABCB1 mRNA]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily C member 1

increases transport

ABCC1 protein results in increased transport of notoginsenoside R1

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

increases transport

ABCC2 protein results in increased transport of notoginsenoside R1

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily G member 2

increases transport

ABCG2 protein results in increased transport of notoginsenoside R1

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

AKT serine/threonine kinase 1

increases phosphorylation
multiple interactions

notoginsenoside R1 results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 results in increased phosphorylation of AKT1 protein]; notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in decreased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

apolipoprotein E

multiple interactions

notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in decreased abundance of Glutathione]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in decreased expression of MIR20A mRNA]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased abundance of Cholesterol]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased abundance of Triglycerides]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of IFNG protein]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of IL2 protein]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of IL6 protein]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of MIR126A mRNA]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of MIR21A mRNA]; notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of TNF protein]

NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932

G

amyloid beta precursor protein

multiple interactions

notoginsenoside R1 inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of APP protein modified form]
notoginsenoside R1 inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased cleavage of CASP3 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased expression of BAX protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK1 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK3 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK8 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK9 protein]

PMID:24975829 PMID:25714973

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

ATP synthase F1 subunit delta

multiple interactions

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in decreased expression of ATP5F1D protein]]; notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in decreased expression of ATP5F1D protein]

NCBI chr 7:9,560,604...9,565,919
Ensembl chr 7:9,560,608...9,565,929

G

BCL2 associated X, apoptosis regulator

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]]; 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]]; Cyclosporine inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]]; notoginsenoside R1 inhibits the reaction [Excitatory Amino Acid Agonists results in increased expression of BAX protein]; notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]
notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of BAX protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased expression of BAX protein]

PMID:19224577 PMID:24975829 PMID:25305180 PMID:33689844

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions
increases expression

notoginsenoside R1 inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of BCL2 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]
notoginsenoside R1 results in increased expression of BCL2
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in decreased expression of BCL2 protein]]; notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in decreased expression of BCL2 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]

PMID:19224577 PMID:20023602 PMID:23170834 PMID:24975829 PMID:25305180

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

bone gamma-carboxyglutamate protein

multiple interactions
increases expression

fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of BGLAP mRNA]

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

BH3 interacting domain death agonist

multiple interactions

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of BID protein modified form]

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

G

caspase 3

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]]; 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]]; Cyclosporine inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of CASP3 protein modified form]; notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased cleavage of CASP3 protein]]; notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased activity of CASP3 protein]; notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased cleavage of CASP3 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased cleavage of CASP3 protein]; notoginsenoside R1 inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]

PMID:23170834 PMID:24437944 PMID:24720662 PMID:24975829 PMID:25305180 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased activity of CASP8 protein]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased activity of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]

PMID:23170834 PMID:25472953

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

choline O-acetyltransferase

increases expression

notoginsenoside R1 results in increased expression of CHAT

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of CHUK protein modified form]

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity

notoginsenoside R1 results in decreased activity of CYP1A2 protein

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 3, subfamily a, polypeptide 2

increases expression

notoginsenoside R1 results in increased expression of CYP3A4 mRNA

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

estrogen receptor 1

multiple interactions
increases expression

notoginsenoside R1 results in increased phosphorylation of and results in increased activity of ESR1 protein
notoginsenoside R1 results in increased expression of ESR1; notoginsenoside R1 results in increased expression of ESR1 mRNA; notoginsenoside R1 results in increased expression of ESR1 protein
[1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole results in decreased activity of ESR1 protein] which results in decreased susceptibility to notoginsenoside R1; [notoginsenoside R1 co-treated with Lipopolysaccharides] results in increased expression of ESR1 protein; fulvestrant inhibits the reaction [[notoginsenoside R1 co-treated with Lipopolysaccharides] results in increased expression of ESR1 protein]

PMID:23170834 PMID:24720662 PMID:25738436 PMID:26362186

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

increases expression

notoginsenoside R1 results in increased expression of ESR2

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

coagulation factor III, tissue factor

multiple interactions

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of F3 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of F3 protein]

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

Fas cell surface death receptor

multiple interactions

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of FAS mRNA]

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fibronectin 1

multiple interactions

notoginsenoside R1 inhibits the reaction [Hydrogen Peroxide results in increased expression of and results in increased secretion of FN1 protein]; notoginsenoside R1 inhibits the reaction [Hydrogen Peroxide results in increased expression of FN1 mRNA]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
increases expression

Cycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]; Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]; fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of GCLC protein]; NFE2L2 promotes the reaction [notoginsenoside R1 results in increased expression of GCLC protein]; notoginsenoside R1 promotes the reaction [Hydrogen Peroxide results in increased expression of GCLC protein]

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate ionotropic receptor NMDA type subunit 1

multiple interactions

[GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to notoginsenoside R1

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2B

multiple interactions

[GRIN1 protein co-treated with GRIN2B protein] results in increased susceptibility to notoginsenoside R1

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

G

glycogen synthase kinase 3 beta

multiple interactions
increases expression

fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]; wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]
notoginsenoside R1 results in increased expression of GSK3B protein modified form

PMID:23170834 PMID:24720662

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

heme oxygenase 1

multiple interactions
increases expression

[astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein
notoginsenoside R1 results in increased expression of HMOX1; notoginsenoside R1 results in increased expression of HMOX1 protein
Cycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; NFE2L2 promotes the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; notoginsenoside R1 promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]

PMID:24437944 PMID:24720662 PMID:25422538

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

intercellular adhesion molecule 1

multiple interactions

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of ICAM1 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]

PMID:23170834 PMID:25472953

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

insulin degrading enzyme

multiple interactions
increases expression

2-chloro-5-nitrobenzanilide inhibits the reaction [notoginsenoside R1 results in increased expression of IDE]

NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440

G

interferon gamma

multiple interactions

notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of IFNG protein]; notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IFNG mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]

PMID:23170834 PMID:24933211 PMID:25472953

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IKBKB protein modified form]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 10

multiple interactions

notoginsenoside R1 promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein]

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 15

multiple interactions

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL15 mRNA]

NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820

G

interleukin 1 alpha

multiple interactions

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IL1A mRNA]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; Fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]

PMID:23170834 PMID:25472953 PMID:25738436

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

multiple interactions

notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of IL2 protein]; notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IL2 mRNA]

PMID:24933211 PMID:25472953

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 6

multiple interactions

notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of IL6 protein]; notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of IL6 protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; notoginsenoside R1 inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL6 protein]
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; Fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

PMID:17655881 PMID:23170834 PMID:24933211 PMID:25472953 PMID:25738436

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin-linked kinase

multiple interactions

notoginsenoside R1 inhibits the reaction [Streptozocin results in increased activity of ILK protein]

NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140

G

integrin subunit alpha 3

multiple interactions

notoginsenoside R1 inhibits the reaction [Glucose results in decreased expression of ITGA3 mRNA]; notoginsenoside R1 inhibits the reaction [Glucose results in decreased expression of ITGA3 protein]; notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGA3 mRNA]; notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGA3 protein]

NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118

G

integrin subunit alpha M

multiple interactions

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGAM protein]

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

integrin subunit beta 1

multiple interactions

notoginsenoside R1 inhibits the reaction [Glucose results in decreased expression of ITGB1 mRNA]; notoginsenoside R1 inhibits the reaction [Glucose results in decreased expression of ITGB1 protein]; notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGB1 mRNA]; notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGB1 protein]

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

integrin subunit beta 2

decreases expression
multiple interactions

notoginsenoside R1 results in decreased expression of ITGB2 protein
notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of ITGB2 protein]

PMID:17655881 PMID:18176958

NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

notoginsenoside R1 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]
fulvestrant inhibits the reaction [notoginsenoside R1 results in increased phosphorylation of MAPK1 protein]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK1 mRNA]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK1 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK1 protein]

PMID:16458614 PMID:16632126 PMID:24437944 PMID:24975829 PMID:25004876

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

fulvestrant inhibits the reaction [notoginsenoside R1 results in increased phosphorylation of MAPK3 protein]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased expression of MAPK3 mRNA]; notoginsenoside R1 inhibits the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] results in increased phosphorylation of MAPK3 protein]; notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK3 protein]
notoginsenoside R1 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]

PMID:16458614 PMID:16632126 PMID:24437944 PMID:24975829 PMID:25004876

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

mitogen-activated protein kinase 9

multiple interactions

notoginsenoside R1 inhibits the reaction [APP protein modified form results in increased phosphorylation of MAPK9 protein]

NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178

G

microRNA 126a

multiple interactions

notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of MIR126A mRNA]

NCBI chr 3:9,415,063...9,415,180
Ensembl chr 3:9,415,063...9,415,180

G

microRNA 20a

multiple interactions

notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in decreased expression of MIR20A mRNA]

NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168

G

microRNA 21

multiple interactions

notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of MIR21A mRNA]

NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348

G

myeloperoxidase

multiple interactions
decreases expression

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein]; notoginsenoside R1 inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
notoginsenoside R1 results in decreased expression of MPO protein

PMID:20023602 PMID:25472953

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

NFE2 like bZIP transcription factor 2

affects localization
multiple interactions

notoginsenoside R1 affects the localization of NFE2L2 protein
NFE2L2 promotes the reaction [notoginsenoside R1 results in increased expression of GCLC protein]; NFE2L2 promotes the reaction [notoginsenoside R1 results in increased expression of HMOX1 protein]; NFE2L2 promotes the reaction [notoginsenoside R1 results in increased expression of NQO1 protein]; notoginsenoside R1 promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in decreased expression of and affects the localization of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 results in increased expression of and affects the localization of NFE2L2 protein]; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] affects the localization of NFE2L2 protein; notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in decreased expression of and affects the localization of NFE2L2 protein]; notoginsenoside R1 results in increased expression of and affects the localization of NFE2L2 protein

PMID:24437944 PMID:24720662 PMID:25422538 PMID:33689844

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]; notoginsenoside R1 promotes the reaction [Lipopolysaccharides results in increased expression of NFKBIA mRNA]
fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein]]; notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased phosphorylation of NFKBIA protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein]; wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein]]

PMID:9102164 PMID:23170834 PMID:25472953 PMID:25738436

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of NOS2 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
[notoginsenoside R1 results in increased phosphorylation of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide; notoginsenoside R1 results in increased phosphorylation of and results in increased activity of NOS2 protein

PMID:23170834 PMID:25472953 PMID:26045775

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

multiple interactions

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of NOS3 protein]

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

Cycloheximide inhibits the reaction [notoginsenoside R1 results in increased expression of NQO1 protein]; Dactinomycin inhibits the reaction [notoginsenoside R1 results in increased expression of NQO1 protein]; fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of NQO1 protein]; NFE2L2 promotes the reaction [notoginsenoside R1 results in increased expression of NQO1 protein]; notoginsenoside R1 promotes the reaction [Hydrogen Peroxide results in increased expression of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group I, member 2

multiple interactions
increases activity
increases response to substance

notoginsenoside R1 binds to and results in increased activity of NR1I2 protein; NR1I2 protein promotes the reaction [notoginsenoside R1 results in increased expression of ABCB1 mRNA]; NR1I2 protein promotes the reaction [notoginsenoside R1 results in increased expression of UGT1A1 mRNA]
notoginsenoside R1 results in increased activity of NR1I2 protein
NR1I2 protein results in increased susceptibility to notoginsenoside R1

NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658

G

poly (ADP-ribose) polymerase 1

multiple interactions

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of PARP1 protein modified form]

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

plasminogen activator, tissue type

increases expression
multiple interactions

notoginsenoside R1 results in increased expression of PLAT mRNA; notoginsenoside R1 results in increased expression of PLAT protein
notoginsenoside R1 results in increased expression of [PLAT protein binds to SERPINE1 protein]

PMID:8018658 PMID:9220151

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

plasminogen activator, urokinase

increases expression

notoginsenoside R1 results in increased expression of PLAU mRNA; notoginsenoside R1 results in increased expression of PLAU protein

NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775

G

peroxisome proliferator-activated receptor gamma

multiple interactions
increases expression

2-chloro-5-nitrobenzanilide inhibits the reaction [notoginsenoside R1 results in increased expression of PPARG]

NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468

G

protein phosphatase 1, regulatory subunit 12A

multiple interactions

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased phosphorylation of PPP1R12A protein]]; notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased phosphorylation of PPP1R12A protein]

NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425

G

presenilin 1

multiple interactions

notoginsenoside R1 inhibits the reaction [[APP gene mutant form co-treated with PSEN1 gene mutant form] results in increased expression of APP protein modified form]

NCBI chr 6:103,323,052...103,375,088
Ensembl chr 6:103,323,120...103,371,650

G

prostaglandin-endoperoxide synthase 2

multiple interactions

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of RELA protein modified form]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein modified form]
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of RELA protein]]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of RELA protein]

PMID:23170834 PMID:25472953 PMID:25738436

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

Rho-associated coiled-coil containing protein kinase 1

multiple interactions

notoginsenoside R1 inhibits the reaction [[Oxygen co-treated with [Oxygen deficiency co-treated with Glucose deficiency]] results in increased expression of ROCK1 protein]

NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571

G

RUNX family transcription factor 2

increases expression
multiple interactions

notoginsenoside R1 results in increased expression of RUNX2 mRNA
fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of RUNX2 mRNA]

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

selectin E

decreases expression

notoginsenoside R1 results in decreased expression of SELE protein

NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741

G

serpin family E member 1

multiple interactions
decreases activity

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; notoginsenoside R1 results in increased expression of [PLAT protein binds to SERPINE1 protein]
notoginsenoside R1 results in decreased activity of SERPINE1 protein

PMID:8018658 PMID:9102164 PMID:16458614

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

solute carrier organic anion transporter family member 1B2

multiple interactions

SLCO1B2 protein binds to and results in increased transport of notoginsenoside R1
SLCO1B3 protein binds to and results in increased transport of notoginsenoside R1

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

Sp7 transcription factor

multiple interactions
increases expression

fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of SP7 mRNA]

NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847

G

secreted protein acidic and cysteine rich

multiple interactions
increases expression

fulvestrant inhibits the reaction [notoginsenoside R1 results in increased expression of SPARC mRNA]

NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396

G

sequestosome 1

affects localization
multiple interactions

notoginsenoside R1 affects the localization of SQSTM1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 affects the localization of SQSTM1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate affects the localization of SQSTM1 protein]]; notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate affects the localization of SQSTM1 protein]

NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673

G

tumor necrosis factor

multiple interactions
decreases expression

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of FN1 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of FN1 mRNA]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; notoginsenoside R1 inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]
notoginsenoside R1 results in decreased expression of TNF
1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; fulvestrant inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in increased expression of TNF protein]; notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of TNF mRNA]; notoginsenoside R1 inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; notoginsenoside R1 inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]

PMID:9102164 PMID:16458614 PMID:16632126 PMID:20023602 PMID:23170834 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

multiple interactions

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A mRNA]

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

tumor protein p53

multiple interactions

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TRP53 mRNA]; notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of TRP53 protein]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

UDP glucuronosyltransferase family 1 member A1

increases expression
multiple interactions

notoginsenoside R1 results in increased expression of UGT1A1 mRNA
NR1I2 protein promotes the reaction [notoginsenoside R1 results in increased expression of UGT1A1 mRNA]

NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465

G

vascular cell adhesion molecule 1

multiple interactions

notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 protein]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

rutin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ABCA1 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of ABCA1 protein]

NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170

G

ATP binding cassette subfamily B member 1A

multiple interactions

Rutin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

acetylcholinesterase

multiple interactions

Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased activity of ACHE protein]; Rutin inhibits the reaction [Acrylamide results in increased expression of ACHE protein]

PMID:32881150 PMID:36657526

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

ATP citrate lyase

decreases activity

Rutin results in decreased activity of ACLY protein

NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320

G

advanced glycosylation end product-specific receptor

multiple interactions

Rutin inhibits the reaction [Glucose results in increased expression of AGER mRNA]

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

angiotensinogen

multiple interactions

Rutin inhibits the reaction [Isoproterenol results in increased expression of AGT protein]

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

aryl hydrocarbon receptor

decreases localization
multiple interactions

Rutin results in decreased localization of AHR protein
Rutin promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

AKT serine/threonine kinase 1

multiple interactions

Rutin inhibits the reaction [Fructose results in decreased phosphorylation of AKT1 protein]
Rutin inhibits the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein]

PMID:22426011 PMID:35304134

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aryl hydrocarbon receptor nuclear translocator

increases localization

Rutin results in increased localization of ARNT protein

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

ataxin 2

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in increased expression of ATXN2 mRNA]

NCBI chr12:34,754,132...34,851,175
Ensembl chr12:34,754,137...34,851,479

G

ataxin 3

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in increased expression of ATXN3 mRNA]

NCBI chr 6:121,072,228...121,107,902
Ensembl chr 6:121,074,448...121,107,902

G

BCL2-associated agonist of cell death

multiple interactions

Rutin inhibits the reaction [Cisplatin results in increased expression of BAD protein]

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

affects expression
multiple interactions
increases expression

Rutin affects the expression of BAX protein
Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX protein]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of BAX mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of BAX protein]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]
Rutin results in increased expression of BAX protein

PMID:15975156 PMID:28811126 PMID:29522708 PMID:32881150 PMID:33413359

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

Bcl-2 binding component 3

multiple interactions

Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of BBC3 mRNA]

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

G

BCL2, apoptosis regulator

affects expression
multiple interactions
decreases expression

Rutin affects the expression of BCL2 protein
Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]
Rutin results in decreased expression of BCL2 protein
Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BCL2 protein]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in decreased expression of BCL2 protein]
Rutin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of BCL2 protein]

PMID:15975156 PMID:19557821 PMID:26062544 PMID:28811126 PMID:29522708 More...

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of BCL2L1 mRNA]

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

bone gamma-carboxyglutamate protein

multiple interactions

[Rutin co-treated with Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased secretion of BGLAP protein

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

B-Raf proto-oncogene, serine/threonine kinase

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased phosphorylation of BRAF protein]

NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463

G

caspase 1

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of CASP1 protein]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

affects cleavage
increases cleavage
multiple interactions
increases expression
increases activity

Rutin affects the cleavage of CASP3 protein
Rutin results in increased cleavage of CASP3 protein
Rutin inhibits the reaction [Cholesterol, Dietary results in increased cleavage of CASP3 protein]; Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of CASP3 mRNA]; Rutin inhibits the reaction [Oxidopamine results in increased expression of CASP3 mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP3 protein]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of CASP3 mRNA]
[Rutin binds to Zinc] which results in increased expression of CASP3 mRNA; [Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of CASP3 protein]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; Rutin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Rutin inhibits the reaction [Oxaliplatin results in increased expression of CASP3 protein]
Rutin results in increased expression of CASP3 mRNA
Rutin results in increased activity of CASP3 protein

PMID:15975156 PMID:24726691 PMID:24908156 PMID:25129099 PMID:26091902 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

increases activity
multiple interactions

Rutin results in increased activity of CASP7 protein
Rutin inhibits the reaction [Oxidopamine results in increased expression of CASP7 mRNA]

PMID:24726691 PMID:25129099

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

multiple interactions
increases expression

[Rutin binds to Zinc] which results in increased expression of CASP8 mRNA
Rutin results in increased expression of CASP8 mRNA

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

Rutin inhibits the reaction [Cisplatin results in decreased expression of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

Rutin inhibits the reaction [bifenthrin results in decreased activity of CAT protein]
Rutin inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]
Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased activity of CAT protein]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT protein]; Rutin inhibits the reaction [Cisplatin results in decreased expression of CAT protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; Rutin inhibits the reaction [Oxygen deficiency results in decreased activity of CAT protein]

PMID:19833193 PMID:21605616 PMID:25478064 PMID:25753322 PMID:29743444 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

carbonyl reductase 1

multiple interactions

Rutin binds to and results in decreased activity of CBR1 protein; Rutin inhibits the reaction [CBR1 protein results in increased metabolism of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone]

PMID:11306090 PMID:18579125

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

C-C motif chemokine ligand 2

multiple interactions
decreases secretion
decreases expression

Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 mRNA]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of CCL2 protein]
Rutin results in decreased secretion of CCL2 protein
Rutin results in decreased expression of CCL2 mRNA

PMID:21756928 PMID:21967610 PMID:25478064

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

multiple interactions
decreases expression

Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of CCL5 mRNA]

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

cellular communication network factor 2

multiple interactions

Rutin inhibits the reaction [Isoproterenol results in increased expression of CCN2 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of CCN2 protein]

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cyclin D1

multiple interactions
decreases expression

[Rutin binds to Zinc] which results in decreased expression of CCND1 mRNA
Rutin results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

Cd68 molecule

decreases expression

Rutin results in decreased expression of CD68 protein

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

G

choline O-acetyltransferase

multiple interactions

Rutin inhibits the reaction [Acrylamide results in decreased expression of CHAT protein]

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

G

collagen type I alpha 1 chain

multiple interactions

[Rutin co-treated with Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

colony stimulating factor 2

multiple interactions

Rutin inhibits the reaction [Dextran Sulfate results in increased expression of CSF2 mRNA]

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

C-X3-C motif chemokine ligand 1

decreases expression

Rutin results in decreased expression of CX3CL1 mRNA

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X-C motif chemokine ligand 10

multiple interactions
decreases secretion
decreases expression

Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]
Rutin results in decreased secretion of CXCL10 protein
Rutin results in decreased expression of CXCL10 mRNA

PMID:21756928 PMID:21967610

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 12

decreases expression
multiple interactions

Rutin results in decreased expression of CXCL12 mRNA
Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of CXCL12 mRNA]

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

cytochrome c, somatic

multiple interactions

Rutin inhibits the reaction [Oxygen deficiency results in increased expression of CYCS mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of CYCS protein]

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression

Rutin results in increased expression of CYP19A1 protein

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

Rutin results in increased expression of CYP1A1 mRNA

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

decreases activity

Rutin results in decreased activity of CYP1B1 protein

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

epidermal growth factor

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of EGF mRNA]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

Rutin inhibits the reaction [TGFA protein affects the localization of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 1

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in increased expression of EGLN1 mRNA]

NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777

G

estrogen receptor 2

increases expression

Rutin results in increased expression of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

Fas associated via death domain

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of FADD mRNA]

NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653

G

fibronectin 1

increases expression
multiple interactions

Rutin results in increased expression of FN1 protein
Rutin inhibits the reaction [Isoproterenol results in increased expression of FN1 protein]

PMID:24117263 PMID:26408079

NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Rutin inhibits the reaction [oxaliplatin results in increased expression of FOS protein]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box O3

multiple interactions

Rutin inhibits the reaction [Cisplatin affects the localization of FOXO3 protein]

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

follicle stimulating hormone receptor

increases expression

Rutin results in increased expression of FSHR protein

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

glial cell derived neurotrophic factor

increases expression

Rutin results in increased expression of GDNF mRNA

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

glutamic--pyruvic transaminase

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]; Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of GPT protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased activity of GPT protein]

PMID:25478064 PMID:25753322 PMID:26062544 PMID:27239252

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX1 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX1 protein]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione-disulfide reductase

decreases activity
multiple interactions

Rutin results in decreased activity of GSR protein
Rutin inhibits the reaction [Cisplatin results in decreased expression of GSR protein]; Rutin inhibits the reaction [Cyclophosphamide results in decreased activity of GSR protein]

PMID:15782287 PMID:21605616 PMID:25753322

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

Rutin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

multiple interactions

[Rutin co-treated with Carbon Tetrachloride] results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interferon gamma

multiple interactions

Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

multiple interactions

[Lipopolysaccharides co-treated with Rutin] results in decreased expression of IGF1 mRNA

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

multiple interactions

Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IGF1R protein]

NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777

G

interleukin 10

multiple interactions
increases expression

Lipopolysaccharides promotes the reaction [Rutin results in increased expression of IL10 mRNA]
Rutin results in increased expression of IL10 mRNA; Rutin results in increased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 18

multiple interactions
decreases expression

Rutin inhibits the reaction [Fructose results in increased expression of IL18 protein]
Rutin results in decreased expression of IL18 mRNA

PMID:22426011 PMID:28693884

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions
decreases expression

Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL1B mRNA]; Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL1B protein]; Rutin inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Rutin inhibits the reaction [Glucose results in increased expression of IL1B protein]
Rutin results in decreased expression of IL1B mRNA
Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of IL1B mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of IL1B protein]
[Rutin co-treated with Meloxicam] affects the reaction [Formaldehyde affects the expression of IL1B protein]; Rutin affects the reaction [Formaldehyde affects the expression of IL1B protein]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; Rutin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA]; Rutin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]

PMID:15652231 PMID:18958421 PMID:19557821 PMID:22426011 PMID:28693884 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions
decreases expression

Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of IL6 protein]; Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
Rutin results in decreased expression of IL6 mRNA; Rutin results in decreased expression of IL6 protein
Lipopolysaccharides inhibits the reaction [Rutin results in decreased expression of IL6 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; Rutin inhibits the reaction [Fructose results in increased expression of IL6 protein]
Rutin inhibits the reaction [Dextran Sulfate results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]

PMID:15652231 PMID:18958421 PMID:21756928 PMID:22426011 PMID:25753322 More...

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

insulin 1

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of INS1 protein]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

insulin receptor

multiple interactions

Rutin inhibits the reaction [Fructose results in decreased phosphorylation of INSR protein]

NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883

G

insulin receptor substrate 1

decreases expression
multiple interactions

Rutin results in decreased expression of IRS1 protein
Rutin inhibits the reaction [Fructose results in decreased phosphorylation of IRS1 protein]
Rutin results in increased susceptibility to [Vitamin E results in decreased expression of IRS1 protein]; Vitamin E results in increased susceptibility to [Rutin results in decreased expression of IRS1 protein]

PMID:20015448 PMID:22426011

NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122

G

integrin subunit alpha M

increases expression
multiple interactions

Rutin results in increased expression of ITGAM protein
Lipopolysaccharides inhibits the reaction [Rutin results in increased expression of ITGAM protein]

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

Janus kinase 1

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of JAK1 mRNA]

NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926

G

Janus kinase 2

multiple interactions

Rutin inhibits the reaction [Fructose results in decreased phosphorylation of JAK2 protein]

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions

Rutin results in decreased expression of JUN protein
Rutin results in increased susceptibility to [Vitamin E results in decreased expression of JUN protein]; Vitamin E results in increased susceptibility to [Rutin results in decreased expression of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

laminin subunit beta 2

increases expression

Rutin results in increased expression of LAMB2 protein

NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549

G

leptin

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of LEP protein]

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

leptin receptor

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]

NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908

G

galectin 9

multiple interactions

Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of LGALS9 protein]

NCBI chr10:63,907,018...63,930,224
Ensembl chr10:63,907,018...63,930,045

G

mitogen activated protein kinase kinase 5

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of MAP2K5 mRNA]

NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983

G

mitogen activated protein kinase 1

multiple interactions
decreases phosphorylation

Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [Glucose results in increased phosphorylation of MAPK1 protein]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK1 protein]
Rutin inhibits the reaction [Acrylamide results in decreased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [pirarubicin results in increased phosphorylation of MAPK1 protein]
Rutin results in decreased phosphorylation of MAPK1 protein

PMID:19557821 PMID:21756928 PMID:22426011 PMID:29522708 PMID:32864822 More...

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 14

multiple interactions

Rutin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK14 protein]

NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589

G

mitogen activated protein kinase 3

multiple interactions
decreases phosphorylation

Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of MAPK3 protein]
Rutin inhibits the reaction [Acrylamide results in decreased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [Fructose results in decreased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [pirarubicin results in increased phosphorylation of MAPK3 protein]
Rutin results in decreased phosphorylation of MAPK3 protein

PMID:19557821 PMID:21756928 PMID:22426011 PMID:29522708 PMID:32864822 More...

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

Rutin inhibits the reaction [Cisplatin results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

microRNA 100

multiple interactions

Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR100 mRNA]

NCBI chr 8:41,901,225...41,901,304
Ensembl chr 8:41,901,225...41,901,304

G

microRNA 125b-1

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR125B1 mRNA]

NCBI chr 8:41,952,966...41,953,052
Ensembl chr 8:41,952,966...41,953,052

G

microRNA 1306

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR1306 mRNA]

NCBI chr11:82,709,651...82,709,723
Ensembl chr11:82,709,637...82,709,719

G

microRNA 152

multiple interactions

Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR152 mRNA]

NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020

G

microRNA 181c

multiple interactions

Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR181C mRNA]

NCBI chr19:23,983,523...23,983,628
Ensembl chr19:23,983,523...23,983,628

G

microRNA 185

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR185 mRNA]

NCBI chr11:82,664,716...82,664,795
Ensembl chr11:82,664,716...82,664,795

G

microRNA 195

multiple interactions

Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR195 mRNA]

NCBI chr10:54,951,838...54,951,924
Ensembl chr10:54,951,838...54,951,924

G

microRNA 196c

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR196C mRNA]

NCBI chr10:81,231,006...81,231,085
Ensembl chr10:81,231,006...81,231,085

G

microRNA 199a-2

multiple interactions

Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR199A2 mRNA]

NCBI chr13:74,582,954...74,583,063
Ensembl chr13:74,582,954...74,583,063

G

microRNA 204

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR204 mRNA]

NCBI chr 1:220,316,931...220,317,040
Ensembl chr 1:220,316,931...220,317,040

G

microRNA 208b

multiple interactions

Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR208B mRNA]

NCBI chr15:28,451,638...28,451,749
Ensembl chr15:28,451,638...28,451,749

G

microRNA 211

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR211 mRNA]

NCBI chr 1:117,777,539...117,777,644
Ensembl chr 1:117,777,539...117,777,644

G

microRNA 22

multiple interactions

Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR22 mRNA]

NCBI chr10:60,307,039...60,307,133
Ensembl chr10:60,307,039...60,307,133

G

microRNA 26b

multiple interactions

Rutin inhibits the reaction [pirarubicin results in decreased expression of MIR26B mRNA]

NCBI chr 9:75,976,596...75,976,680
Ensembl chr 9:75,976,596...75,976,680

G

microRNA 296

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR296 mRNA]

NCBI chr 3:163,051,838...163,051,915
Ensembl chr 3:163,051,838...163,051,915

G

microRNA 30c-1

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR30C1 mRNA]

NCBI chr 5:134,349,237...134,349,325
Ensembl chr 5:134,349,237...134,349,325

G

microRNA 3558

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR3558 mRNA]

NCBI chr 6:7,181,751...7,181,864
Ensembl chr 6:7,181,751...7,181,864

G

microRNA 3584

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR3584 mRNA]

NCBI chr 1:246,786,249...246,786,329
Ensembl chr 1:246,786,249...246,786,329

G

microRNA 3588

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR3588 mRNA]

NCBI chr11:16,245,611...16,245,716
Ensembl chr11:16,245,611...16,245,716

G

microRNA 365b

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR365B mRNA]

NCBI chr10:64,686,255...64,686,340
Ensembl chr10:64,686,252...64,686,351

G

microRNA 494

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR494 mRNA]

NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793

G

microRNA 6216

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR6216 mRNA]

NCBI chr 3:44,756,861...44,756,938
Ensembl chr 3:44,756,861...44,756,938

G

microRNA 664-2

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR664-2 mRNA]

NCBI chr13:96,793,099...96,793,157
Ensembl chr13:96,793,099...96,793,157

G

microRNA 760

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of MIR760 mRNA]

NCBI chr 2:210,392,616...210,392,695
Ensembl chr 2:210,392,616...210,392,695

G

matrix metallopeptidase 2

multiple interactions

Rutin results in decreased expression of and results in decreased activity of MMP2 protein
Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP2 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP2 protein]

PMID:26408079 PMID:29743444

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 9

decreases expression
multiple interactions

Rutin results in decreased expression of MMP9 mRNA
Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP9 protein]

PMID:16304905 PMID:29743444

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased activity of MPO protein]

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mannose receptor, C type 1

increases expression
multiple interactions

Rutin results in increased expression of MRC1 protein
[Lipopolysaccharides co-treated with Rutin] results in increased expression of MRC1 protein

NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857

G

NFE2 like bZIP transcription factor 2

multiple interactions

Rutin promotes the reaction [Carbon Tetrachloride results in increased expression of NFE2L2 protein]
[Rutin co-treated with Hydrogen Peroxide] affects the localization of NFE2L2 protein; Rutin inhibits the reaction [Acrylamide results in decreased expression of NFE2L2 protein]

PMID:22902988 PMID:31412289 PMID:36657526

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

Rutin inhibits the reaction [Glucose results in increased degradation of and results in decreased expression of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NLR family, pyrin domain containing 3

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of NLRP3 protein]

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

G

nitric oxide synthase 2

multiple interactions
decreases expression

Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of NOS2 protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of NOS2 protein]
Rutin results in decreased expression of NOS2 mRNA; Rutin results in decreased expression of NOS2 protein
Rutin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Rutin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]

PMID:11500931 PMID:12512693 PMID:22902988 PMID:25080890 PMID:25753322 More...

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

N-ethylmaleimide sensitive factor, vesicle fusing ATPase

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in decreased expression of NSF mRNA]

NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386

G

neuronal vesicle trafficking associated 1

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in decreased expression of NSG1 mRNA]

NCBI chr14:72,648,771...72,670,521
Ensembl chr14:72,648,741...72,670,514

G

OPA1, mitochondrial dynamin like GTPase

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in decreased expression of OPA1 mRNA]

NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109

G

Parkinsonism associated deglycase

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in increased expression of PARK7 mRNA]

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

G

patatin-like phospholipase domain containing 3

decreases expression

Rutin results in decreased expression of PNPLA3 mRNA

NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077

G

paraoxonase 1

multiple interactions
increases expression

Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON1 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON1 protein]
Rutin results in increased expression of PON1 mRNA

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

paraoxonase 3

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON3 mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PON3 protein]

NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855

G

peroxisome proliferator activated receptor alpha

multiple interactions

Rutin inhibits the reaction [Fructose results in decreased expression of PPARA protein]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor delta

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARD mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARD protein]

NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968

G

peptidylprolyl isomerase D

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in increased expression of PPID mRNA]

NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221

G

parkin RBR E3 ubiquitin protein ligase

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in increased expression of PRKN mRNA]

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

G

phosphatase and tensin homolog

multiple interactions

Rutin inhibits the reaction [Cisplatin results in increased phosphorylation of PTEN protein]

NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838

G

prostaglandin-endoperoxide synthase 2

multiple interactions
decreases expression

[Rutin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of PTGS2 mRNA; Rutin inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]; Rutin inhibits the reaction [Glucose results in increased expression of PTGS2 protein]
Rutin results in decreased expression of PTGS2 mRNA
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of PTGS2 protein]; Rutin inhibits the reaction [Dextran Sulfate results in increased expression of PTGS2 mRNA]; Rutin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of PTGS2 protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein]

PMID:11500931 PMID:15652231 PMID:19557821 PMID:21756928 PMID:22902988 More...

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

PYD and CARD domain containing

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of PYCARD protein]

NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955

G

RAP1A, member of RAS oncogene family

multiple interactions

Rutin inhibits the reaction [pirarubicin results in increased expression of RAP1A mRNA]; Rutin inhibits the reaction [pirarubicin results in increased expression of RAP1A protein]

NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Rutin inhibits the reaction [Glucose affects the localization of RELA protein]; Rutin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RELA protein]
Rutin inhibits the reaction [Carbon Tetrachloride affects the localization of RELA protein]

PMID:19557821 PMID:21756928 PMID:29522708

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RUNX family transcription factor 2

multiple interactions

[Rutin co-treated with Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 mRNA

NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167

G

sirtuin 1

increases expression

Rutin results in increased expression of SIRT1 mRNA; Rutin results in increased expression of SIRT1 protein

NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260

G

signaling lymphocytic activation molecule family member 1

increases expression
multiple interactions

Rutin results in increased expression of SLAMF1 protein
Lipopolysaccharides inhibits the reaction [Rutin results in increased expression of SLAMF1 protein]

NCBI chr13:84,270,316...84,305,497
Ensembl chr13:84,270,316...84,305,497

G

solute carrier family 22 member 1

multiple interactions

Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A1 protein]

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 12

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 mRNA]; Rutin inhibits the reaction [Fructose results in increased expression of SLC22A12 protein]

NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555

G

solute carrier family 22 member 2

multiple interactions

Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A2 protein]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 22 member 6

multiple interactions

Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 mRNA]; Rutin inhibits the reaction [Fructose results in decreased expression of SLC22A6 protein]

NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173

G

solute carrier family 2 member 9

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 mRNA SNP]; Rutin inhibits the reaction [Fructose results in increased expression of SLC2A9 protein SNP]

NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981

G

solute carrier organic anion transporter family member 1B2

multiple interactions

Rutin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein]

NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981

G

solute carrier organic anion transporter family, member 2b1

multiple interactions
affects localization

Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Cholic Acid]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of estrone sulfate]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium]; Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Taurocholic Acid]
Rutin affects the localization of SLCO2B1 protein

NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353

G

SMAD family member 2

multiple interactions

Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of SMAD2 mRNA]

NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323

G

SMAD family member 4

multiple interactions

Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of SMAD4 mRNA]

NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438

G

suppressor of cytokine signaling 3

multiple interactions

Rutin inhibits the reaction [Fructose results in increased expression of SOCS3 protein]

NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787

G

superoxide dismutase 1

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

sorbitol dehydrogenase

multiple interactions

[Rutin co-treated with Meloxicam] inhibits the reaction [Formaldehyde affects the activity of SORD protein]; Rutin inhibits the reaction [Formaldehyde affects the activity of SORD protein]

NCBI chr 3:109,184,697...109,216,133
Ensembl chr 3:109,184,676...109,216,133

G

steroidogenic acute regulatory protein

increases expression

Rutin results in increased expression of STAR protein

NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672

G

signal transducer and activator of transcription 3

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of STAT3 mRNA]; Rutin inhibits the reaction [Fructose results in increased phosphorylation of STAT3 protein]

PMID:22426011 PMID:26062544

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

transforming growth factor alpha

multiple interactions

Rutin inhibits the reaction [TGFA protein affects the localization of EGFR protein]

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

transforming growth factor, beta 1

multiple interactions

Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of TGFB1 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of TGFB1 mRNA]; Rutin inhibits the reaction [Isoproterenol results in increased expression of TGFB1 protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of TGFB1 mRNA]

PMID:22902988 PMID:24117263 PMID:27239252 PMID:28693884

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

tyrosine hydroxylase

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in decreased expression of TH mRNA]

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

G

tumor necrosis factor

multiple interactions
decreases expression

Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased expression of TNF mRNA]; Rutin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] results in increased secretion of TNF protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]; Rutin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL8 protein]; Rutin inhibits the reaction [Glucose results in increased expression of TNF mRNA]; Rutin inhibits the reaction [Glucose results in increased expression of TNF protein]
Rutin results in decreased expression of TNF mRNA; Rutin results in decreased expression of TNF protein
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Rutin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
Rutin inhibits the reaction [Carrageenan results in increased expression of TNF protein]; Rutin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Rutin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; Rutin inhibits the reaction [Fructose results in increased expression of TNF protein]

PMID:14654164 PMID:18958421 PMID:19557821 PMID:21605616 PMID:21756928 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

tumor protein p53

multiple interactions

Rutin inhibits the reaction [Cholesterol, Dietary results in increased expression of TP53 mRNA]
Rutin inhibits the reaction [Cisplatin results in increased expression of TP53 protein]
Rutin inhibits the reaction [Carbon Tetrachloride results in increased expression of TRP53 protein]

PMID:27239252 PMID:29522708 PMID:29962303

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

ubiquitin C-terminal hydrolase L1

multiple interactions

Rutin inhibits the reaction [Oxidopamine results in increased expression of UCHL1 mRNA]

NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590

G

vascular cell adhesion molecule 1

multiple interactions

Rutin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of VCAM1 protein]

NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958

G

vascular endothelial growth factor A

multiple interactions
decreases expression

Rutin results in decreased secretion of and results in decreased expression of VEGFA protein; Rutin results in increased susceptibility to [Vitamin E results in decreased expression of VEGFA mRNA]; Rutin results in increased susceptibility to [Vitamin E results in decreased secretion of and results in decreased expression of VEGFA protein]; Vitamin E results in increased susceptibility to [Rutin results in decreased expression of VEGFA mRNA]; Vitamin E results in increased susceptibility to [Rutin results in decreased secretion of and results in decreased expression of VEGFA protein]
Rutin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Rutin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]

PMID:20015448 PMID:33413359

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

xanthine dehydrogenase

multiple interactions

Rutin inhibits the reaction [Cyclophosphamide results in increased activity of XDH protein]

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

spiramycin II

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

acetylspiramycin results in increased expression of FOS mRNA; acetylspiramycin results in increased expression of FOS protein

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

sucralose

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

gastrin

increases secretion

trichlorosucrose results in increased secretion of GAST protein

NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496

G

taste 1 receptor member 2

multiple interactions
affects binding

trichlorosucrose results in increased activity of [TAS1R2 protein binds to TAS1R3 protein]
trichlorosucrose binds to TAS1R2 protein

PMID:20173092 PMID:20302879

NCBI chr 5:151,909,617...151,925,760
Ensembl chr 5:151,830,701...151,925,345

G

taste 1 receptor member 3

multiple interactions
affects binding

trichlorosucrose results in increased activity of [TAS1R2 protein binds to TAS1R3 protein]
trichlorosucrose binds to TAS1R3 protein

PMID:20173092 PMID:20302879

NCBI chr 5:166,468,703...166,472,759
Ensembl chr 5:166,469,589...166,472,742

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19811
chemical entity	19840
atom	19809
nonmetal atom	19747
oxygen atom	19520
oxygen molecular entity	19490
organooxygen compound	19137
carbohydrates and carbohydrate derivatives	15269
carbohydrate derivative	14290
disaccharide derivative	464
(2R,3R,4R)-2-[(2R,3S,4R,5R)-4,6-Dihydroxy-5-(sulfoamino)-2-(sulfooxymethyl)oxan-3-yl]oxy-4,5-dihydroxy-3-sulfooxy-3,4-dihydro-2H-pyran-6-carboxylic acid	0
(2R,3R,4R)-2-[(2R,3S,4R,5R,6S)-4,6-Dihydroxy-5-(sulfoamino)-2-(sulfooxymethyl)oxan-3-yl]oxy-4,5-dihydroxy-3-sulfooxy-3,4-dihydro-2H-pyran-6-carboxylic acid	0
(2R,3R,4R,5S,6Z)-4,5-dihydroxy-6-(hydroxyimino)-2-(hydroxymethyl)piperidin-3-yl 4-O-methyl-alpha-D-maltoside	0
(2R,3R,4R,5S,6Z)-4,5-dihydroxy-6-(hydroxyimino)-2-(hydroxymethyl)piperidin-3-yl alpha-D-maltoside	0
(2R,3S,4S,5R,6R)-3,4,5-Trihydroxy-6-[(2R,3R,4R,5R,6S)-6-hydroxy-5-(sulfoamino)-4-sulfooxy-2-(sulfooxymethyl)oxan-3-yl]oxyoxane-2-carboxylic acid	0
(2S)-1-O-(9Z,12Z)-octadecadienoyl-2-O-(7Z,10Z)-hexadecadienoyl-3-O-(alpha-D-galactopyranosyl(1->6)-beta-D-galactopyranosyl)-sn-glycerol	0
(2S)-poncirin	0
(2S,3R,4R)-2-[(2R,3S,4R,5R,6R)-4,6-Dihydroxy-5-(sulfoamino)-2-(sulfooxymethyl)oxan-3-yl]oxy-3,4,5-trihydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid	0
(2S,3R,4R)-2-[(2R,3S,4R,5R,6R)-4,6-Dihydroxy-5-(sulfoamino)-2-(sulfooxymethyl)oxan-3-yl]oxy-4,5-dihydroxy-3-sulfooxy-3,4-dihydro-2H-pyran-6-carboxylic acid	0
(2S,3S,4S,5R,6R)-3,4,5-Trihydroxy-6-[(2R,3R,4R,5R)-6-hydroxy-5-(sulfoamino)-4-sulfooxy-2-(sulfooxymethyl)oxan-3-yl]oxyoxane-2-carboxylic acid	0
(2S,3S,4S,5R,6R)-3,4,5-Trihydroxy-6-[(2R,3R,4R,5R,6S)-6-hydroxy-5-(sulfoamino)-4-sulfooxy-2-(sulfooxymethyl)oxan-3-yl]oxyoxane-2-carboxylic acid	0
(2S,3S,4S,5R,6R)-6-[(2R,3S,4R,5R)-4,6-Dihydroxy-5-(sulfoamino)-2-(sulfooxymethyl)oxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid	0
(3beta,9beta,10alpha,22E,24R)-24,25-dihydroxy-4,4,9,14-tetramethyl-19-norcholesta-5,22-dien-3-yl 6-O-beta-D-glucopyranosyl-beta-D-glucopyranoside	0
(R)-vicianin	0
(alpha-D-Man)-(1->4)-(alpha-D-GlcN)-(1->6)-1-O-(6-thiohexylphosphono)-D-myo-inositol	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(3'-O-acetyl)-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1-O-acetylmaltose +	0
2''-O-(4-sinapoylarabinosyl)isoscoparin	0
2''-O-(6-feruloylglucosyl)isovitexin	0
2''-O-(6-sinapoylglucosyl)isovitexin	0
2''-O-(beta-D-glucosyl)isovitexin	0
2''-O-alpha-L-arabinopyranosylisoscoparin	0
2''-O-beta-D-glucosylisoscoparin	0
2''-O-rhamnosylscoparin	0
2,3-dihydroxypropyl 2-O-alpha-D-glucopyranosyl-beta-D-galactofuranoside	0
2,5-anhydro-3-O-(2-O-sulfo-alpha-L-idopyranuronosyl)-D-glucitol	0
2,6-dideoxy-4-O-methyl-alpha-D-arabino-hexopyranosyl-(1->3)-4-O-acetyl-2-O-methyl-alpha-L-fucopyranose	0
2-N-acetyl-alpha-D-glucosaminopyranosyl-(1->3)-2-N-acetyl-6-(5-aminopentyl phosphoryl)-alpha-D-glucosaminopyranosyl-(1->2)-(2R)-3-hydroxypropanoate	0
2-N-acetyl-alpha-D-glucosaminopyranosyl-(1->3)-2-N-acetyl-6-(5-aminopentyl phosphoryl)-alpha-D-glucosaminopyranosyl-(1->2)-(2R)-3-hydroxypropanoate dimer	0
2-O-(N-acetyl-alpha-D-galactosaminyl)-L-fucitol	0
2-O-[6-O-octanoyl-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl]-D-glyceric acid	0
2-O-[alpha-D-glucosyl-(1->6)-alpha-D-glucosyl]-D-glyceric acid	0
2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-O-phospho-D-glyceric acid	0
2-O-[alpha-D-mannosyl-(1->2)-alpha-D-glucosyl]-D-glyceric acid	0
23(R),24(S),25-trihydroxycucurbit-5-ene 3-O-\{[beta-glucopyranosyl(1->6)]-O-beta-glucopyranosyl\}-25-O-beta-glucopyranoside	0
2alpha-acetoxy-28-acetylrubiarboside G	0
3',4',5,7-tetrahydroxy-3-methoxyflavone-7-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside	0
3,6-di-O-methyl-beta-D-glucopyranosyl-(1->4)-alpha-L-rhamnopyranose	0
3-(hexadecylsulfonyl)-2-[(hexadecylsulfonyl)methyl]propyl alpha-D-galactosyl-(1->4)-beta-D-galactoside	0
3-(hexadecylsulfonyl)-2-[(hexadecylsulfonyl)methyl]propyl beta-D-galactosyl-(1->4)-beta-D-glucoside	0
3-O-alpha-rhamnopyranosyl-(1->4)-beta-glucopyranosyl-17-hydroxygeranyllinalool	0
3-O-sulfo-beta-D-GlcA-(1->3)-1-O-allyl-D-Gal	0
3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-bis(long-chain acyl)-sn-glycerol	0
3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-didodecanoyl-sn-glycerol	0
3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-dioctoanoyl-sn-glycerol	0
3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-2-mono(long-chain acyl)-sn-glycerol	0
3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-2-octoanoyl-sn-glycerol	0
3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-mono(long-chain acyl)-sn-glycerol	0
3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-monododecanoyl-sn-glycerol	0
3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-monooctanoyl-sn-glycerol	0
3-hydroxyphloretin 2'-O-xylosylglucoside	0
3S-hydrangenol 4'-O-alpha-L-rhamnopyranoysl-(1->3)-beta-D-glucopyranoside	0
3beta-[(O-beta-D-glucopyranosyl-(1->3)-4,6-dideoxy-2-O-methyl-beta-D-gulopyranosyl)]-5beta,14beta-dihydroxy-19-oxocard-20(22)enolide	0
4',5,7-trihydroxy-3-methoxyflavone-7-O-alpha-L-arabinofuranosyl(1->6)-beta-D-glucopyranoside	0
4',5,7-trihydroxy-3-methoxyflavone-7-O-rutinoside	0
4-O-methyl-alpha-L-rhamnopyranosyl-(1->4)-2-O-methyl-alpha-L-fucopyranose	0
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside	15
4-nitrophenyl beta-lactoside	0
5,6,7,4'-tetrahydroxyflavonol-3-O-rutinoside	0
5-hydroxy-2-methylchromone-7-O-rutinoside	0
5-hydroxy-6-methoxy-2-methylchromone-7-O-rutinoside	0
5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronide]	0
6-C-[2'-O-alpha-L-rhamnopyranosyl-(1''->2')]-alpha-L-arabinopyranosylluteolin	0
6-C-[2-O-alpha-L-rhamnopyranosyl-(1''->2')]-beta-D-xylopyranosylluteolin	0
6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside +	0
6-O-(trans-feruloyl)-beta-D-galactopyranosyl-(1->4)-D-galactopyranose	0
6-deoxy-alpha-L-Talp2,4Ac2-(1->3)-beta-D-GlcpO[CH2]5NH2	0
6-deoxy-alpha-L-Talp2Ac-(1->3)-beta-D-GlcpO[CH2]5NH2	0
6-hydroxyluteolin 7-O-laminaribioside	0
7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]chrysoeriol	0
7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]isoorientin	0
7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]isoscoparin	0
7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]isovitexin	0
7-O-[beta-D-arabinopyranosyl-(1->6)-beta-D-glucosyl]apigenin	0
7-O-[beta-D-arabinopyranosyl-(1->6)-beta-D-glucosyl]luteolin	0
7-O-methoxy gossypetin 3-O-rutinoside	0
7-O-methylvitexin 2''-O-alpha-L-rhamnoside	0
7-O-methylvitexin 2''-O-beta-L-rhamnoside	0
7-hydroxyflavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside]	0
D-Galp3S-(1->4)-D-Glcp	0
D-galactosyl-N-acetyl-alpha-D-galactosaminide	0
Delta(4)-beta-D-GlcpA-(1->4)-D-GlcpNS6S	0
Delta(4)-beta-D-GlcpA2S-(1->4)-beta-D-GlcpNS6S	0
Goyaglycoside H	0
Lyciumoside I	0
Mogroside II-A1	0
Mogroside II-A2	0
N-(3-\{[alpha-D-GalN-(1->4)-alpha-D-GalN-yl]oxy\}propyl)-21-(biotinylamino)-4,7,10,13,16,19-hexaoxadodecan-1-amide	0
N-(3-\{[alpha-D-GalNAc-(1->4)-alpha-D-GalNAc-yl]oxy\}propyl)-21-(biotinylamino)-4,7,10,13,16,19-hexaoxadodecan-1-amide	0
N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminide	0
N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminide	0
O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-serine +	0
O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonine	0
Ys-II	0
[P-6-[CH2]5NH2]-alpha-D-GlcpNAc-(1->3)-[P-6-[CH2]5NH2]-alpha-D-GlcpNAc-(1->2)-D-GroA	0
\{[3,4-dihydroxy-5-(hydroxymethyl)-2-\{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy\}oxolan-2-yl]methoxy\}sulfonic acid	0
\{[3,4-dihydroxy-5-(hydroxymethyl)-5-\{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy\}oxolan-2-yl]methoxy\}sulfonic acid	0
acacetin-8-C-neohesperidoside	0
aclacinomycin S	0
acteoside	45
acutoside A	0
adxanthromycin B	0
albibrissinoside A	0
alpha-D-Gal-(1->3)-alpha-D-Gal-OMe	0
alpha-D-Gal-(1->4)-alpha-D-Gal-OMe	0
alpha-D-Gal-(1->4)-beta-D-Gal-OEt	0
alpha-D-GalNpAc-(1->3)-alpha-D-GalpNAc-OMe	0
alpha-D-GalNpAc-(1->3)-beta-D-GalpNAc-OMe	0
alpha-D-Galp 2S-(1->4)-beta-D-Galp	0
alpha-D-Galp-(1->4)-beta-D-Galp-O(CH2)2S(CH2)2CO2Me	0
alpha-D-Galp-(1->4)-beta-D-Galp-O(CH2)2S(CH2)2CONH2	0
alpha-D-Glcp-(1->2)-alpha-D-GlcpO[CH2]5NH2	0
alpha-D-Glcp-(1->4)-alpha-D-GalpO[CH2]2NH2	0
alpha-D-GlcpA-(1->6)-alpha-D-GlcpO[CH2]5NH2	0
alpha-D-GlcpNS-(1->4)-alpha-L-IdopA2S	0
alpha-D-Man3Me-(1->4)-alpha-D-Man3Me	0
alpha-D-Manp-(1->3)-alpha-D-Rhap4NFoO[CH2]5CO2Me	0
alpha-D-Rhap2,3Me24NFo-(1->3)-alpha-D-Rhap4NFoO[CH2]5CO2Me	0
alpha-D-Rhap2Me4NFo-(1->3)-alpha-D-Rhap4NFoO[CH2]5CO2Me	0
alpha-D-Rhap4NFo-(1->3)-alpha-D-Rhap4NFoO[CH2]5CO2Me	0
alpha-Kdo-(2->4)-5,6-dehydro-alpha-Kdo-OAll	0
alpha-Kdo-(2->4)-alpha-Kdo-OAll	0
alpha-Kdo-(2->8)-alpha-7-O-Me-Kdo	0
alpha-Kdo-(2->8)-alpha-Kdo-OAll	0
alpha-Kdo-(2->8)-alpha-Kdo-OAll II(1),I(7)-lactone	0
alpha-Kdo1Me-(2->8)-alpha-Kdo-OAll	0
alpha-L-Fucp-(1->2)-alpha-L-FucpO[CH2]6NH2	0
alpha-L-Fucp2Me-(1->2)-beta-D-Galp4Me	0
alpha-L-Rhap-(1->3)-alpha-L-RhapO[CH2]5NH2	0
alpha-L-Rhap-(1->3)-beta-D-Glcp-O[CH2]2SH	0
alpha-L-Rhap-(1->3)-beta-D-GlcpO[CH2]5NH2	0
alpha-L-Rhap-(1->4)-D-ribitol-5-phosphate	0
alpha-L-Rhap2,3Me2-(1->2)-alpha-L-Rhap3Me	0
alpha-L-fucosyl-(1->2)-beta-D-galactoside	0
alpha-L-threo-hex-4-enopyranuronosyl-(1->4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-Glcp	0
amaranthin	0
amino disaccharide +	0
amygdalin +	7
anthemis glycoside A	0
anthemis glycoside B	0
apigenin-7-O-gentiobioside	0
astragaloside III	0
attenoside	0
bayogenin 3-O-cellobioside	0
beta-D-Gal-(1->4)-beta-D-Glc-OMe	0
beta-D-Galf-(1->3)-alpha-D-Manp-OMe	0
beta-D-Galf-(1->6)-alpha-D-Manp-OMe	0
beta-D-Galp-(1->4)-alpha-D-GlcpNAc-OMe	0
beta-D-Galp6S-(1->4)-D-Glcp	0
beta-D-GlcA-(1->3)-beta-D-Gal-OC6H4-4-OMe	0
beta-D-GlcA3S-(1->3)-beta-D-Gal-OC6H4-4-OMe	0
beta-D-GlcA3S-(1->3)-beta-D-Gal-OC6H4-4-[CH2]2NHC(O)[CH2]3SH	0
beta-D-GlcA3S-(1->3)-beta-D-Gal-OMe	0
beta-D-GlcA3S-(1->4)-D-Xylp	0
beta-D-Glcp-(1->3)-beta-D-GlcpAOCH2CH2NH2	0
beta-D-Glcp-(1->4)-alpha-D-GlcpOCH2CH2NH2	0
beta-D-Glcp3,6Me2-(1->4)-alpha-L-Rhap2,3-Me2	0
beta-D-GlcpA-(1->4)-beta-D-GlcpOCH2CH2NH2	0
beta-D-GlcpA2S-(1->4)-alpha-D-GlcpNS6S	0
beta-D-GlcpA3S -(1->4)-beta-D-Xylp	0
beta-D-Manp-(1->2)-alpha-D-ManpO[CH2]5NH2	0
beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminide +	0
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide	0
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminide +	0
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminide +	0
beta-D-galactosyl-(1->4)-beta-D-glucoside	0
beta-D-gentiobiosyl crocetin +	58
beta-L-Rhap-(1->3)-beta-D-GlcpO[CH2]5NH2	0
calicheamicin +	0
cassiaoccidentalin B	0
chloroeremomycin	0
chrysoeriol 7-O-gentiobioside	0
cimifoetiside A	0
cimifoetiside B	0
cleistanthin C +	0
crocin-1	58
cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside]	0
cyanidin 3-O-rutinoside +	0
cyanidin 3-O-rutinoside 5-O-beta-D-glucoside	0
decyl beta-D-maltopyranoside	0
delphinidin 3-O-rutinoside-7-O-beta-D-glucoside	0
demethylmacrocin	0
diosmin	26
dipsacussaponin A	0
disaccharide phosphate +	2
dodecyl beta-D-maltoside	0
dutomycin	0
epivancomycin	0
eprinomectin component B1a +	4
eprinomectin component B1b +	4
eriocitrin	10
eriodictoyl-7-O-sophoroside	0
flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside]	0
flavonol 3-O-D-xylosyl-D-galactoside	0
flavonol 3-O-D-xylosyl-D-glucoside	0
flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside]s	0
flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside]s +	0
flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside	0
formononetin 7-O-rutinoside	0
furanocandin	0
furcatin	0
genistin 7-O-gentiobioside	0
ginsenoside C-Y	0
ginsenoside Mc	0
ginsenoside Mx	0
ginsenoside Rb2	2
ginsenoside Rb3	0
ginsenoside Rc	1
ginsenoside Re	84
ginsenoside Rf	4
ginsenoside Rg2	17
glochierioside A	0
glochierioside B	0
glycosyl glycoside derivative +	0
glycosylfructose derivative	0
glycosylfucose derivative	0
glycosylgalactose derivative +	0
glycosylglucose derivative +	0
glycosylmannose derivative +	0
glycosylpentose derivative	0
glycosylrhamnose derivative +	0
glycosylxylose derivative +	0
gypenoside LXXV	13
gypenoside XVII	0
gypsogenin 3-O-rhamnosylglucosiduronic acid	0
hellebrin	0
heparin disaccharide +	0
hesperidin +	83
hydrangenol 4'-O-beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside	0
irilone-4'-O-[beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside]	0
isorhamnetin 3-O-alpha-L-[6''''-p-coumaroyl-beta-D-glucopyranosyl-(1->2)-rhamnopyranoside]	0
isorhamnetin 3-O-robinobioside	0
isorhamnetin-3-O-rutinoside	0
isovitexin 2''-O-arabinoside	0
isovitexin 2''-O-beta-D-glucoside	0
josamycin	47
kaempferol 3-O-alpha-L-[6'''-p-coumaroyl-beta-D-glucopyranosyl-(1->2)-rhamnopyranoside]	0
kaempferol 3-O-beta-D-glucosylgalactoside	0
kaempferol 3-O-gentiobioside-7-O-rhamnoside	0
kaempferol 3-beta-gentiobioside	0
kaempferol-3-rutinoside	0
kalopanaxsaponin A	0
keto-disaccharide derivative	0
linalool 3,6-oxide primeveroside	0
locoracemoside B	0
locoracemoside C	0
lucumin	0
luteolin 6-C-[beta-D-glucosyl-(1->2)-alpha-L-arabinoside]	0
luteolin 7-O-neohesperidoside	0
luteolin-7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide]	0
lyciumoside IV +	0
macrocin	0
malonylapiin	0
mannioside A	0
maysin	0
methyl 2-O-alpha-L-fucopyranosyl-beta-D-galactoside	0
methyl 3-(\{2-[(2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-beta-D-glucopyranosyl)oxy]ethyl\}sulfanyl)propanoate	0
methyl alpha-L-rhamnosyl-(1->2)-3-(2-glycerylphospho)-beta-D-galactoside	0
methyl alpha-L-rhamnosyl-(1->2)-beta-D-galactoside	0
methyl hesperidin	0
momordicoside A	0
momordicoside C	0
momordicoside S	0
multiflorin B	0
multinoside A	0
mycothiols +	0
myricetin 3-O-[(6-O-trans-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]	0
naringin	162
naringin chalcone	0
narirutin	0
neoeriocitrin	3
neohesperidin	0
neohesperidin dihydrochalcone	9
neohesperidoside +	165
nicotianoside I	0
nicotianoside II	0
niruriside	0
notoginsenoside R1	82
octyl 6-O-beta-D-galactofuranosyl-alpha-D-glucopyranoside	0
oritavancin +	0
papulacandin A	0
papulacandin B	0
papulacandin C	0
pectolinarin	0
pedunculosumoside C	0
pelargonidin 3-O-rutinoside	0
pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside	0
phleomycin D1 +	0
physcion 8-gentiobioside	0
pinen-10-yl vicianoside	0
pinocembrin 7-rhamnosylglucoside	0
pradimicin A	0
pradimicin C	0
premithramycin A2'	0
quercetin 3-O-[beta-D-xylosyl-(1->2)-beta-D-glucoside]	0
quercetin 3-O-alpha-(6'''-caffeoylglucosyl-beta-1,2-rhamnoside)	0
quercetin 3-O-alpha-L-[6'''-p-coumaroyl-beta-D-glucopyranosyl-(1->2)-rhamnopyranoside]	0
quercetin 3-O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranoside	0
quercetin 3-O-arabinoside 7-O-rhamnoside	0
quercetin 3-O-beta-D-glucopyranosyl-(1->2)-rhamnopyranoside	0
quercetin 3-beta-gentiobioside	0
quercetin-7-O-[alpha-L-rhamnopyranosyl(1->6)-beta-D-galactopyranoside]	0
rubiarbonol A 3-O-beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside	0
rubiarboside G 28-acetate	0
rubiarboside G 28-al	0
rutin	152
sapinmusaponin Q	0
scillaren A	0
scroside D	0
sesaminol 2-O-beta-D-gentiobioside	0
sinapoyl-isovitexin 2''-O-arabinoside	0
sophoroside +	6
spiramycin I	0
spiramycin II	1
sucralose	3
torvoside H	0
tylosin	0
vitexin 2''-O-alpha-L-rhamnoside	0
vitexin 2''-O-beta-D-glucoside	0
vitexin 2''-O-beta-L-rhamnoside	0
withalongolide H	0
yuccalan	0
Path 2
Term	Annotations
CHEBI ontology	19811
subatomic particle	19809
composite particle	19809
hadron	19840
baryon	19809
nucleon	19809
atomic nucleus	19809
atom	19809
main group element atom	19759
p-block element atom	19759
carbon group element atom	19708
carbon atom	19734
organic molecular entity	19705
heteroorganic entity	19459
organochalcogen compound	19222
organooxygen compound	19137
carbohydrates and carbohydrate derivatives	15269
carbohydrate	15284
oligosaccharide	619
disaccharide	524
disaccharide derivative	464
(2R,3R,4R)-2-[(2R,3S,4R,5R)-4,6-Dihydroxy-5-(sulfoamino)-2-(sulfooxymethyl)oxan-3-yl]oxy-4,5-dihydroxy-3-sulfooxy-3,4-dihydro-2H-pyran-6-carboxylic acid	0
(2R,3R,4R)-2-[(2R,3S,4R,5R,6S)-4,6-Dihydroxy-5-(sulfoamino)-2-(sulfooxymethyl)oxan-3-yl]oxy-4,5-dihydroxy-3-sulfooxy-3,4-dihydro-2H-pyran-6-carboxylic acid	0
(2R,3R,4R,5S,6Z)-4,5-dihydroxy-6-(hydroxyimino)-2-(hydroxymethyl)piperidin-3-yl 4-O-methyl-alpha-D-maltoside	0
(2R,3R,4R,5S,6Z)-4,5-dihydroxy-6-(hydroxyimino)-2-(hydroxymethyl)piperidin-3-yl alpha-D-maltoside	0
(2R,3S,4S,5R,6R)-3,4,5-Trihydroxy-6-[(2R,3R,4R,5R,6S)-6-hydroxy-5-(sulfoamino)-4-sulfooxy-2-(sulfooxymethyl)oxan-3-yl]oxyoxane-2-carboxylic acid	0
(2S)-1-O-(9Z,12Z)-octadecadienoyl-2-O-(7Z,10Z)-hexadecadienoyl-3-O-(alpha-D-galactopyranosyl(1->6)-beta-D-galactopyranosyl)-sn-glycerol	0
(2S)-poncirin	0
(2S,3R,4R)-2-[(2R,3S,4R,5R,6R)-4,6-Dihydroxy-5-(sulfoamino)-2-(sulfooxymethyl)oxan-3-yl]oxy-3,4,5-trihydroxy-3,4-dihydro-2H-pyran-6-carboxylic acid	0
(2S,3R,4R)-2-[(2R,3S,4R,5R,6R)-4,6-Dihydroxy-5-(sulfoamino)-2-(sulfooxymethyl)oxan-3-yl]oxy-4,5-dihydroxy-3-sulfooxy-3,4-dihydro-2H-pyran-6-carboxylic acid	0
(2S,3S,4S,5R,6R)-3,4,5-Trihydroxy-6-[(2R,3R,4R,5R)-6-hydroxy-5-(sulfoamino)-4-sulfooxy-2-(sulfooxymethyl)oxan-3-yl]oxyoxane-2-carboxylic acid	0
(2S,3S,4S,5R,6R)-3,4,5-Trihydroxy-6-[(2R,3R,4R,5R,6S)-6-hydroxy-5-(sulfoamino)-4-sulfooxy-2-(sulfooxymethyl)oxan-3-yl]oxyoxane-2-carboxylic acid	0
(2S,3S,4S,5R,6R)-6-[(2R,3S,4R,5R)-4,6-Dihydroxy-5-(sulfoamino)-2-(sulfooxymethyl)oxan-3-yl]oxy-3,4-dihydroxy-5-sulfooxyoxane-2-carboxylic acid	0
(3beta,9beta,10alpha,22E,24R)-24,25-dihydroxy-4,4,9,14-tetramethyl-19-norcholesta-5,22-dien-3-yl 6-O-beta-D-glucopyranosyl-beta-D-glucopyranoside	0
(R)-vicianin	0
(alpha-D-Man)-(1->4)-(alpha-D-GlcN)-(1->6)-1-O-(6-thiohexylphosphono)-D-myo-inositol	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(3'-O-acetyl)-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-(6'-O-acetyl)-beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside	0
1,3,6-trihydroxy-2-methyl-9,10-anthraquinone-3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-glucopyranoside	0
1-O-acetylmaltose +	0
2''-O-(4-sinapoylarabinosyl)isoscoparin	0
2''-O-(6-feruloylglucosyl)isovitexin	0
2''-O-(6-sinapoylglucosyl)isovitexin	0
2''-O-(beta-D-glucosyl)isovitexin	0
2''-O-alpha-L-arabinopyranosylisoscoparin	0
2''-O-beta-D-glucosylisoscoparin	0
2''-O-rhamnosylscoparin	0
2,3-dihydroxypropyl 2-O-alpha-D-glucopyranosyl-beta-D-galactofuranoside	0
2,5-anhydro-3-O-(2-O-sulfo-alpha-L-idopyranuronosyl)-D-glucitol	0
2,6-dideoxy-4-O-methyl-alpha-D-arabino-hexopyranosyl-(1->3)-4-O-acetyl-2-O-methyl-alpha-L-fucopyranose	0
2-N-acetyl-alpha-D-glucosaminopyranosyl-(1->3)-2-N-acetyl-6-(5-aminopentyl phosphoryl)-alpha-D-glucosaminopyranosyl-(1->2)-(2R)-3-hydroxypropanoate	0
2-N-acetyl-alpha-D-glucosaminopyranosyl-(1->3)-2-N-acetyl-6-(5-aminopentyl phosphoryl)-alpha-D-glucosaminopyranosyl-(1->2)-(2R)-3-hydroxypropanoate dimer	0
2-O-(N-acetyl-alpha-D-galactosaminyl)-L-fucitol	0
2-O-[6-O-octanoyl-alpha-D-glucosyl-(1->6)-alpha-D-glucosyl]-D-glyceric acid	0
2-O-[alpha-D-glucosyl-(1->6)-alpha-D-glucosyl]-D-glyceric acid	0
2-O-[alpha-D-mannopyranosyl-(1->2)-alpha-D-glucopyranosyl]-3-O-phospho-D-glyceric acid	0
2-O-[alpha-D-mannosyl-(1->2)-alpha-D-glucosyl]-D-glyceric acid	0
23(R),24(S),25-trihydroxycucurbit-5-ene 3-O-\{[beta-glucopyranosyl(1->6)]-O-beta-glucopyranosyl\}-25-O-beta-glucopyranoside	0
2alpha-acetoxy-28-acetylrubiarboside G	0
3',4',5,7-tetrahydroxy-3-methoxyflavone-7-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside	0
3,6-di-O-methyl-beta-D-glucopyranosyl-(1->4)-alpha-L-rhamnopyranose	0
3-(hexadecylsulfonyl)-2-[(hexadecylsulfonyl)methyl]propyl alpha-D-galactosyl-(1->4)-beta-D-galactoside	0
3-(hexadecylsulfonyl)-2-[(hexadecylsulfonyl)methyl]propyl beta-D-galactosyl-(1->4)-beta-D-glucoside	0
3-O-alpha-rhamnopyranosyl-(1->4)-beta-glucopyranosyl-17-hydroxygeranyllinalool	0
3-O-sulfo-beta-D-GlcA-(1->3)-1-O-allyl-D-Gal	0
3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-bis(long-chain acyl)-sn-glycerol	0
3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-didodecanoyl-sn-glycerol	0
3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-1,2-dioctoanoyl-sn-glycerol	0
3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-2-mono(long-chain acyl)-sn-glycerol	0
3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-2-octoanoyl-sn-glycerol	0
3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-mono(long-chain acyl)-sn-glycerol	0
3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-monododecanoyl-sn-glycerol	0
3-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-monooctanoyl-sn-glycerol	0
3-hydroxyphloretin 2'-O-xylosylglucoside	0
3S-hydrangenol 4'-O-alpha-L-rhamnopyranoysl-(1->3)-beta-D-glucopyranoside	0
3beta-[(O-beta-D-glucopyranosyl-(1->3)-4,6-dideoxy-2-O-methyl-beta-D-gulopyranosyl)]-5beta,14beta-dihydroxy-19-oxocard-20(22)enolide	0
4',5,7-trihydroxy-3-methoxyflavone-7-O-alpha-L-arabinofuranosyl(1->6)-beta-D-glucopyranoside	0
4',5,7-trihydroxy-3-methoxyflavone-7-O-rutinoside	0
4-O-methyl-alpha-L-rhamnopyranosyl-(1->4)-2-O-methyl-alpha-L-fucopyranose	0
4-\{[4-(dimethylamino)phenyl]diazenyl\}phenyl-beta-lactoside	15
4-nitrophenyl beta-lactoside	0
5,6,7,4'-tetrahydroxyflavonol-3-O-rutinoside	0
5-hydroxy-2-methylchromone-7-O-rutinoside	0
5-hydroxy-6-methoxy-2-methylchromone-7-O-rutinoside	0
5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronide]	0
6-C-[2'-O-alpha-L-rhamnopyranosyl-(1''->2')]-alpha-L-arabinopyranosylluteolin	0
6-C-[2-O-alpha-L-rhamnopyranosyl-(1''->2')]-beta-D-xylopyranosylluteolin	0
6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside +	0
6-O-(trans-feruloyl)-beta-D-galactopyranosyl-(1->4)-D-galactopyranose	0
6-deoxy-alpha-L-Talp2,4Ac2-(1->3)-beta-D-GlcpO[CH2]5NH2	0
6-deoxy-alpha-L-Talp2Ac-(1->3)-beta-D-GlcpO[CH2]5NH2	0
6-hydroxyluteolin 7-O-laminaribioside	0
7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]chrysoeriol	0
7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]isoorientin	0
7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]isoscoparin	0
7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]isovitexin	0
7-O-[beta-D-arabinopyranosyl-(1->6)-beta-D-glucosyl]apigenin	0
7-O-[beta-D-arabinopyranosyl-(1->6)-beta-D-glucosyl]luteolin	0
7-O-methoxy gossypetin 3-O-rutinoside	0
7-O-methylvitexin 2''-O-alpha-L-rhamnoside	0
7-O-methylvitexin 2''-O-beta-L-rhamnoside	0
7-hydroxyflavanone 7-O-[beta-L-rhamnosyl-(1->2)-beta-D-glucoside]	0
D-Galp3S-(1->4)-D-Glcp	0
D-galactosyl-N-acetyl-alpha-D-galactosaminide	0
Delta(4)-beta-D-GlcpA-(1->4)-D-GlcpNS6S	0
Delta(4)-beta-D-GlcpA2S-(1->4)-beta-D-GlcpNS6S	0
Goyaglycoside H	0
Lyciumoside I	0
Mogroside II-A1	0
Mogroside II-A2	0
N-(3-\{[alpha-D-GalN-(1->4)-alpha-D-GalN-yl]oxy\}propyl)-21-(biotinylamino)-4,7,10,13,16,19-hexaoxadodecan-1-amide	0
N-(3-\{[alpha-D-GalNAc-(1->4)-alpha-D-GalNAc-yl]oxy\}propyl)-21-(biotinylamino)-4,7,10,13,16,19-hexaoxadodecan-1-amide	0
N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminide	0
N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminide	0
O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-serine +	0
O-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonine	0
Ys-II	0
[P-6-[CH2]5NH2]-alpha-D-GlcpNAc-(1->3)-[P-6-[CH2]5NH2]-alpha-D-GlcpNAc-(1->2)-D-GroA	0
\{[3,4-dihydroxy-5-(hydroxymethyl)-2-\{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy\}oxolan-2-yl]methoxy\}sulfonic acid	0
\{[3,4-dihydroxy-5-(hydroxymethyl)-5-\{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy\}oxolan-2-yl]methoxy\}sulfonic acid	0
acacetin-8-C-neohesperidoside	0
aclacinomycin S	0
acteoside	45
acutoside A	0
adxanthromycin B	0
albibrissinoside A	0
alpha-D-Gal-(1->3)-alpha-D-Gal-OMe	0
alpha-D-Gal-(1->4)-alpha-D-Gal-OMe	0
alpha-D-Gal-(1->4)-beta-D-Gal-OEt	0
alpha-D-GalNpAc-(1->3)-alpha-D-GalpNAc-OMe	0
alpha-D-GalNpAc-(1->3)-beta-D-GalpNAc-OMe	0
alpha-D-Galp 2S-(1->4)-beta-D-Galp	0
alpha-D-Galp-(1->4)-beta-D-Galp-O(CH2)2S(CH2)2CO2Me	0
alpha-D-Galp-(1->4)-beta-D-Galp-O(CH2)2S(CH2)2CONH2	0
alpha-D-Glcp-(1->2)-alpha-D-GlcpO[CH2]5NH2	0
alpha-D-Glcp-(1->4)-alpha-D-GalpO[CH2]2NH2	0
alpha-D-GlcpA-(1->6)-alpha-D-GlcpO[CH2]5NH2	0
alpha-D-GlcpNS-(1->4)-alpha-L-IdopA2S	0
alpha-D-Man3Me-(1->4)-alpha-D-Man3Me	0
alpha-D-Manp-(1->3)-alpha-D-Rhap4NFoO[CH2]5CO2Me	0
alpha-D-Rhap2,3Me24NFo-(1->3)-alpha-D-Rhap4NFoO[CH2]5CO2Me	0
alpha-D-Rhap2Me4NFo-(1->3)-alpha-D-Rhap4NFoO[CH2]5CO2Me	0
alpha-D-Rhap4NFo-(1->3)-alpha-D-Rhap4NFoO[CH2]5CO2Me	0
alpha-Kdo-(2->4)-5,6-dehydro-alpha-Kdo-OAll	0
alpha-Kdo-(2->4)-alpha-Kdo-OAll	0
alpha-Kdo-(2->8)-alpha-7-O-Me-Kdo	0
alpha-Kdo-(2->8)-alpha-Kdo-OAll	0
alpha-Kdo-(2->8)-alpha-Kdo-OAll II(1),I(7)-lactone	0
alpha-Kdo1Me-(2->8)-alpha-Kdo-OAll	0
alpha-L-Fucp-(1->2)-alpha-L-FucpO[CH2]6NH2	0
alpha-L-Fucp2Me-(1->2)-beta-D-Galp4Me	0
alpha-L-Rhap-(1->3)-alpha-L-RhapO[CH2]5NH2	0
alpha-L-Rhap-(1->3)-beta-D-Glcp-O[CH2]2SH	0
alpha-L-Rhap-(1->3)-beta-D-GlcpO[CH2]5NH2	0
alpha-L-Rhap-(1->4)-D-ribitol-5-phosphate	0
alpha-L-Rhap2,3Me2-(1->2)-alpha-L-Rhap3Me	0
alpha-L-fucosyl-(1->2)-beta-D-galactoside	0
alpha-L-threo-hex-4-enopyranuronosyl-(1->4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-Glcp	0
amaranthin	0
amino disaccharide +	0
amygdalin +	7
anthemis glycoside A	0
anthemis glycoside B	0
apigenin-7-O-gentiobioside	0
astragaloside III	0
attenoside	0
bayogenin 3-O-cellobioside	0
beta-D-Gal-(1->4)-beta-D-Glc-OMe	0
beta-D-Galf-(1->3)-alpha-D-Manp-OMe	0
beta-D-Galf-(1->6)-alpha-D-Manp-OMe	0
beta-D-Galp-(1->4)-alpha-D-GlcpNAc-OMe	0
beta-D-Galp6S-(1->4)-D-Glcp	0
beta-D-GlcA-(1->3)-beta-D-Gal-OC6H4-4-OMe	0
beta-D-GlcA3S-(1->3)-beta-D-Gal-OC6H4-4-OMe	0
beta-D-GlcA3S-(1->3)-beta-D-Gal-OC6H4-4-[CH2]2NHC(O)[CH2]3SH	0
beta-D-GlcA3S-(1->3)-beta-D-Gal-OMe	0
beta-D-GlcA3S-(1->4)-D-Xylp	0
beta-D-Glcp-(1->3)-beta-D-GlcpAOCH2CH2NH2	0
beta-D-Glcp-(1->4)-alpha-D-GlcpOCH2CH2NH2	0
beta-D-Glcp3,6Me2-(1->4)-alpha-L-Rhap2,3-Me2	0
beta-D-GlcpA-(1->4)-beta-D-GlcpOCH2CH2NH2	0
beta-D-GlcpA2S-(1->4)-alpha-D-GlcpNS6S	0
beta-D-GlcpA3S -(1->4)-beta-D-Xylp	0
beta-D-Manp-(1->2)-alpha-D-ManpO[CH2]5NH2	0
beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminide +	0
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide	0
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminide +	0
beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminide +	0
beta-D-galactosyl-(1->4)-beta-D-glucoside	0
beta-D-gentiobiosyl crocetin +	58
beta-L-Rhap-(1->3)-beta-D-GlcpO[CH2]5NH2	0
calicheamicin +	0
cassiaoccidentalin B	0
chloroeremomycin	0
chrysoeriol 7-O-gentiobioside	0
cimifoetiside A	0
cimifoetiside B	0
cleistanthin C +	0
crocin-1	58
cyanidin 3-O-[beta-D-xylosyl-(1->2)-beta-D-galactoside]	0
cyanidin 3-O-rutinoside +	0
cyanidin 3-O-rutinoside 5-O-beta-D-glucoside	0
decyl beta-D-maltopyranoside	0
delphinidin 3-O-rutinoside-7-O-beta-D-glucoside	0
demethylmacrocin	0
diosmin	26
dipsacussaponin A	0
disaccharide phosphate +	2
dodecyl beta-D-maltoside	0
dutomycin	0
epivancomycin	0
eprinomectin component B1a +	4
eprinomectin component B1b +	4
eriocitrin	10
eriodictoyl-7-O-sophoroside	0
flavanone 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside]	0
flavonol 3-O-D-xylosyl-D-galactoside	0
flavonol 3-O-D-xylosyl-D-glucoside	0
flavonol 3-O-[alpha-L-rhamnosyl-(1->6)-beta-D-glucoside]s	0
flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside]s +	0
flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside	0
formononetin 7-O-rutinoside	0
furanocandin	0
furcatin	0
genistin 7-O-gentiobioside	0
ginsenoside C-Y	0
ginsenoside Mc	0
ginsenoside Mx	0
ginsenoside Rb2	2
ginsenoside Rb3	0
ginsenoside Rc	1
ginsenoside Re	84
ginsenoside Rf	4
ginsenoside Rg2	17
glochierioside A	0
glochierioside B	0
glycosyl glycoside derivative +	0
glycosylfructose derivative	0
glycosylfucose derivative	0
glycosylgalactose derivative +	0
glycosylglucose derivative +	0
glycosylmannose derivative +	0
glycosylpentose derivative	0
glycosylrhamnose derivative +	0
glycosylxylose derivative +	0
gypenoside LXXV	13
gypenoside XVII	0
gypsogenin 3-O-rhamnosylglucosiduronic acid	0
hellebrin	0
heparin disaccharide +	0
hesperidin +	83
hydrangenol 4'-O-beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside	0
irilone-4'-O-[beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside]	0
isorhamnetin 3-O-alpha-L-[6''''-p-coumaroyl-beta-D-glucopyranosyl-(1->2)-rhamnopyranoside]	0
isorhamnetin 3-O-robinobioside	0
isorhamnetin-3-O-rutinoside	0
isovitexin 2''-O-arabinoside	0
isovitexin 2''-O-beta-D-glucoside	0
josamycin	47
kaempferol 3-O-alpha-L-[6'''-p-coumaroyl-beta-D-glucopyranosyl-(1->2)-rhamnopyranoside]	0
kaempferol 3-O-beta-D-glucosylgalactoside	0
kaempferol 3-O-gentiobioside-7-O-rhamnoside	0
kaempferol 3-beta-gentiobioside	0
kaempferol-3-rutinoside	0
kalopanaxsaponin A	0
keto-disaccharide derivative	0
linalool 3,6-oxide primeveroside	0
locoracemoside B	0
locoracemoside C	0
lucumin	0
luteolin 6-C-[beta-D-glucosyl-(1->2)-alpha-L-arabinoside]	0
luteolin 7-O-neohesperidoside	0
luteolin-7-O-[beta-D-glucuronosyl-(1->2)-beta-D-glucuronide]	0
lyciumoside IV +	0
macrocin	0
malonylapiin	0
mannioside A	0
maysin	0
methyl 2-O-alpha-L-fucopyranosyl-beta-D-galactoside	0
methyl 3-(\{2-[(2-acetamido-2-deoxy-3-O-beta-D-galactopyranosyl-beta-D-glucopyranosyl)oxy]ethyl\}sulfanyl)propanoate	0
methyl alpha-L-rhamnosyl-(1->2)-3-(2-glycerylphospho)-beta-D-galactoside	0
methyl alpha-L-rhamnosyl-(1->2)-beta-D-galactoside	0
methyl hesperidin	0
momordicoside A	0
momordicoside C	0
momordicoside S	0
multiflorin B	0
multinoside A	0
mycothiols +	0
myricetin 3-O-[(6-O-trans-4-coumaroyl-beta-D-glucosyl)-(1->2)-alpha-L-rhamnoside]	0
naringin	162
naringin chalcone	0
narirutin	0
neoeriocitrin	3
neohesperidin	0
neohesperidin dihydrochalcone	9
neohesperidoside +	165
nicotianoside I	0
nicotianoside II	0
niruriside	0
notoginsenoside R1	82
octyl 6-O-beta-D-galactofuranosyl-alpha-D-glucopyranoside	0
oritavancin +	0
papulacandin A	0
papulacandin B	0
papulacandin C	0
pectolinarin	0
pedunculosumoside C	0
pelargonidin 3-O-rutinoside	0
pelargonidin 3-O-rutinoside 5-O-beta-D-glucoside	0
phleomycin D1 +	0
physcion 8-gentiobioside	0
pinen-10-yl vicianoside	0
pinocembrin 7-rhamnosylglucoside	0
pradimicin A	0
pradimicin C	0
premithramycin A2'	0
quercetin 3-O-[beta-D-xylosyl-(1->2)-beta-D-glucoside]	0
quercetin 3-O-alpha-(6'''-caffeoylglucosyl-beta-1,2-rhamnoside)	0
quercetin 3-O-alpha-L-[6'''-p-coumaroyl-beta-D-glucopyranosyl-(1->2)-rhamnopyranoside]	0
quercetin 3-O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranoside	0
quercetin 3-O-arabinoside 7-O-rhamnoside	0
quercetin 3-O-beta-D-glucopyranosyl-(1->2)-rhamnopyranoside	0
quercetin 3-beta-gentiobioside	0
quercetin-7-O-[alpha-L-rhamnopyranosyl(1->6)-beta-D-galactopyranoside]	0
rubiarbonol A 3-O-beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranoside	0
rubiarboside G 28-acetate	0
rubiarboside G 28-al	0
rutin	152
sapinmusaponin Q	0
scillaren A	0
scroside D	0
sesaminol 2-O-beta-D-gentiobioside	0
sinapoyl-isovitexin 2''-O-arabinoside	0
sophoroside +	6
spiramycin I	0
spiramycin II	1
sucralose	3
torvoside H	0
tylosin	0
vitexin 2''-O-alpha-L-rhamnoside	0
vitexin 2''-O-beta-D-glucoside	0
vitexin 2''-O-beta-L-rhamnoside	0
withalongolide H	0
yuccalan	0

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