reducing agent - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	reducing agent	go back to main search page
Accession:	CHEBI:63247	browse the term
Definition:	The element or compound in a reduction-oxidation (redox) reaction that donates an electron to another species.
Synonyms:	related_synonym:	reducer; reducers; reducing agents; reductant; reductants
	xref:	Wikipedia:Reducing_agent

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Genes (218)

1,4-dithiothreitol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine A1 receptor

multiple interactions

[Dithiothreitol co-treated with Cadmium Chloride] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; [Dithiothreitol co-treated with Dithionitrobenzoic Acid] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]; Dithiothreitol inhibits the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

AKT serine/threonine kinase 1

multiple interactions

Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aminolevulinate dehydratase

multiple interactions
increases activity

Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]]
Dithiothreitol results in increased activity of ALAD protein
[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]; Cadmium affects the reaction [[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]]; lead nitrate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; triethyllead acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; triethyllead acetate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]
cadmium acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; Dithiothreitol inhibits the reaction [2,2'-dithienyl diselenide results in decreased activity of ALAD protein]; Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]; Zinc Acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]

PMID:2061546 PMID:20472051 PMID:21360559 PMID:21910133 PMID:22180340 More...

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

apurinic/apyrimidinic endodeoxyribonuclease 1

multiple interactions

Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein]

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

androgen receptor

multiple interactions

Dithiothreitol inhibits the reaction [cadmium sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [Copper Sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [zinc chloride inhibits the reaction [Androgens binds to AR protein]]

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

arsenite methyltransferase

multiple interactions
increases reduction

Dithiothreitol promotes the reaction [AS3MT protein results in increased methylation of Arsenic]
Dithiothreitol results in increased reduction of AS3MT protein
Dithiothreitol promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]

PMID:15025511 PMID:25349987

NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872

G

activating transcription factor 3

increases expression

Dithiothreitol results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 4

increases expression

Dithiothreitol results in increased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

ATPase copper transporting alpha

multiple interactions

Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein]

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

BCL2, apoptosis regulator

multiple interactions

Dithiothreitol inhibits the reaction [arsenic trioxide results in increased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

calumenin

increases expression

Dithiothreitol results in increased expression of CALU protein

NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593

G

caspase 1

multiple interactions

Dithiothreitol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions

[Dithiothreitol co-treated with Peroxynitrous Acid] results in increased metabolism of CASP3 protein; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]; Dithiothreitol inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide results in decreased activity of CASP3 protein]; Dithiothreitol promotes the reaction [1-(N-(3-ammoniopropyl)-N-(n-propyl)amino)diazen-1-ium-1,2-diolate results in increased metabolism of CASP3 protein]
Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]]
Dithiothreitol inhibits the reaction [1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one inhibits the reaction [[Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]]

PMID:9388267 PMID:9441900 PMID:9706149 PMID:9755104 PMID:10673743 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP8 protein]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]; CAT protein inhibits the reaction [Dithiothreitol results in increased abundance of Hydrogen Peroxide]

PMID:7491977 PMID:32493877

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

carbonyl reductase 1

multiple interactions

Dithiothreitol inhibits the reaction [S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]]

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

cyclin D1

decreases expression

Dithiothreitol results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin G2

increases expression

Dithiothreitol results in increased expression of CCNG2 mRNA

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

G

cadherin 1

multiple interactions

Dithiothreitol inhibits the reaction [4-cresol sulfate results in decreased expression of CDH1 protein]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

CF transmembrane conductance regulator

multiple interactions

Dithiothreitol inhibits the reaction [Glutathione results in decreased activity of CFTR protein]

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of CHUK protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]]

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Dithiothreitol inhibits the reaction [1-nitropyrene results in increased degradation of CYP1A1 protein]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450 family 7 subfamily A member 1

increases activity

Dithiothreitol results in increased activity of CYP7A1 protein

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

Dithiothreitol results in increased expression of DDIT3 mRNA
indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of DDIT3 mRNA]

PMID:17332266 PMID:23123503 PMID:27226639

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

Dithiothreitol results in increased expression of DNAJB9 mRNA

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

eukaryotic translation initiation factor 2A

multiple interactions

Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2A protein

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases phosphorylation

Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2AK3 protein
Dithiothreitol results in increased phosphorylation of EIF2AK3 protein

PMID:12486162 PMID:25321315

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions
increases phosphorylation

EIF2S1 protein mutant form inhibits the reaction [Dithiothreitol results in increased phosphorylation of EIF2S1 protein]

PMID:30385349 PMID:34244458

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions
increases expression

Dithiothreitol results in increased phosphorylation of and results in increased activity of ERN1 protein
Dithiothreitol results in increased expression of ERN1 protein

PMID:12486162 PMID:25321315

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

estrogen receptor 1

multiple interactions

fulvestrant inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

coagulation factor III, tissue factor

increases activity

Dithiothreitol results in increased activity of F3 protein

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fibroblast growth factor 21

increases expression
increases secretion
multiple interactions

Dithiothreitol results in increased expression of FGF21 mRNA
Dithiothreitol results in increased secretion of FGF21 protein
indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of FGF21 mRNA]

PMID:23123503 PMID:27226639

NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454

G

growth arrest and DNA-damage-inducible, alpha

increases expression

Dithiothreitol results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

Dithiothreitol inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Dithiothreitol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HIF1A protein alternative form]

PMID:14695184 PMID:17658243

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

multiple interactions

Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of HMOX1 protein]
Dithiothreitol inhibits the reaction [farrerol results in increased expression of HMOX1 protein]; Dithiothreitol inhibits the reaction [hydroquinone results in increased expression of HMOX1 protein]

PMID:23290930 PMID:24489685 PMID:26111761

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hydroxysteroid 11-beta dehydrogenase 2

multiple interactions
increases activity

Dithiothreitol inhibits the reaction [perfluorodecanoic acid results in decreased activity of HSD11B2 protein]; Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein]; Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein]; perfluorodecanoic acid inhibits the reaction [Dithiothreitol results in increased activity of HSD11B2 protein]

PMID:12901862 PMID:26859423 PMID:36878351

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions
increases activity

Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD3B1 protein]
Dithiothreitol results in increased activity of HSD3B1 protein

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

heat shock protein 90 beta family member 1

multiple interactions

Dactinomycin inhibits the reaction [Dithiothreitol results in increased expression of HSP90B1 mRNA]; Dithiothreitol results in increased expression of and affects the localization of HSP90B1 mRNA

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 5

increases expression

Dithiothreitol metabolite results in increased expression of HSPA5 protein; Dithiothreitol results in increased expression of HSPA5 mRNA; Dithiothreitol results in increased expression of HSPA5 protein

PMID:15710169 PMID:17332266 PMID:17416481 PMID:21692457 PMID:23123503 More...

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]]
Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]

PMID:17067557 PMID:20584749

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 1 alpha

multiple interactions

[Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 5

multiple interactions

Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]]

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 5 receptor subunit alpha

multiple interactions

Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]]

NCBI chr 4:139,630,652...139,664,593
Ensembl chr 4:139,632,066...139,668,544

G

inhibin subunit beta E

increases expression

Dithiothreitol results in increased expression of INHBE mRNA

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

insulin 1

decreases activity
multiple interactions

Dithiothreitol results in decreased activity of INS1 protein
Dithiothreitol affects the reaction [oxophenylarsine results in decreased activity of INS1 protein]; Dithiothreitol inhibits the reaction [INS1 protein results in increased uptake of Glucose]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kinesin family member 5A

multiple interactions

Dithiothreitol inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein]

NCBI chr 7:63,051,894...63,089,024
Ensembl chr 7:63,049,424...63,092,858

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions

Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]]

NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800

G

mitogen activated protein kinase 1

multiple interactions

Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]; Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein]

PMID:11035063 PMID:23370007

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

Dithiothreitol inhibits the reaction [Sodium Selenite results in decreased activity of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

microsomal glutathione S-transferase 1

multiple interactions

Dithiothreitol inhibits the reaction [[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]

PMID:16125204 PMID:16386761

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

methionine sulfoxide reductase B2

increases reduction

Dithiothreitol results in increased reduction of MSRB2 protein

NCBI chr17:81,974,378...82,000,044
Ensembl chr17:81,974,196...82,000,043

G

methionine sulfoxide reductase B3

increases reduction

Dithiothreitol results in increased reduction of MSRB3 protein

NCBI chr 7:56,260,985...56,426,004
Ensembl chr 7:56,303,308...56,425,496

G

myosin light chain kinase

multiple interactions

Dithiothreitol inhibits the reaction [4-cresol sulfate results in increased phosphorylation of MYLK protein]

NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261

G

N-acetyltransferase 1

increases activity
multiple interactions

Dithiothreitol results in increased activity of NAT1 protein
Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of NAT1 protein]

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

NFE2 like bZIP transcription factor 2

multiple interactions

Dithiothreitol inhibits the reaction [diallyl trisulfide affects the localization of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]]
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]

PMID:9281604 PMID:14762100 PMID:16219905

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions

Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]]
Dithiothreitol inhibits the reaction [ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate results in increased activity of NFKBIA protein]

PMID:17067557 PMID:19509257

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]
Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]
Dithiothreitol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]

PMID:7532384 PMID:9706149 PMID:9755104 PMID:15907790

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

Dithiothreitol inhibits the reaction [arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [Thiram inhibits the reaction [Dexamethasone binds to NR3C1 protein]]
Dithiothreitol inhibits the reaction [Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]

PMID:2226332 PMID:2298732 PMID:15250541 PMID:16857225

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

neurogranin

multiple interactions

Dithiothreitol inhibits the reaction [chloramine-T affects the phosphorylation of NRGN protein]

NCBI chr 8:37,255,462...37,263,659
Ensembl chr 8:37,256,930...37,257,516

G

nudix hydrolase 9

multiple interactions

Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium Chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [manganese chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Manganese results in increased activity of NUDT9 protein]]

NCBI chr14:5,675,376...5,693,332
Ensembl chr14:5,675,382...5,693,142

G

oxoglutarate dehydrogenase

multiple interactions

Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of OGDH protein]; Dithiothreitol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein]

NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479

G

purinergic receptor P2X 2

multiple interactions

Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]

NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891

G

3'-phosphoadenosine 5'-phosphosulfate synthase 1

increases activity

Dithiothreitol results in increased activity of PAPSS1 protein

NCBI chr 2:220,040,343...220,114,399
Ensembl chr 2:220,040,312...220,114,395

G

poly (ADP-ribose) polymerase 1

multiple interactions

Dithiothreitol inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]
Dithiothreitol inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein]; Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]

PMID:11035063 PMID:18022205 PMID:20438634

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

programmed cell death 6 interacting protein

increases expression

Dithiothreitol results in increased expression of PDCD6IP protein

NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773

G

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3

increases expression

Dithiothreitol results in increased expression of PLOD3 protein

NCBI chr12:19,676,384...19,686,945
Ensembl chr12:19,676,386...19,686,960

G

PPARG coactivator 1 alpha

increases expression

Dithiothreitol results in increased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

multiple interactions

Dithiothreitol affects the reaction [4-cresol sulfate affects the localization of PTK2 protein]

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine phosphatase, non-receptor type 1

multiple interactions

Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in increased glutathionylation of PTPN1 protein]
[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein; CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]

PMID:16781456 PMID:32493877

NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504

G

reticulocalbin 2

increases expression

Dithiothreitol results in increased expression of RCN2 protein

NCBI chr 8:56,449,206...56,466,253
Ensembl chr 8:56,449,206...56,466,251

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases activity

Dithiothreitol inhibits the reaction [cinnamaldehyde results in increased glutathionylation of RELA protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]
Dithiothreitol results in increased activity of RELA protein
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]

PMID:7491977 PMID:9281604 PMID:16219905 PMID:20351055

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

S100 calcium binding protein A2

multiple interactions

Dithiothreitol inhibits the reaction [Copper promotes the reaction [S100A2 protein binds to S100A2 protein]]; Dithiothreitol inhibits the reaction [S100A2 protein binds to S100A2 protein]

NCBI chr 2:176,077,081...176,078,325

G

S100 calcium-binding protein A4

multiple interactions

Dithiothreitol inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]]

NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254

G

solute carrier family 16 member 1

multiple interactions

Dithiothreitol inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid]

NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611

G

snail family transcriptional repressor 1

multiple interactions

Dithiothreitol inhibits the reaction [4-cresol sulfate results in increased expression of SNAI1 protein]

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

snail family transcriptional repressor 2

multiple interactions

Dithiothreitol inhibits the reaction [4-cresol sulfate results in increased expression of SNAI2 protein]

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

superoxide dismutase 1

affects folding
multiple interactions

Dithiothreitol affects the folding of SOD1 protein
Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]]
[Dithiothreitol results in increased reduction of SOD1 protein] promotes the reaction [Hydrogen Peroxide results in increased oxidation of SOD1 protein modified form]; [Dithiothreitol results in increased reduction of SOD1 protein] which results in increased susceptibility to Hydrogen Peroxide; Dithiothreitol results in increased reduction of and results in decreased activity of SOD1 protein; Zinc promotes the reaction [Dithiothreitol affects the folding of SOD1 protein]

PMID:22867017 PMID:26694608 PMID:26699812

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions
increases expression

[Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; [Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

signal transducer and activator of transcription 6

multiple interactions

Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]]

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

G

Thy-1 cell surface antigen

multiple interactions

Dithiothreitol inhibits the reaction [sodium arsenite promotes the reaction [THY1 protein binds to THY1 protein]]

NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659

G

toll-like receptor 4

multiple interactions

Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions

[Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA]
Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]; [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]]

PMID:7476933 PMID:7532384 PMID:9281604 PMID:9388267 PMID:16219905

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

DNA topoisomerase II alpha

multiple interactions

Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]]

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53

multiple interactions

Dithiothreitol inhibits the reaction [[Cadmium Chloride results in decreased activity of TP53 protein] inhibits the reaction [TP53 protein binds to TP53 gene]]; Dithiothreitol inhibits the reaction [Glutathione Disulfide results in increased glutathionylation of TP53 protein]; Dithiothreitol inhibits the reaction [Glutathione results in increased glutathionylation of TP53 protein]

PMID:17555331 PMID:25446071

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

transient receptor potential cation channel, subfamily A, member 1

multiple interactions

Dithiothreitol inhibits the reaction [[hydroquinone results in increased activity of TRPA1 protein] which results in increased import of Calcium]; Dithiothreitol inhibits the reaction [hydroquinone results in increased activity of TRPA1 protein]

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

G

transient receptor potential cation channel, subfamily C, member 5

multiple interactions
increases activity

Dithiothreitol inhibits the reaction [Mercuric Chloride results in increased activity of TRPC5 protein]
Dithiothreitol results in increased activity of TRPC5 protein

NCBI chr X:107,946,163...108,230,991
Ensembl chr X:107,939,131...108,230,991

G

transient receptor potential cation channel, subfamily M, member 4

multiple interactions

Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in increased expression of TRPM4 protein]

NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532

G

thioredoxin 1

multiple interactions

Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]]

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

vimentin

multiple interactions

Dithiothreitol inhibits the reaction [4-cresol sulfate results in increased expression of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

X-box binding protein 1

increases splicing

Dithiothreitol results in increased splicing of XBP1 mRNA

PMID:23123503 PMID:34244458

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

G

xanthine dehydrogenase

multiple interactions

Dithiothreitol inhibits the reaction [chloramine affects the activity of XDH protein]

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

dithioerythritol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 1 member 5

multiple interactions

Dithioerythritol inhibits the reaction [Thiazoles analog results in decreased activity of SLC1A5 protein]

NCBI chr 1:77,456,849...77,470,952
Ensembl chr 1:77,456,694...77,470,952

G

solute carrier family 22 member 4

multiple interactions

Dithioerythritol inhibits the reaction [Cadmium results in decreased activity of SLC22A4 protein]; Dithioerythritol inhibits the reaction [Mercury results in decreased activity of SLC22A4 protein]; Dithioerythritol inhibits the reaction [methylmercuric chloride results in decreased activity of SLC22A4 protein]

NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720

G

solute carrier family 22 member 5

multiple interactions

Dithioerythritol inhibits the reaction [Mercuric Chloride results in decreased transport of SLC22A5 protein]; Dithioerythritol inhibits the reaction [Methylmercury Compounds results in decreased transport of SLC22A5 protein]; Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]]

PMID:19041296 PMID:22900493

NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309

G

solute carrier family 25 member 20

multiple interactions

Dithioerythritol inhibits the reaction [Hydrogen Peroxide results in decreased activity of SLC25A20 protein]
Dithioerythritol inhibits the reaction [Mercuric Chloride results in decreased activity of SLC25A20 protein]; Dithioerythritol inhibits the reaction [methylmercuric chloride results in decreased activity of SLC25A20 protein]

PMID:23402788 PMID:25849418

NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512

iron(2+) sulfate (anhydrous)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily F member 1

increases expression

ferrous sulfate results in increased expression of ABCF1 mRNA

NCBI chr20:2,802,519...2,815,433
Ensembl chr20:2,802,488...2,815,433

G

aconitase 1

multiple interactions

[nickel chloride results in increased activity of ACO1 protein] inhibits the reaction [ferrous sulfate results in increased expression of FTL protein]

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

G

actin alpha 2, smooth muscle

multiple interactions

[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of ACTA2 protein

NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554

G

AKT serine/threonine kinase 1

multiple interactions
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

amyloid beta precursor protein

multiple interactions

(22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate inhibits the reaction [[ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in decreased expression of SYP protein]; (22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate inhibits the reaction [[ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in increased expression of GFAP protein]; (22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate inhibits the reaction [[ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in increased phosphorylation of MAPT protein]; [ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in decreased expression of SYP protein; [ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in increased expression of GFAP protein; [ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in increased phosphorylation of MAPT protein

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1

multiple interactions

[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein; Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]; dicarbine inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]

NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838

G

BCL2-associated agonist of cell death

decreases expression

ferrous sulfate results in decreased expression of BAD mRNA

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

ferrous sulfate results in increased expression of BAX protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of BAX protein]

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
increases expression
multiple interactions

ferrous sulfate results in decreased expression of BCL2 protein
ferrous sulfate results in increased expression of BCL2 mRNA
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in decreased expression of BCL2 protein]

PMID:28583816 PMID:33554279

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL2-related protein A1

increases expression

ferrous sulfate results in increased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

caspase 3

increases cleavage
decreases activity
multiple interactions

ferrous sulfate results in increased cleavage of CASP3 protein
ferrous sulfate results in decreased activity of CASP3 protein
[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP3 protein; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP3 mRNA; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP3 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP3 mRNA]
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased cleavage of CASP3 protein]

PMID:17879260 PMID:28583816 PMID:33554279

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

multiple interactions

[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP7 protein; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP7 mRNA; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of CASP7 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CASP7 mRNA]

NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729

G

catalase

multiple interactions

CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased degradation of Hyaluronic Acid]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

caveolin 1

affects localization

ferrous sulfate affects the localization of CAV1 protein

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

C-C motif chemokine ligand 17

decreases expression

ferrous sulfate results in decreased expression of CCL17 mRNA

NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819

G

C-C motif chemokine ligand 19

decreases expression

ferrous sulfate results in decreased expression of CCL19 mRNA

NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308

G

C-C motif chemokine ligand 20

increases expression

ferrous sulfate results in increased expression of CCL20 mRNA

PMID:19428942 PMID:21540303

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 21

decreases expression

ferrous sulfate results in decreased expression of CCL21 mRNA

NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686

G

C-C motif chemokine ligand 24

decreases expression

ferrous sulfate results in decreased expression of CCL24 mRNA

NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893

G

C-C motif chemokine ligand 9

decreases expression

ferrous sulfate results in decreased expression of CCL15 mRNA

NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369

G

C-C motif chemokine receptor 6

decreases expression

ferrous sulfate results in decreased expression of CCR6 mRNA

NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603

G

C-C motif chemokine receptor 7

decreases expression

ferrous sulfate results in decreased expression of CCR7 mRNA

NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309

G

C-C motif chemokine receptor 8

decreases expression

ferrous sulfate results in decreased expression of CCR8 mRNA

NCBI chr 8:119,826,332...119,828,292
Ensembl chr 8:119,826,568...119,827,629

G

CD44 molecule

multiple interactions

[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of CD44 protein]

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

cyclin-dependent kinase inhibitor 1A

increases expression

ferrous sulfate results in increased expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CCAAT/enhancer binding protein beta

increases expression

ferrous sulfate results in increased expression of CEBPB mRNA

NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]; Filipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

C-reactive protein

decreases expression

ferrous sulfate results in decreased expression of CRP mRNA; ferrous sulfate results in decreased expression of CRP protein

PMID:17119383 PMID:19428942

NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178

G

colony stimulating factor 2

increases expression

ferrous sulfate results in increased expression of CSF2 mRNA

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

C-X-C motif chemokine ligand 10

increases expression

ferrous sulfate results in increased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 11

increases expression

ferrous sulfate results in increased expression of CXCL11 mRNA

NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271

G

C-X-C motif chemokine ligand 13

decreases expression

ferrous sulfate results in decreased expression of CXCL13 mRNA

NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933

G

C-X-C motif chemokine ligand 14

decreases expression

ferrous sulfate results in decreased expression of CXCL14 mRNA

NCBI chr17:8,317,930...8,325,956
Ensembl chr17:8,317,933...8,324,839

G

C-X-C motif chemokine ligand 2

increases expression

ferrous sulfate results in increased expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine receptor 2

decreases expression

ferrous sulfate results in decreased expression of CXCR2 mRNA

NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]; ferrous sulfate inhibits the reaction [picolinic acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

DnaJ heat shock protein family (Hsp40) member B1

decreases response to substance

DNAJB1 protein results in decreased susceptibility to ferrous sulfate

NCBI chr19:24,522,731...24,526,419
Ensembl chr19:24,522,717...24,526,458

G

egl-9 family hypoxia-inducible factor 1

increases activity

ferrous sulfate results in increased activity of EGLN1 protein

NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777

G

early growth response 1

decreases expression

ferrous sulfate results in decreased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

endothelial PAS domain protein 1

multiple interactions

ferrous sulfate inhibits the reaction [galangin results in increased expression of EPAS1 protein]; ferrous sulfate inhibits the reaction [Quercetin results in increased expression of EPAS1 protein]

NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228

G

erb-b2 receptor tyrosine kinase 2

multiple interactions

ferrous sulfate inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]; ferrous sulfate inhibits the reaction [Quercetin results in decreased expression of and results in increased ubiquitination of ERBB2 protein]

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

coagulation factor X

decreases activity

ferrous sulfate results in decreased activity of F10 protein

NCBI chr16:76,468,834...76,488,141
Ensembl chr16:76,468,838...76,488,141

G

coagulation factor II, thrombin

decreases activity

ferrous sulfate results in decreased activity of F2 protein

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

ferritin light chain 1

multiple interactions
increases expression

[nickel chloride results in increased activity of ACO1 protein] inhibits the reaction [ferrous sulfate results in increased expression of FTL protein]
ferrous sulfate results in increased expression of FTL1 protein

PMID:16039939 PMID:28993186

NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725

G

glutamate-cysteine ligase, catalytic subunit

multiple interactions
decreases expression

ferrous sulfate promotes the reaction [SNCA protein results in decreased expression of GCLC protein]
ferrous sulfate results in decreased expression of GCLC protein

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glial cell derived neurotrophic factor

decreases response to substance

GDNF protein results in decreased susceptibility to ferrous sulfate

NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209

G

glial fibrillary acidic protein

multiple interactions

(22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate inhibits the reaction [[ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in increased expression of GFAP protein]; [ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in increased expression of GFAP protein

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

G

glutathione peroxidase 1

increases expression
multiple interactions

ferrous sulfate results in increased expression of GPX1 protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of GPX1 protein]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glycogen synthase kinase 3 beta

increases phosphorylation

ferrous sulfate results in increased phosphorylation of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

H2A.X variant histone

increases expression
multiple interactions

ferrous sulfate results in increased expression of H2AX protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of H2AX protein]

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

ferrous sulfate inhibits the reaction [Chromium results in increased expression of HIF1A protein]; ferrous sulfate inhibits the reaction [Cobalt results in increased expression of HIF1A protein]; ferrous sulfate inhibits the reaction [galangin results in increased expression of HIF1A protein]; ferrous sulfate inhibits the reaction [Nickel results in increased expression of HIF1A protein]; ferrous sulfate inhibits the reaction [Quercetin results in increased expression of HIF1A protein]

PMID:16386771 PMID:17973296

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

multiple interactions
increases expression

ferrous sulfate inhibits the reaction [2,2'-Dipyridyl analog inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]]; ferrous sulfate inhibits the reaction [2,2'-Dipyridyl analog inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Cadmium Chloride results in increased activity of HMOX1 protein]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 mRNA]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [sulforaphane results in increased expression of HMOX1 mRNA]]
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of HMOX1 protein]

PMID:20934533 PMID:26945724 PMID:28583816

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

HRas proto-oncogene, GTPase

affects localization
multiple interactions

ferrous sulfate affects the localization of HRAS protein
ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

heat shock protein 90 alpha family class A member 1

multiple interactions

ferrous sulfate inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

deferiprone inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]; Filipin inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]; N,N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid inhibits the reaction [ferrous sulfate results in increased activity of [CHUK protein binds to IKBKB protein]]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 10 receptor subunit beta

decreases expression

ferrous sulfate results in decreased expression of IL10RB mRNA

NCBI chr11:30,646,494...30,668,081
Ensembl chr11:30,652,096...30,668,074

G

interleukin 1 beta

multiple interactions
increases expression

[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of IL1B protein]
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of IL1B protein]

PMID:23692848 PMID:28583816

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

increases expression

ferrous sulfate results in increased expression of IL1RN mRNA

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 36 receptor antagonist

decreases expression

ferrous sulfate results in decreased expression of IL36RN mRNA

NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016

G

interleukin 4

increases expression

ferrous sulfate results in increased expression of IL4 protein

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

decreases expression

ferrous sulfate results in decreased expression of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

increases expression

ferrous sulfate results in increased expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kallikrein 1

decreases activity

ferrous sulfate results in decreased activity of KLK1 protein

NCBI chr 1:94,642,644...94,646,760
Ensembl chr 1:94,642,687...94,646,754

G

leptin

increases expression

ferrous sulfate results in increased expression of LEP mRNA

NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262

G

lymphotoxin alpha

increases expression
decreases expression

ferrous sulfate results in increased expression of LTA mRNA
ferrous sulfate results in decreased expression of LTA mRNA

PMID:19428942 PMID:21540303

NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859

G

mitogen-activated protein kinase kinase 6

multiple interactions
increases phosphorylation

ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]; Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAP2K6 protein]

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

G

mitogen-activated protein kinase kinase kinase 14

multiple interactions

MAP3K14 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; MAP3K14 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]

NCBI chr10:88,165,349...88,215,558
Ensembl chr10:88,165,351...88,215,523

G

mitogen activated protein kinase kinase kinase 7

affects localization
increases activity
multiple interactions

ferrous sulfate affects the localization of MAP3K7 protein
ferrous sulfate results in increased activity of MAP3K7 protein
ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]; Filipin inhibits the reaction [ferrous sulfate promotes the reaction [MAP3K7 protein results in increased phosphorylation of MAP2K6 protein]]; Filipin inhibits the reaction [ferrous sulfate results in increased activity of MAP3K7 protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]

NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; Deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]

PMID:17172471 PMID:19608791

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; deferiprone inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; Filipin inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; SB 203580 promotes the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]

PMID:17172471 PMID:19608791

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

microtubule-associated protein tau

multiple interactions

(22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate inhibits the reaction [[ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in increased phosphorylation of MAPT protein]; [ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in increased phosphorylation of MAPT protein

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

microRNA 146a

multiple interactions

[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA; Curcumin inhibits the reaction [[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA]; Resveratrol analog inhibits the reaction [[ferrous sulfate co-treated with aluminum sulfate] results in increased expression of MIR146A mRNA]

NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610

G

matrix metallopeptidase 13

multiple interactions
increases expression

[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MMP13 protein]
Diltiazem promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]; Nimodipine promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]; Verapamil promotes the reaction [ferrous sulfate results in increased expression of MMP13 protein]

PMID:23692848 PMID:27095094

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

metallothionein 1

increases expression
multiple interactions

ferrous sulfate results in increased expression of MT1A mRNA
[Zinc Sulfate co-treated with ferrous sulfate] results in increased expression of and affects the localization of MT1A protein; ferrous sulfate results in increased expression of and affects the localization of MT1A protein

PMID:17241390 PMID:19679144

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

G

metallothionein 2A

multiple interactions

[Zinc Sulfate co-treated with ferrous sulfate] results in increased expression of and affects the localization of MT2A protein; ferrous sulfate results in increased expression of and affects the localization of MT2A protein

NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784

G

MYB proto-oncogene, transcription factor

multiple interactions

[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of MYB protein

NCBI chr 1:15,939,771...15,973,367
Ensembl chr 1:15,939,761...15,973,057

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [Ethacrynic Acid affects the localization of NFE2L2 protein]]; ferrous sulfate inhibits the reaction [Deferoxamine inhibits the reaction [phenethyl isothiocyanate results in increased expression of and affects the localization of NFE2L2 protein]]
ferrous sulfate results in increased expression of NFE2L2 mRNA
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NFE2L2 mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NFE2L2 protein]; Acetylcysteine inhibits the reaction [ferrous sulfate affects the localization of NFE2L2 protein]; ferrous sulfate results in increased expression of and affects the localization of NFE2L2 protein

PMID:26945724 PMID:28583816

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]
[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of NFKB1 protein; [ferrous sulfate co-treated with aluminum sulfate] results in increased expression of and results in increased activity of [RELA protein binds to NFKB1 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of NFKB1 protein]

PMID:17879260 PMID:22099153 PMID:23692848

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor alpha

multiple interactions
increases phosphorylation

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; Acetylcysteine inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; HRAS protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; MAP3K14 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; SB 203580 promotes the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; U 0126 inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]
[Ascorbic Acid co-treated with ferrous sulfate] results in decreased expression of NFKBIA protein; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in decreased expression of NFKBIA protein]

PMID:17172471 PMID:17879260 PMID:28583816

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

ferrous sulfate results in increased expression of NQO1 protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

ferrous sulfate promotes the reaction [MAP3K7 protein binds to HRAS protein binds to PIK3R1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]

NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631

G

prostate transmembrane protein, androgen induced 1

increases expression

ferrous sulfate results in increased expression of PMEPA1 mRNA

NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454

G

paraoxonase 1

multiple interactions

[Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]; [Ascorbic Acid co-treated with ferrous sulfate] inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid]; [Ascorbic Acid co-treated with ferrous sulfate] results in decreased activity of PON1 protein

PMID:12871208 PMID:15375178

NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360

G

prostaglandin-endoperoxide synthase 2

increases expression
multiple interactions

ferrous sulfate results in increased expression of PTGS2 protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
affects localization

[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of [NFKB1 protein binds to RELA protein]]
ferrous sulfate affects the localization of RELA protein
2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [ferrous sulfate affects the localization of RELA protein]
[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of RELA protein; [ferrous sulfate co-treated with aluminum sulfate] results in increased expression of and results in increased activity of [RELA protein binds to NFKB1 protein]; [Hyaluronic Acid co-treated with Chondroitin Sulfates] inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased activity of RELA protein]

PMID:17879260 PMID:22099153 PMID:23692848 PMID:28583816

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

selectin P ligand

increases expression

ferrous sulfate results in increased expression of SELPLG mRNA

NCBI chr12:42,796,690...42,809,908
Ensembl chr12:42,796,580...42,812,585

G

solute carrier family 11 member 2

decreases expression

ferrous sulfate results in decreased expression of SLC11A2 mRNA

NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145

G

solute carrier family 40 member 1

multiple interactions

SLC40A1 protein inhibits the reaction [ferrous sulfate results in increased abundance of Reactive Oxygen Species]; SLC40A1 protein inhibits the reaction [ferrous sulfate results in increased uptake of Iron]

NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481

G

synuclein alpha

multiple interactions

ferrous sulfate inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]; ferrous sulfate inhibits the reaction [SNCA protein results in decreased expression of SOD1 protein]; ferrous sulfate promotes the reaction [SNCA protein results in decreased activity of SOD1 protein]; ferrous sulfate promotes the reaction [SNCA protein results in decreased expression of GCLC protein]; ferrous sulfate promotes the reaction [SNCA protein results in increased abundance of Reactive Oxygen Species]

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

G

superoxide dismutase 1

multiple interactions
decreases activity

ferrous sulfate inhibits the reaction [SNCA protein results in decreased expression of SOD1 protein]; ferrous sulfate promotes the reaction [SNCA protein results in decreased activity of SOD1 protein]
ferrous sulfate results in decreased activity of SOD1 protein

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

increases activity
decreases expression

ferrous sulfate results in increased activity of SOD2 protein
ferrous sulfate results in decreased expression of SOD2 protein

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

secreted phosphoprotein 1

decreases expression

ferrous sulfate results in decreased expression of SPP1 mRNA

NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162

G

signal transducer and activator of transcription 1

increases phosphorylation

ferrous sulfate results in increased phosphorylation of STAT1 protein

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

multiple interactions

[ferrous sulfate co-treated with Copper Sulfate] promotes the reaction [Hydrogen Peroxide affects the localization of STAT3 protein]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

synaptophysin

multiple interactions

(22R, 25R)-20alpha-spirost-5-en-3beta-yl hexanoate inhibits the reaction [[ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in decreased expression of SYP protein]; [ferrous sulfate co-treated with APP protein alternative form co-treated with Buthionine Sulfoximine] results in decreased expression of SYP protein

NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745

G

taste 1 receptor member 3

affects response to substance

TAS1R3 protein affects the susceptibility to ferrous sulfate

NCBI chr 5:166,468,703...166,472,759
Ensembl chr 5:166,469,589...166,472,742

G

transferrin

multiple interactions
increases expression

ferrous sulfate promotes the reaction [TF protein results in increased uptake of Iron]
ferrous sulfate results in increased expression of TF protein

PMID:11335103 PMID:28993186

NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511

G

transferrin receptor

decreases expression

ferrous sulfate results in decreased expression of TFRC mRNA
ferrous sulfate results in decreased expression of TFRC protein

PMID:10966897 PMID:16039939 PMID:28993186

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

TIMP metallopeptidase inhibitor 1

multiple interactions
increases expression

Diltiazem inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein]; Nimodipine inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein]; Verapamil inhibits the reaction [ferrous sulfate results in increased expression of TIMP1 protein]

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

toll-like receptor 2

multiple interactions

[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR2 protein]

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 4

multiple interactions

[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TLR4 protein]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

increases expression
multiple interactions
increases secretion

ferrous sulfate results in increased expression of TNF mRNA; ferrous sulfate results in increased expression of TNF protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased secretion of TNF protein]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of TNF protein]; Dimethyl Sulfoxide inhibits the reaction [ferrous sulfate promotes the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]]; ferrous sulfate promotes the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]; MAP3K14 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]; MAP3K7 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]; PIK3R1 protein affects the reaction [ferrous sulfate results in increased secretion of TNF protein]; tetramethylthiourea inhibits the reaction [ferrous sulfate promotes the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]]; U 0126 inhibits the reaction [ferrous sulfate results in increased secretion of TNF protein]
[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF mRNA; [Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF protein; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF mRNA]; CAT protein inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF protein]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF mRNA]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [[Ascorbic Acid co-treated with ferrous sulfate] results in increased expression of TNF protein]
ferrous sulfate inhibits the reaction [Deferoxamine results in decreased activity of TNF protein]; ferrous sulfate inhibits the reaction [Mimosine results in decreased activity of TNF protein]

PMID:7539275 PMID:15550384 PMID:15963385 PMID:17172471 PMID:19428942 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNFRSF1A-associated via death domain

decreases expression

ferrous sulfate results in decreased expression of TRADD mRNA

NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638

G

transient receptor potential cation channel, subfamily M, member 5

affects response to substance

TRPM5 protein affects the susceptibility to ferrous sulfate

NCBI chr 1:198,254,956...198,277,824
Ensembl chr 1:198,255,723...198,277,654

G

transient receptor potential cation channel, subfamily V, member 1

increases activity

ferrous sulfate results in increased activity of TRPV1 protein

NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513

G

X-C motif chemokine receptor 1

decreases expression

ferrous sulfate results in decreased expression of XCR1 mRNA

NCBI chr 8:123,479,454...123,516,168
Ensembl chr 8:123,479,590...123,487,226

L-1,4-dithiothreitol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenosine A1 receptor

multiple interactions

[Dithiothreitol co-treated with Cadmium Chloride] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; [Dithiothreitol co-treated with Dithionitrobenzoic Acid] inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]; Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]; Dithiothreitol inhibits the reaction [Dithionitrobenzoic Acid inhibits the reaction [2-chloro-N(6)cyclopentyladenosine binds to ADORA1 protein]]

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

G

AKT serine/threonine kinase 1

multiple interactions

Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

aminolevulinate dehydratase

multiple interactions
increases activity

Dithiothreitol inhibits the reaction [Cadmium Chloride inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein]]
Dithiothreitol results in increased activity of ALAD protein
[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]; Cadmium affects the reaction [[Zinc co-treated with Dithiothreitol] inhibits the reaction [Lead results in decreased activity of ALAD protein]]; lead nitrate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; lead nitrate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; triethyllead acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; triethyllead acetate inhibits the reaction [zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]]; zinc chloride promotes the reaction [Dithiothreitol results in increased activity of ALAD protein]
cadmium acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]; Dithiothreitol inhibits the reaction [2,2'-dithienyl diselenide results in decreased activity of ALAD protein]; Dithiothreitol inhibits the reaction [ebselen results in decreased activity of ALAD protein]; Zinc Acetate inhibits the reaction [Dithiothreitol results in increased activity of ALAD protein]

PMID:2061546 PMID:20472051 PMID:21360559 PMID:21910133 PMID:22180340 More...

NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474

G

apurinic/apyrimidinic endodeoxyribonuclease 1

multiple interactions

Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein]

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

androgen receptor

multiple interactions

Dithiothreitol inhibits the reaction [cadmium sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [Copper Sulfate inhibits the reaction [Androgens binds to AR protein]]; Dithiothreitol inhibits the reaction [zinc chloride inhibits the reaction [Androgens binds to AR protein]]

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

arsenite methyltransferase

multiple interactions
increases reduction

Dithiothreitol promotes the reaction [AS3MT protein results in increased methylation of Arsenic]
Dithiothreitol results in increased reduction of AS3MT protein
Dithiothreitol promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]

PMID:15025511 PMID:25349987

NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872

G

activating transcription factor 3

increases expression

Dithiothreitol results in increased expression of ATF3 mRNA

NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631

G

activating transcription factor 4

increases expression

Dithiothreitol results in increased expression of ATF4 mRNA

NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446

G

ATPase copper transporting alpha

multiple interactions

Dithiothreitol inhibits the reaction [Ethylmaleimide results in increased glutathionylation of ATP7A protein]

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

G

BCL2, apoptosis regulator

multiple interactions

Dithiothreitol inhibits the reaction [arsenic trioxide results in increased expression of BCL2 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

calumenin

increases expression

Dithiothreitol results in increased expression of CALU protein

NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593

G

caspase 1

multiple interactions

Dithiothreitol inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein]

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions

[Dithiothreitol co-treated with Peroxynitrous Acid] results in increased metabolism of CASP3 protein; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]; Dithiothreitol inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [chelerythrine results in increased cleavage of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide results in decreased activity of CASP3 protein]; Dithiothreitol promotes the reaction [1-(N-(3-ammoniopropyl)-N-(n-propyl)amino)diazen-1-ium-1,2-diolate results in increased metabolism of CASP3 protein]
Dithiothreitol inhibits the reaction [1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one inhibits the reaction [[Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]]
Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]]

PMID:9388267 PMID:9441900 PMID:9706149 PMID:9755104 PMID:10673743 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP8 protein]

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

Dithiothreitol inhibits the reaction [2-methyl-3-(2-((4-nitrooxybutyloxy)carbonyl)vinyl)phenyl ursodeoxycholic acid ester results in decreased activity of CASP9 protein]

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]; CAT protein inhibits the reaction [Dithiothreitol results in increased abundance of Hydrogen Peroxide]

PMID:7491977 PMID:32493877

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

carbonyl reductase 1

multiple interactions

Dithiothreitol inhibits the reaction [S-Nitrosoglutathione inhibits the reaction [CBR1 protein results in increased reduction of S-Nitrosoglutathione]]

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

cyclin D1

decreases expression

Dithiothreitol results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin G2

increases expression

Dithiothreitol results in increased expression of CCNG2 mRNA

NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830

G

cadherin 1

multiple interactions

Dithiothreitol inhibits the reaction [4-cresol sulfate results in decreased expression of CDH1 protein]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

CF transmembrane conductance regulator

multiple interactions

Dithiothreitol inhibits the reaction [Glutathione results in decreased activity of CFTR protein]

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of CHUK protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]]

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

Dithiothreitol inhibits the reaction [1-nitropyrene results in increased degradation of CYP1A1 protein]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450 family 7 subfamily A member 1

increases activity

Dithiothreitol results in increased activity of CYP7A1 protein

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

Dithiothreitol results in increased expression of DDIT3 mRNA
indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of DDIT3 mRNA]

PMID:17332266 PMID:23123503 PMID:27226639

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

DnaJ heat shock protein family (Hsp40) member B9

increases expression

Dithiothreitol results in increased expression of DNAJB9 mRNA

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

eukaryotic translation initiation factor 2A

multiple interactions

Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2A protein

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases phosphorylation

Dithiothreitol results in increased phosphorylation of and results in increased activity of EIF2AK3 protein
Dithiothreitol results in increased phosphorylation of EIF2AK3 protein

PMID:12486162 PMID:25321315

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions
increases phosphorylation

EIF2S1 protein mutant form inhibits the reaction [Dithiothreitol results in increased phosphorylation of EIF2S1 protein]

PMID:30385349 PMID:34244458

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions
increases expression

Dithiothreitol results in increased phosphorylation of and results in increased activity of ERN1 protein
Dithiothreitol results in increased expression of ERN1 protein

PMID:12486162 PMID:25321315

NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029

G

estrogen receptor 1

multiple interactions

fulvestrant inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein]; Tamoxifen inhibits the reaction [Dithiothreitol results in increased activity of ESR1 protein]

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

coagulation factor III, tissue factor

increases activity

Dithiothreitol results in increased activity of F3 protein

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

fibroblast growth factor 21

increases expression
increases secretion
multiple interactions

Dithiothreitol results in increased expression of FGF21 mRNA
Dithiothreitol results in increased secretion of FGF21 protein
indolo(3,2-b)carbazole inhibits the reaction [Dithiothreitol results in increased expression of FGF21 mRNA]

PMID:23123503 PMID:27226639

NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454

G

growth arrest and DNA-damage-inducible, alpha

increases expression

Dithiothreitol results in increased expression of GADD45A mRNA

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

Dithiothreitol inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Dithiothreitol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of HIF1A protein alternative form]

PMID:14695184 PMID:17658243

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

multiple interactions

Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of HMOX1 protein]
Dithiothreitol inhibits the reaction [farrerol results in increased expression of HMOX1 protein]; Dithiothreitol inhibits the reaction [hydroquinone results in increased expression of HMOX1 protein]

PMID:23290930 PMID:24489685 PMID:26111761

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

hydroxysteroid 11-beta dehydrogenase 2

multiple interactions
increases activity

Dithiothreitol inhibits the reaction [perfluorodecanoic acid results in decreased activity of HSD11B2 protein]; Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein]; Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein]; perfluorodecanoic acid inhibits the reaction [Dithiothreitol results in increased activity of HSD11B2 protein]

PMID:12901862 PMID:26859423 PMID:36878351

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

multiple interactions
increases activity

Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD3B1 protein]
Dithiothreitol results in increased activity of HSD3B1 protein

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

heat shock protein 90 beta family member 1

multiple interactions

Dactinomycin inhibits the reaction [Dithiothreitol results in increased expression of HSP90B1 mRNA]; Dithiothreitol results in increased expression of and affects the localization of HSP90B1 mRNA

NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788

G

heat shock protein family A (Hsp70) member 5

increases expression

Dithiothreitol metabolite results in increased expression of HSPA5 protein; Dithiothreitol results in increased expression of HSPA5 mRNA; Dithiothreitol results in increased expression of HSPA5 protein

PMID:15710169 PMID:17332266 PMID:17416481 PMID:21692457 PMID:23123503 More...

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of IKBKB protein]]
Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]; Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]

PMID:17067557 PMID:20584749

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 1 alpha

multiple interactions

[Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]

NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions

Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 5

multiple interactions

Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]]

NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213

G

interleukin 5 receptor subunit alpha

multiple interactions

Dithiothreitol inhibits the reaction [Thiazoles analog inhibits the reaction [IL5 protein binds to IL5RA protein]]

NCBI chr 4:139,630,652...139,664,593
Ensembl chr 4:139,632,066...139,668,544

G

inhibin subunit beta E

increases expression

Dithiothreitol results in increased expression of INHBE mRNA

NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172

G

insulin 1

decreases activity
multiple interactions

Dithiothreitol results in decreased activity of INS1 protein
Dithiothreitol affects the reaction [oxophenylarsine results in decreased activity of INS1 protein]; Dithiothreitol inhibits the reaction [INS1 protein results in increased uptake of Glucose]

NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of JUN protein]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kinesin family member 5A

multiple interactions

Dithiothreitol inhibits the reaction [cupric chloride results in decreased activity of KIF5A protein]

NCBI chr 7:63,051,894...63,089,024
Ensembl chr 7:63,049,424...63,092,858

G

mitogen-activated protein kinase kinase kinase 5

multiple interactions

Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]]

NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800

G

mitogen activated protein kinase 1

multiple interactions

Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]; Dithiothreitol promotes the reaction [MAPK1 protein binds to APEX1 protein]
Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]

PMID:11035063 PMID:23370007

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Dithiothreitol inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

Dithiothreitol inhibits the reaction [Sodium Selenite results in decreased activity of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

microsomal glutathione S-transferase 1

multiple interactions

Dithiothreitol inhibits the reaction [[1-hydroxy-2-oxo-3-(3-aminopropyl)-3-isopropyl-1-triazene results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-nitrosocysteine results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [[S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased activity of MGST1 protein]; Dithiothreitol inhibits the reaction [Gallic Acid results in increased activity of MGST1 protein]

PMID:16125204 PMID:16386761

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

methionine sulfoxide reductase B2

increases reduction

Dithiothreitol results in increased reduction of MSRB2 protein

NCBI chr17:81,974,378...82,000,044
Ensembl chr17:81,974,196...82,000,043

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methionine sulfoxide reductase B3

increases reduction

Dithiothreitol results in increased reduction of MSRB3 protein

NCBI chr 7:56,260,985...56,426,004
Ensembl chr 7:56,303,308...56,425,496

G

myosin light chain kinase

multiple interactions

Dithiothreitol inhibits the reaction [4-cresol sulfate results in increased phosphorylation of MYLK protein]

NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261

G

N-acetyltransferase 1

multiple interactions
increases activity

Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of NAT1 protein]
Dithiothreitol results in increased activity of NAT1 protein

NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520

G

NFE2 like bZIP transcription factor 2

multiple interactions

Dithiothreitol inhibits the reaction [diallyl trisulfide affects the localization of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]
Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [nitroaspirin inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IL1B protein] results in increased activity of [NFKB1 protein binds to NFKB1 protein]]]

PMID:9281604 PMID:14762100 PMID:16219905

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

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NFKB inhibitor alpha

multiple interactions

Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]]
Dithiothreitol inhibits the reaction [ent-1,3,6,11-tetrahydroxykaur-16-ene-15-one 3,11-diacetate results in increased activity of NFKBIA protein]

PMID:17067557 PMID:19509257

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nitric oxide synthase 2

multiple interactions

Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in decreased activity of CASP3 protein]; Dithiothreitol inhibits the reaction [[NOS2 protein results in increased abundance of Nitric Oxide] which results in increased metabolism of CASP3 protein]
Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]
Dithiothreitol inhibits the reaction [Carbaryl inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]

PMID:7532384 PMID:9706149 PMID:9755104 PMID:15907790

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

Dithiothreitol inhibits the reaction [diallyl trisulfide results in increased expression of NQO1 protein]

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

Dithiothreitol inhibits the reaction [arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [Thiram inhibits the reaction [Dexamethasone binds to NR3C1 protein]]
Dithiothreitol inhibits the reaction [Mercuric Chloride inhibits the reaction [Triamcinolone Acetonide binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [methyl methanethiosulfonate inhibits the reaction [Dexamethasone binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [dexamethasone 21-methanesulfonate binds to NR3C1 protein]]; Dithiothreitol inhibits the reaction [sodium arsenite inhibits the reaction [Dexamethasone binds to NR3C1 protein]]

PMID:2226332 PMID:2298732 PMID:15250541 PMID:16857225

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

neurogranin

multiple interactions

Dithiothreitol inhibits the reaction [chloramine-T affects the phosphorylation of NRGN protein]

NCBI chr 8:37,255,462...37,263,659
Ensembl chr 8:37,256,930...37,257,516

G

nudix hydrolase 9

multiple interactions

Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium Chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Magnesium results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [manganese chloride results in increased activity of NUDT9 protein]]; Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Manganese results in increased activity of NUDT9 protein]]

NCBI chr14:5,675,376...5,693,332
Ensembl chr14:5,675,382...5,693,142

G

oxoglutarate dehydrogenase

multiple interactions

Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of OGDH protein]; Dithiothreitol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein]

NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479

G

purinergic receptor P2X 2

multiple interactions

Dithiothreitol inhibits the reaction [Hydrogen Peroxide promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX2 protein]]

NCBI chr12:46,338,979...46,342,891
Ensembl chr12:46,339,549...46,342,891

G

3'-phosphoadenosine 5'-phosphosulfate synthase 1

increases activity

Dithiothreitol results in increased activity of PAPSS1 protein

NCBI chr 2:220,040,343...220,114,399
Ensembl chr 2:220,040,312...220,114,395

G

poly (ADP-ribose) polymerase 1

multiple interactions

Dithiothreitol inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein]
Dithiothreitol inhibits the reaction [arsenic trioxide results in increased cleavage of PARP1 protein]; Dithiothreitol inhibits the reaction [withaferin A results in increased cleavage of PARP1 protein]

PMID:11035063 PMID:18022205 PMID:20438634

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

programmed cell death 6 interacting protein

increases expression

Dithiothreitol results in increased expression of PDCD6IP protein

NCBI chr 8:113,590,998...113,646,795
Ensembl chr 8:113,590,998...113,646,773

G

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3

increases expression

Dithiothreitol results in increased expression of PLOD3 protein

NCBI chr12:19,676,384...19,686,945
Ensembl chr12:19,676,386...19,686,960

G

PPARG coactivator 1 alpha

increases expression

Dithiothreitol results in increased expression of PPARGC1A mRNA

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Dithiothreitol inhibits the reaction [3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

multiple interactions

Dithiothreitol affects the reaction [4-cresol sulfate affects the localization of PTK2 protein]

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

protein tyrosine phosphatase, non-receptor type 1

multiple interactions

Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in increased glutathionylation of PTPN1 protein]
[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein; CAT protein inhibits the reaction [[9,10-phenanthrenequinone co-treated with Dithiothreitol] results in decreased activity of and results in increased oxidation of PTPN1 protein]

PMID:16781456 PMID:32493877

NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504

G

reticulocalbin 2

increases expression

Dithiothreitol results in increased expression of RCN2 protein

NCBI chr 8:56,449,206...56,466,253
Ensembl chr 8:56,449,206...56,466,251

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
increases activity

[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]
Dithiothreitol results in increased activity of RELA protein
Dithiothreitol inhibits the reaction [cinnamaldehyde results in increased glutathionylation of RELA protein]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]

PMID:7491977 PMID:9281604 PMID:16219905 PMID:20351055

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

S100 calcium binding protein A2

multiple interactions

Dithiothreitol inhibits the reaction [Copper promotes the reaction [S100A2 protein binds to S100A2 protein]]; Dithiothreitol inhibits the reaction [S100A2 protein binds to S100A2 protein]

NCBI chr 2:176,077,081...176,078,325

G

S100 calcium-binding protein A4

multiple interactions

Dithiothreitol inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]]

NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254

G

solute carrier family 16 member 1

multiple interactions

Dithiothreitol inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid]

NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611

G

snail family transcriptional repressor 1

multiple interactions

Dithiothreitol inhibits the reaction [4-cresol sulfate results in increased expression of SNAI1 protein]

NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969

G

snail family transcriptional repressor 2

multiple interactions

Dithiothreitol inhibits the reaction [4-cresol sulfate results in increased expression of SNAI2 protein]

NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200

G

superoxide dismutase 1

affects folding
multiple interactions

Dithiothreitol affects the folding of SOD1 protein
Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]]
[Dithiothreitol results in increased reduction of SOD1 protein] promotes the reaction [Hydrogen Peroxide results in increased oxidation of SOD1 protein modified form]; [Dithiothreitol results in increased reduction of SOD1 protein] which results in increased susceptibility to Hydrogen Peroxide; Dithiothreitol results in increased reduction of and results in decreased activity of SOD1 protein; Zinc promotes the reaction [Dithiothreitol affects the folding of SOD1 protein]

PMID:22867017 PMID:26694608 PMID:26699812

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

multiple interactions
increases expression

[Dithiothreitol co-treated with IL1A protein] results in increased expression of SOD2 protein; [Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol promotes the reaction [IL1A protein results in increased expression of SOD2 mRNA]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA]

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

signal transducer and activator of transcription 6

multiple interactions

Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine promotes the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]]; Dithiothreitol inhibits the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [polyethylene glycol-superoxide dismutase results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [Polyethylene Glycols results in increased oxidation of STAT6 protein]; Dithiothreitol inhibits the reaction [SOD1 protein affects the reaction [Asbestos, Serpentine results in increased oxidation of STAT6 protein]]

NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495

G

Thy-1 cell surface antigen

multiple interactions

Dithiothreitol inhibits the reaction [sodium arsenite promotes the reaction [THY1 protein binds to THY1 protein]]

NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659

G

toll-like receptor 4

multiple interactions

Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides promotes the reaction [TLR4 protein binds to TLR4 protein]]]; Dithiothreitol inhibits the reaction [4-hydroxy-2-nonenal inhibits the reaction [Lipopolysaccharides results in increased activity of TLR4 protein]]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions

[Dithiothreitol co-treated with TNF protein] results in increased expression of SOD2 protein; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Dithiothreitol inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Dithiothreitol promotes the reaction [TNF protein results in increased expression of SOD2 mRNA]; TNF protein promotes the reaction [Dithiothreitol results in increased expression of SOD2 mRNA]
Dithiothreitol inhibits the reaction [TNF protein results in increased expression of NOS2 mRNA]
[Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides promotes the reaction [[RELA protein co-treated with NFKB1 protein] binds to TNF promoter]]]; [Pertussis Toxin co-treated with Dithiothreitol] inhibits the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Dithiothreitol inhibits the reaction [Nitric Oxide Donors inhibits the reaction [[TNF protein co-treated with Galactosamine] results in increased activity of CASP3 protein]]

PMID:7476933 PMID:7532384 PMID:9281604 PMID:9388267 PMID:16219905

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

DNA topoisomerase II alpha

multiple interactions

Dithiothreitol inhibits the reaction [Cannabidiol metabolite inhibits the reaction [TOP2A protein results in increased hydrolysis of Adenosine Triphosphate]]

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53

multiple interactions

Dithiothreitol inhibits the reaction [[Cadmium Chloride results in decreased activity of TP53 protein] inhibits the reaction [TP53 protein binds to TP53 gene]]; Dithiothreitol inhibits the reaction [Glutathione Disulfide results in increased glutathionylation of TP53 protein]; Dithiothreitol inhibits the reaction [Glutathione results in increased glutathionylation of TP53 protein]

PMID:17555331 PMID:25446071

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

transient receptor potential cation channel, subfamily A, member 1

multiple interactions

Dithiothreitol inhibits the reaction [[hydroquinone results in increased activity of TRPA1 protein] which results in increased import of Calcium]; Dithiothreitol inhibits the reaction [hydroquinone results in increased activity of TRPA1 protein]

NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570

G

transient receptor potential cation channel, subfamily C, member 5

multiple interactions
increases activity

Dithiothreitol inhibits the reaction [Mercuric Chloride results in increased activity of TRPC5 protein]
Dithiothreitol results in increased activity of TRPC5 protein

NCBI chr X:107,946,163...108,230,991
Ensembl chr X:107,939,131...108,230,991

G

transient receptor potential cation channel, subfamily M, member 4

multiple interactions

Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in increased expression of TRPM4 protein]

NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532

G

thioredoxin 1

multiple interactions

Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]]

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

vimentin

multiple interactions

Dithiothreitol inhibits the reaction [4-cresol sulfate results in increased expression of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

X-box binding protein 1

increases splicing

Dithiothreitol results in increased splicing of XBP1 mRNA

PMID:23123503 PMID:34244458

NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693

G

xanthine dehydrogenase

multiple interactions

Dithiothreitol inhibits the reaction [chloramine affects the activity of XDH protein]

NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268

monothioglycerol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

heme oxygenase 1

increases expression

thioglycerol results in increased expression of HMOX1 mRNA

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

sodium hydrogensulfite

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; [sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein; Ascorbic Acid inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; KT 5720 inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; PTGS2 protein affects the susceptibility to [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; Vitamin E inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cytochrome c oxidase subunit 4i1

decreases expression

sodium bisulfite results in decreased expression of COX4 mRNA

NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921

G

mitochondrially encoded ATP synthase membrane subunit 6

decreases expression

sodium bisulfite results in decreased expression of ATP6 mRNA

NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599

G

mitochondrially encoded ATP synthase membrane subunit 8

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of ATP8 mRNA]

NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
Ensembl chr MT:7,758...7,961

G

mitochondrially encoded cytochrome c oxidase I

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of COX1 mRNA]

NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867

G

mitochondrially encoded cytochrome c oxidase II

decreases expression

sodium bisulfite results in decreased expression of COX2 mRNA

NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689

G

mitochondrially encoded cytochrome c oxidase III

multiple interactions
decreases expression

TFAM protein inhibits the reaction [sodium bisulfite results in decreased expression of COX3 mRNA]

NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382

G

nitric oxide synthase 2

multiple interactions

sodium bisulfite inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear respiratory factor 1

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of NRF1 mRNA]
sodium bisulfite results in decreased expression of NRF1 mRNA; sodium bisulfite results in decreased expression of NRF1 protein

NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328

G

PPARG coactivator 1 alpha

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of PPARGC1A mRNA]
sodium bisulfite results in decreased expression of PPARGC1A mRNA; sodium bisulfite results in decreased expression of PPARGC1A protein

NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656

G

prostaglandin E receptor 2

multiple interactions

[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGER2 protein

NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714

G

prostaglandin E receptor 4

multiple interactions

[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGER4 protein

NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670

G

prostaglandin E synthase

multiple interactions

[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGES mRNA

NCBI chr 3:14,177,892...14,189,236

G

prostaglandin E synthase 2

multiple interactions

[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGES2 mRNA

NCBI chr 3:15,690,501...15,697,688
Ensembl chr 3:15,690,501...15,697,688

G

prostaglandin-endoperoxide synthase 1

multiple interactions

[SC 560 results in decreased activity of PTGS1 protein] promotes the reaction [[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]]

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Cyclic AMP]; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]; [SC 560 results in decreased activity of PTGS1 protein] promotes the reaction [[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]]; [sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGS2 protein; Ascorbic Acid inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGS2 protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGS2 protein]; PTGS2 protein affects the susceptibility to [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; Vitamin E inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGS2 protein]
sodium bisulfite inhibits the reaction [Rotenone results in increased expression of PTGS2 mRNA]; sodium bisulfite inhibits the reaction [Rotenone results in increased expression of PTGS2 protein]

PMID:21873648 PMID:25086357

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

transcription factor A, mitochondrial

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [sodium bisulfite results in decreased expression of TFAM mRNA]; TFAM protein inhibits the reaction [sodium bisulfite results in decreased expression of COX3 mRNA]
sodium bisulfite results in decreased expression of TFAM mRNA; sodium bisulfite results in decreased expression of TFAM protein

NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292

G

tumor necrosis factor

multiple interactions

sodium bisulfite inhibits the reaction [Rotenone results in increased expression of TNF mRNA]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

sodium selenide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 2

multiple interactions

ABCC2 protein affects the reaction [sodium selenide results in increased transport of arsenite]; sodium selenide inhibits the reaction [arsenite results in increased expression of ABCC2 protein]

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 4

multiple interactions

sodium selenide inhibits the reaction [arsenite results in increased expression of ABCC4 protein]

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

NFE2 like bZIP transcription factor 2

multiple interactions

sodium selenide inhibits the reaction [Mercuric Chloride promotes the reaction [Lipopolysaccharides results in increased expression of NFE2L2 protein]]; sodium selenide inhibits the reaction [Mercuric Chloride results in increased expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

thioredoxin 1

decreases expression
multiple interactions

sodium selenide results in decreased expression of TXN protein
sodium selenide inhibits the reaction [Mercuric Chloride results in decreased expression of TXN protein]

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

sodium sulfite

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

multiple interactions

[NOS1 co-treated with sodium sulfite co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased oxidation of ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

caspase 3

multiple interactions

6-isopropoxy-9-oxoxanthene-2-carboxylic acid inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; [sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein; Ascorbic Acid inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; Dizocilpine Maleate inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; KT 5720 inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; PTGS2 protein affects the susceptibility to [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; Vitamin E inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

glutamic--pyruvic transaminase

increases export

sodium sulfite results in increased export of GPT protein

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

nitric oxide synthase 1

multiple interactions

[NOS1 co-treated with sodium sulfite co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased oxidation of ALB protein

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

prostaglandin E receptor 2

multiple interactions

[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGER2 protein

NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714

G

prostaglandin E receptor 4

multiple interactions

[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGER4 protein

NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670

G

prostaglandin E synthase

multiple interactions

[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGES mRNA

NCBI chr 3:14,177,892...14,189,236

G

prostaglandin E synthase 2

multiple interactions

[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGES2 mRNA

NCBI chr 3:15,690,501...15,697,688
Ensembl chr 3:15,690,501...15,697,688

G

prostaglandin-endoperoxide synthase 1

multiple interactions

[SC 560 results in decreased activity of PTGS1 protein] promotes the reaction [[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]]

NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Cyclic AMP]; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]; [SC 560 results in decreased activity of PTGS1 protein] promotes the reaction [[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased abundance of Dinoprostone]]; [sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGS2 protein; Ascorbic Acid inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGS2 protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGS2 protein]; PTGS2 protein affects the susceptibility to [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]; Vitamin E inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased expression of PTGS2 protein]

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

receptor interacting serine/threonine kinase 1

increases expression

sodium sulfite results in increased expression of RIPK1 protein

NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824

TCEP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arsenite methyltransferase

multiple interactions
increases reduction
affects folding

tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased methylation of Arsenic]
tris(2-carboxyethyl)phosphine results in increased reduction of AS3MT protein
tris(2-carboxyethyl)phosphine affects the folding of AS3MT protein
tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased chemical synthesis of methylarsonite]; tris(2-carboxyethyl)phosphine promotes the reaction [AS3MT protein results in increased methylation of arsenite]

PMID:15025511 PMID:22955273 PMID:25349987

NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872

G

crystallin, gamma D

decreases oxidation

[tris(2-carboxyethyl)phosphine results in decreased oxidation of CRYGD protein] which results in decreased oxidation of CRYGD mRNA mutant form; tris(2-carboxyethyl)phosphine results in decreased oxidation of CRYGD protein

NCBI chr 9:66,442,057...66,443,668
Ensembl chr 9:66,442,054...66,444,067

G

metal-regulatory transcription factor 1

multiple interactions

tris(2-carboxyethyl)phosphine inhibits the reaction [Cadmium promotes the reaction [MTF1 protein binds to MTF1 protein]]; tris(2-carboxyethyl)phosphine inhibits the reaction [Copper promotes the reaction [MTF1 protein binds to MTF1 protein]]

NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136

G

nei-like DNA glycosylase 1

multiple interactions

[tris(2-carboxyethyl)phosphine co-treated with Edetic Acid] inhibits the reaction [Copper results in decreased activity of NEIL1 protein]; tris(2-carboxyethyl)phosphine inhibits the reaction [Hydrogen Peroxide results in decreased activity of NEIL1 protein]

NCBI chr 8:57,550,142...57,556,884
Ensembl chr 8:57,550,147...57,556,258

G

solute carrier family 34 member 1

decreases activity

tris(2-carboxyethyl)phosphine results in decreased activity of SLC34A1 protein

NCBI chr17:9,218,876...9,233,852
Ensembl chr17:9,218,876...9,233,852

G

thioredoxin 1

multiple interactions

tris(2-carboxyethyl)phosphine inhibits the reaction [chromium hexavalent ion results in increased oxidation of TXN protein]; tris(2-carboxyethyl)phosphine inhibits the reaction [sodium chromate(VI) results in increased oxidation of TXN protein]

PMID:19135121 PMID:19703554

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin 2

multiple interactions

tris(2-carboxyethyl)phosphine inhibits the reaction [chromium hexavalent ion results in increased oxidation of TXN2 protein]

NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359

tin(II) chloride (anhydrous)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2, apoptosis regulator

multiple interactions

[stannous chloride results in increased activity of HMOX1 protein] which results in increased expression of BCL2 protein

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

[stannous chloride results in increased activity of HMOX1 protein] which results in increased expression of BCL2L1 protein

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

G

dentin matrix acidic phosphoprotein 1

increases expression

stannous chloride results in increased expression of DMP1 mRNA

NCBI chr14:5,528,441...5,542,078
Ensembl chr14:5,528,431...5,539,323

G

estrogen receptor 1

multiple interactions
increases activity
affects response to substance
decreases expression

stannous chloride inhibits the reaction [Estradiol binds to ESR1 protein]
stannous chloride results in increased activity of ESR1 protein
ESR1 protein affects the susceptibility to stannous chloride
stannous chloride results in decreased expression of ESR1 mRNA; stannous chloride results in decreased expression of ESR1 protein

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

coagulation factor III, tissue factor

increases expression

stannous chloride results in increased expression of F3 protein

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

G

FOS like 1, AP-1 transcription factor subunit

increases expression

stannous chloride results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

heme oxygenase 1

multiple interactions
increases activity

[stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Heme; [stannous chloride results in increased activity of HMOX1 protein] which results in decreased abundance of Superoxides; [stannous chloride results in increased activity of HMOX1 protein] which results in increased expression of BCL2 protein; [stannous chloride results in increased activity of HMOX1 protein] which results in increased expression of BCL2L1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

orosomucoid 1

increases expression

stannous chloride results in increased expression of ORM1 mRNA

NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154

G

phosphate regulating endopeptidase X-linked

increases expression

stannous chloride results in increased expression of PHEX mRNA

NCBI chr X:37,607,553...37,856,183
Ensembl chr X:37,610,760...37,854,469

G

scavenger receptor class B, member 1

increases expression

stannous chloride results in increased expression of SCARB1 mRNA

NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647

G

solute carrier family 2 member 1

increases expression

stannous chloride results in increased expression of SLC2A1 mRNA

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

transferrin receptor

increases expression

stannous chloride results in increased expression of TFRC mRNA

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

TSC22 domain family, member 3

multiple interactions

[stannous chloride results in increased abundance of Tin] inhibits the reaction [Hydrocortisone results in increased expression of TSC22D3 mRNA]

NCBI chr X:104,217,898...104,277,886
Ensembl chr X:104,217,925...104,276,861

G

vascular endothelial growth factor A

increases expression

stannous chloride results in increased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19811
role	19818
chemical role	19422
reducing agent	218
1,4-dithiothreitol +	98
TCEP	7
ammonium thioglycolate	0
ammonium thiosulfate	0
dithioerythritol	4
iron(2+) sulfate (anhydrous) +	107
iron(2+) sulfate heptahydrate	0
iron(2+) sulfate monohydrate	0
monothioglycerol +	1
mycothiol +	0
phenylsilane	0
pyrite	0
sodium ascorbate	0
sodium dithionite	0
sodium hydrogensulfite	18
sodium oxalate	0
sodium selenide	4
sodium sulfite	11
sodium thioglycolate	0
tin(II) chloride (anhydrous) +	14
tin(II) chloride dihydrate	0
triethylsilane	0
triphenylphosphine	0

paths to the root