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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:peptidomimetic
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Accession:CHEBI:63175 term browser browse the term
Definition:A small protein-like chain designed to mimic a peptide.
Synonyms:related_synonym: peptidomimetics
 xref: Wikipedia:Peptidomimetic


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B 581 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFKB1 nuclear factor kappa B subunit 1 decreases activity EXP B 581 results in decreased activity of NFKB1 protein CTD PMID:12085227 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha decreases phosphorylation EXP B 581 results in decreased phosphorylation of NFKBIA protein CTD PMID:12085227 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases activity EXP B 581 results in decreased activity of RELA protein CTD PMID:12085227 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
icatibant term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions ISO [icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of AGT protein] CTD PMID:38027817 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,690,776...230,745,576 		JBrowse link
G BDKRB2 bradykinin receptor B2 multiple interactions EXP
ISO		 icatibant binds to and results in decreased activity of BDKRB2 protein; icatibant inhibits the reaction [FR 190997 binds to and results in increased activity of BDKRB2 protein]; icatibant inhibits the reaction [KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein]
icatibant binds to and results in decreased activity of BDKRB2 protein; icatibant inhibits the reaction [KNG1 protein modified form binds to BDKRB2 protein]
[icatibant binds to and results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Chondroitin Sulfates; [icatibant binds to and results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Streptozocin; [icatibant binds to and results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Vincristine; [icatibant results in decreased activity of BDKRB2 protein] inhibits the reaction [Valsartan results in increased abundance of Cyclic GMP]; [icatibant results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to benazepril; [icatibant results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Valsartan; icatibant binds to and results in decreased activity of BDKRB2 protein; icatibant inhibits the reaction [[KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein] which results in increased abundance of Inositol Phosphates]		 CTD PMID:10666510 PMID:12727271 PMID:15140628 PMID:16982965 PMID:17347322 More... NCBI chr14:96,204,839...96,244,164
Ensembl chr14:96,204,679...96,244,166 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions ISO icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased expression of ICAM1 protein]] CTD PMID:16401625 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IL6 interleukin 6 multiple interactions ISO [icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of IL6 protein] CTD PMID:38027817 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G KLK1 kallikrein 1 multiple interactions ISO icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased expression of ICAM1 protein]]; icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased expression of TGFB1 protein]]; icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased phosphorylation of MAPK8 protein]]; icatibant inhibits the reaction [KLK1 protein results in increased abundance of Nitric Oxide] CTD PMID:16401625 NCBI chr19:50,819,146...50,823,787
Ensembl chr19:50,819,146...50,823,787 		JBrowse link
G KNG1 kininogen 1 multiple interactions
decreases activity		 EXP
ISO		 icatibant inhibits the reaction [KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein]
icatibant inhibits the reaction [KNG1 protein modified form binds to BDKRB2 protein]
icatibant results in decreased activity of KNG1
[icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of KNG1 protein]; icatibant inhibits the reaction [[KNG1 protein alternative form binds to and results in increased activity of BDKRB2 protein] which results in increased abundance of Inositol Phosphates]; icatibant inhibits the reaction [KNG1 protein inhibits the reaction [Potassium Chloride results in increased secretion of TAC1 protein]]; icatibant inhibits the reaction [KNG1 results in increased expression of PTGS2 mRNA]; icatibant inhibits the reaction [KNG1 results in increased secretion of TAC1 protein]		 CTD PMID:1334751 PMID:15140628 PMID:15750287 PMID:16696851 PMID:17347322 More... NCBI chr 3:186,717,359...186,744,410
Ensembl chr 3:186,717,348...186,744,410 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases activity
multiple interactions		 EXP icatibant results in increased activity of MAPK3 protein
FR 173657 inhibits the reaction [icatibant results in increased activity of MAPK3 protein]		 CTD PMID:11139431 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased phosphorylation of MAPK8 protein]] CTD PMID:16401625 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G PLAT plasminogen activator, tissue type decreases expression EXP icatibant results in decreased expression of PLAT protein CTD PMID:16321614 NCBI chr 8:42,174,718...42,207,565
Ensembl chr 8:42,174,718...42,207,709 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO icatibant inhibits the reaction [KNG1 results in increased expression of PTGS2 mRNA] CTD PMID:15750287 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G TAC1 tachykinin precursor 1 multiple interactions ISO icatibant inhibits the reaction [KNG1 protein inhibits the reaction [Potassium Chloride results in increased secretion of TAC1 protein]]; icatibant inhibits the reaction [KNG1 results in increased secretion of TAC1 protein] CTD PMID:16696851 PMID:22198006 NCBI chr 7:97,732,086...97,740,472
Ensembl chr 7:97,732,084...97,740,472 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO [icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]; icatibant inhibits the reaction [KLK1 protein inhibits the reaction [Gentamicins results in increased expression of TGFB1 protein]] CTD PMID:16401625 PMID:38027817 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TNF tumor necrosis factor multiple interactions ISO [icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of TNF protein] CTD PMID:38027817 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
telaprevir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP telaprevir inhibits the reaction [CYP3A4 protein results in increased metabolism of Simvastatin] CTD PMID:24927617 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      biological role 25929
        biochemical role 25162
          peptidomimetic 17
            B 581 3
            L-685,458 + 0
            LTX-109 0
            MI-1148 0
            N-(3-\{[(N-\{2-[(alpha-Glu-Leu-Ala)NH]ethyl\}-Trp)amino]methyl\}benzoyl)-Leu-Thr-Val 0
            N-(3-\{[(N-\{2-[(beta-Ala-Leu-Ala)NH]ethyl\}-Trp)amino]methyl\}benzoyl)-Leu-Thr-Val 0
            N-[3-(\{[N-\{2-[(alpha-Glu-Leu-Ala)NH]ethyl\}-N-(indol-3-ylacetyl)Gly]amino\}methyl)benzoyl]-Leu-Thr-Val 0
            N-[3-(\{[N-\{2-[(beta-Ala-Leu-Ala)NH]ethyl\}-N-(indol-3-ylacetyl)Gly]amino\}methyl)benzoyl]-Leu-Thr-Val 0
            N-succinyl-Leu-Tyr-7-amido-4-methylcoumarin 0
            XJB-5-131 0
            boceprevir 0
            decanoyl-L-Arg-L-Val-L-Lys-L-Arg-chloromethylketone 0
            icatibant + 13
            icatibant acetate 0
            remikiren 0
            telaprevir 1
paths to the root