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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mononitrotoluene
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Accession:CHEBI:63171 term browser browse the term
Definition:A nitrotoluene bearing a single nitro substituent at any position. A 'closed class'.
Synonyms:related_synonym: mononitrotoluenes
 xref: Wikipedia:Mononitrotoluene



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2-nitrotoluene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actg2 actin, gamma 2, smooth muscle, enteric decreases expression ISO 2-nitrotoluene results in decreased expression of ACTG2 mRNA CTD PMID:16460773 NCBI chr 6:83,489,891...83,513,233
Ensembl chr 6:83,489,887...83,513,247
JBrowse link
G Actn1 actinin, alpha 1 decreases expression ISO 2-nitrotoluene results in decreased expression of ACTN1 mRNA CTD PMID:16460773 NCBI chr12:80,214,316...80,307,165
Ensembl chr12:80,214,321...80,307,145
JBrowse link
G Actn4 actinin alpha 4 decreases expression ISO 2-nitrotoluene results in decreased expression of ACTN4 mRNA CTD PMID:16460773 NCBI chr 7:28,592,673...28,661,799
Ensembl chr 7:28,592,673...28,661,765
JBrowse link
G Akap10 A kinase (PRKA) anchor protein 10 decreases expression EXP 2-nitrotoluene results in decreased expression of AKAP10 mRNA CTD PMID:15612046 NCBI chr11:61,756,029...61,821,134
Ensembl chr11:61,762,133...61,821,078
JBrowse link
G Akt2 thymoma viral proto-oncogene 2 increases expression ISO 2-nitrotoluene results in increased expression of AKT2 mRNA CTD PMID:16460773 NCBI chr 7:27,290,977...27,340,251
Ensembl chr 7:27,290,977...27,340,251
JBrowse link
G Arf4 ADP-ribosylation factor 4 decreases expression ISO 2-nitrotoluene results in decreased expression of ARF4 mRNA CTD PMID:16460773 NCBI chr14:26,359,289...26,377,997
Ensembl chr14:26,359,229...26,386,239
JBrowse link
G Arid3a AT rich interactive domain 3A (BRIGHT-like) increases expression EXP 2-nitrotoluene results in increased expression of ARID3A mRNA CTD PMID:15612046 NCBI chr10:79,762,877...79,790,852
Ensembl chr10:79,762,877...79,790,852
JBrowse link
G Bnip3l BCL2/adenovirus E1B interacting protein 3-like increases expression ISO 2-nitrotoluene results in increased expression of BNIP3L mRNA CTD PMID:16460773 NCBI chr14:67,222,688...67,246,580
Ensembl chr14:67,222,688...67,246,326
JBrowse link
G Ccn3 cellular communication network factor 3 decreases expression ISO 2-nitrotoluene results in decreased expression of CCN3 mRNA CTD PMID:16460773 NCBI chr15:54,609,306...54,617,158
Ensembl chr15:54,609,098...54,617,435
JBrowse link
G Ccng1 cyclin G1 increases expression EXP 2-nitrotoluene results in increased expression of CCNG1 mRNA CTD PMID:15618236 NCBI chr11:40,639,379...40,646,155
Ensembl chr11:40,639,379...40,646,138
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) decreases expression
increases expression
ISO
EXP
2-nitrotoluene results in decreased expression of CDKN1A mRNA
2-nitrotoluene results in increased expression of CDKN1A mRNA
CTD PMID:15618236 PMID:16460773 NCBI chr17:29,309,953...29,319,696
Ensembl chr17:29,309,950...29,319,701
JBrowse link
G Cish cytokine inducible SH2-containing protein decreases expression EXP 2-nitrotoluene results in decreased expression of CISH mRNA CTD PMID:15618236 NCBI chr 9:107,173,858...107,179,983
Ensembl chr 9:107,173,225...107,179,983
JBrowse link
G Col1a2 collagen, type I, alpha 2 decreases expression ISO 2-nitrotoluene results in decreased expression of COL1A2 mRNA CTD PMID:16460773 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Ctnnb1 catenin (cadherin associated protein), beta 1 increases mutagenesis EXP 2-nitrotoluene results in increased mutagenesis of CTNNB1 gene CTD PMID:13678655 NCBI chr 9:120,762,466...120,789,573
Ensembl chr 9:120,758,282...120,789,573
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 increases expression EXP 2-nitrotoluene results in increased expression of CYP2B10 mRNA CTD PMID:15618236 NCBI chr 7:25,597,083...25,626,049
Ensembl chr 7:25,597,045...25,626,049
JBrowse link
G Cyp2j6 cytochrome P450, family 2, subfamily j, polypeptide 6 increases expression EXP 2-nitrotoluene results in increased expression of CYP2J6 mRNA CTD PMID:15612046 NCBI chr 4:96,404,375...96,452,513
Ensembl chr 4:96,404,375...96,441,898
JBrowse link
G Ecm1 extracellular matrix protein 1 decreases expression EXP 2-nitrotoluene results in decreased expression of ECM1 mRNA CTD PMID:15612046 NCBI chr 3:95,641,459...95,646,915
Ensembl chr 3:95,641,459...95,646,881
JBrowse link
G Egfr epidermal growth factor receptor decreases expression EXP 2-nitrotoluene results in decreased expression of EGFR mRNA CTD PMID:15618236 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) decreases expression ISO 2-nitrotoluene results in decreased expression of FAS mRNA CTD PMID:16460773 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172
JBrowse link
G Fat1 FAT atypical cadherin 1 decreases expression ISO 2-nitrotoluene results in decreased expression of FAT1 mRNA CTD PMID:16460773 NCBI chr 8:45,386,137...45,505,294
Ensembl chr 8:45,388,484...45,505,294
JBrowse link
G Fgfrl1 fibroblast growth factor receptor-like 1 decreases expression EXP 2-nitrotoluene results in decreased expression of FGFRL1 protein CTD PMID:22434383 NCBI chr 5:108,842,051...108,854,816
Ensembl chr 5:108,840,248...108,854,790
JBrowse link
G Fhit fragile histidine triad gene decreases expression EXP 2-nitrotoluene results in decreased expression of FHIT mRNA; 2-nitrotoluene results in decreased expression of FHIT protein CTD PMID:15618236 NCBI chr14:11,307,679...12,919,681
Ensembl chr14:11,307,738...12,919,681
JBrowse link
G Fos FBJ osteosarcoma oncogene decreases expression ISO 2-nitrotoluene results in decreased expression of FOS mRNA CTD PMID:16460773 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
JBrowse link
G Fosl1 fos-like antigen 1 decreases expression ISO 2-nitrotoluene results in decreased expression of FOSL1 mRNA CTD PMID:16460773 NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974
JBrowse link
G Fzd2 frizzled class receptor 2 decreases expression ISO 2-nitrotoluene results in decreased expression of FZD2 mRNA CTD PMID:16460773 NCBI chr11:102,495,257...102,498,884
Ensembl chr11:102,495,222...102,498,884
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible 45 alpha decreases expression ISO 2-nitrotoluene results in decreased expression of GADD45A mRNA CTD PMID:16460773 NCBI chr 6:67,012,080...67,014,391
Ensembl chr 6:67,012,080...67,014,441
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta increases expression EXP 2-nitrotoluene results in increased expression of GADD45B mRNA CTD PMID:15618236 NCBI chr10:80,765,925...80,768,038
Ensembl chr10:80,765,907...80,768,038
JBrowse link
G Gnaq guanine nucleotide binding protein, alpha q polypeptide decreases expression ISO 2-nitrotoluene results in decreased expression of GNAQ mRNA CTD PMID:16460773 NCBI chr19:16,110,048...16,365,884
Ensembl chr19:16,110,195...16,364,827
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects expression ISO 2-nitrotoluene affects the expression of GSK3B mRNA CTD PMID:16460773 NCBI chr16:37,909,363...38,066,446
Ensembl chr16:37,909,363...38,066,446
JBrowse link
G Gtf2ird1 general transcription factor II I repeat domain-containing 1 decreases expression EXP 2-nitrotoluene results in decreased expression of GTF2IRD1 protein CTD PMID:22434383 NCBI chr 5:134,386,515...134,485,628
Ensembl chr 5:134,386,510...134,485,570
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO 2-nitrotoluene results in increased expression of IGF1 mRNA CTD PMID:16460773 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression ISO 2-nitrotoluene results in increased expression of IGFBP2 mRNA CTD PMID:16460773 NCBI chr 1:72,863,639...72,891,633
Ensembl chr 1:72,863,662...72,891,633
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression ISO 2-nitrotoluene results in increased expression of IGFBP3 mRNA CTD PMID:16460773 NCBI chr11:7,156,086...7,165,498
Ensembl chr11:7,156,086...7,163,923
JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 increases expression ISO 2-nitrotoluene results in increased expression of IGFBP6 mRNA CTD PMID:16460773 NCBI chr15:102,052,621...102,057,947
Ensembl chr15:102,052,797...102,057,946
JBrowse link
G Igh-VJ558 immunoglobulin heavy chain (J558 family) increases expression EXP 2-nitrotoluene results in increased expression of IGH-VJ558 protein CTD PMID:22434383
G Il7 interleukin 7 increases expression EXP 2-nitrotoluene results in increased expression of IL7 mRNA CTD PMID:15612046 NCBI chr 3:7,637,088...7,678,820
Ensembl chr 3:7,635,054...7,678,820
JBrowse link
G Ilk integrin linked kinase decreases expression ISO 2-nitrotoluene results in decreased expression of ILK mRNA CTD PMID:16460773 NCBI chr 7:105,385,797...105,392,132
Ensembl chr 7:105,385,799...105,392,132
JBrowse link
G Inhba inhibin beta-A decreases expression EXP 2-nitrotoluene results in decreased expression of INHBA mRNA CTD PMID:15618236 NCBI chr13:16,178,841...16,206,194
Ensembl chr13:16,186,436...16,206,206
JBrowse link
G Itga8 integrin alpha 8 decreases expression ISO 2-nitrotoluene results in decreased expression of ITGA8 mRNA CTD PMID:16460773 NCBI chr 2:12,111,443...12,306,796
Ensembl chr 2:12,111,443...12,306,733
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) decreases expression ISO 2-nitrotoluene results in decreased expression of ITGB1 mRNA CTD PMID:16460773 NCBI chr 8:129,412,135...129,460,060
Ensembl chr 8:129,412,135...129,459,681
JBrowse link
G Itgb2 integrin beta 2 increases expression ISO 2-nitrotoluene results in increased expression of ITGB2 mRNA CTD PMID:16460773 NCBI chr10:77,366,164...77,401,542
Ensembl chr10:77,366,086...77,401,542
JBrowse link
G Krt10 keratin 10 decreases expression EXP 2-nitrotoluene results in decreased expression of KRT10 protein CTD PMID:22434383 NCBI chr11:99,276,080...99,288,631
Ensembl chr11:99,276,080...99,280,190
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression EXP 2-nitrotoluene results in decreased expression of LEF1 mRNA CTD PMID:15612046 NCBI chr 3:130,903,946...131,018,006
Ensembl chr 3:130,904,120...131,018,005
JBrowse link
G Mapkapk2 MAP kinase-activated protein kinase 2 increases expression ISO 2-nitrotoluene results in increased expression of MAPKAPK2 mRNA CTD PMID:16460773 NCBI chr 1:130,981,437...131,025,580
Ensembl chr 1:130,981,437...131,025,563
JBrowse link
G Msln mesothelin increases expression ISO 2-nitrotoluene results in increased expression of MSLN mRNA CTD PMID:16460773 NCBI chr17:25,967,587...25,973,352
Ensembl chr17:25,967,587...25,973,352
JBrowse link
G Myc myelocytomatosis oncogene increases expression ISO 2-nitrotoluene results in increased expression of MYC mRNA CTD PMID:16460773 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223
JBrowse link
G Nras neuroblastoma ras oncogene increases expression ISO 2-nitrotoluene results in increased expression of NRAS mRNA CTD PMID:16460773 NCBI chr 3:102,965,601...102,975,230
Ensembl chr 3:102,965,601...102,975,230
JBrowse link
G Pard3 par-3 family cell polarity regulator increases expression EXP 2-nitrotoluene results in increased expression of PARD3 protein CTD PMID:22434383 NCBI chr 8:127,790,131...128,338,767
Ensembl chr 8:127,790,643...128,338,767
JBrowse link
G Pld3 phospholipase D family, member 3 increases expression EXP 2-nitrotoluene results in increased expression of PLD3 mRNA CTD PMID:15612046 NCBI chr 7:27,230,843...27,252,663
Ensembl chr 7:27,231,425...27,252,643
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A decreases expression ISO 2-nitrotoluene results in decreased expression of PPP1R12A mRNA CTD PMID:16460773 NCBI chr10:107,997,913...108,115,846
Ensembl chr10:107,998,054...108,120,336
JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta increases expression ISO 2-nitrotoluene results in increased expression of PPP2R2B mRNA CTD PMID:16460773 NCBI chr18:42,777,811...43,192,842
Ensembl chr18:42,770,497...43,216,192
JBrowse link
G Prkcz protein kinase C, zeta increases expression ISO 2-nitrotoluene results in increased expression of PRKCZ mRNA CTD PMID:16460773 NCBI chr 4:155,344,575...155,445,885
Ensembl chr 4:155,344,586...155,445,818
JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase decreases expression EXP 2-nitrotoluene results in decreased expression of RAD18 protein CTD PMID:22434383 NCBI chr 6:112,596,812...112,673,650
Ensembl chr 6:112,596,811...112,673,647
JBrowse link
G Rala v-ral simian leukemia viral oncogene A (ras related) decreases expression ISO 2-nitrotoluene results in decreased expression of RALA mRNA CTD PMID:16460773 NCBI chr13:18,055,160...18,118,802
Ensembl chr13:18,055,156...18,118,824
JBrowse link
G S100a4 S100 calcium binding protein A4 increases expression EXP 2-nitrotoluene results in increased expression of S100A4 mRNA CTD PMID:15612046 NCBI chr 3:90,511,077...90,513,352
Ensembl chr 3:90,511,078...90,513,352
JBrowse link
G Slc9a3r1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 increases expression EXP 2-nitrotoluene results in increased expression of SLC9A3R1 protein CTD PMID:22434383 NCBI chr11:115,054,138...115,072,009
Ensembl chr11:115,054,167...115,072,007
JBrowse link
G St7l suppression of tumorigenicity 7-like decreases expression EXP 2-nitrotoluene results in decreased expression of ST7L mRNA CTD PMID:15612046 NCBI chr 3:104,771,822...104,837,384
Ensembl chr 3:104,771,321...104,837,380
JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity EXP 2-nitrotoluene results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr11:100,671,557...100,741,407
Ensembl chr11:100,671,557...100,741,550
JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression ISO 2-nitrotoluene results in decreased expression of TGFB2 mRNA CTD PMID:16460773 NCBI chr 1:186,354,984...186,441,504
Ensembl chr 1:186,354,989...186,438,186
JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression ISO 2-nitrotoluene results in decreased expression of TGFB3 mRNA CTD PMID:16460773 NCBI chr12:86,103,517...86,125,815
Ensembl chr12:86,103,519...86,125,815
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor II increases expression ISO 2-nitrotoluene results in increased expression of TGFBR2 mRNA CTD PMID:16460773 NCBI chr 9:115,916,763...116,004,431
Ensembl chr 9:115,913,361...116,004,428
JBrowse link
G Tph1 tryptophan hydroxylase 1 increases expression EXP 2-nitrotoluene results in increased expression of TPH1 mRNA CTD PMID:15612046 NCBI chr 7:46,294,065...46,321,961
Ensembl chr 7:46,294,065...46,321,961
JBrowse link
G Trp53 transformation related protein 53 increases mutagenesis EXP 2-nitrotoluene results in increased mutagenesis of TRP53 gene CTD PMID:13678655 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699
JBrowse link
G Wnt4 wingless-type MMTV integration site family, member 4 increases expression ISO 2-nitrotoluene results in increased expression of WNT4 mRNA CTD PMID:16460773 NCBI chr 4:137,004,946...137,026,812
Ensembl chr 4:137,004,800...137,027,037
JBrowse link
G Wwox WW domain-containing oxidoreductase decreases expression EXP 2-nitrotoluene results in decreased expression of WWOX mRNA; 2-nitrotoluene results in decreased expression of WWOX protein CTD PMID:15618236 NCBI chr 8:115,166,377...116,079,451
Ensembl chr 8:115,166,395...116,079,447
JBrowse link
4-nitrotoluene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cish cytokine inducible SH2-containing protein decreases expression EXP 4-nitrotoluene results in decreased expression of CISH mRNA CTD PMID:15618236 NCBI chr 9:107,173,858...107,179,983
Ensembl chr 9:107,173,225...107,179,983
JBrowse link
G Egfr epidermal growth factor receptor decreases expression EXP 4-nitrotoluene results in decreased expression of EGFR protein CTD PMID:15618236 NCBI chr11:16,700,153...16,868,158
Ensembl chr11:16,702,203...16,868,158
JBrowse link
G Egr1 early growth response 1 increases expression EXP 4-nitrotoluene results in increased expression of EGR1 mRNA CTD PMID:15618236 NCBI chr18:34,994,260...34,998,009
Ensembl chr18:34,992,876...34,998,037
JBrowse link
G Esr2 estrogen receptor 2 (beta) affects binding ISO 4-nitrotoluene binds to ESR2 protein CTD PMID:12224631 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
JBrowse link
G Inhba inhibin beta-A decreases expression EXP 4-nitrotoluene results in decreased expression of INHBA mRNA CTD PMID:15618236 NCBI chr13:16,178,841...16,206,194
Ensembl chr13:16,186,436...16,206,206
JBrowse link
G Junb jun B proto-oncogene increases expression EXP 4-nitrotoluene results in increased expression of JUNB mRNA CTD PMID:15618236 NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP 4-nitrotoluene promotes the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] CTD PMID:17015962 NCBI chr 3:135,290,416...135,397,728
Ensembl chr 3:135,290,416...135,397,308
JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 decreases expression ISO 4-nitrotoluene results in decreased expression of SLC6A3 mRNA CTD PMID:15265578 NCBI chr13:73,684,270...73,726,791
Ensembl chr13:73,684,866...73,726,791
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21876
    chemical entity 21874
      molecular entity 21837
        polyatomic entity 21763
          molecule 21370
            organic molecule 21385
              C-nitro compound 10589
                nitrotoluene 3846
                  mononitrotoluene 70
                    2-nitrotoluene 65
                    3-nitrotoluene 0
                    4-nitrotoluene 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 21876
    subatomic particle 21838
      composite particle 21838
        hadron 21864
          baryon 21864
            nucleon 21864
              atomic nucleus 21864
                atom 21838
                  main group element atom 21760
                    p-block element atom 21786
                      carbon group element atom 21601
                        carbon atom 21518
                          organic molecular entity 21518
                            organic molecule 21385
                              organic cyclic compound 20983
                                carbocyclic compound 19268
                                  benzenoid aromatic compound 18178
                                    benzenes 17913
                                      toluenes 6335
                                        nitrotoluene 3846
                                          mononitrotoluene 70
                                            2-nitrotoluene 65
                                            3-nitrotoluene 0
                                            4-nitrotoluene 8
paths to the root