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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:mononitrotoluene
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Accession:CHEBI:63171 term browser browse the term
Definition:A nitrotoluene bearing a single nitro substituent at any position. A 'closed class'.
Synonyms:related_synonym: mononitrotoluenes
 xref: Wikipedia:Mononitrotoluene



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2-nitrotoluene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTG2 actin gamma 2, smooth muscle decreases expression ISO 2-nitrotoluene results in decreased expression of ACTG2 mRNA CTD PMID:16460773 NCBI chr 2:73,893,008...73,919,865
Ensembl chr 2:73,892,314...73,919,865
JBrowse link
G ACTN1 actinin alpha 1 decreases expression ISO 2-nitrotoluene results in decreased expression of ACTN1 mRNA CTD PMID:16460773 NCBI chr14:68,874,128...68,979,302
Ensembl chr14:68,874,128...68,979,440
JBrowse link
G ACTN4 actinin alpha 4 decreases expression ISO 2-nitrotoluene results in decreased expression of ACTN4 mRNA CTD PMID:16460773 NCBI chr19:38,647,649...38,731,589
Ensembl chr19:38,647,649...38,731,589
JBrowse link
G AKAP10 A-kinase anchoring protein 10 decreases expression ISO 2-nitrotoluene results in decreased expression of AKAP10 mRNA CTD PMID:15612046 NCBI chr17:19,904,302...19,977,828
Ensembl chr17:19,904,302...19,978,343
JBrowse link
G AKT2 AKT serine/threonine kinase 2 increases expression ISO 2-nitrotoluene results in increased expression of AKT2 mRNA CTD PMID:16460773 NCBI chr19:40,230,317...40,285,345
Ensembl chr19:40,230,317...40,285,536
JBrowse link
G ARF4 ADP ribosylation factor 4 decreases expression ISO 2-nitrotoluene results in decreased expression of ARF4 mRNA CTD PMID:16460773 NCBI chr 3:57,571,363...57,597,344
Ensembl chr 3:57,571,363...57,598,220
JBrowse link
G ARID3A AT-rich interaction domain 3A increases expression ISO 2-nitrotoluene results in increased expression of ARID3A mRNA CTD PMID:15612046 NCBI chr19:925,732...975,939
Ensembl chr19:925,781...975,939
JBrowse link
G BNIP3L BCL2 interacting protein 3 like increases expression ISO 2-nitrotoluene results in increased expression of BNIP3L mRNA CTD PMID:16460773 NCBI chr 8:26,383,054...26,413,127
Ensembl chr 8:26,383,054...26,505,636
JBrowse link
G CCN3 cellular communication network factor 3 decreases expression ISO 2-nitrotoluene results in decreased expression of CCN3 mRNA CTD PMID:16460773 NCBI chr 8:119,416,446...119,424,434
Ensembl chr 8:119,416,446...119,424,434
JBrowse link
G CCNG1 cyclin G1 increases expression ISO 2-nitrotoluene results in increased expression of CCNG1 mRNA CTD PMID:15618236 NCBI chr 5:163,437,571...163,457,640
Ensembl chr 5:163,437,569...163,446,151
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A decreases expression
increases expression
ISO 2-nitrotoluene results in decreased expression of CDKN1A mRNA
2-nitrotoluene results in increased expression of CDKN1A mRNA
CTD PMID:15618236 PMID:16460773 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CISH cytokine inducible SH2 containing protein decreases expression ISO 2-nitrotoluene results in decreased expression of CISH mRNA CTD PMID:15618236 NCBI chr 3:50,606,489...50,611,774
Ensembl chr 3:50,606,489...50,611,774
JBrowse link
G COL1A2 collagen type I alpha 2 chain decreases expression ISO 2-nitrotoluene results in decreased expression of COL1A2 mRNA CTD PMID:16460773 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
JBrowse link
G CTNNB1 catenin beta 1 increases mutagenesis ISO 2-nitrotoluene results in increased mutagenesis of CTNNB1 gene CTD PMID:13678655 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases expression ISO 2-nitrotoluene results in increased expression of CYP2B10 mRNA CTD PMID:15618236 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G ECM1 extracellular matrix protein 1 decreases expression ISO 2-nitrotoluene results in decreased expression of ECM1 mRNA CTD PMID:15612046 NCBI chr 1:150,508,109...150,513,789
Ensembl chr 1:150,508,062...150,513,789
JBrowse link
G EGFR epidermal growth factor receptor decreases expression ISO 2-nitrotoluene results in decreased expression of EGFR mRNA CTD PMID:15618236 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G FAS Fas cell surface death receptor decreases expression ISO 2-nitrotoluene results in decreased expression of FAS mRNA CTD PMID:16460773 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605
JBrowse link
G FAT1 FAT atypical cadherin 1 decreases expression ISO 2-nitrotoluene results in decreased expression of FAT1 mRNA CTD PMID:16460773 NCBI chr 4:186,587,794...186,726,696
Ensembl chr 4:186,587,794...186,726,722
JBrowse link
G FGFRL1 fibroblast growth factor receptor like 1 decreases expression ISO 2-nitrotoluene results in decreased expression of FGFRL1 protein CTD PMID:22434383 NCBI chr 4:1,010,212...1,026,898
Ensembl chr 4:1,009,936...1,026,898
JBrowse link
G FHIT fragile histidine triad diadenosine triphosphatase decreases expression ISO 2-nitrotoluene results in decreased expression of FHIT mRNA; 2-nitrotoluene results in decreased expression of FHIT protein CTD PMID:15618236 NCBI chr 3:59,747,277...61,251,452
Ensembl chr 3:59,747,277...61,251,459
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO 2-nitrotoluene results in decreased expression of FOS mRNA CTD PMID:16460773 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit decreases expression ISO 2-nitrotoluene results in decreased expression of FOSL1 mRNA CTD PMID:16460773 NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573
JBrowse link
G FZD2 frizzled class receptor 2 decreases expression ISO 2-nitrotoluene results in decreased expression of FZD2 mRNA CTD PMID:16460773 NCBI chr17:44,557,484...44,561,262
Ensembl chr17:44,557,484...44,561,262
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha decreases expression ISO 2-nitrotoluene results in decreased expression of GADD45A mRNA CTD PMID:16460773 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G GADD45B growth arrest and DNA damage inducible beta increases expression ISO 2-nitrotoluene results in increased expression of GADD45B mRNA CTD PMID:15618236 NCBI chr19:2,476,127...2,478,257
Ensembl chr19:2,476,122...2,478,259
JBrowse link
G GNAQ G protein subunit alpha q decreases expression ISO 2-nitrotoluene results in decreased expression of GNAQ mRNA CTD PMID:16460773 NCBI chr 9:77,716,097...78,031,811
Ensembl chr 9:77,716,097...78,031,811
JBrowse link
G GSK3B glycogen synthase kinase 3 beta affects expression ISO 2-nitrotoluene affects the expression of GSK3B mRNA CTD PMID:16460773 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G GTF2IRD1 GTF2I repeat domain containing 1 decreases expression ISO 2-nitrotoluene results in decreased expression of GTF2IRD1 protein CTD PMID:22434383 NCBI chr 7:74,453,906...74,602,605
Ensembl chr 7:74,453,790...74,602,605
JBrowse link
G IGF1 insulin like growth factor 1 increases expression ISO 2-nitrotoluene results in increased expression of IGF1 mRNA CTD PMID:16460773 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IGFBP2 insulin like growth factor binding protein 2 increases expression ISO 2-nitrotoluene results in increased expression of IGFBP2 mRNA CTD PMID:16460773 NCBI chr 2:216,632,828...216,664,436
Ensembl chr 2:216,632,828...216,664,436
JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 increases expression ISO 2-nitrotoluene results in increased expression of IGFBP3 mRNA CTD PMID:16460773 NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874
JBrowse link
G IGFBP6 insulin like growth factor binding protein 6 increases expression ISO 2-nitrotoluene results in increased expression of IGFBP6 mRNA CTD PMID:16460773 NCBI chr12:53,097,667...53,102,340
Ensembl chr12:53,097,436...53,102,345
JBrowse link
G IL7 interleukin 7 increases expression ISO 2-nitrotoluene results in increased expression of IL7 mRNA CTD PMID:15612046 NCBI chr 8:78,675,044...78,805,463
Ensembl chr 8:78,675,743...78,805,523
JBrowse link
G ILK integrin linked kinase decreases expression ISO 2-nitrotoluene results in decreased expression of ILK mRNA CTD PMID:16460773 NCBI chr11:6,603,774...6,610,870
Ensembl chr11:6,603,708...6,610,874
JBrowse link
G INHBA inhibin subunit beta A decreases expression ISO 2-nitrotoluene results in decreased expression of INHBA mRNA CTD PMID:15618236 NCBI chr 7:41,685,114...41,705,406
Ensembl chr 7:41,667,168...41,705,834
JBrowse link
G ITGA8 integrin subunit alpha 8 decreases expression ISO 2-nitrotoluene results in decreased expression of ITGA8 mRNA CTD PMID:16460773 NCBI chr10:15,513,954...15,719,922
Ensembl chr10:15,513,954...15,719,922
JBrowse link
G ITGB1 integrin subunit beta 1 decreases expression ISO 2-nitrotoluene results in decreased expression of ITGB1 mRNA CTD PMID:16460773 NCBI chr10:32,900,318...32,958,230
Ensembl chr10:32,887,273...33,005,792
JBrowse link
G ITGB2 integrin subunit beta 2 increases expression ISO 2-nitrotoluene results in increased expression of ITGB2 mRNA CTD PMID:16460773 NCBI chr21:44,885,953...44,928,815
Ensembl chr21:44,885,953...44,931,989
JBrowse link
G KRT10 keratin 10 decreases expression ISO 2-nitrotoluene results in decreased expression of KRT10 protein CTD PMID:22434383 NCBI chr17:40,818,117...40,822,614
Ensembl chr17:40,818,117...40,822,614
JBrowse link
G LEF1 lymphoid enhancer binding factor 1 decreases expression ISO 2-nitrotoluene results in decreased expression of LEF1 mRNA CTD PMID:15612046 NCBI chr 4:108,047,548...108,168,932
Ensembl chr 4:108,047,545...108,168,956
JBrowse link
G MAPKAPK2 MAPK activated protein kinase 2 increases expression ISO 2-nitrotoluene results in increased expression of MAPKAPK2 mRNA CTD PMID:16460773 NCBI chr 1:206,684,905...206,734,281
Ensembl chr 1:206,684,905...206,734,281
JBrowse link
G MSLN mesothelin increases expression ISO 2-nitrotoluene results in increased expression of MSLN mRNA CTD PMID:16460773 NCBI chr16:760,734...768,865
Ensembl chr16:760,734...768,865
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression ISO 2-nitrotoluene results in increased expression of MYC mRNA CTD PMID:16460773 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NRAS NRAS proto-oncogene, GTPase increases expression ISO 2-nitrotoluene results in increased expression of NRAS mRNA CTD PMID:16460773 NCBI chr 1:114,704,469...114,716,771
Ensembl chr 1:114,704,469...114,716,771
JBrowse link
G PARD3 par-3 family cell polarity regulator increases expression ISO 2-nitrotoluene results in increased expression of PARD3 protein CTD PMID:22434383 NCBI chr10:34,109,561...34,815,296
Ensembl chr10:34,109,560...34,815,325
JBrowse link
G PLD3 phospholipase D family member 3 increases expression ISO 2-nitrotoluene results in increased expression of PLD3 mRNA CTD PMID:15612046 NCBI chr19:40,348,695...40,378,485
Ensembl chr19:40,348,456...40,380,439
JBrowse link
G PPP1R12A protein phosphatase 1 regulatory subunit 12A decreases expression ISO 2-nitrotoluene results in decreased expression of PPP1R12A mRNA CTD PMID:16460773 NCBI chr12:79,773,563...79,935,460
Ensembl chr12:79,773,563...79,935,460
JBrowse link
G PPP2R2B protein phosphatase 2 regulatory subunit Bbeta increases expression ISO 2-nitrotoluene results in increased expression of PPP2R2B mRNA CTD PMID:16460773 NCBI chr 5:146,580,742...147,081,520
Ensembl chr 5:146,580,742...147,084,784
JBrowse link
G PRKCZ protein kinase C zeta increases expression ISO 2-nitrotoluene results in increased expression of PRKCZ mRNA CTD PMID:16460773 NCBI chr 1:2,048,504...2,185,395
Ensembl chr 1:2,050,411...2,185,395
JBrowse link
G RAD18 RAD18 E3 ubiquitin protein ligase decreases expression ISO 2-nitrotoluene results in decreased expression of RAD18 protein CTD PMID:22434383 NCBI chr 3:8,877,075...8,963,472
Ensembl chr 3:8,775,402...8,963,773
JBrowse link
G RALA RAS like proto-oncogene A decreases expression ISO 2-nitrotoluene results in decreased expression of RALA mRNA CTD PMID:16460773 NCBI chr 7:39,623,572...39,708,120
Ensembl chr 7:39,623,565...39,708,120
JBrowse link
G S100A4 S100 calcium binding protein A4 increases expression ISO 2-nitrotoluene results in increased expression of S100A4 mRNA CTD PMID:15612046 NCBI chr 1:153,543,621...153,545,806
Ensembl chr 1:153,543,613...153,550,136
JBrowse link
G SLC9A3R1 SLC9A3 regulator 1 increases expression ISO 2-nitrotoluene results in increased expression of SLC9A3R1 protein CTD PMID:22434383 NCBI chr17:74,748,628...74,769,353
Ensembl chr17:74,748,628...74,769,353
JBrowse link
G ST7L suppression of tumorigenicity 7 like decreases expression ISO 2-nitrotoluene results in decreased expression of ST7L mRNA CTD PMID:15612046 NCBI chr 1:112,517,803...112,619,684
Ensembl chr 1:112,523,514...112,620,825
JBrowse link
G STAT5B signal transducer and activator of transcription 5B decreases activity ISO 2-nitrotoluene results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr17:42,199,177...42,288,370
Ensembl chr17:42,199,177...42,276,707
JBrowse link
G TGFB2 transforming growth factor beta 2 decreases expression ISO 2-nitrotoluene results in decreased expression of TGFB2 mRNA CTD PMID:16460773 NCBI chr 1:218,345,336...218,444,619
Ensembl chr 1:218,345,336...218,444,619
JBrowse link
G TGFB3 transforming growth factor beta 3 decreases expression ISO 2-nitrotoluene results in decreased expression of TGFB3 mRNA CTD PMID:16460773 NCBI chr14:75,958,097...75,983,011
Ensembl chr14:75,958,097...75,983,011
JBrowse link
G TGFBR2 transforming growth factor beta receptor 2 increases expression ISO 2-nitrotoluene results in increased expression of TGFBR2 mRNA CTD PMID:16460773 NCBI chr 3:30,606,356...30,694,142
Ensembl chr 3:30,606,601...30,694,142
JBrowse link
G TP53 tumor protein p53 increases mutagenesis ISO 2-nitrotoluene results in increased mutagenesis of TRP53 gene CTD PMID:13678655 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TPH1 tryptophan hydroxylase 1 increases expression ISO 2-nitrotoluene results in increased expression of TPH1 mRNA CTD PMID:15612046 NCBI chr11:18,017,555...18,046,269
Ensembl chr11:18,017,555...18,046,269
JBrowse link
G WNT4 Wnt family member 4 increases expression ISO 2-nitrotoluene results in increased expression of WNT4 mRNA CTD PMID:16460773 NCBI chr 1:22,117,313...22,143,097
Ensembl chr 1:22,117,313...22,143,969
JBrowse link
G WWOX WW domain containing oxidoreductase decreases expression ISO 2-nitrotoluene results in decreased expression of WWOX mRNA; 2-nitrotoluene results in decreased expression of WWOX protein CTD PMID:15618236 NCBI chr16:78,099,654...79,212,667
Ensembl chr16:78,099,400...79,212,667
JBrowse link
4-nitrotoluene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CISH cytokine inducible SH2 containing protein decreases expression ISO 4-nitrotoluene results in decreased expression of CISH mRNA CTD PMID:15618236 NCBI chr 3:50,606,489...50,611,774
Ensembl chr 3:50,606,489...50,611,774
JBrowse link
G EGFR epidermal growth factor receptor decreases expression ISO 4-nitrotoluene results in decreased expression of EGFR protein CTD PMID:15618236 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EGR1 early growth response 1 increases expression ISO 4-nitrotoluene results in increased expression of EGR1 mRNA CTD PMID:15618236 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G ESR2 estrogen receptor 2 affects binding EXP 4-nitrotoluene binds to ESR2 protein CTD PMID:12224631 NCBI chr14:64,226,707...64,338,613
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G INHBA inhibin subunit beta A decreases expression ISO 4-nitrotoluene results in decreased expression of INHBA mRNA CTD PMID:15618236 NCBI chr 7:41,685,114...41,705,406
Ensembl chr 7:41,667,168...41,705,834
JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit increases expression ISO 4-nitrotoluene results in increased expression of JUNB mRNA CTD PMID:15618236 NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO 4-nitrotoluene promotes the reaction [Lipopolysaccharides results in increased activity of NFKB1 protein] CTD PMID:17015962 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G SLC6A3 solute carrier family 6 member 3 decreases expression ISO 4-nitrotoluene results in decreased expression of SLC6A3 mRNA CTD PMID:15265578 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 25408
    chemical entity 25382
      molecular entity 25347
        polyatomic entity 25302
          molecule 24691
            organic molecule 24660
              C-nitro compound 11690
                nitrotoluene 3839
                  mononitrotoluene 68
                    2-nitrotoluene 63
                    3-nitrotoluene 0
                    4-nitrotoluene 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 25408
    subatomic particle 25365
      composite particle 25365
        hadron 25376
          baryon 25376
            nucleon 25376
              atomic nucleus 25376
                atom 25365
                  main group element atom 25260
                    p-block element atom 25271
                      carbon group element atom 24833
                        carbon atom 24809
                          organic molecular entity 24809
                            organic molecule 24660
                              organic cyclic compound 23984
                                carbocyclic compound 21774
                                  benzenoid aromatic compound 19601
                                    benzenes 19239
                                      toluenes 6413
                                        nitrotoluene 3839
                                          mononitrotoluene 68
                                            2-nitrotoluene 63
                                            3-nitrotoluene 0
                                            4-nitrotoluene 8
paths to the root