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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sphingosine-1-phosphate receptor agonist
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Accession:CHEBI:63114 term browser browse the term
Definition:An agonist that binds to and activates sphingosine 1-phosphate receptors.
Synonyms:related_synonym: EDG receptor agonist;   S1P receptor agonist;   S1P receptor agonists;   SIP agonist;   SIP agonists;   sphingosine-1-phosphate receptor agonists
 alt_id: CHEBI:63172


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fingolimod hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression
ISO [Fingolimod Hydrochloride results in increased abundance of 27-hydroxycholesterol] which results in increased expression of ABCA1 mRNA; NPC1 protein affects the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]; UVI 3003 inhibits the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]
Fingolimod Hydrochloride results in increased expression of ABCA1 mRNA; Fingolimod Hydrochloride results in increased expression of ABCA1 protein
CTD PMID:20056921 NCBI chr 5:69,857,717...69,983,042
Ensembl chr 5:69,857,771...69,983,015
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]; Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of ACTA2 protein] CTD PMID:24893116 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Adm adrenomedullin multiple interactions EXP Fingolimod Hydrochloride promotes the reaction [Mercuric Chloride results in increased expression of ADM mRNA]; Fingolimod Hydrochloride promotes the reaction [Mercuric Chloride results in increased expression of ADM protein] CTD PMID:15680492 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein] CTD PMID:25939952 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO Fingolimod Hydrochloride promotes the reaction [APOA1 protein results in increased secretion of Cholesterol] CTD PMID:20056921 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Atg12 autophagy related 12 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG12 protein CTD PMID:25939952 NCBI chr18:40,721,799...40,732,143
Ensembl chr18:40,721,800...40,732,126
JBrowse link
G Atg3 autophagy related 3 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG3 protein CTD PMID:25939952 NCBI chr11:60,585,192...60,613,706
Ensembl chr11:60,585,171...60,613,718
JBrowse link
G Atg5 autophagy related 5 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG5 protein CTD PMID:25939952 NCBI chr20:49,301,783...49,393,147
Ensembl chr20:49,318,308...49,393,140
JBrowse link
G Atg7 autophagy related 7 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG7 protein CTD PMID:25939952 NCBI chr 4:146,570,113...146,777,093
Ensembl chr 4:146,598,413...146,777,124
JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression ISO Fingolimod Hydrochloride results in increased expression of BDNF mRNA CTD PMID:24859201 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Becn1 beclin 1 multiple interactions ISO BECN1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of BECN1 protein]; Fingolimod Hydrochloride results in increased expression of and results in increased cleavage of BECN1 protein CTD PMID:25939952 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
ISO 3-methyladenine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP3 protein]
Fingolimod Hydrochloride results in increased activity of CASP3 protein
CTD PMID:25939952, PMID:29654831 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
ISO Fingolimod Hydrochloride results in increased cleavage of CASP8 protein
SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP8 protein]
CTD PMID:25939952 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases response to substance
increases expression
ISO 3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid inhibits the reaction [Fingolimod Hydrochloride results in increased expression of CCL2 protein]
CCL2 results in increased susceptibility to Fingolimod Hydrochloride
CTD PMID:23043544 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO Fingolimod Hydrochloride results in decreased expression of CCND1 mRNA
Estradiol inhibits the reaction [Fingolimod Hydrochloride results in decreased expression of CCND1 mRNA]; Fingolimod Hydrochloride inhibits the reaction [Estradiol results in decreased expression of CCND1 mRNA]
CTD PMID:29654831 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Fingolimod Hydrochloride results in increased expression of CCNG2 mRNA CTD PMID:24356939 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA] CTD PMID:24893116 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA] CTD PMID:24893116 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO Fingolimod Hydrochloride results in increased expression of COMT mRNA CTD PMID:29654831 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions
decreases expression
ISO Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of CXCR4 mRNA]
Fingolimod Hydrochloride results in decreased expression of CXCR4 mRNA
CTD PMID:29654831 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CYP19A1 mRNA CTD PMID:29654831 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CYP1A1 mRNA CTD PMID:29654831 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CYP1B1 mRNA CTD PMID:29654831 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of ESR1 protein] CTD PMID:29654831 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
decreases expression
ISO Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of ESR2 protein]
Fingolimod Hydrochloride results in decreased expression of ESR2 protein
CTD PMID:29654831 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Fingolimod Hydrochloride results in increased expression of FOS mRNA CTD PMID:24859201 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein] CTD PMID:25980589 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Hdac1 histone deacetylase 1 affects binding
multiple interactions
ISO Fingolimod Hydrochloride metabolite binds to HDAC1 protein
Fingolimod Hydrochloride metabolite inhibits the reaction [S1PR1 protein binds to HDAC1 protein]; SPHK2 protein promotes the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]
CTD PMID:24859201 NCBI chr 5:147,716,664...147,743,723
Ensembl chr 5:147,716,664...147,743,723
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Fingolimod Hydrochloride results in increased expression of HMGCR mRNA CTD PMID:24356939 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Fingolimod Hydrochloride results in increased expression of HMGCS1 mRNA CTD PMID:24356939 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO Fingolimod Hydrochloride results in increased expression of IDI1 mRNA CTD PMID:24356939 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of IL1B protein] CTD PMID:24893116 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of IL6 protein] CTD PMID:24893116 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Fingolimod Hydrochloride results in decreased activity of KCNH2 protein CTD PMID:25223691 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO Fingolimod Hydrochloride results in increased expression of KLHL24 mRNA CTD PMID:24356939 NCBI chr11:84,613,101...84,643,674
Ensembl chr11:84,615,760...84,633,504
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Fingolimod Hydrochloride results in increased phosphorylation of MAPK1 protein CTD PMID:25939952 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Fingolimod Hydrochloride results in increased phosphorylation of MAPK3 protein CTD PMID:25939952 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein] CTD PMID:25980589 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Fingolimod Hydrochloride results in decreased phosphorylation of MTOR protein CTD PMID:25939952 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 multiple interactions
increases expression
ISO NPC1 protein affects the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]
Fingolimod Hydrochloride results in increased expression of NPC1 protein
CTD PMID:20056921 NCBI chr18:3,616,878...3,662,656
Ensembl chr18:3,616,878...3,662,683
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO 3-methyladenine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; BECN1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein] CTD PMID:25939952 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Fingolimod Hydrochloride results in increased expression of PDCD4 mRNA CTD PMID:24356939 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Plcb4 phospholipase C, beta 4 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein] CTD PMID:25980589 NCBI chr 3:128,601,163...128,971,720
Ensembl chr 3:128,756,799...128,971,746
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions
increases expression
ISO necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased expression of RIPK1 protein] CTD PMID:25939952 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression
multiple interactions
ISO Fingolimod Hydrochloride results in increased expression of RIPK3 protein
RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]
CTD PMID:25939952 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO Fingolimod Hydrochloride results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25939952 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions
decreases activity
decreases expression
ISO Fingolimod Hydrochloride inhibits the reaction [SPHK2 protein results in increased expression of S1PR1 protein]; Fingolimod Hydrochloride metabolite inhibits the reaction [S1PR1 protein binds to HDAC1 protein]
Fingolimod Hydrochloride analog results in decreased activity of S1PR1 protein
Fingolimod Hydrochloride results in decreased expression of S1PR1 protein
[3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid results in decreased activity of S1PR1 protein] which results in decreased susceptibility to Fingolimod Hydrochloride
CTD PMID:23043544, PMID:24420784, PMID:24859201 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein] CTD PMID:25980589 NCBI chr17:13,799,383...13,812,877
Ensembl chr17:13,799,383...13,812,704
JBrowse link
G Sphk2 sphingosine kinase 2 multiple interactions
increases response to substance
increases phosphorylation
ISO Fingolimod Hydrochloride inhibits the reaction [SPHK2 protein results in increased expression of S1PR1 protein]; SPHK2 protein promotes the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]
SPHK2 results in increased susceptibility to Fingolimod Hydrochloride
SPHK2 protein results in increased phosphorylation of Fingolimod Hydrochloride
CTD PMID:23043544, PMID:24859201 NCBI chr 1:101,692,972...101,700,604
Ensembl chr 1:101,692,973...101,697,277
JBrowse link
G Sqle squalene epoxidase increases expression ISO Fingolimod Hydrochloride results in increased expression of SQLE mRNA CTD PMID:24356939 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO Fingolimod Hydrochloride affects the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]; SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP8 protein]; SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]
Fingolimod Hydrochloride results in decreased expression of SQSTM1 protein
CTD PMID:25939952 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 decreases phosphorylation ISO Fingolimod Hydrochloride results in decreased phosphorylation of TFE3 protein CTD PMID:29945972 NCBI chr  X:15,574,579...15,587,826
Ensembl chr  X:15,575,934...15,587,419
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA] CTD PMID:24893116 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of TNF protein] CTD PMID:24893116 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein] CTD PMID:25939952 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of VEGFA mRNA] CTD PMID:24893116 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfd vascular endothelial growth factor D increases expression ISO Fingolimod Hydrochloride results in increased expression of VEGFD mRNA CTD PMID:24859201 NCBI chr  X:31,816,480...31,852,239
Ensembl chr  X:31,816,436...31,851,715
JBrowse link
sphingosine 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of AKT1 protein
sphingosine 1-phosphate results in increased phosphorylation of AKT1 protein
CTD PMID:15946935, PMID:16365044 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions
ISO sphingosine 1-phosphate results in decreased expression of BAX mRNA
sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]
CTD PMID:24399507 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein] CTD PMID:24399507, PMID:24420784 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO sphingosine 1-phosphate results in increased expression of CCN2 mRNA CTD PMID:25690654 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
ISO sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]
CTD PMID:18612546 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 decreases expression ISO sphingosine 1-phosphate results in decreased expression of CXCR1 mRNA CTD PMID:16224106 NCBI chr 9:81,466,430...81,469,299
Ensembl chr 9:81,466,332...81,469,274
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO sphingosine 1-phosphate results in increased expression of CYP17A1 mRNA CTD PMID:15666826 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation
multiple interactions
ISO sphingosine 1-phosphate results in increased phosphorylation of EGFR protein
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of EGFR protein]
CTD PMID:26518876 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Fn1 fibronectin 1 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1; Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; SB 203580 inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein] CTD PMID:21998146, PMID:22406263 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions
increases expression
ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein] CTD PMID:25980589 NCBI chr 1:233,382,778...233,622,584
Ensembl chr 1:233,382,708...233,622,786
JBrowse link
G Hgf hepatocyte growth factor increases expression ISO sphingosine 1-phosphate results in increased expression of HGF mRNA CTD PMID:19349368 NCBI chr 4:15,435,460...15,505,377
Ensembl chr 4:15,433,295...15,505,362
JBrowse link
G Hrk harakiri, BCL2 interacting protein multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA] CTD PMID:24399507, PMID:24420784 NCBI chr12:44,008,879...44,029,211 JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO sphingosine 1-phosphate results in increased expression of IGF1 mRNA CTD PMID:19349368 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL6 mRNA] CTD PMID:26518876 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA] CTD PMID:15741222 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMA3 mRNA CTD PMID:15541073 NCBI chr18:3,704,866...3,941,215
Ensembl chr18:3,705,916...3,940,838
JBrowse link
G Lamb3 laminin subunit beta 3 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMB3 mRNA CTD PMID:15541073 NCBI chr13:112,031,614...112,073,187
Ensembl chr13:112,031,594...112,073,186
JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMC2 mRNA CTD PMID:15541073 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK1 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form
CTD PMID:16365044, PMID:18612546, PMID:22251058, PMID:22406263, PMID:26518876 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK3 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form
CTD PMID:16365044, PMID:18612546, PMID:22251058, PMID:22406263, PMID:26518876 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression
ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 protein]
sphingosine 1-phosphate results in increased expression of MMP2 mRNA; sphingosine 1-phosphate results in increased expression of MMP2 protein
CTD PMID:26518876 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression
ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]
sphingosine 1-phosphate results in increased expression of MMP9 mRNA; sphingosine 1-phosphate results in increased expression of MMP9 protein
CTD PMID:25980589, PMID:26518876 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nrp1 neuropilin 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA] CTD PMID:15741222 NCBI chr19:61,332,351...61,486,166
Ensembl chr19:61,332,351...61,485,858
JBrowse link
G Nrp2 neuropilin 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP2 mRNA] CTD PMID:15741222 NCBI chr 9:69,496,875...69,609,802
Ensembl chr 9:69,497,121...69,612,087
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression ISO sphingosine 1-phosphate results in increased expression of PECAM1 protein CTD PMID:19349368 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Plcb4 phospholipase C, beta 4 increases expression
multiple interactions
ISO sphingosine 1-phosphate results in increased expression of PLCB4 protein
Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]
CTD PMID:25980589 NCBI chr 3:128,601,163...128,971,720
Ensembl chr 3:128,756,799...128,971,746
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Bezafibrate results in increased activity of PPARA protein] which results in decreased abundance of sphingosine 1-phosphate CTD PMID:18024222 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 promotes the reaction [Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; MK 2206 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Suramin promotes the reaction [JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]
sphingosine 1-phosphate results in increased expression of PTGS2 mRNA; sphingosine 1-phosphate results in increased expression of PTGS2 protein
CTD PMID:18612546, PMID:26518876 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate affects the localization of RELA protein modified form] CTD PMID:26518876 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 increases response to substance
increases expression
multiple interactions
EXP
ISO
S1PR1 protein results in increased susceptibility to sphingosine 1-phosphate
sphingosine 1-phosphate results in increased expression of S1PR1 mRNA
sphingosine 1-phosphate binds to and results in increased activity of S1PR1 protein
CTD PMID:20844107, PMID:24399507 NCBI chr 2:218,654,406...218,658,761
Ensembl chr 2:218,654,554...218,658,761
JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 multiple interactions
increases uptake
increases activity
ISO
EXP
S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]
sphingosine 1-phosphate results in increased uptake of S1PR2 protein
sphingosine 1-phosphate results in increased activity of S1PR2 protein
[JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] results in decreased susceptibility to [sphingosine 1-phosphate co-treated with Glucose]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] which results in decreased susceptibility to sphingosine 1-phosphate; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1
CTD PMID:18612546, PMID:22406263, PMID:26518876 NCBI chr 8:21,984,914...21,995,806
Ensembl chr 8:21,984,914...21,995,806
JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 multiple interactions
increases expression
ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] CTD PMID:18612546, PMID:25980589 NCBI chr17:13,799,383...13,812,877
Ensembl chr17:13,799,383...13,812,704
JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [Thalidomide results in increased activity of SMPD2 protein] CTD PMID:15741222 NCBI chr20:46,212,070...46,215,183
Ensembl chr20:46,211,892...46,215,120
JBrowse link
G Sphk1 sphingosine kinase 1 increases chemical synthesis
multiple interactions
ISO SPHK1 protein results in increased chemical synthesis of sphingosine 1-phosphate
[resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 mRNA]; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 protein]
CTD PMID:22251058, PMID:24399507, PMID:26045781 NCBI chr10:105,498,728...105,504,401
Ensembl chr10:105,498,728...105,504,393
JBrowse link
G Spns2 sphingolipid transporter 2 increases secretion
multiple interactions
ISO SPNS2 protein results in increased secretion of sphingosine 1-phosphate
TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate]
CTD PMID:29772789 NCBI chr10:59,010,428...59,049,482
Ensembl chr10:59,010,428...59,049,482
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate] CTD PMID:29772789 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of TNF mRNA]; sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] CTD PMID:18981156, PMID:26518876 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] CTD PMID:18981156 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19718
      biological role 19717
        pharmacological role 18795
          agonist 18188
            sphingosine-1-phosphate receptor agonist 85
              fingolimod + 0
              fingolimod hydrochloride 57
              fingolimod phosphate 0
              sphingosine 1-phosphate 38
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.