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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:sphingosine-1-phosphate receptor agonist
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Accession:CHEBI:63114 term browser browse the term
Definition:An agonist that binds to and activates sphingosine 1-phosphate receptors.
Synonyms:related_synonym: EDG receptor agonist;   S1P receptor agonist;   S1P receptor agonists;   SIP agonist;   SIP agonists;   sphingosine-1-phosphate receptor agonists
 alt_id: CHEBI:63172



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fingolimod hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression
ISO [Fingolimod Hydrochloride results in increased abundance of 27-hydroxycholesterol] which results in increased expression of ABCA1 mRNA; NPC1 protein affects the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]; UVI 3003 inhibits the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]
Fingolimod Hydrochloride results in increased expression of ABCA1 mRNA; Fingolimod Hydrochloride results in increased expression of ABCA1 protein
CTD PMID:20056921 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]; Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of ACTA2 protein] CTD PMID:24893116 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adm adrenomedullin multiple interactions EXP Fingolimod Hydrochloride promotes the reaction [Mercuric Chloride results in increased expression of ADM mRNA]; Fingolimod Hydrochloride promotes the reaction [Mercuric Chloride results in increased expression of ADM protein] CTD PMID:15680492 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein] CTD PMID:25939952 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO Fingolimod Hydrochloride promotes the reaction [APOA1 protein results in increased secretion of Cholesterol] CTD PMID:20056921 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Atg12 autophagy related 12 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG12 protein CTD PMID:25939952 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
JBrowse link
G Atg3 autophagy related 3 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG3 protein CTD PMID:25939952 NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224
JBrowse link
G Atg5 autophagy related 5 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG5 protein CTD PMID:25939952 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atg7 autophagy related 7 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG7 protein CTD PMID:25939952 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Fingolimod Hydrochloride results in decreased expression of BCL2 mRNA CTD PMID:28662296 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression ISO Fingolimod Hydrochloride results in increased expression of BDNF mRNA CTD PMID:24859201 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 multiple interactions ISO BECN1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of BECN1 protein]; Fingolimod Hydrochloride results in increased expression of and results in increased cleavage of BECN1 protein CTD PMID:25939952 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
ISO 3-methyladenine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP3 protein]
Fingolimod Hydrochloride results in increased activity of CASP3 protein
CTD PMID:25939952 PMID:29654831 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
ISO Fingolimod Hydrochloride results in increased cleavage of CASP8 protein
SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP8 protein]
CTD PMID:25939952 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases response to substance
increases expression
ISO 3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid inhibits the reaction [Fingolimod Hydrochloride results in increased expression of CCL2 protein]
CCL2 results in increased susceptibility to Fingolimod Hydrochloride
CTD PMID:23043544 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO Fingolimod Hydrochloride results in decreased expression of CCND1 mRNA
Estradiol inhibits the reaction [Fingolimod Hydrochloride results in decreased expression of CCND1 mRNA]; Fingolimod Hydrochloride inhibits the reaction [Estradiol results in decreased expression of CCND1 mRNA]
CTD PMID:29654831 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Fingolimod Hydrochloride results in increased expression of CCNG2 mRNA CTD PMID:24356939 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CCR4 mRNA CTD PMID:28662296 NCBI chr 8:114,176,256...114,182,155
Ensembl chr 8:114,176,974...114,178,056
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CCR7 mRNA CTD PMID:28662296 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Cd19 CD19 molecule decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CD19 mRNA CTD PMID:28662296 NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975
JBrowse link
G Cd28 Cd28 molecule decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CD28 mRNA CTD PMID:28662296 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Cd3e CD3e molecule decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CD3E mRNA CTD PMID:28662296 NCBI chr 8:45,303,848...45,315,297
Ensembl chr 8:45,303,852...45,315,022
JBrowse link
G Cd40lg CD40 ligand decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CD40LG mRNA CTD PMID:28662296 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cd8a CD8a molecule decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CD8A mRNA CTD PMID:28662296 NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA] CTD PMID:24893116 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA] CTD PMID:24893116 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO Fingolimod Hydrochloride results in increased expression of COMT mRNA CTD PMID:29654831 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions
decreases expression
ISO Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of CXCR4 mRNA]
Fingolimod Hydrochloride results in decreased expression of CXCR4 mRNA
CTD PMID:29654831 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CYP19A1 mRNA CTD PMID:29654831 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CYP1A1 mRNA CTD PMID:29654831 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CYP1B1 mRNA CTD PMID:29654831 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of ESR1 protein] CTD PMID:29654831 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
decreases expression
ISO Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of ESR2 protein]
Fingolimod Hydrochloride results in decreased expression of ESR2 protein
CTD PMID:29654831 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Fingolimod Hydrochloride results in increased expression of FOS mRNA CTD PMID:24859201 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxp3 forkhead box P3 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of FOXP3 mRNA CTD PMID:28662296 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein] CTD PMID:25980589 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Hdac1 histone deacetylase 1 affects binding
multiple interactions
ISO Fingolimod Hydrochloride metabolite binds to HDAC1 protein
Fingolimod Hydrochloride metabolite inhibits the reaction [S1PR1 protein binds to HDAC1 protein]; SPHK2 protein promotes the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]
CTD PMID:24859201 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Fingolimod Hydrochloride results in increased expression of HMGCR mRNA CTD PMID:24356939 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Fingolimod Hydrochloride results in increased expression of HMGCS1 mRNA CTD PMID:24356939 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO Fingolimod Hydrochloride results in increased expression of IDI1 mRNA CTD PMID:24356939 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of IL1B protein] CTD PMID:24893116 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of IL6 protein] CTD PMID:24893116 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Fingolimod Hydrochloride results in decreased activity of KCNH2 protein CTD PMID:25223691 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO Fingolimod Hydrochloride results in increased expression of KLHL24 mRNA CTD PMID:24356939 NCBI chr11:80,843,621...80,877,693
Ensembl chr11:80,846,755...80,877,636
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Fingolimod Hydrochloride results in increased phosphorylation of MAPK1 protein CTD PMID:25939952 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Fingolimod Hydrochloride results in increased phosphorylation of MAPK3 protein CTD PMID:25939952 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein] CTD PMID:25980589 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Fingolimod Hydrochloride results in decreased phosphorylation of MTOR protein CTD PMID:25939952 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 multiple interactions
increases expression
ISO NPC1 protein affects the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]
Fingolimod Hydrochloride results in increased expression of NPC1 protein
CTD PMID:20056921 NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO 3-methyladenine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; BECN1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein] CTD PMID:25939952 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Fingolimod Hydrochloride results in increased expression of PDCD4 mRNA CTD PMID:24356939 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Plcb4 phospholipase C, beta 4 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein] CTD PMID:25980589 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions
increases expression
ISO necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased expression of RIPK1 protein] CTD PMID:25939952 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression
multiple interactions
ISO Fingolimod Hydrochloride results in increased expression of RIPK3 protein
RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]
CTD PMID:25939952 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO Fingolimod Hydrochloride results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25939952 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions
decreases activity
decreases expression
ISO Fingolimod Hydrochloride inhibits the reaction [SPHK2 protein results in increased expression of S1PR1 protein]; Fingolimod Hydrochloride metabolite inhibits the reaction [S1PR1 protein binds to HDAC1 protein]
Fingolimod Hydrochloride analog results in decreased activity of S1PR1 protein
Fingolimod Hydrochloride results in decreased expression of S1PR1 protein
[3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid results in decreased activity of S1PR1 protein] which results in decreased susceptibility to Fingolimod Hydrochloride
CTD PMID:23043544 PMID:24420784 PMID:24859201 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681
JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein] CTD PMID:25980589 NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505
JBrowse link
G Sphk2 sphingosine kinase 2 multiple interactions
increases response to substance
increases phosphorylation
ISO Fingolimod Hydrochloride inhibits the reaction [SPHK2 protein results in increased expression of S1PR1 protein]; SPHK2 protein promotes the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]
SPHK2 results in increased susceptibility to Fingolimod Hydrochloride
SPHK2 protein results in increased phosphorylation of Fingolimod Hydrochloride
CTD PMID:23043544 PMID:24859201 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
JBrowse link
G Sqle squalene epoxidase increases expression ISO Fingolimod Hydrochloride results in increased expression of SQLE mRNA CTD PMID:24356939 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO Fingolimod Hydrochloride affects the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]; SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP8 protein]; SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]
Fingolimod Hydrochloride results in decreased expression of SQSTM1 protein
CTD PMID:25939952 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 decreases phosphorylation ISO Fingolimod Hydrochloride results in decreased phosphorylation of TFE3 protein CTD PMID:29945972 NCBI chr  X:14,729,547...14,742,830
Ensembl chr  X:14,729,550...14,742,571
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA] CTD PMID:24893116 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of TNF protein] CTD PMID:24893116 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein] CTD PMID:25939952 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of VEGFA mRNA] CTD PMID:24893116 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vegfd vascular endothelial growth factor D increases expression ISO Fingolimod Hydrochloride results in increased expression of VEGFD mRNA CTD PMID:24859201 NCBI chr  X:30,073,122...30,108,413
Ensembl chr  X:30,074,163...30,108,295
JBrowse link
sphingosine 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of AKT1 protein
sphingosine 1-phosphate results in increased phosphorylation of AKT1 protein
CTD PMID:15946935 PMID:16365044 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions
ISO sphingosine 1-phosphate results in decreased expression of BAX mRNA
sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]
CTD PMID:24399507 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein] CTD PMID:24399507 PMID:24420784 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO sphingosine 1-phosphate results in increased expression of CCN2 mRNA CTD PMID:25690654 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
ISO sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]
CTD PMID:18612546 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 decreases expression ISO sphingosine 1-phosphate results in decreased expression of CXCR1 mRNA CTD PMID:16224106 NCBI chr 9:75,768,124...75,771,122
Ensembl chr 9:75,766,770...75,771,084
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO sphingosine 1-phosphate results in increased expression of CYP17A1 mRNA CTD PMID:15666826 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation
multiple interactions
ISO sphingosine 1-phosphate results in increased phosphorylation of EGFR protein
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of EGFR protein]
CTD PMID:26518876 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Fn1 fibronectin 1 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1; Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; SB 203580 inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein] CTD PMID:21998146 PMID:22406263 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions
increases expression
ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein] CTD PMID:25980589 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3A protein]; Wortmannin inhibits the reaction [sphingosine 1-phosphate inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3A protein]] CTD PMID:25769802 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO sphingosine 1-phosphate affects the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]; Wortmannin affects the reaction [sphingosine 1-phosphate affects the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]] CTD PMID:25769802 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hgf hepatocyte growth factor increases expression ISO sphingosine 1-phosphate results in increased expression of HGF mRNA CTD PMID:19349368 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hrk harakiri, BCL2 interacting protein multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA] CTD PMID:24399507 PMID:24420784 NCBI chr12:38,387,484...38,409,652 JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO sphingosine 1-phosphate results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO sphingosine 1-phosphate results in increased expression of IGF1 mRNA CTD PMID:19349368 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
increases secretion
ISO sphingosine 1-phosphate results in increased expression of IL1B mRNA
Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]; S1PR1 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]
CTD PMID:32401414 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL6 mRNA] CTD PMID:26518876 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation ISO sphingosine 1-phosphate results in increased phosphorylation of JAK2 protein CTD PMID:32401414 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA] CTD PMID:15741222 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMA3 mRNA CTD PMID:15541073 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353
JBrowse link
G Lamb3 laminin subunit beta 3 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMB3 mRNA CTD PMID:15541073 NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405
JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMC2 mRNA CTD PMID:15541073 NCBI chr13:65,284,664...65,344,200
Ensembl chr13:65,284,664...65,344,200
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK1 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form
CTD PMID:16365044 PMID:18612546 PMID:22251058 PMID:22406263 PMID:26518876 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK3 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form
CTD PMID:16365044 PMID:18612546 PMID:22251058 PMID:22406263 PMID:26518876 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression
ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 protein]
sphingosine 1-phosphate results in increased expression of MMP2 mRNA; sphingosine 1-phosphate results in increased expression of MMP2 protein
CTD PMID:26518876 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression
ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]
sphingosine 1-phosphate results in increased expression of MMP9 mRNA; sphingosine 1-phosphate results in increased expression of MMP9 protein
CTD PMID:25980589 PMID:26518876 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nrp1 neuropilin 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA] CTD PMID:15741222 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
JBrowse link
G Nrp2 neuropilin 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP2 mRNA] CTD PMID:15741222 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression ISO sphingosine 1-phosphate results in increased expression of PECAM1 protein CTD PMID:19349368 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Plcb4 phospholipase C, beta 4 increases expression
multiple interactions
ISO sphingosine 1-phosphate results in increased expression of PLCB4 protein
Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]
CTD PMID:25980589 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Bezafibrate results in increased activity of PPARA protein] which results in decreased abundance of sphingosine 1-phosphate CTD PMID:18024222 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 promotes the reaction [Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; MK 2206 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Suramin promotes the reaction [JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]
sphingosine 1-phosphate results in increased expression of PTGS2 mRNA; sphingosine 1-phosphate results in increased expression of PTGS2 protein
CTD PMID:18612546 PMID:26518876 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate affects the localization of RELA protein modified form] CTD PMID:26518876 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 increases response to substance
multiple interactions
increases expression
EXP
ISO
S1PR1 protein results in increased susceptibility to sphingosine 1-phosphate
S1PR1 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]
sphingosine 1-phosphate results in increased expression of S1PR1 mRNA
sphingosine 1-phosphate binds to and results in increased activity of S1PR1 protein
CTD PMID:20844107 PMID:24399507 PMID:32401414 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681
JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 multiple interactions
increases uptake
increases activity
ISO
EXP
S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]
sphingosine 1-phosphate results in increased uptake of S1PR2 protein
sphingosine 1-phosphate results in increased activity of S1PR2 protein
[JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] results in decreased susceptibility to [sphingosine 1-phosphate co-treated with Glucose]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] which results in decreased susceptibility to sphingosine 1-phosphate; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1
CTD PMID:18612546 PMID:22406263 PMID:26518876 NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574
JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 multiple interactions
increases expression
ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] CTD PMID:18612546 PMID:25980589 NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505
JBrowse link
G S1pr5 sphingosine-1-phosphate receptor 5 multiple interactions ISO Endocannabinoids inhibits the reaction [sphingosine 1-phosphate binds to and results in increased activity of S1PR5 protein]; sphingosine 1-phosphate binds to and results in increased activity of S1PR5 protein CTD PMID:30102254 NCBI chr 8:19,786,676...19,791,862
Ensembl chr 8:19,786,663...19,791,795
JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [Thalidomide results in increased activity of SMPD2 protein] CTD PMID:15741222 NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441
JBrowse link
G Sphk1 sphingosine kinase 1 increases chemical synthesis
multiple interactions
ISO SPHK1 protein results in increased chemical synthesis of sphingosine 1-phosphate
[resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 mRNA]; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 protein]
CTD PMID:22251058 PMID:24399507 PMID:26045781 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
G Spns2 sphingolipid transporter 2 increases secretion
multiple interactions
ISO SPNS2 protein results in increased secretion of sphingosine 1-phosphate
TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate]
CTD PMID:29772789 NCBI chr10:57,067,348...57,105,969
Ensembl chr10:57,066,897...57,105,957
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
multiple interactions
ISO sphingosine 1-phosphate results in increased phosphorylation of STAT3 protein
Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]
CTD PMID:32401414 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate] CTD PMID:29772789 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of TNF mRNA]; sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] CTD PMID:18981156 PMID:26518876 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] CTD PMID:18981156 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        pharmacological role 18837
          agonist 18260
            sphingosine-1-phosphate receptor agonist 99
              fingolimod + 0
              fingolimod hydrochloride 66
              fingolimod phosphate 0
              sphingosine 1-phosphate 45
paths to the root