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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:fingolimod hydrochloride
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Accession:CHEBI:63112 term browser browse the term
Definition:The hydrochloride salt of 2-amino-2-[2-(4-octylphenyl) ethyl]-1,3-propanediol (fingolimod).
Synonyms:related_synonym: 2-Amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol hydrochloride;   2-amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol hydrochloride;   FTY-720;   FTY720;   Fingolimod HCl;   Formula=C19H34ClNO2;   Gilenya;   InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H;   InChIKey=SWZTYAVBMYWFGS-UHFFFAOYSA-N;   SMILES=Cl.CCCCCCCCc1ccc(CCC(N)(CO)CO)cc1
 alt_id: MESH:D000068876
 xref: CAS:162359-56-0;   KEGG:D04187
 xref_mesh: MESH:D000068876
 xref: PMID:21045200;   PMID:21045201;   PMID:21130737;   PMID:21280229;   PMID:21394595;   PMID:21456524;   PMID:21459808;   PMID:21514226;   PMID:21628899;   PMID:21652609;   PMID:21719706;   PMID:21838759;   PMID:21845450;   PMID:21906625;   PMID:21955849;   Reaxys:7837310



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fingolimod hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression
ISO [Fingolimod Hydrochloride results in increased abundance of 27-hydroxycholesterol] which results in increased expression of ABCA1 mRNA; NPC1 protein affects the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]; UVI 3003 inhibits the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]
Fingolimod Hydrochloride results in increased expression of ABCA1 mRNA; Fingolimod Hydrochloride results in increased expression of ABCA1 protein
CTD PMID:20056921 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of ACTA2 mRNA]; Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of ACTA2 protein] CTD PMID:24893116 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adm adrenomedullin multiple interactions EXP Fingolimod Hydrochloride promotes the reaction [Mercuric Chloride results in increased expression of ADM mRNA]; Fingolimod Hydrochloride promotes the reaction [Mercuric Chloride results in increased expression of ADM protein] CTD PMID:15680492 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein] CTD PMID:25939952 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO Fingolimod Hydrochloride promotes the reaction [APOA1 protein results in increased secretion of Cholesterol] CTD PMID:20056921 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G Atg12 autophagy related 12 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG12 protein CTD PMID:25939952 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
JBrowse link
G Atg3 autophagy related 3 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG3 protein CTD PMID:25939952 NCBI chr11:55,624,928...55,653,212
Ensembl chr11:55,624,917...55,653,224
JBrowse link
G Atg5 autophagy related 5 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG5 protein CTD PMID:25939952 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atg7 autophagy related 7 increases expression ISO Fingolimod Hydrochloride results in increased expression of ATG7 protein CTD PMID:25939952 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Fingolimod Hydrochloride results in decreased expression of BCL2 mRNA CTD PMID:28662296 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor increases expression ISO Fingolimod Hydrochloride results in increased expression of BDNF mRNA CTD PMID:24859201 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Becn1 beclin 1 multiple interactions ISO BECN1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of BECN1 protein]; Fingolimod Hydrochloride results in increased expression of and results in increased cleavage of BECN1 protein CTD PMID:25939952 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage
ISO 3-methyladenine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP3 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP3 protein]
Fingolimod Hydrochloride results in increased activity of CASP3 protein
CTD PMID:25939952 PMID:29654831 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
ISO Fingolimod Hydrochloride results in increased cleavage of CASP8 protein
SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP8 protein]
CTD PMID:25939952 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases response to substance
increases expression
ISO 3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid inhibits the reaction [Fingolimod Hydrochloride results in increased expression of CCL2 protein]
CCL2 results in increased susceptibility to Fingolimod Hydrochloride
CTD PMID:23043544 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO Fingolimod Hydrochloride results in decreased expression of CCND1 mRNA
Estradiol inhibits the reaction [Fingolimod Hydrochloride results in decreased expression of CCND1 mRNA]; Fingolimod Hydrochloride inhibits the reaction [Estradiol results in decreased expression of CCND1 mRNA]
CTD PMID:29654831 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Fingolimod Hydrochloride results in increased expression of CCNG2 mRNA CTD PMID:24356939 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Ccr4 C-C motif chemokine receptor 4 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CCR4 mRNA CTD PMID:28662296 NCBI chr 8:114,176,256...114,182,155
Ensembl chr 8:114,176,974...114,178,056
JBrowse link
G Ccr7 C-C motif chemokine receptor 7 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CCR7 mRNA CTD PMID:28662296 NCBI chr10:84,098,193...84,108,309
Ensembl chr10:84,097,381...84,108,309
JBrowse link
G Cd19 CD19 molecule decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CD19 mRNA CTD PMID:28662296 NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975
JBrowse link
G Cd28 Cd28 molecule decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CD28 mRNA CTD PMID:28662296 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Cd3e CD3e molecule decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CD3E mRNA CTD PMID:28662296 NCBI chr 8:45,303,848...45,315,297
Ensembl chr 8:45,303,852...45,315,022
JBrowse link
G Cd40lg CD40 ligand decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CD40LG mRNA CTD PMID:28662296 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cd8a CD8a molecule decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CD8A mRNA CTD PMID:28662296 NCBI chr 4:103,365,804...103,370,041
Ensembl chr 4:103,365,804...103,370,040
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA] CTD PMID:24893116 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of COL3A1 mRNA] CTD PMID:24893116 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO Fingolimod Hydrochloride results in increased expression of COMT mRNA CTD PMID:29654831 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions
decreases expression
ISO Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of CXCR4 mRNA]
Fingolimod Hydrochloride results in decreased expression of CXCR4 mRNA
CTD PMID:29654831 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CYP19A1 mRNA CTD PMID:29654831 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CYP1A1 mRNA CTD PMID:29654831 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of CYP1B1 mRNA CTD PMID:29654831 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of ESR1 protein] CTD PMID:29654831 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
decreases expression
ISO Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of ESR2 protein]
Fingolimod Hydrochloride results in decreased expression of ESR2 protein
CTD PMID:29654831 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Fingolimod Hydrochloride results in increased expression of FOS mRNA CTD PMID:24859201 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxp3 forkhead box P3 decreases expression ISO Fingolimod Hydrochloride results in decreased expression of FOXP3 mRNA CTD PMID:28662296 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Gnaq G protein subunit alpha q multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein] CTD PMID:25980589 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Hdac1 histone deacetylase 1 affects binding
multiple interactions
ISO Fingolimod Hydrochloride metabolite binds to HDAC1 protein
Fingolimod Hydrochloride metabolite inhibits the reaction [S1PR1 protein binds to HDAC1 protein]; SPHK2 protein promotes the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]
CTD PMID:24859201 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Fingolimod Hydrochloride results in increased expression of HMGCR mRNA CTD PMID:24356939 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Fingolimod Hydrochloride results in increased expression of HMGCS1 mRNA CTD PMID:24356939 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression ISO Fingolimod Hydrochloride results in increased expression of IDI1 mRNA CTD PMID:24356939 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of IL1B protein] CTD PMID:24893116 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of IL6 protein] CTD PMID:24893116 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Fingolimod Hydrochloride results in decreased activity of KCNH2 protein CTD PMID:25223691 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO Fingolimod Hydrochloride results in increased expression of KLHL24 mRNA CTD PMID:24356939 NCBI chr11:80,843,621...80,877,693
Ensembl chr11:80,846,755...80,877,636
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Fingolimod Hydrochloride results in increased phosphorylation of MAPK1 protein CTD PMID:25939952 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Fingolimod Hydrochloride results in increased phosphorylation of MAPK3 protein CTD PMID:25939952 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein] CTD PMID:25980589 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO Fingolimod Hydrochloride results in decreased phosphorylation of MTOR protein CTD PMID:25939952 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 multiple interactions
increases expression
ISO NPC1 protein affects the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein]
Fingolimod Hydrochloride results in increased expression of NPC1 protein
CTD PMID:20056921 NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO 3-methyladenine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; BECN1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pifithrin inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein] CTD PMID:25939952 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Fingolimod Hydrochloride results in increased expression of PDCD4 mRNA CTD PMID:24356939 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Plcb4 phospholipase C, beta 4 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein] CTD PMID:25980589 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions
increases expression
ISO necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased expression of RIPK1 protein] CTD PMID:25939952 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression
multiple interactions
ISO Fingolimod Hydrochloride results in increased expression of RIPK3 protein
RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]
CTD PMID:25939952 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO Fingolimod Hydrochloride results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25939952 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions
decreases activity
decreases expression
ISO Fingolimod Hydrochloride inhibits the reaction [SPHK2 protein results in increased expression of S1PR1 protein]; Fingolimod Hydrochloride metabolite inhibits the reaction [S1PR1 protein binds to HDAC1 protein]
Fingolimod Hydrochloride analog results in decreased activity of S1PR1 protein
Fingolimod Hydrochloride results in decreased expression of S1PR1 protein
[3-amino-4-(3-hexylphenylamino)-4-oxobutylphosphonic acid results in decreased activity of S1PR1 protein] which results in decreased susceptibility to Fingolimod Hydrochloride
CTD PMID:23043544 PMID:24420784 PMID:24859201 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681
JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein] CTD PMID:25980589 NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505
JBrowse link
G Sphk2 sphingosine kinase 2 multiple interactions
increases response to substance
increases phosphorylation
ISO Fingolimod Hydrochloride inhibits the reaction [SPHK2 protein results in increased expression of S1PR1 protein]; SPHK2 protein promotes the reaction [Fingolimod Hydrochloride metabolite binds to HDAC1 protein]
SPHK2 results in increased susceptibility to Fingolimod Hydrochloride
SPHK2 protein results in increased phosphorylation of Fingolimod Hydrochloride
CTD PMID:23043544 PMID:24859201 NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
JBrowse link
G Sqle squalene epoxidase increases expression ISO Fingolimod Hydrochloride results in increased expression of SQLE mRNA CTD PMID:24356939 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO Fingolimod Hydrochloride affects the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]; SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP8 protein]; SQSTM1 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]
Fingolimod Hydrochloride results in decreased expression of SQSTM1 protein
CTD PMID:25939952 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tfe3 transcription factor binding to IGHM enhancer 3 decreases phosphorylation ISO Fingolimod Hydrochloride results in decreased phosphorylation of TFE3 protein CTD PMID:29945972 NCBI chr  X:14,729,547...14,742,830
Ensembl chr  X:14,729,550...14,742,571
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA] CTD PMID:24893116 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of TNF protein] CTD PMID:24893116 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation
ISO Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; necrostatin-1 inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; pyrazolanthrone inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein]; RIPK3 mutant form inhibits the reaction [Fingolimod Hydrochloride results in increased phosphorylation of TP53 protein] CTD PMID:25939952 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Fingolimod Hydrochloride inhibits the reaction [Paraquat results in increased expression of VEGFA mRNA] CTD PMID:24893116 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vegfd vascular endothelial growth factor D increases expression ISO Fingolimod Hydrochloride results in increased expression of VEGFD mRNA CTD PMID:24859201 NCBI chr  X:30,073,122...30,108,413
Ensembl chr  X:30,074,163...30,108,295
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        immunomodulator 14905
          immunosuppressive agent 13739
            fingolimod hydrochloride 66
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      halogen 18181
                        chlorine atom 18025
                          chlorine molecular entity 18025
                            elemental chlorine 8462
                              monoatomic chlorine 8446
                                chloride 8446
                                  chloride salt 8446
                                    organic chloride salt 918
                                      hydrochloride 686
                                        fingolimod hydrochloride 66
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