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ONTOLOGY REPORT - ANNOTATIONS


Term:fingolimod hydrochloride
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Accession:CHEBI:63112 term browser browse the term
Definition:The hydrochloride salt of 2-amino-2-[2-(4-octylphenyl) ethyl]-1,3-propanediol (fingolimod).
Synonyms:related_synonym: 2-Amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol hydrochloride;   2-amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol hydrochloride;   FTY-720;   FTY720;   Fingolimod HCl;   Formula=C19H34ClNO2;   Gilenya;   InChI=1S/C19H33NO2.ClH/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22;/h9-12,21-22H,2-8,13-16,20H2,1H3;1H;   InChIKey=SWZTYAVBMYWFGS-UHFFFAOYSA-N;   SMILES=Cl.CCCCCCCCc1ccc(CCC(N)(CO)CO)cc1
 alt_id: MESH:D000068876
 xref: CAS:162359-56-0 "ChemIDplus";   KEGG:D04187
 xref_mesh: MESH:D000068876
 xref: PMID:21045200 "Europe PMC";   PMID:21045201 "Europe PMC";   PMID:21130737 "Europe PMC";   PMID:21280229 "Europe PMC";   PMID:21394595 "Europe PMC";   PMID:21456524 "Europe PMC";   PMID:21459808 "Europe PMC";   PMID:21514226 "Europe PMC";   PMID:21628899 "Europe PMC";   PMID:21652609 "Europe PMC";   PMID:21719706 "Europe PMC";   PMID:21838759 "Europe PMC";   PMID:21845450 "Europe PMC";   PMID:21906625 "Europe PMC";   PMID:21955849 "Europe PMC";   Reaxys:7837310 "Reaxys"


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fingolimod hydrochloride term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca1 ATP binding cassette subfamily A member 1 JBrowse link 5 69,857,717 69,983,042 RGD:6480464
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Adm adrenomedullin JBrowse link 1 175,443,189 175,447,260 RGD:6480464
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:6480464
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:6480464
G Atg12 autophagy related 12 JBrowse link 18 40,721,799 40,732,143 RGD:6480464
G Atg3 autophagy related 3 JBrowse link 11 60,585,192 60,613,706 RGD:6480464
G Atg5 autophagy related 5 JBrowse link 20 49,301,783 49,393,147 RGD:6480464
G Atg7 autophagy related 7 JBrowse link 4 146,570,113 146,777,093 RGD:6480464
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:6480464
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Ccng2 cyclin G2 JBrowse link 14 16,267,572 16,276,068 RGD:6480464
G Col1a1 collagen type I alpha 1 chain JBrowse link 10 82,745,801 82,762,790 RGD:6480464
G Col3a1 collagen type III alpha 1 chain JBrowse link 9 52,023,295 52,059,221 RGD:6480464
G Comt catechol-O-methyltransferase JBrowse link 11 86,715,981 86,735,630 RGD:6480464
G Cxcr4 C-X-C motif chemokine receptor 4 JBrowse link 13 45,314,952 45,318,856 RGD:6480464
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:6480464
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:6480464
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:6480464
G Hdac1 histone deacetylase 1 JBrowse link 5 147,716,664 147,743,723 RGD:6480464
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:6480464
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 JBrowse link 2 52,427,351 52,445,082 RGD:6480464
G Idi1 isopentenyl-diphosphate delta isomerase 1 JBrowse link 17 57,976,266 57,984,036 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Klhl24 kelch-like family member 24 JBrowse link 11 84,613,101 84,643,674 RGD:6480464
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:6480464
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:6480464
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:6480464
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6480464
G Npc1 NPC intracellular cholesterol transporter 1 JBrowse link 18 3,616,878 3,662,656 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Pdcd4 programmed cell death 4 JBrowse link 1 274,616,625 274,648,204 RGD:6480464
G Plcb4 phospholipase C, beta 4 JBrowse link 3 128,601,163 128,971,720 RGD:6480464
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:6480464
G Ripk3 receptor-interacting serine-threonine kinase 3 JBrowse link 15 34,470,796 34,479,741 RGD:6480464
G Rps6kb1 ribosomal protein S6 kinase B1 JBrowse link 10 73,824,200 73,865,503 RGD:6480464
G S1pr1 sphingosine-1-phosphate receptor 1 JBrowse link 2 218,654,406 218,658,761 RGD:6480464
G S1pr3 sphingosine-1-phosphate receptor 3 JBrowse link 17 13,799,383 13,812,877 RGD:6480464
G Sphk2 sphingosine kinase 2 JBrowse link 1 101,692,972 101,700,604 RGD:6480464
G Sqle squalene epoxidase JBrowse link 7 99,609,929 99,624,803 RGD:6480464
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6480464
G Tfe3 transcription factor binding to IGHM enhancer 3 JBrowse link X 15,574,579 15,587,826 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464
G Vegfd vascular endothelial growth factor D JBrowse link X 31,816,480 31,852,239 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        immunomodulator 12650
          immunosuppressive agent 11918
            fingolimod hydrochloride 57
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      halogen 17734
                        chlorine atom 17467
                          chlorine molecular entity 17467
                            elemental chlorine 8342
                              monoatomic chlorine 8323
                                chloride 8323
                                  chloride salt 8323
                                    organic chloride salt 579
                                      hydrochloride 348
                                        fingolimod hydrochloride 57
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.