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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:purmorphamine
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Accession:CHEBI:63053 term browser browse the term
Definition:A member of the class of purines that is purine substituted at C-2 by a 1-naphthyloxy group, at C-4 by a 4-morpholinophenylamino group, and at N-9 by a cyclohexyl group.
Synonyms:exact_synonym: 9-cyclohexyl-N-[4-(morpholin-4-yl)phenyl]-2-(naphthalen-1-yloxy)-9H-purin-6-amine
 related_synonym: Formula=C31H32N6O2;   InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35);   InChIKey=FYBHCRQFSFYWPY-UHFFFAOYSA-N;   SMILES=N1=CN(C=2N=C(N=C(C12)NC=3C=CC(=CC3)N4CCOCC4)OC=5C=6C=CC=CC6C=CC5)C7CCCCC7
 xref: CAS:483367-10-8;   LINCS:LSM-3649
 xref_mesh: MESH:C470893
 xref: PMID:12465946;   PMID:15979909;   PMID:16408088;   PMID:21345011;   PMID:21354477;   PMID:21898541;   PMID:23147751;   PMID:23228449;   PMID:25341035;   PMID:25792653;   Patent:US2004157864;   Reaxys:10500685;   Wikipedia:Purmorphamine


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purmorphamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO purmorphamine inhibits the reaction [resveratrol results in decreased expression of [BCR protein mutant form binds to ABL1 protein mutant form]] CTD PMID:22397755 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Bcr BCR activator of RhoGEF and GTPase multiple interactions ISO purmorphamine inhibits the reaction [resveratrol results in decreased expression of [BCR protein mutant form binds to ABL1 protein mutant form]] CTD PMID:22397755 NCBI chr20:13,471,679...13,596,497
Ensembl chr20:13,471,668...13,597,016
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        growth regulator 5020
          osteogenesis regulator 161
            purmorphamine 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organic heteropolycyclic compound 18059
                                    organic heterobicyclic compound 16869
                                      imidazopyrimidine 5611
                                        purines 5609
                                          purine 4575
                                            9H-purine 4384
                                              purmorphamine 2
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