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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiopyranopyrimidine
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Accession:CHEBI:62886 term browser browse the term
Definition:Any organic heterobicyclic compound containing ortho-fused thiopyran and pyrimidine rings.
Synonyms:related_synonym: thinopyrimidine;   thinopyrimidines;   thiopyranopyrimidines


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XAV939 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axin2 axin 2 multiple interactions ISO XAV939 inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA] CTD PMID:24534281 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
EXP XAV939 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCND1 mRNA]; XAV939 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCND1 protein]
XAV939 results in decreased expression of CCND1 mRNA; XAV939 results in decreased expression of CCND1 protein
CTD PMID:24231000 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO XAV939 results in decreased expression of CCND2 mRNA CTD PMID:27226553 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO XAV939 results in decreased expression of CCND3 mRNA CTD PMID:27226553 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions
ISO XAV939 results in increased expression of CDH1 protein
XAV939 promotes the reaction [thymoquinone results in increased expression of CDH1 protein]
CTD PMID:32112862 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 decreases expression
multiple interactions
ISO XAV939 results in decreased expression of CDH2 protein
XAV939 promotes the reaction [thymoquinone results in decreased expression of CDH2 protein]
CTD PMID:32112862 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO
EXP
XAV939 inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]; XAV939 inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]; XAV939 promotes the reaction [thymoquinone results in decreased expression of and results in increased phosphorylation of CTNNB1 protein]; XAV939 results in decreased expression of and results in increased phosphorylation of CTNNB1 protein
XAV939 results in decreased expression of CTNNB1 mRNA
XAV939 results in decreased expression of CTNNB1 protein
XAV939 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CTNNB1 protein]
CTD PMID:24231000, PMID:24534281, PMID:25061499, PMID:27226553, PMID:32112862 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 multiple interactions ISO XAV939 inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein] CTD PMID:24534281 NCBI chr 5:166,464,170...166,513,030
Ensembl chr 5:166,464,252...166,513,027
JBrowse link
G Ebf1 EBF transcription factor 1 decreases expression ISO XAV939 results in decreased expression of EBF1 mRNA CTD PMID:27226553 NCBI chr10:23,654,849...24,051,627
Ensembl chr10:23,661,013...24,050,209
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases phosphorylation
ISO XAV939 promotes the reaction [thymoquinone results in decreased phosphorylation of GSK3B protein]
XAV939 results in decreased phosphorylation of GSK3B protein
CTD PMID:32112862 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G LOC100361706 lambda-chain C1-region-like decreases expression ISO XAV939 results in decreased expression of IGLL1 mRNA CTD PMID:27226553 NCBI chr11:86,094,822...86,096,399
Ensembl chr11:86,094,567...86,096,397
JBrowse link
G Nkd1 NKD inhibitor of WNT signaling pathway 1 multiple interactions ISO XAV939 inhibits the reaction [Lithium Chloride results in increased expression of NKD1 mRNA] CTD PMID:24534281 NCBI chr19:19,434,720...19,509,087
Ensembl chr19:19,436,333...19,509,087
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO XAV939 binds to and results in decreased activity of PARP1 protein CTD PMID:28001384 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 decreases activity ISO XAV939 results in decreased activity of PARP2 protein CTD PMID:28001384 NCBI chr15:27,739,416...27,749,650
Ensembl chr15:27,739,251...27,749,648
JBrowse link
G Tnks tankyrase affects binding
decreases activity
multiple interactions
ISO XAV939 binds to TNKS protein
XAV939 results in decreased activity of TNKS protein
XAV939 inhibits the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride binds to TNKS protein]
CTD PMID:22297980, PMID:28001384 NCBI chr16:60,925,093...61,067,192
Ensembl chr16:60,925,093...61,067,192
JBrowse link
G Tnks2 tankyrase 2 multiple interactions ISO XAV939 binds to and results in decreased activity of TNKS2 protein CTD PMID:28001384
G Utp3 UTP3, small subunit processome component decreases expression ISO XAV939 results in decreased expression of UTP3 mRNA CTD PMID:27226553 NCBI chr14:21,153,998...21,155,652
Ensembl chr14:21,154,000...21,155,652
JBrowse link
G Vim vimentin decreases expression
multiple interactions
ISO XAV939 results in decreased expression of VIM protein
XAV939 promotes the reaction [thymoquinone results in decreased expression of VIM protein]
CTD PMID:32112862 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Vpreb1 V-set pre-B cell surrogate light chain 1 decreases expression ISO XAV939 results in decreased expression of VPREB1 mRNA CTD PMID:27226553 NCBI chr11:88,376,256...88,377,133
Ensembl chr11:88,376,256...88,377,133
JBrowse link
G Wnt7a Wnt family member 7A decreases activity ISO XAV939 results in decreased activity of WNT7A protein CTD PMID:25174399 NCBI chr 4:122,994,425...123,040,609
Ensembl chr 4:122,994,425...123,040,609
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          nitrogen atom 18565
            nitrogen molecular entity 18565
              organonitrogen compound 18338
                organonitrogen heterocyclic compound 17485
                  thiopyranopyrimidine 20
                    LDW639 0
                    XAV939 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  organic heteropolycyclic compound 17844
                                    organic heterobicyclic compound 16765
                                      thiopyranopyrimidine 20
                                        LDW639 0
                                        XAV939 20
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.