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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:XAV939
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Accession:CHEBI:62878 term browser browse the term
Definition:A thiopyranopyrimidine in which a 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine skeleton is substituted at C-4 by a hydroxy group and at C-2 by a para-(trifluoromethyl)phenyl group.
Synonyms:exact_synonym: 2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol
 related_synonym: 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol;   Formula=C14H11F3N2OS;   InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20);   InChIKey=KLGQSVMIPOVQAX-UHFFFAOYSA-N;   SMILES=Oc1nc(nc2CCSCc12)-c1ccc(cc1)C(F)(F)F
 xref: LINCS:LSM-5303
 xref_mesh: MESH:C544261
 xref: PMID:19759537;   PMID:20565110;   PMID:21077691;   PMID:21706018;   Reaxys:20421945


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XAV939 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Axin2 axin 2 multiple interactions ISO XAV939 inhibits the reaction [Lithium Chloride results in increased expression of AXIN2 mRNA] CTD PMID:24534281 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
EXP XAV939 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCND1 mRNA]; XAV939 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCND1 protein]
XAV939 results in decreased expression of CCND1 mRNA; XAV939 results in decreased expression of CCND1 protein
CTD PMID:24231000 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 decreases expression ISO XAV939 results in decreased expression of CCND2 mRNA CTD PMID:27226553 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO XAV939 results in decreased expression of CCND3 mRNA CTD PMID:27226553 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions
ISO XAV939 results in increased expression of CDH1 protein
XAV939 promotes the reaction [thymoquinone results in increased expression of CDH1 protein]
CTD PMID:32112862 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 decreases expression
multiple interactions
ISO XAV939 results in decreased expression of CDH2 protein
XAV939 promotes the reaction [thymoquinone results in decreased expression of CDH2 protein]
CTD PMID:32112862 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
ISO
EXP
XAV939 inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein]; XAV939 inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]; XAV939 promotes the reaction [thymoquinone results in decreased expression of and results in increased phosphorylation of CTNNB1 protein]; XAV939 results in decreased expression of and results in increased phosphorylation of CTNNB1 protein
XAV939 results in decreased expression of CTNNB1 mRNA
XAV939 results in decreased expression of CTNNB1 protein
XAV939 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CTNNB1 protein]
CTD PMID:24231000, PMID:24534281, PMID:25061499, PMID:27226553, PMID:32112862 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Ctnnbip1 catenin, beta-interacting protein 1 multiple interactions ISO XAV939 inhibits the reaction [CTNNB1 protein binds to CTNNBIP1 protein] CTD PMID:24534281 NCBI chr 5:166,464,170...166,513,030
Ensembl chr 5:166,464,252...166,513,027
JBrowse link
G Ebf1 EBF transcription factor 1 decreases expression ISO XAV939 results in decreased expression of EBF1 mRNA CTD PMID:27226553 NCBI chr10:23,654,849...24,051,627
Ensembl chr10:23,661,013...24,050,209
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
decreases phosphorylation
ISO XAV939 promotes the reaction [thymoquinone results in decreased phosphorylation of GSK3B protein]
XAV939 results in decreased phosphorylation of GSK3B protein
CTD PMID:32112862 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G LOC100361706 lambda-chain C1-region-like decreases expression ISO XAV939 results in decreased expression of IGLL1 mRNA CTD PMID:27226553 NCBI chr11:86,094,822...86,096,399
Ensembl chr11:86,094,567...86,096,397
JBrowse link
G Nkd1 NKD inhibitor of WNT signaling pathway 1 multiple interactions ISO XAV939 inhibits the reaction [Lithium Chloride results in increased expression of NKD1 mRNA] CTD PMID:24534281 NCBI chr19:19,434,720...19,509,087
Ensembl chr19:19,436,333...19,509,087
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO XAV939 binds to and results in decreased activity of PARP1 protein CTD PMID:28001384 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Parp2 poly (ADP-ribose) polymerase 2 decreases activity ISO XAV939 results in decreased activity of PARP2 protein CTD PMID:28001384 NCBI chr15:27,739,416...27,749,650
Ensembl chr15:27,739,251...27,749,648
JBrowse link
G Tnks tankyrase affects binding
decreases activity
multiple interactions
ISO XAV939 binds to TNKS protein
XAV939 results in decreased activity of TNKS protein
XAV939 inhibits the reaction [N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride binds to TNKS protein]
CTD PMID:22297980, PMID:28001384 NCBI chr16:60,925,093...61,067,192
Ensembl chr16:60,925,093...61,067,192
JBrowse link
G Tnks2 tankyrase 2 multiple interactions ISO XAV939 binds to and results in decreased activity of TNKS2 protein CTD PMID:28001384
G Utp3 UTP3, small subunit processome component decreases expression ISO XAV939 results in decreased expression of UTP3 mRNA CTD PMID:27226553 NCBI chr14:21,153,998...21,155,652
Ensembl chr14:21,154,000...21,155,652
JBrowse link
G Vim vimentin decreases expression
multiple interactions
ISO XAV939 results in decreased expression of VIM protein
XAV939 promotes the reaction [thymoquinone results in decreased expression of VIM protein]
CTD PMID:32112862 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Vpreb1 V-set pre-B cell surrogate light chain 1 decreases expression ISO XAV939 results in decreased expression of VPREB1 mRNA CTD PMID:27226553 NCBI chr11:88,376,256...88,377,133
Ensembl chr11:88,376,256...88,377,133
JBrowse link
G Wnt7a Wnt family member 7A decreases activity ISO XAV939 results in decreased activity of WNT7A protein CTD PMID:25174399 NCBI chr 4:122,994,425...123,040,609
Ensembl chr 4:122,994,425...123,040,609
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        refrigerant 17418
          tetrafluoromethane 6330
            trifluoromethyl group 6330
              (trifluoromethyl)benzenes 6330
                XAV939 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            organic hydride 18249
                              organic fundamental parent 18249
                                hydrocarbon 17969
                                  halohydrocarbon 13937
                                    haloalkane 11657
                                      fluoroalkane 7110
                                        fluoromethanes 6330
                                          tetrafluoromethane 6330
                                            trifluoromethyl group 6330
                                              (trifluoromethyl)benzenes 6330
                                                XAV939 19
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.