|
G
|
Acp5
|
acid phosphatase 5, tartrate resistant
|
multiple interactions
|
ISO
|
crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]]
|
CTD |
PMID:30580027 |
|
NCBI chr 8:28,939,984...28,946,639
Ensembl chr 8:28,939,985...28,943,929
|
|
G
|
Acta2
|
actin alpha 2, smooth muscle
|
multiple interactions
|
EXP
|
crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
|
CTD |
PMID:32633567 |
|
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:241,159,724...241,172,503
|
|
G
|
Akt2
|
AKT serine/threonine kinase 2
|
multiple interactions
|
ISO
|
crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA]
|
CTD |
PMID:30580027 |
|
NCBI chr 1:92,004,705...92,061,420
Ensembl chr 1:92,014,859...92,061,420
|
|
G
|
Alpl
|
alkaline phosphatase, biomineralization associated
|
multiple interactions
|
EXP
|
crocin inhibits the reaction [Tartrazine results in increased activity of ALPL protein]
|
CTD |
PMID:30657462 |
|
NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167
|
|
G
|
Atg5
|
autophagy related 5
|
multiple interactions
|
EXP
|
crocin inhibits the reaction [Blood Glucose results in increased expression of ATG5 protein]; crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in increased expression of ATG5 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased expression of ATG5 protein]]
|
CTD |
PMID:33021114 |
|
NCBI chr20:49,380,835...49,471,826
Ensembl chr20:49,380,813...49,471,821
|
|
G
|
Bambi
|
BMP and activin membrane-bound inhibitor
|
multiple interactions
|
EXP
|
crocin inhibits the reaction [Cisplatin results in decreased expression of BAMBI mRNA]
|
CTD |
PMID:32259551 |
|
NCBI chr17:58,816,438...58,821,003
Ensembl chr17:58,816,442...58,821,247
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
multiple interactions increases expression
|
EXP ISO
|
crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; crocin inhibits the reaction [Diazinon results in increased expression of BAX mRNA]; crocin inhibits the reaction [Diazinon results in increased expression of BAX protein]; crocin inhibits the reaction [Malathion results in increased expression of BAX protein] crocin results in increased expression of BAX mRNA crocin inhibits the reaction [Zearalenone results in increased expression of BAX protein]
|
CTD |
PMID:23523949 PMID:26231423 PMID:27353299 PMID:32886819 PMID:32920515 PMID:35274200 More...
|
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
multiple interactions decreases expression
|
ISO EXP
|
[crocin co-treated with Paraquat] results in decreased expression of BCL2 mRNA; crocin inhibits the reaction [Zearalenone results in decreased expression of BCL2 protein] crocin results in decreased expression of BCL2 mRNA crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]
|
CTD |
PMID:26231423 PMID:31911963 PMID:32886819 PMID:32920515 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
|
|
G
|
Bdnf
|
brain-derived neurotrophic factor
|
increases expression
|
EXP
|
crocin results in increased expression of BDNF mRNA; crocin results in increased expression of BDNF protein
|
CTD |
PMID:24401376 |
|
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:116,619,633...116,670,657
|
|
G
|
Becn1
|
beclin 1
|
multiple interactions
|
EXP
|
crocin inhibits the reaction [Blood Glucose results in increased expression of BECN1 protein]; crocin inhibits the reaction [Blood Glucose results in increased phosphorylation of BECN1 protein]; crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in increased expression of BECN1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased expression of BECN1 protein]]
|
CTD |
PMID:33021114 |
|
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,731,650...86,747,002
|
|
G
|
Birc5
|
baculoviral IAP repeat-containing 5
|
decreases expression
|
ISO
|
crocin results in decreased expression of BIRC5 mRNA
|
CTD |
PMID:32886819 |
|
NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,572,080...103,582,155
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions increases cleavage increases expression increases activity
|
EXP ISO
|
crocin affects the reaction [Ethanol results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased activity of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased cleavage of CASP3 protein]; crocin inhibits the reaction [Diazinon results in increased expression of CASP3 protein modified form]; crocin inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]; crocin inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]; crocin inhibits the reaction [Tartrazine results in increased expression of CASP3 protein] crocin results in increased cleavage of CASP3 protein Acetylcysteine inhibits the reaction [crocin results in increased activity of CASP3 protein]; MIR34A mRNA inhibits the reaction [crocin results in increased activity of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; PTPN4 protein affects the reaction [crocin results in increased activity of CASP3 protein] crocin inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA] crocin results in increased expression of CASP3 mRNA
|
CTD |
PMID:23523949 PMID:25637687 PMID:25899501 PMID:26807765 PMID:27353299 PMID:30672053 PMID:31911963 PMID:32870427 PMID:32886819 PMID:32920515 PMID:35085590 PMID:35274200 More...
|
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Casp8
|
caspase 8
|
increases activity
|
ISO
|
crocin results in increased activity of CASP8 protein
|
CTD |
PMID:32886819 |
|
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:67,758,033...67,806,699
|
|
G
|
Casp9
|
caspase 9
|
multiple interactions increases activity
|
EXP ISO
|
crocin inhibits the reaction [Diazinon results in increased cleavage of CASP9 protein]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP9 protein] crocin results in increased activity of CASP9 protein
|
CTD |
PMID:27353299 PMID:32886819 PMID:35274200 |
|
Ensembl chr 5:159,391,188...159,409,648
|
|
G
|
Cat
|
catalase
|
multiple interactions increases activity decreases activity increases expression
|
EXP ISO
|
crocin inhibits the reaction [Arsenic Trioxide results in decreased activity of CAT protein]; crocin inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]; crocin inhibits the reaction [Cyclophosphamide results in decreased activity of CAT protein]; crocin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; crocin inhibits the reaction [Tartrazine results in decreased activity of CAT protein]; crocin inhibits the reaction [Tartrazine results in decreased expression of CAT protein] crocin results in increased activity of CAT protein crocin inhibits the reaction [Patulin results in increased activity of CAT protein]; crocin inhibits the reaction [Zearalenone results in increased activity of CAT protein] crocin results in decreased activity of CAT protein crocin results in increased expression of CAT protein
|
CTD |
PMID:23488790 PMID:25899501 PMID:26231423 PMID:26584762 PMID:29217164 PMID:29409856 PMID:32870427 PMID:32886819 PMID:32920515 More...
|
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Ccnd1
|
cyclin D1
|
decreases expression
|
ISO
|
crocin results in decreased expression of CCND1 mRNA
|
CTD |
PMID:32886819 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
|
|
G
|
Ckm
|
creatine kinase, M-type
|
multiple interactions
|
EXP
|
crocin inhibits the reaction [Diazinon results in increased activity of CKM protein]
|
CTD |
PMID:23523949 |
|
NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:88,189,485...88,199,719
|
|
G
|
Col2a1
|
collagen type II alpha 1 chain
|
multiple interactions
|
EXP
|
[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Allantoin]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]
|
CTD |
PMID:24709313 |
|
NCBI chr 7:130,977,561...131,006,627
Ensembl chr 7:130,977,561...131,006,627
|
|
G
|
Creb1
|
cAMP responsive element binding protein 1
|
multiple interactions
|
EXP
|
crocin results in increased expression of and results in increased phosphorylation of CREB1 protein
|
CTD |
PMID:24401376 |
|
NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:73,397,306...73,466,339
|
|
G
|
Cycs
|
cytochrome c, somatic
|
multiple interactions
|
EXP
|
crocin inhibits the reaction [Diazinon affects the localization of CYCS protein]
|
CTD |
PMID:23523949 |
|
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816 Ensembl chr18:80,982,668...80,984,816
|
|
G
|
Cyp2e1
|
cytochrome P450, family 2, subfamily e, polypeptide 1
|
multiple interactions decreases activity
|
EXP
|
crocin inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYP2E1 mRNA]; crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of CYP2E1 protein] crocin results in decreased activity of CYP2E1 protein
|
CTD |
PMID:25899501 PMID:32633567 |
|
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:205,267,505...205,293,495
|
|
G
|
Foxp2
|
forkhead box P2
|
increases expression
|
ISO
|
crocin results in increased expression of FOXP2 protein
|
CTD |
PMID:36988377 |
|
NCBI chr 4:44,099,848...44,677,700
Ensembl chr 4:44,099,959...44,677,696
|
|
G
|
Glo1
|
glyoxalase 1
|
multiple interactions
|
ISO
|
crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein]
|
CTD |
PMID:30580027 |
|
NCBI chr20:8,665,061...8,683,095
Ensembl chr20:8,665,061...8,683,191
|
|
G
|
Got2
|
glutamic-oxaloacetic transaminase 2
|
multiple interactions
|
EXP
|
crocin inhibits the reaction [Tartrazine results in increased activity of GOT2 protein]
|
CTD |
PMID:30657462 |
|
NCBI chr19:9,180,428...9,206,113
Ensembl chr19:9,180,431...9,206,111
|
|
G
|
Gpt
|
glutamic--pyruvic transaminase
|
multiple interactions
|
EXP ISO
|
crocin inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; crocin inhibits the reaction [Cisplatin results in increased activity of GPT protein]; crocin inhibits the reaction [Tartrazine results in increased activity of GPT protein] crocin inhibits the reaction [Zearalenone results in increased expression of GPT protein]
|
CTD |
PMID:26231423 PMID:30657462 PMID:32259551 PMID:32633567 |
|
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:110,296,206...110,300,160
|
|
G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions
|
EXP
|
crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of HMOX1 protein]
|
CTD |
PMID:32920515 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,472,884...13,479,818
|
|
G
|
Hspa1l
|
heat shock protein family A (Hsp70) member 1 like
|
multiple interactions
|
EXP
|
crocin inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA]
|
CTD |
PMID:25637687 |
|
NCBI chr20:3,853,496...3,860,223
Ensembl chr20:3,853,331...3,876,877
|
|
G
|
Il10
|
interleukin 10
|
multiple interactions
|
EXP
|
crocin inhibits the reaction [Doxorubicin results in decreased expression of IL10 protein]
|
CTD |
PMID:26807765 |
|
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:45,025,087...45,029,580
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
EXP
|
[geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]; crocin inhibits the reaction [Cyclophosphamide results in increased expression of IL1B protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of IL1B protein]
|
CTD |
PMID:23488790 PMID:24709313 PMID:26807765 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions decreases expression
|
EXP ISO
|
crocin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of IL6 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 mRNA]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; crocin inhibits the reaction [Cyclophosphamide results in increased expression of IL6 protein]; crocin inhibits the reaction [Ethanol results in decreased expression of IL6 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of IL6 protein] crocin results in decreased expression of IL6 mRNA
|
CTD |
PMID:23488790 PMID:25637687 PMID:25899501 PMID:29409856 PMID:32633567 PMID:32886819 PMID:32920515 More...
|
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
G
|
Ins1
|
insulin 1
|
multiple interactions
|
EXP
|
crocin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]
|
CTD |
PMID:29409856 |
|
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
|
|
G
|
Jak2
|
Janus kinase 2
|
multiple interactions
|
ISO
|
crocin affects the expression of and affects the phosphorylation of JAK2 protein
|
CTD |
PMID:32886819 |
|
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:236,408,662...236,468,762
|
|
G
|
Keap1
|
Kelch-like ECH-associated protein 1
|
multiple interactions
|
EXP
|
crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of KEAP1 protein]
|
CTD |
PMID:32920515 |
|
NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:28,044,555...28,054,042
|
|
G
|
Ldlr
|
low density lipoprotein receptor
|
multiple interactions
|
EXP
|
crocin inhibits the reaction [Diazinon results in decreased expression of LDLR mRNA]
|
CTD |
PMID:24132704 |
|
NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:28,546,146...28,570,675
|
|
G
|
Map1lc3b
|
microtubule-associated protein 1 light chain 3 beta
|
multiple interactions
|
EXP
|
[Quercetin co-treated with crocin] inhibits the reaction [Blood Glucose results in increased lipidation of MAP1LC3B protein]; crocin inhibits the reaction [Blood Glucose results in increased lipidation of MAP1LC3B protein]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased lipidation of MAP1LC3B protein]]
|
CTD |
PMID:33021114 |
|
NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358 Ensembl chr16:66,574,407...66,584,358
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions decreases phosphorylation
|
EXP ISO
|
crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK1 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK1 protein] crocin results in decreased phosphorylation of MAPK1 protein
|
CTD |
PMID:24132704 PMID:28689058 PMID:32886819 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions decreases phosphorylation
|
EXP ISO
|
crocin inhibits the reaction [bisphenol A results in increased phosphorylation of MAPK3 protein]; crocin inhibits the reaction [Diazinon results in decreased phosphorylation of MAPK3 protein] crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA] crocin results in decreased phosphorylation of MAPK3 protein
|
CTD |
PMID:24132704 PMID:28689058 PMID:30580027 PMID:32886819 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
G
|
Mir122
|
microRNA 122
|
multiple interactions decreases expression
|
EXP ISO
|
crocin inhibits the reaction [bisphenol A results in increased expression of MIR122 mRNA] crocin results in decreased expression of MIR122
|
CTD |
PMID:28689058 PMID:36988377 |
|
NCBI chr18:61,028,817...61,028,901
|
|
G
|
Mir29b1
|
microRNA 29b-1
|
increases expression multiple interactions
|
EXP
|
crocin results in increased expression of MIR29B1 mRNA Cisplatin inhibits the reaction [crocin results in increased expression of MIR29B1 mRNA]; crocin inhibits the reaction [Cisplatin results in decreased expression of MIR29B1 mRNA]
|
CTD |
PMID:32259551 |
|
NCBI chr 4:60,618,334...60,618,414
|
|
G
|
Mir34a
|
microRNA 34a
|
multiple interactions
|
ISO
|
MIR34A mRNA inhibits the reaction [crocin results in increased activity of CASP3 protein]; MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein]
|
CTD |
PMID:35085590 |
|
NCBI chr 5:165,815,952...165,816,053
Ensembl chr 5:165,815,952...165,816,053
|
|
G
|
Mir9-1
|
microRNA 9-1
|
multiple interactions increases expression
|
EXP
|
Cisplatin inhibits the reaction [crocin results in increased expression of MIR9-1 mRNA]; crocin inhibits the reaction [Cisplatin results in decreased expression of MIR9-1 mRNA]
|
CTD |
PMID:32259551 |
|
NCBI chr 2:175,974,971...175,975,059
|
|
G
|
Mpo
|
myeloperoxidase
|
multiple interactions
|
EXP
|
crocin inhibits the reaction [Ethanol results in increased activity of MPO protein]
|
CTD |
PMID:25637687 |
|
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056
|
|
G
|
Myc
|
MYC proto-oncogene, bHLH transcription factor
|
decreases expression
|
ISO
|
crocin results in decreased expression of MYC mRNA
|
CTD |
PMID:32886819 |
|
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028
|
|
G
|
Mycn
|
MYCN proto-oncogene, bHLH transcription factor
|
decreases response to substance decreases expression multiple interactions
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ISO
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MYCN results in decreased susceptibility to crocin crocin results in decreased expression of MYCN protein crocin results in decreased expression of and results in decreased stability of MYCN mRNA; MYCN protein inhibits the reaction [crocin results in increased cleavage of CASP3 protein]; MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein]
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CTD |
PMID:30672053 |
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NCBI chr 6:41,446,683...41,452,584
Ensembl chr 6:41,446,684...41,452,508
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G
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Myd88
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MYD88, innate immune signal transduction adaptor
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multiple interactions
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EXP
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crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of MYD88 protein]
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CTD |
PMID:32259551 |
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NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:127,952,161...127,956,230
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G
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Nfe2l2
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NFE2 like bZIP transcription factor 2
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multiple interactions
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EXP
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crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 protein]; crocin inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 protein]
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CTD |
PMID:32259551 PMID:32920515 |
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NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090
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G
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Nqo1
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NAD(P)H quinone dehydrogenase 1
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multiple interactions
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EXP
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crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NQO1 protein]
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CTD |
PMID:32920515 |
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NCBI chr19:52,205,374...52,220,267
Ensembl chr19:52,205,314...52,220,260
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G
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Ostm1
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osteoclastogenesis associated transmembrane protein 1
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multiple interactions
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ISO
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[crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA]
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CTD |
PMID:30580027 |
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NCBI chr20:47,653,696...47,769,248
Ensembl chr20:47,653,670...47,769,237
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G
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Parp1
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poly (ADP-ribose) polymerase 1
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multiple interactions increases cleavage
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ISO
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MYCN protein inhibits the reaction [crocin results in increased cleavage of PARP1 protein]
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CTD |
PMID:30672053 |
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NCBI chr13:94,839,484...94,871,295
Ensembl chr13:94,839,433...94,871,567
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G
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Pparg
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peroxisome proliferator-activated receptor gamma
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multiple interactions
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EXP
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crocin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARG protein]
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CTD |
PMID:32633567 |
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NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
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G
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Prkab1
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protein kinase AMP-activated non-catalytic subunit beta 1
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multiple interactions
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EXP
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crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in increased phosphorylation of PRKAB1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased phosphorylation of PRKAB1 protein]]
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CTD |
PMID:33021114 |
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NCBI chr12:46,248,971...46,259,487
Ensembl chr12:46,249,010...46,259,482
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G
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Ptgs2
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prostaglandin-endoperoxide synthase 2
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decreases expression multiple interactions
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ISO EXP
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crocin results in decreased expression of PTGS2 mRNA crocin inhibits the reaction [Cyclophosphamide results in increased expression of PTGS2 protein]
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CTD |
PMID:23488790 PMID:32886819 |
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NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
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G
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Ptpn4
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protein tyrosine phosphatase, non-receptor type 4
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multiple interactions increases expression
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ISO
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MIR34A mRNA inhibits the reaction [crocin results in increased expression of PTPN4 protein]; PTPN4 protein affects the reaction [crocin results in increased activity of CASP3 protein]
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CTD |
PMID:35085590 |
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NCBI chr13:33,324,808...33,504,957
Ensembl chr13:33,324,808...33,504,957
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G
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Rela
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RELA proto-oncogene, NF-kB subunit
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multiple interactions
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EXP
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crocin inhibits the reaction [Arsenic Trioxide results in increased expression of RELA protein]; crocin inhibits the reaction [Streptozocin results in increased expression of RELA protein]
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CTD |
PMID:29409856 PMID:32920515 |
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NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
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G
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Smad2
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SMAD family member 2
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decreases expression multiple interactions
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EXP
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crocin results in decreased expression of SMAD2 protein Cisplatin inhibits the reaction [crocin results in decreased expression of SMAD2 protein]; crocin inhibits the reaction [Cisplatin results in increased expression of SMAD2 protein]
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CTD |
PMID:32259551 |
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NCBI chr18:72,124,792...72,193,345
Ensembl chr18:72,124,863...72,187,388
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G
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Snca
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synuclein alpha
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multiple interactions
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EXP
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crocin inhibits the reaction [Malathion results in increased expression of SNCA mRNA]; crocin inhibits the reaction [Malathion results in increased expression of SNCA protein]
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CTD |
PMID:35274200 |
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NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315
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G
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Sod1
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superoxide dismutase 1
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increases expression multiple interactions
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EXP
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crocin results in increased expression of SOD1 protein crocin inhibits the reaction [Tartrazine results in decreased expression of SOD1 protein]
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CTD |
PMID:32870427 |
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NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399
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G
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Spry2
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sprouty RTK signaling antagonist 2
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increases expression
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ISO
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crocin results in increased expression of SPRY2 protein
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CTD |
PMID:36988377 |
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NCBI chr15:89,106,809...89,111,926
Ensembl chr15:89,103,731...89,115,074
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G
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Sqstm1
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sequestosome 1
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multiple interactions
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EXP
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crocin inhibits the reaction [Blood Glucose results in decreased expression of SQSTM1 protein]; crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in decreased expression of SQSTM1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in decreased expression of SQSTM1 protein]]
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CTD |
PMID:33021114 |
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NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750
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G
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Stat3
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signal transducer and activator of transcription 3
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multiple interactions
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ISO
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crocin affects the expression of and affects the phosphorylation of STAT3 protein
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CTD |
PMID:32886819 |
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NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
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G
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Tgfb1
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transforming growth factor, beta 1
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multiple interactions
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EXP
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crocin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]; crocin inhibits the reaction [Blood Glucose results in increased expression of TGFB1 protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of TGFB1 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; crocin promotes the reaction [Quercetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]]; crocin promotes the reaction [Quercetin inhibits the reaction [Blood Glucose results in increased expression of TGFB1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TGFB1 protein]]; Quercetin promotes the reaction [crocin inhibits the reaction [Blood Glucose results in increased expression of TGFB1 protein]]
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CTD |
PMID:29409856 PMID:32259551 PMID:32633567 PMID:33021114 |
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NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899
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G
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Tgfbr1
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transforming growth factor, beta receptor 1
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multiple interactions
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EXP
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crocin inhibits the reaction [Cisplatin results in increased expression of TGFBR1 protein]
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CTD |
PMID:32259551 |
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NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:66,449,293...66,527,260
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G
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Tlr4
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toll-like receptor 4
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multiple interactions
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EXP
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crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 mRNA]; crocin inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of TLR4 protein]
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CTD |
PMID:29409856 PMID:32259551 |
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NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:85,161,192...85,175,007
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G
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Tnf
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tumor necrosis factor
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multiple interactions decreases expression
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EXP ISO
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crocin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF mRNA]; crocin inhibits the reaction [Arsenic Trioxide results in increased expression of TNF protein]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; crocin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; crocin inhibits the reaction [Cyclophosphamide results in increased expression of TNF protein]; crocin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; crocin inhibits the reaction [Ethanol results in decreased expression of TNF protein] crocin results in decreased expression of TNF mRNA
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CTD |
PMID:23488790 PMID:25637687 PMID:25899501 PMID:26807765 PMID:32633567 PMID:32886819 PMID:32920515 More...
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
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G
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Tnfsf11
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TNF superfamily member 11
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multiple interactions
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ISO
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[crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of AKT2 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of MAPK3 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of OSTM1 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]; crocin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in decreased activity of GLO1 protein]; crocin promotes the reaction [pyrazolanthrone inhibits the reaction [TNFSF11 protein results in increased activity of ACP5 protein]]
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CTD |
PMID:30580027 |
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NCBI chr15:60,083,008...60,114,479
Ensembl chr15:60,083,008...60,114,479
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G
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Tnnt2
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troponin T2, cardiac type
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multiple interactions
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EXP
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crocin inhibits the reaction [Doxorubicin results in increased expression of TNNT2 protein]
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CTD |
PMID:26807765 |
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NCBI chr13:49,819,123...49,837,125
Ensembl chr13:49,822,304...49,837,125
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G
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Tp53
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tumor protein p53
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multiple interactions
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ISO
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crocin inhibits the reaction [Paraquat results in increased expression of TRP53 mRNA]; crocin inhibits the reaction [Zearalenone results in increased expression of TRP53 protein]
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CTD |
PMID:26231423 PMID:31911963 |
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NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
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G
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Traf6
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TNF receptor associated factor 6
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multiple interactions
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ISO
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crocin inhibits the reaction [[TNFSF11 protein co-treated with pyrazolanthrone] results in increased expression of TRAF6 mRNA]
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CTD |
PMID:30580027 |
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NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:108,418,513...108,443,328
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G
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Vgf
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VGF nerve growth factor inducible
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increases expression
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EXP
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crocin results in increased expression of VGF protein
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CTD |
PMID:24401376 |
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NCBI chr12:25,274,004...25,281,803
Ensembl chr12:25,273,333...25,282,703
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