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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
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Accession:CHEBI:62434 term browser browse the term
Definition:An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC 2.7.10.1).
Synonyms:related_synonym: AATK inhibitor;   AATYK inhibitor;   AATYK2 inhibitor;   AATYK3 inhibitor;   ACH inhibitor;   ALK inhibitor;   ALK inhibitors;   ARK inhibitor;   ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type) inhibitor;   ATP:[protein]-L-tyrosine O-phosphotransferase (receptor-type) inhibitors;   AXL inhibitor;   BRT inhibitor;   Bek inhibitor;   Bfgfr inhibitor;   Bsk inhibitor;   C-FMS inhibitor;   CAK inhibitor;   CCK4 inhibitor;   CD115 inhibitor;   CD135 inhibitor;   CDw135 inhibitor;   CFD1 inhibitor;   CKIT inhibitor;   CSF1R inhibitor;   Cek1 inhibitor;   Cek10 inhibitor;   Cek11 inhibitor;   Cek2 inhibitor;   Cek3 inhibitor;   Cek5 inhibitor;   Cek6 inhibitor;   Cek7 inhibitor;   DAlk inhibitor;   DDR1 inhibitor;   DDR2 inhibitor;   DKFZp434C1418 inhibitor;   DRT inhibitor;   DTK inhibitor;   Dek inhibitor;   Drosophila Eph kinase inhibitor;   EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitors;   EC 2.7.10.1 inhibitor;   EC 2.7.10.1 inhibitors;   ECK inhibitor;   EDDR1 inhibitor;   EGFR inhibitor;   EPH inhibitor;   EPHA1 inhibitor;   EPHA2 inhibitor;   EPHA6 inhibitor;   EPHA7 inhibitor;   EPHA8 inhibitor;   EPHB1 inhibitor;   EPHB2 inhibitor;   EPHB3 inhibitor;   EPHB4 inhibitor;   EPHT inhibitor;   EPHT2 inhibitor;   EPHT3 inhibitor;   EPHX inhibitor;   ERBB inhibitor;   ERBB1 inhibitor;   ERBB2 inhibitor;   ERBB3 inhibitor;   ERBB4 inhibitor;   ERK inhibitor;   Ebk inhibitor;   Eek inhibitor;   Ehk2 inhibitor;   Ehk3 inhibitor;   Elk inhibitor;   EphB5 inhibitor;   Eyk inhibitor;   FGFR1 inhibitor;   FGFR2 inhibitor;   FGFR3 inhibitor;   FGFR4 inhibitor;   FLG inhibitor;   FLK1 inhibitor;   FLK2 inhibitor;   FLT1 inhibitor;   FLT2 inhibitor;   FLT3 inhibitor;   FLT4 inhibitor;   FMS inhibitor;   Fv2 inhibitor;   HBGFR inhibitor;   HEK11 inhibitor;   HEK2 inhibitor;   HEK3 inhibitor;   HEK5 inhibitor;   HEK6 inhibitor;   HEP inhibitor;   HER2 inhibitor;   HER3 inhibitor;   HER4 inhibitor;   HGFR inhibitor;   HSCR1 inhibitor;   HTK inhibitor;   IGF1R inhibitor;   INSR inhibitor;   INSRR inhibitor;   IR inhibitor;   IRR inhibitor;   JTK12 inhibitor;   JTK13 inhibitor;   JTK14 inhibitor;   JWS inhibitor;   K-SAM inhibitor;   KDR inhibitor;   KGFR inhibitor;   KIA0641 inhibitor;   KIAA1079 inhibitor;   KIAA1459 inhibitor;   KIT inhibitor;   KLG inhibitor;   Kil inhibitor;   Kin15 inhibitor;   Kin16 inhibitor;   LTK inhibitor;   MCF3 inhibitor;   MEN2A/B inhibitor;   MER inhibitor;   MERTK inhibitor;   MEhk1 inhibitor;   MST1R inhibitor;   MTC1 inhibitor;   MUSK inhibitor;   Mdk1 inhibitor;   Mdk2 inhibitor;   Mdk5 inhibitor;   Mep inhibitor;   Mlk1 inhibitor;   Mlk2 inhibitor;   Mrk inhibitor;   Myk1 inhibitor;   N-SAM inhibitor;   NEP inhibitor;   NET inhibitor;   NGL inhibitor;   NOK inhibitor;   NTRK1 inhibitor;   NTRK2 inhibitor;   NTRK3 inhibitor;   NTRK4 inhibitor;   NTRKR1 inhibitor;   NTRKR2 inhibitor;   NTRKR3 inhibitor;   NYK inhibitor;   Neu inhibitor;   Nsk2 inhibitor;   Nuk inhibitor;   PCL inhibitor;   PDGFR inhibitor;   PDGFRA inhibitor;   PDGFRB inhibitor;   PHB6 inhibitor;   PTK inhibitor;   PTK3 inhibitor;   PTK7 inhibitor;   RET inhibitor;   RON inhibitor;   ROR1 inhibitor;   ROR2 inhibitor;   ROS1 inhibitor;   RSE inhibitor;   RTK inhibitor;   RYK inhibitor;   SEA inhibitor;   SKY inhibitor;   STK inhibitor;   STK1 inhibitor;   Sek2 inhibitor;   Sek3 inhibitor;   Sek4 inhibitor;   Sfr inhibitor;   TEK inhibitor;   TIE inhibitor;   TIE1 inhibitor;   TIE2 inhibitor;   TIF inhibitor;   TKT inhibitor;   TRK inhibitor;   TRKA inhibitor;   TRKB inhibitor;   TRKC inhibitor;   TRKE inhibitor;   TYK1 inhibitor;   TYRO10 inhibitor;   TYRO3 inhibitor;   TYRO7 inhibitor;   Tyro11 inhibitor;   Tyro5 inhibitor;   Tyro6 inhibitor;   UFO inhibitor;   VEGFR1 inhibitor;   VEGFR2 inhibitor;   VEGFR3 inhibitor;   Vik inhibitor;   YK1 inhibitor;   Yrk inhibitor;   anaplastic lymphoma kinase inhibitor;   anaplastic lymphoma kinase inhibitors;   ephrin-B3 receptor tyrosine kinase inhibitor;   insulin receptor protein-tyrosine kinase inhibitor;   neurite outgrowth regulating kinase inhibitor;   nork inhibitor;   novel oncogene with kinase-domain inhibitor;   receptor protein-tyrosine kinase inhibitor;   receptor protein-tyrosine kinase inhibitors
 xref: Wikipedia:Anaplastic_lymphoma_kinase

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Path 1
Term Annotations click to browse term
  CHEBI ontology 0
    role 0
      biological role 0
        inhibitor 0
          enzyme inhibitor 0
            EC 2.* (transferase) inhibitor 0
              EC 2.7.* (P-containing group transferase) inhibitor 0
                EC 2.7.10.* (protein-tyrosine kinase) inhibitor 0
                  EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor 0
                    1-(3-\{5-[4-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl\}phenyl)-3-(2-phenoxyphenyl)urea 0
                    1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea 0
                    2,5-dihydroxycinnamic acid methyl ester 0
                    3,21-dioxoolean-18-en-28-oic acid 0
                    AEE788 0
                    AMG-925 0
                    ASP-3026 0
                    AZD3463 0
                    BAY-826 0
                    BMS-754807 0
                    CP-724714 0
                    DDR1-IN-1 0
                    DDR1-IN-2 0
                    Ki11502 0
                    N-\{4-[(3-bromophenyl)amino]quinazolin-6-yl\}but-2-ynamide 0
                    PD-153035 0
                    PD-153035 hydrochloride 0
                    PD-166866 + 0
                    PD158780 0
                    PD173074 0
                    PDGF receptor tyrosine kinase inhibitor III 0
                    PQIP 0
                    SB 431542 0
                    SU11652 0
                    TTT-3002 0
                    ZM 323881 hydrochloride 0
                    alectinib 0
                    alectinib hydrochloride 0
                    brivanib + 0
                    brivanib alaninate 0
                    c-Met tyrosine kinase inhibitor + 0
                    ceritinib 0
                    crenolanib 0
                    crizotinib + 0
                    ebselen 0
                    entrectinib 0
                    fruquintinib 0
                    gilteritinib 0
                    lenvatinib 0
                    lenvatinib mesylate 0
                    linifanib 0
                    lorlatinib 0
                    orantinib 0
                    pexidartinib 0
                    quizartinib 0
                    rac-crizotinib 0
                    repotrectinib 0
                    sapitinib 0
                    semaxanib 0
                    sunitinib + 0
                    tandutinib 0
                    tesevatinib 0
                    vatalanib + 0
                    vatalanib succinate 0
                    xestospongin C 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 0
    role 0
      biological role 0
        inhibitor 0
          enzyme inhibitor 0
            EC 2.* (transferase) inhibitor 0
              EC 2.7.* (P-containing group transferase) inhibitor 0
                protein kinase inhibitor 0
                  tyrosine kinase inhibitor 0
                    EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor 0
                      1-(3-\{5-[4-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl\}phenyl)-3-(2-phenoxyphenyl)urea 0
                      1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea 0
                      2,5-dihydroxycinnamic acid methyl ester 0
                      3,21-dioxoolean-18-en-28-oic acid 0
                      AEE788 0
                      AMG-925 0
                      ASP-3026 0
                      AZD3463 0
                      BAY-826 0
                      BMS-754807 0
                      CP-724714 0
                      DDR1-IN-1 0
                      DDR1-IN-2 0
                      Ki11502 0
                      N-\{4-[(3-bromophenyl)amino]quinazolin-6-yl\}but-2-ynamide 0
                      PD-153035 0
                      PD-153035 hydrochloride 0
                      PD-166866 + 0
                      PD158780 0
                      PD173074 0
                      PDGF receptor tyrosine kinase inhibitor III 0
                      PQIP 0
                      SB 431542 0
                      SU11652 0
                      TTT-3002 0
                      ZM 323881 hydrochloride 0
                      alectinib 0
                      alectinib hydrochloride 0
                      brivanib + 0
                      brivanib alaninate 0
                      c-Met tyrosine kinase inhibitor + 0
                      ceritinib 0
                      crenolanib 0
                      crizotinib + 0
                      ebselen 0
                      entrectinib 0
                      fruquintinib 0
                      gilteritinib 0
                      lenvatinib 0
                      lenvatinib mesylate 0
                      linifanib 0
                      lorlatinib 0
                      orantinib 0
                      pexidartinib 0
                      quizartinib 0
                      rac-crizotinib 0
                      repotrectinib 0
                      sapitinib 0
                      semaxanib 0
                      sunitinib + 0
                      tandutinib 0
                      tesevatinib 0
                      vatalanib + 0
                      vatalanib succinate 0
                      xestospongin C 0
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