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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:metamizole(1-)
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Accession:CHEBI:62086 term browser browse the term
Definition:An organosulfonate oxoanion resulting from the removal of a proton from the sulfonic acid group of metamizole.
Synonyms:exact_synonym: [(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino]methanesulfonate
 related_synonym: (antipyrinylmethylamino)methanesulfonate;   Formula=C13H16N3O4S;   InChI=1S/C13H17N3O4S/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11/h4-8H,9H2,1-3H3,(H,18,19,20)/p-1;   InChIKey=LVWZTYCIRDMTEY-UHFFFAOYSA-M;   N-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)-N-methylaminomethanesulfonate;   SMILES=CN(CS([O-])(=O)=O)c1c(C)n(C)n(-c2ccccc2)c1=O;   [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonate;   metamizole anion
 cyclic_relationship: is_conjugate_base_of CHEBI:62088


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metamizole sodium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone multiple interactions EXP Dipyrone inhibits the reaction [IL1B protein results in increased secretion of CRH protein]; Dipyrone inhibits the reaction [IL6 protein results in increased secretion of CRH protein]; Dipyrone inhibits the reaction [Lipopolysaccharides results in increased secretion of CRH protein]; Dipyrone inhibits the reaction [TNF protein results in increased secretion of CRH protein] CTD PMID:11852909 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP Dipyrone promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein] CTD PMID:15309881 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Dipyrone inhibits the reaction [IL1B protein results in increased secretion of CRH protein] CTD PMID:11852909 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Dipyrone inhibits the reaction [IL6 protein results in increased secretion of CRH protein] CTD PMID:11852909 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO Dipyrone analog results in decreased activity of PTGS1 protein; Dipyrone results in decreased activity of PTGS1 protein CTD PMID:12242329, PMID:16141368 NCBI chr 3:15,560,685...15,582,339
Ensembl chr 3:15,560,712...15,582,344
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions EXP Dipyrone promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein] CTD PMID:15309881 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Dipyrone inhibits the reaction [TNF protein results in increased secretion of CRH protein] CTD PMID:11852909 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19769
      molecular entity 19767
        ion 15857
          organic ion 8311
            organic anion 2998
              organosulfonate oxoanion 28
                metamizole(1-) 7
                  metamizole sodium 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19655
                    main group molecular entity 19655
                      p-block molecular entity 19655
                        chalcogen molecular entity 19359
                          oxygen molecular entity 19320
                            oxide 11430
                              oxoanion 8428
                                chalcogen oxoanion 530
                                  sulfur oxoanion 529
                                    sulfonate 28
                                      organosulfonate oxoanion 28
                                        metamizole(1-) 7
                                          metamizole sodium 7
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