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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:metamizole(1-)
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Accession:CHEBI:62086 term browser browse the term
Definition:An organosulfonate oxoanion resulting from the removal of a proton from the sulfonic acid group of metamizole.
Synonyms:exact_synonym: [(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)(methyl)amino]methanesulfonate
 related_synonym: (antipyrinylmethylamino)methanesulfonate;   Formula=C13H16N3O4S;   InChI=1S/C13H17N3O4S/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11/h4-8H,9H2,1-3H3,(H,18,19,20)/p-1;   InChIKey=LVWZTYCIRDMTEY-UHFFFAOYSA-M;   N-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)-N-methylaminomethanesulfonate;   SMILES=CN(CS([O-])(=O)=O)c1c(C)n(C)n(-c2ccccc2)c1=O;   [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonate;   metamizole anion
 cyclic_relationship: is_conjugate_base_of CHEBI:62088


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metamizole sodium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crh corticotropin releasing hormone multiple interactions EXP Dipyrone inhibits the reaction [IL1B protein results in increased secretion of CRH protein]; Dipyrone inhibits the reaction [IL6 protein results in increased secretion of CRH protein]; Dipyrone inhibits the reaction [Lipopolysaccharides results in increased secretion of CRH protein]; Dipyrone inhibits the reaction [TNF protein results in increased secretion of CRH protein] CTD PMID:11852909 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP Dipyrone promotes the reaction [Hydrochloric Acid results in increased expression of EGFR protein] CTD PMID:15309881 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Dipyrone inhibits the reaction [IL1B protein results in increased secretion of CRH protein] CTD PMID:11852909 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Dipyrone inhibits the reaction [IL6 protein results in increased secretion of CRH protein] CTD PMID:11852909 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases activity ISO Dipyrone analog results in decreased activity of PTGS1 protein; Dipyrone results in decreased activity of PTGS1 protein CTD PMID:12242329 PMID:16141368 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Tgfa transforming growth factor alpha multiple interactions EXP Dipyrone promotes the reaction [Hydrochloric Acid results in increased expression of TGFA protein] CTD PMID:15309881 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Dipyrone inhibits the reaction [TNF protein results in increased secretion of CRH protein] CTD PMID:11852909 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      molecular entity 19819
        ion 16059
          organic ion 9147
            organic anion 3056
              organosulfonate oxoanion 29
                metamizole(1-) 7
                  metamizole sodium 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    main group molecular entity 19716
                      p-block molecular entity 19716
                        chalcogen molecular entity 19469
                          oxygen molecular entity 19445
                            oxide 11762
                              oxoanion 8899
                                chalcogen oxoanion 540
                                  sulfur oxoanion 539
                                    sulfonate 29
                                      organosulfonate oxoanion 29
                                        metamizole(1-) 7
                                          metamizole sodium 7
paths to the root